β-cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion

Diabetes

Volumn 62, Issue 5, 2013, Pages 1527-1536

  Kaihara, Kelly A ^a   Dickson, Lorna M ^a   Jacobson, David A ^b   Tamarina, Natalia ^a   Roe, Michael W ^c   Philipson, Louis H ^a   Wicksteed, Barton ^a  

^a University of Chicago ^*  (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CYCLIC AMP DEPENDENT PROTEIN KINASE; EXENDIN 4; GLUCOSE; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; ENZYME ACTIVATION; EXOCYTOSIS; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; INSULIN RELEASE; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANIMALS; CROSSES, GENETIC; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INDUCTION; GLUCOSE CLAMP TECHNIQUE; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; KINETICS; MICE; MUTANT PROTEINS; PATCH-CLAMP TECHNIQUES; PEPTIDES; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN SUBUNITS; SECOND MESSENGER SYSTEMS; UP-REGULATION; VENOMS;

EID: 84876532885     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-1013     Document Type: Article

References (50)

1. Cerasi E, Luft R. The plasma insulin response to glucose infusion in healthy subjects and in diabetes mellitus. Acta Endocrinol (Copenh) 1967;55:278-304
2. Curry DL, Bennett LL, Grodsky GM. Dynamics of insulin secretion by the perfused rat pancreas. Endocrinology 1968;83:572-584
3. Marcelli-Tourvieille S, Hubert T, Pattou F, Vantyghem MC. Acute insulin response (AIR): review of protocols and clinical interest in islet transplantation. Diabetes Metab 2006;32:295-303 (Pubitemid 44410142)
4. Straub SG, Sharp GW. Glucose-stimulated signaling pathways in biphasic insulin secretion. Diabetes Metab Res Rev 2002;18:451-463 (Pubitemid 36041600)
5. Thiebaud D, Jacot E, DeFronzo RA, Maeder E, Jequier E, Felber JP. The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man. Diabetes 1982;31:957-963 (Pubitemid 12005566)
6. Bagdade JD, Bierman EL, Porte D Jr. The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. J Clin Invest 1967;46:1549-1557
7. Ferrannini E. The stunned beta cell: a brief history. Cell Metab 2010;11:349-352
8. Kahn SE, Prigeon RL, McCulloch DK, et al. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 1993;42:1663-1672 (Pubitemid 23318125)
9. Porte D Jr, Kahn SE. Beta-cell dysfunction and failure in type 2 diabetes: potential mechanisms. Diabetes 2001;50(Suppl 1):S160-S163
10. Nesher R, Anteby E, Yedovizky M, Warwar N, Kaiser N, Cerasi E. Beta-cell protein kinases and the dynamics of the insulin response to glucose. Diabetes 2002;51(Suppl 1):S68-S73 (Pubitemid 34761497)
11. Seino S, Shibasaki T. PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. Physiol Rev 2005;85:1303-1342 (Pubitemid 41362272)
12. Shibasaki T, Takahashi H, Miki T, et al. Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc Natl Acad Sci USA 2007;104:19333-19338
13. Renström E, Eliasson L, Rorsman P. Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells. J Physiol 1997;502:105-118 (Pubitemid 27322979)
14. Kang GX, Joseph JW, Chepurny OG, et al. Epac-selective cAMP analog 8-pCPT-2′-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells. J Biol Chem 2003;278:8279-8285 (Pubitemid 36800574)
15. Kashima Y, Miki T, Shibasaki T, et al. Critical role of cAMP-GEFII - Rim2 complex in incretin-potentiated insulin secretion. J Biol Chem 2001;276:46046-46053
16. Hatakeyama H, Kishimoto T, Nemoto T, Kasai H, Takahashi N. Rapid glucose sensing by protein kinase A for insulin exocytosis in mouse pancreatic islets. J Physiol 2006;570:271-282
17. Takahashi N, Kadowaki T, Yazaki Y, Ellis-Davies GC, Miyashita Y, Kasai H. Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic beta cells. Proc Natl Acad Sci USA 1999;96:760-765 (Pubitemid 29061282)
18. Niswender CM, Willis BS, Wallen A, et al. Cre recombinase-dependent expression of a constitutively active mutant allele of the catalytic subunit of protein kinase A. Genesis 2005;43:109-119 (Pubitemid 41780910)
19. Wicksteed B, Brissova M, Yan W, et al. Conditional gene targeting in mouse pancreatic β-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes 2010;59:3090-3098
20. Wicksteed B, Uchizono Y, Alarcon C, McCuaig JF, Shalev A, Rhodes CJ. A cis-element in the 5′ untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation. Cell Metab 2007;5:221-227 (Pubitemid 46335592)
21. Clegg CH, Correll LA, Cadd GG, McKnight GS. Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit. J Biol Chem 1987;262:13111-13119
22. Berglund ED, Li CY, Poffenberger G, et al. Glucose metabolism in vivo in four commonly used inbred mouse strains. Diabetes 2008;57:1790-1799
23. Rae J, Cooper K, Gates P, Watsky M. Low access resistance perforated patch recordings using amphotericin B. J Neurosci Methods 1991;37:15-26
24. Hemmings BA. cAMP mediated proteolysis of the catalytic subunit of cAMP-dependent protein kinase. FEBS Lett 1986;196:126-130 (Pubitemid 16048196)
25. Richardson JM, Howard P, Massa JS, Maurer RA. Post-transcriptional regulation of cAMP-dependent protein kinase activity by cAMP in GH3 pituitary tumor cells. Evidence for increased degradation of catalytic subunit in the presence of cAMP. J Biol Chem 1990;265:13635-13640
26. Malaisse WJ, Malaisse-Lagae F. The role of cyclic AMP in insulin release. Experientia 1984;40:1068-1074
27. Alarcon C, Wicksteed B, Rhodes CJ. Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level. Diabetologia 2006;49:2920-2929 (Pubitemid 44730295)
28. Saha PK, Kojima H, Martinez-Botas J, Sunehag AL, Chan L. Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice. J Biol Chem 2004;279:35150-35158 (Pubitemid 39100511)
29. Kim JH, Stewart TP, Soltani-Bejnood M, et al. Phenotypic characterization of polygenic type 2 diabetes in TALLYHO/JngJ mice. J Endocrinol 2006;191:437-446 (Pubitemid 44830619)
30. Pan W, Ciociola E, Saraf M, et al. Metabolic consequences of ENPP1 overexpression in adipose tissue. Am J Physiol Endocrinol Metab 2011;301:E901-E911
31. Hammond LE, Neschen S, Romanelli AJ, et al. Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs. J Biol Chem 2005;280:25629-25636 (Pubitemid 40962271)
32. Brunzell JD, Robertson RP, Lerner RL, et al. Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests. J Clin Endocrinol Metab 1976;42:222-229
33. Polonsky KS, Given BD, Hirsch LJ, et al. Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. N Engl J Med 1988;318:1231-1239
34. Fehse F, Trautmann M, Holst JJ, et al. Exenatide augments first- and second-phase insulin secretion in response to intravenous glucose in subjects with type 2 diabetes. J Clin Endocrinol Metab 2005;90:5991-5997 (Pubitemid 41606516)
35. Hill RS, Oberwetter JM, Boyd AE 3rd. Increase in cAMP levels in beta-cell line potentiates insulin secretion without altering cytosolic free-calcium concentration. Diabetes 1987;36:440-446 (Pubitemid 18023186)
36. Dov A, Abramovitch E, Warwar N, Nesher R. Diminished phosphodiesterase-8B potentiates biphasic insulin response to glucose. Endocrinology 2008;149:741-748 (Pubitemid 351159343)
37. Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000;351:95-105
38. Poppe H, Rybalkin SD, Rehmann H, et al. Cyclic nucleotide analogs as probes of signaling pathways. Nat Methods 2008;5:277-278 (Pubitemid 351455143)
39. Gloerich M, Bos JL. Epac: defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol 2010;50:355-375
40. Song WJ, Seshadri M, Ashraf U, et al. Snapin mediates incretin action and augments glucose-dependent insulin secretion. Cell Metab 2011;13:308-319
41. Zhang C-L, Katoh M, Shibasaki T, et al. The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. Science 2009;325:607-610
42. Nagy G, Reim K, Matti U, et al. Regulation of releasable vesicle pool sizes by protein kinase A-dependent phosphorylation of SNAP-25. Neuron 2004;41:417-429 (Pubitemid 38228352)
43. Vikman J, Svensson H, Huang YC, et al. Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells. Am J Physiol Endocrinol Metab 2009;297:E452-E461
44. Baba T, Sakisaka T, Mochida S, Takai Y. PKA-catalyzed phosphorylation of tomosyn and its implication in Ca2+-dependent exocytosis of neurotransmitter. J Cell Biol 2005;170:1113-1125 (Pubitemid 41362643)
45. Zhang W, Lilja L, Mandic SA, et al. Tomosyn is expressed in beta-cells and negatively regulates insulin exocytosis. Diabetes 2006;55:574-581 (Pubitemid 43343212)
46. Bhatnagar S, Oler AT, Rabaglia ME, et al. Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion. PLoS Genet 2011;7:e1002323
47. Foster LJ, Yeung B, Mohtashami M, Ross K, Trimble WS, Klip A. Binary interactions of the SNARE proteins syntaxin-4, SNAP23, and VAMP-2 and their regulation by phosphorylation. Biochemistry 1998;37:11089-11096 (Pubitemid 28368936)
48. Brown H, Larsson O, Bränström R, et al. Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis. EMBO J 1998;17:5048-5058 (Pubitemid 28408470)
49. Zhang H, Kelley WL, Chamberlain LH, Burgoyne RD, Wollheim CB, Lang J. Cysteine-string proteins regulate exocytosis of insulin independent from transmembrane ion fluxes. FEBS Lett 1998;437:267-272 (Pubitemid 28511172)
50. Evans GJ, Morgan A. Regulation of the exocytotic machinery by cAMP-dependent protein kinase: implications for presynaptic plasticity. Biochem Soc Trans 2003;31:824-827 (Pubitemid 36981136)