Cocoa-rich diet attenuates beta cell mass loss and function in young Zucker diabetic fatty rats by preventing oxidative stress and beta cell apoptosis

Molecular Nutrition and Food Research

Volumn 59, Issue 4, 2015, Pages 820-824

  Fernández Millán, Elisa ^a   Cordero Herrera, Isabel ^b   Ramos, Sonia ^b   Escrivá, Fernando ^a,c   Alvarez, Carmen ^a,c   Goya, Luis ^b   Martín, María Angeles ^a,b  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b INSTITUTE OF FOOD SCIENCE   (Spain)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Apoptotic pathway; Glucose homeostasis; Glutathione enzymes; Pancreas; Type 2 diabetes mellitus

Indexed keywords

ANIMALIA; RATTUS; THEOBROMA CACAO;

ANTIOXIDANT; BAX PROTEIN, RAT; BCL2L1 PROTEIN, RAT; CASP3 PROTEIN, RAT; CASPASE 3; GLUTATHIONE PEROXIDASE; PLANT EXTRACT; POLYPHENOL; PROTEIN BAX; PROTEIN BCL X;

ANIMAL; APOPTOSIS; CACAO; CHEMISTRY; DIABETES MELLITUS, EXPERIMENTAL; DIET; DRUG EFFECTS; GENETICS; HYPERGLYCEMIA; MALE; METABOLISM; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; RAT; ZUCKER RAT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CACAO; CASPASE 3; DIABETES MELLITUS, EXPERIMENTAL; DIET; GLUTATHIONE PEROXIDASE; HYPERGLYCEMIA; INSULIN-SECRETING CELLS; MALE; OXIDATIVE STRESS; PLANT EXTRACTS; POLYPHENOLS; RATS; RATS, ZUCKER;

EID: 84925955052     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201400746     Document Type: Article

References (23)

1. Chaturvedi, N. The burden of diabetes and its complications: trends and implications for intervention. Diabetes Res. Clin. Pract. 2007, 76, S3-S12.
2. Guillausseau, P. J. Meas, T. Virally, M. Laloi-Michelin, M. et al. Abnormalities in insulin secretion in type 2 diabetes mellitus. Diabetes Metab. 2008, 34, S43-S48.
3. Bensellam, M. Laybutt, D. R. Jonas, J. C. The molecular mechanisms of pancreatic b-cell glucotoxicity: recent findings and future research directions. Mol. Cell Endocrinol. 2012, 364, 1-27.
4. Robertson, R. P. Antioxidant drugs for treating beta-cell oxidative stress in type 2 diabetes: glucose-centric versus insulin-centric. Ther. Discov. Med. 2010, 9, 132-137.
5. Del Rio, D. Rodriguez-Mateos, A. Spencer, J. P. E. Tognolini, M. et al. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid. Redox Signal. 2013, 18, 1818-1892.
6. Ali, F. Ismail, A. Kersten, S. Molecular mechanisms underlying the potential antiobesity-related diseases effect of cocoa polyphenols. Mol. Nutr. Food Res. 2014, 58, 33-48.
7. Gu, Y. Lambert, J. D. Modulation of metabolic syndrome-related inflammation by cocoa. Mol. Nutr. Food Res. 2013, 57, 948-61.
8. Dorenkott, M. R. Griffin, L. E. Goodrich, K. M. Thompson-Witrick, K. A. et al. Oligomeric cocoa procyanidins possess enhanced bioactivity compared to monomeric and polymeric cocoa procyanidins for preventing the development of obesity, insulin resistance, and impaired glucose tolerance during high-fat feeding. J. Agric. Food Chem. 2014, 62, 2216-2227.
9. Jalil, A. M. M. Ismail, A. Pei, C. P. Hamid, M. et al. Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obese-diabetic (Ob-db) rats. J. Agric. Food Chem. 2008, 56, 7877-7884.
10. Yamashita, Y. Okabe, M. Natsume, M. Ashida, H. Prevention mechanisms of glucose intolerance and obesity by cacao liquor procyanidin extract in high-fat diet-fed C57BL/6 mice. Arch. Biochem. Biophys. 2012, 527, 95-104
11. Grassi, D. Desideri, G. Necozione, S. Lippi, C. et al. Blood pressure is reduced and insulin sensitivity increased in glucose-intolerant, hypertensive subjects after 15 days of consuming high-polyphenol dark chocolate. J. Nutr. 2008, 138, 1671-1676.
12. Mellor, D. D. Sathyapalan, T. Kilpatrick, E. S. Beckett, S. et al. High-cocoa polyphenol-rich chocolate improves HDL cholesterol in Type 2 diabetes patients. Diabet. Med. 2010, 27, 1318-1321.
13. Fernández-Millán, E. Ramos, S. Alvarez, C. Bravo, L. et al. Microbial phenolic metabolites improve glucose-stimulated insulin secretion and protect pancreatic beta cells against tert-butyl hydroperoxide-induced toxicity via ERKs and PKC pathways. Food Chem. Toxicol. 2014, 66, 245-253.
14. Martín, M. A. Fernández-Millán, E. Ramos, S. Bravo, L. et al. Cocoa flavonoid epicatechin protects pancreatic beta cell viability and function against oxidative stress. Mol. Nutr. Food Res. 2014, 58, 447-456.
15. Etgen, G. J. Oldham, B. A. Profiling of Zucker diabetic fatty rats in their progression to the overt diabetic state. Metabolism 2000, 49, 684-688.
16. Rodríguez-Ramiro, I. Ramos, S. López-Oliva, E. Agis-Torres, A. et al. Cocoa-rich diet prevents azoxymethane-induced colonic preneoplastic lesions in rats by restraining oxidative stress and cell proliferation and inducing apoptosis. Mol. Nutr. Food Res. 2011, 55, 1895-1989.
17. Granado Serrano, A. B. Martín, M. A. Bravo, L. Goya, L. et al. A diet rich in cocoa attenuates N-nitrosodiethylamine-induced liver injury in rats. Food Chem. Toxicol. 2009, 47, 2499-2506.
18. Fu, Z. Yuskavage, J. Liu, D. Dietary flavonol epicatechin prevents the onset of type 1 diabetes in nonobese diabetic mice. J. Agric. Food Chem. 2013, 61, 4303-4309.
19. Drews, G. Krippeit-Drews, P. Düfer, M. Oxidative stress and beta-cell dysfunction. Pflugers Arch. 2010, 460, 703-718.
20. Rodriguez-Ramiro, I. Ramos, S. Bravo, L. Goya, L. et al. Procyanidin B2 and a cocoa polyphenolic extract inhibit acrylamide-induced apoptosis in human Caco-2 cells by preventing oxidative stress and activation of JNK pathway. J. Nutr. Biochem. 2011, 221, 86-194.
21. Mathijs, I. Da Cunha, D. A. Himpe, E. Ladriere, L. et al. Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high-fat diet-fed mice and protects beta cells from ER stress-induced apoptosis. Mol. Nutr. Food Res. 2014, 58, 1980-1990.
22. Harmon, J. S. Bogdani, M. Parazzoli, S. D. Mak, S. S. et al. β-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice. Endocrinology 2009, 150, 4855-4862.
23. Mahadevan, J. Parazzoli, S. Oseid, E. Hertzel, A. V. et al. Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats. Diabetes 2013, 62, 3582-3588.