Transient oxidative stress damages mitochondrial machinery inducing persistent β-cell dysfunction

Journal of Biological Chemistry

Volumn 284, Issue 35, 2009, Pages 23602-23612

  Li, Ning ^a   Brun, Thierry ^a   Cnop, Miriam ^b   Cunha, Daniel A ^b   Eizirik, Decio L ^b   Maechler, Pierre ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b ERASME HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ATP GENERATION; CELL DYSFUNCTION; DOWN-REGULATION; GLUCOSE METABOLISM; INSULIN SECRETING CELLS; INSULIN SECRETION; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL RESPIRATION; OXYGEN CONSUMPTION; RAT ISLETS; REACTIVE OXYGEN SPECIES; RESPIRATORY CHAINS; TRANSIENT EXPOSURE; UP-REGULATION;

CELL MEMBRANES; GLUCOSE; INSULIN; MACHINERY; OXIDATIVE STRESS; OXYGEN; PHYSIOLOGY;

CYTOLOGY;

ADENOSINE TRIPHOSPHATE; GLUCOSE; INSULIN; MITOCHONDRIAL TRANSCRIPTION FACTOR A PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL STRESS; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; INSULIN RELEASE; MITOCHONDRIAL DNA DISORDER; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN; UPREGULATION;

ANIMALS; CELL LINE, TUMOR; GENE EXPRESSION; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; MITOCHONDRIA; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES;

RATTUS;

EID: 69949132408     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.024323     Document Type: Article

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