Calcium/calmodulin-dependent kinase IV controls glucose-induced Irs2 expression in mouse beta cells via activation of cAMP response element-binding protein

Diabetologia

Volumn 54, Issue 5, 2011, Pages 1109-1120

  Persaud, S J ^a   Liu, B ^a   Sampaio, H Barbosa ^a   Jones, P M ^a   Muller, D S ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Beta cell; CaMKIV; CREB; Irs2

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE IV; CALCIUM ION; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOSE; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; NIFEDIPINE; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SYNTHESIS; EXPRESSION VECTOR; GENE SILENCING; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 4; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GLUCOSE; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-SECRETING CELLS; MICE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 79954633239     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2050-7     Document Type: Article

References (49)

1. SE Kahn 2001 Beta cell failure: causes and consequences Int J Clin Pract 123 13 18
2. AE Butler J Janson S Bonner-Weir R Ritzel RA Rizza PC Butler 2003 Beta cell deficit and increased beta cell apoptosis in humans with type 2 diabetes Diabetes 52 102 110 12502499 10.2337/diabetes.52.1.102 1:CAS:528: DC%2BD3sXisVaisA%3D%3D (Pubitemid 36042113)
3. S Deng M Vatamaniuk X Huang, et al. 2004 Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects Diabetes 53 624 632 14988246 10.2337/diabetes.53.3.624 1:CAS:528:DC%2BD2cXhvFelu78%3D (Pubitemid 38270631)
4. DM Muoio CB Newgard 2008 Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta cell failure in type 2 diabetes Nat Rev Mol Cell Biol 9 193 205 18200017 10.1038/nrm2327 1:CAS:528: DC%2BD1cXitlGnurg%3D (Pubitemid 351301824)
5. SE Kahn DB Carr MV Faulenbach KM Utzschneider 2008 An examination of beta cell function measures and their potential use for estimating beta cell mass Diabetes Obes Metab 4 63 76 10.1111/j.1463-1326.2008.00945.x
6. JL Chiasson R Rabasa-Lhoret 2004 Prevention of type 2 diabetes: insulin resistance and beta cell function Diabetes 53 S34 S38 15561919 10.2337/diabetes.53.suppl-3.S34 1:CAS:528:DC%2BD2cXhtVOls7zE (Pubitemid 39564520)
7. KS Polonsky 2000 Dynamics of insulin secretion in obesity and diabetes Int J Obes Relat Metab Disord 2 S29 S31 (Pubitemid 30461943)
8. Buchanan 2001 Pancreatic B-cell defects in gestational diabetes: implications for the pathogenesis and prevention of type 2 diabetes J Clin Endocrinol Metab 86 989 993 11238474 10.1210/jc.86.3.989 1:CAS:528: DC%2BD3MXitFWns7s%3D (Pubitemid 32322970)
9. AE Butler J Janson WC Soeller PC Butler 2003 Increased beta cell apoptosis prevents adaptive increase in beta cell mass in mouse model of type 2 diabetes: evidence for role of islet amyloid formation rather than direct action of amyloid Diabetes 52 2304 2314 12941770 10.2337/diabetes.52.9.2304 1:CAS:528:DC%2BD3sXntFeqtbY%3D (Pubitemid 37059501)
10. RL Hull K Kodama KM Utzschneider DB Carr RL Prigeon SE Kahn 2005 Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation Diabetologia 48 1350 1358 15937671 10.1007/s00125-005-1772-9 1:CAS:528:DC%2BD2MXmtlCktLw%3D (Pubitemid 41186101)
11. JA Parsons TC Brelje RL Sorenson 1992 Adaptation of islets of Langerhans to pregnancy: increased islet cell proliferation and insulin secretion correlates with the onset of placental lactogen secretion Endocrinology 130 1459 1466 1537300 10.1210/en.130.3.1459 1:CAS:528:DyaK38XhvVygt74%3D
12. S Bonner-Weir D Deery JL Leahy GC Weir 1989 Compensatory growth of pancreatic beta cells in adult rats after short-term glucose infusion Diabetes 38 49 53 2642434 10.2337/diabetes.38.1.49 1:CAS:528:DyaL1MXhslSrsbo%3D (Pubitemid 19021816)
13. M Paris C Bernard-Kargar MF Berthault L Bouwens A Ktorza 2003 Specific and combined effects of insulin and glucose on functional pancreatic beta cell mass in vivo in adult rats Endocrinology 144 2717 2727 12746336 10.1210/en.2002-221112 1:CAS:528:DC%2BD3sXktFegsLw%3D (Pubitemid 36629925)
14. GM Teil N Trivedi JC Jonas, et al. 2001 Adaptation of beta cell mass to substrate oversupply: enhanced function with normal gene expression Am J Physiol Endocrinol Metab 280 E788 E796
15. D Muller PM Jones SJ Persaud 2006 Autocrine anti-apoptotic and proliferative effects of insulin in pancreatic beta cells FEBS Lett 580 6977 6980 17161395 10.1016/j.febslet.2006.11.066 1:CAS:528:DC%2BD28Xhtleitr7K (Pubitemid 44909144)
16. R Aikin S Hanley D Maysinger, et al. 2006 Autocrine insulin action activates Akt and increases survival of isolated human islets Diabetologia 49 2900 2909 17053882 10.1007/s00125-006-0476-0 1:CAS:528:DC%2BD28XhtFylt7fN (Pubitemid 44730293)
17. I Amacker-Francoys S Mohanty M Niessen GA Spinas T Trub 2005 The metabolisable hexoses d-glucose and d-mannose enhance the expression of IRS-2 but not of IRS-1 in pancreatic beta cells Exp Clin Endocrinol Diabetes 113 423 429 16151975 10.1055/s-2005-865803 1:CAS:528:DC%2BD2MXhtVKnsbzE (Pubitemid 41360747)
18. MK Lingohr I Briaud LM Dickson, et al. 2006 Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta cells J Biol Chem 281 15884 15892 16574657 10.1074/jbc.M600356200 1:CAS:528:DC%2BD28Xlt1Cktb0%3D (Pubitemid 43848480)
19. N Kubota K Tobe Y Terauchi, et al. 2000 Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta cell hyperplasia Diabetes 49 1880 1889 11078455 10.2337/diabetes.49.11.1880 1:CAS:528:DC%2BD3cXnvVOmt7g%3D
20. DJ Withers JS Gutierrez H Towery, et al. 1998 Disruption of IRS-2 causes type 2 diabetes in mice Nature 391 900 904 9495343 10.1038/36116 1:CAS:528:DyaK1cXhsFyksr0%3D (Pubitemid 28157668)
21. AM Hennige DJ Burks U Ozcan, et al. 2003 Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes J Clin Invest 112 1521 1532 14617753 1:CAS:528:DC%2BD3sXptFWqtL4%3D (Pubitemid 38056278)
22. S Park X Dong TL Fisher, et al. 2006 Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function J Biol Chem 281 1159 1168 16272563 10.1074/jbc.M508307200 1:CAS:528:DC%2BD28Xit1SjsA%3D%3D
23. L Redmond AH Kashani A Ghosh 2002 Calcium regulation of dendritic growth via CaM kinase IV and CREB-mediated transcription Neuron 34 999 1010 12086646 10.1016/S0896-6273(02)00737-7 1:CAS:528:DC%2BD38XltVygu7o%3D (Pubitemid 34722288)
24. X Yu K Murao Y Sayo, et al. 2004 The role of calcium/calmodulin-dependent protein kinase cascade in glucose upregulation of insulin gene expression Diabetes 53 1475 1481 15161751 10.2337/diabetes.53.6.1475 1:CAS:528: DC%2BD2cXkslCgs74%3D (Pubitemid 38697659)
25. N Ban Y Yamada Y Someya, et al. 2000 Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression Diabetes 49 1142 1148 10909971 10.2337/diabetes.49.7.1142 1:CAS:528: DC%2BD3cXkslOqtrs%3D (Pubitemid 30439088)
26. US Jhala G Canettieri RA Screaton, et al. 2003 cAMP promotes pancreatic beta cell survival via CREB-mediated induction of IRS2 Genes Dev 17 1575 1580 12842910 10.1101/gad.1097103 1:CAS:528:DC%2BD3sXlsV2rurc%3D (Pubitemid 36828785)
27. A King J Lock G Xu S Bonner-Weir GC Weir 2005 Islet transplantation outcomes in mice are better with fresh islets and exendin-4 treatment Diabetologia 48 2074 2079 16132945 10.1007/s00125-005-1922-0 1:CAS:528:DC%2BD2MXhtVyltb%2FP (Pubitemid 41416919)
28. A Papadimitriou AJ King PM Jones SJ Persaud 2007 Anti-apoptotic effects of arachidonic acid and prostaglandin E2 in pancreatic beta cells Cell Physiol Biochem 20 607 616 17762187 10.1159/000107544 1:CAS:528:DC%2BD2sXps1SgtL8%3D (Pubitemid 47340621)
29. Muller DS, Jones PM, Persaud SJ (2007) Expression of a potent anti-apoptotic protein in MIN6 b-cells using METAFECTENE PRO. Available from www.biontex.com/con-4-6-4/cms/upload/pdf/Muller-MP-en.pdf . Accessed 4 January 2011
30. D Muller GC Huang S Amiel PM Jones SJ Persaud 2006 Identification of insulin signaling elements in human beta cells: autocrine regulation of insulin gene expression Diabetes 55 2835 2842 17003350 10.2337/db06-0532 1:CAS:528:DC%2BD28XhtVGlsrfO (Pubitemid 44923684)
31. 2+/calmodulin- dependent protein kinases type I, II, and IV J Biol Chem 271 3066 3073 8621702 10.1074/jbc.271.6.3066 1:CAS:528:DyaK28XhtVWqurc%3D (Pubitemid 26060524)
32. PD Murray TJ Kingsbury BK Krueger 2009 Failure of Ca(2+)-activated, CREB-dependent transcription in astrocytes Glia 57 828 834 19031446 10.1002/glia.20809
33. 2+/calmodulin- dependent protein kinase type IV/Gr-deficient mice J Neurosci 20 6459 6472 10964952 1:CAS:528:DC%2BD3cXmsVyhu7s%3D
34. 2+/ calmodulin-dependent protein kinases II and IV both promote survival but differ in their effects on axon growth in spiral ganglion neurons J Neurosci Res 72 169 184 12671991 10.1002/jnr.10551 1:CAS:528:DC%2BD3sXivFWku7c%3D (Pubitemid 36389883)
35. S Yano H Tokumitsu TR Soderling 1998 Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway Nature 396 584 587 9859994 10.1038/25147 1:CAS:528:DyaK1cXotVWnsLo%3D (Pubitemid 28563720)
36. V Sée AL Boutillier H Bito JP Loeffler 2001 Calcium/calmodulin- dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons FASEB J 15 134 144 11149901 10.1096/fj.00-0106com (Pubitemid 32061664)
37. K Deisseroth EK Heist RW Tsien 1998 Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons Nature 392 198 202 9515967 10.1038/32448 1:CAS:528:DyaK1cXhvFeks70%3D (Pubitemid 28162795)
38. D Jansson ACH Ng A Fu C Depatie M Al Azzabi RA Screaton 2008 Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2 Proc Natl Acad Sci U S A 105 10161 10166 18626018 10.1073/pnas.0800796105
39. K Pechhold K Koczwara X Zhu, et al. 2009 Blood glucose levels regulate pancreatic beta cell proliferation during experimentally-induced and spontaneous autoimmune diabetes in mice PLos ONE 4 e4827 19287497 10.1371/journal.pone. 0004827
40. S Bonner-Weir 1994 Regulation of pancreatic beta cell mass in vivo Recent Prog Horm Res 49 91 104 8146438 1:CAS:528:DyaK2cXktVWjsr4%3D (Pubitemid 24976622)
41. A Hoorens CM Van de G Kloppel D Pipeleers 1996 Glucose promotes survival of rat pancreatic beta cells by activating synthesis of proteins which suppress a constitutive apoptotic program J Clin Invest 98 1568 1574 8833905 10.1172/JCI118950 1:CAS:528:DyaK28XmtVCmu7g%3D (Pubitemid 26327866)
42. 2+/calmodulin-dependent protein kinase IV: role in transcriptional regulation J Biol Chem 269 15520 15527 8195196 1:CAS:528:DyaK2cXksFWgt7k%3D
43. 2+ and cAMP signalling in the insulin-secreting MIN6 β-cell line J Biol Chem 280 31294 31302 15987680 10.1074/jbc.M505657200 1:CAS:528:DC%2BD2MXpsVCmu7k%3D (Pubitemid 41291867)
44. H Ishihara T Asano K Tsukuda, et al. 1993 Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets Diabetologia 36 1139 1145 8270128 10.1007/BF00401058 1:CAS:528:DyaK2cXhvVenu78%3D (Pubitemid 23314564)
45. MS Arrázola L Varela-Nallar M Colombres, et al. 2009 Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway J Cell Physiol 221 658 667 19711354 10.1002/jcp.21902
46. T Jin L Liu 2008 The Wnt signalling pathway effector TCF7L2 and type 2 diabetes mellitus Mol Endocrinol 22 2383 2392 18599616 10.1210/me.2008-0135 1:CAS:528:DC%2BD1cXhtleitbjE
47. T Jin 2008 The Wnt signalling pathway and diabetes mellitus Diabetologia 51 1771 1780 18696049 10.1007/s00125-008-1084-y 1:CAS:528:DC%2BD1cXhtVOnurzF
48. Z Liu JF Habener 2008 Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation J Biol Chem 283 8723 8735 18216022 10.1074/jbc.M706105200 1:CAS:528: DC%2BD1cXjsFCgt7o%3D
49. MK Loder XG da Silva A McDonald GA Rutter 2008 TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic beta cells Biochem Soc Trans 36 357 359 18481957 10.1042/BST0360357 1:CAS:528:DC%2BD1cXmtVKlsLk%3D (Pubitemid 351839331)