-
1
-
-
84959055157
-
History and practice: Antibodies in infectious diseases
-
Hey, A. History and practice: antibodies in infectious diseases. Microbiol. Spectr. http://dx. doi. org/10. 1128/microbiolspec. AID-0026-2014 (2015).
-
(2015)
Microbiol. Spectr.
-
-
Hey, A.1
-
2
-
-
84928571820
-
History of passive antibody administration for prevention and treatment of infectious diseases
-
Graham, B. S. & Ambrosino, D. M. History of passive antibody administration for prevention and treatment of infectious diseases. Curr. Opin. HIV AIDS 10, 129-134 (2015).
-
(2015)
Curr. Opin. HIV AIDS
, vol.10
, pp. 129-134
-
-
Graham, B.S.1
Ambrosino, D.M.2
-
3
-
-
85014635920
-
Therapeutic antibodies for infectious diseases
-
Sparrow, E., Friede, M., Sheikh, M. & Torvaldsen, S. Therapeutic antibodies for infectious diseases. Bull. World Health Organ. 95, 235-237 (2017).
-
(2017)
Bull. World Health Organ.
, vol.95
, pp. 235-237
-
-
Sparrow, E.1
Friede, M.2
Sheikh, M.3
Torvaldsen, S.4
-
4
-
-
80052790031
-
Antibodies in infectious diseases: Polyclonals, monoclonals and niche biotechnology
-
Berry, J. D. & Gaudet, R. G. Antibodies in infectious diseases: polyclonals, monoclonals and niche biotechnology. N. Biotechnol. 28, 489-501 (2011).
-
(2011)
N. Biotechnol.
, vol.28
, pp. 489-501
-
-
Berry, J.D.1
Gaudet, R.G.2
-
5
-
-
72049112028
-
Monoclonal antibody-based therapies for microbial diseases
-
Saylor, C., Dadachova, E. & Casadevall, A. Monoclonal antibody-based therapies for microbial diseases. Vaccine 27 (Suppl. 6), G38-G46 (2009).
-
(2009)
Vaccine
, vol.27
, pp. G38-G46
-
-
Saylor, C.1
Dadachova, E.2
Casadevall, A.3
-
6
-
-
84866679186
-
Tools to therapeutically harness the human antibody response
-
Wilson, P. C. & Andrews, S. F. Tools to therapeutically harness the human antibody response. Nat. Rev. Immunol. 12, 709-719 (2012).
-
(2012)
Nat. Rev. Immunol.
, vol.12
, pp. 709-719
-
-
Wilson, P.C.1
Andrews, S.F.2
-
7
-
-
85030671126
-
What are the most powerful immunogen design vaccine strategies? Reverse vaccinology 2. 0 shows great promise
-
Burton, D. R. What are the most powerful immunogen design vaccine strategies? Reverse vaccinology 2. 0 shows great promise. Cold Spring Harb. Perspect. Biol. 9, a030262 (2017).
-
(2017)
Cold Spring Harb. Perspect. Biol.
, vol.9
, pp. a030262
-
-
Burton, D.R.1
-
8
-
-
84890290033
-
Cross-neutralizing human anti-poliovirus antibodies bind the recognition site for cellular receptor
-
Chen, Z. et al. Cross-neutralizing human anti-poliovirus antibodies bind the recognition site for cellular receptor. Proc. Natl Acad. Sci. USA 110, 20242-20247 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 20242-20247
-
-
Chen, Z.1
-
9
-
-
84943167225
-
Isolation and characterization of broad and ultrapotent human monoclonal antibodies with therapeutic activity against Chikungunya virus
-
Smith, S. A. et al. Isolation and characterization of broad and ultrapotent human monoclonal antibodies with therapeutic activity against Chikungunya virus. Cell Host Microbe 18, 86-95 (2015).
-
(2015)
Cell Host Microbe
, vol.18
, pp. 86-95
-
-
Smith, S.A.1
-
10
-
-
84871978126
-
Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein
-
Tahara, M. et al. Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein. J. Virol. 87, 666-675 (2013).
-
(2013)
J. Virol.
, vol.87
, pp. 666-675
-
-
Tahara, M.1
-
11
-
-
85014096226
-
Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors
-
Gilman, M. S. et al. Rapid profiling of RSV antibody repertoires from the memory B cells of naturally infected adult donors. Sci. Immunol. 1, eaaj1879 (2016).
-
(2016)
Sci. Immunol.
, vol.1
, pp. eaaj1879
-
-
Gilman, M.S.1
-
12
-
-
84884413000
-
Cross-neutralization of four paramyxoviruses by a human monoclonal antibody
-
Corti, D. et al. Cross-neutralization of four paramyxoviruses by a human monoclonal antibody. Nature 501, 439-443 (2013).
-
(2013)
Nature
, vol.501
, pp. 439-443
-
-
Corti, D.1
-
13
-
-
73849089855
-
Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128?131A complex
-
Macagno, A. et al. Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128?131A complex. J. Virol. 84, 1005-1013 (2010).
-
(2010)
J. Virol.
, vol.84
, pp. 1005-1013
-
-
Macagno, A.1
-
14
-
-
84978910758
-
Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection
-
Stettler, K. et al. Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection. Science 353, 823-826 (2016).
-
(2016)
Science
, vol.353
, pp. 823-826
-
-
Stettler, K.1
-
15
-
-
84948964373
-
Arenavirus glycan shield promotes neutralizing antibody evasion and protracted infection
-
Sommerstein, R. et al. Arenavirus glycan shield promotes neutralizing antibody evasion and protracted infection. PLoS Pathog. 11, e1005276 (2015).
-
(2015)
PLoS Pathog.
, vol.11
, pp. e1005276
-
-
Sommerstein, R.1
-
16
-
-
58149487645
-
Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection
-
Sather, D. N. et al. Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection. J. Virol. 83, 757-769 (2009).
-
(2009)
J. Virol.
, vol.83
, pp. 757-769
-
-
Sather, D.N.1
-
17
-
-
79955389756
-
The neutralization breadth of HIV?1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection
-
Gray, E. S. et al. The neutralization breadth of HIV?1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection. J. Virol. 85, 4828-4840 (2011).
-
(2011)
J. Virol.
, vol.85
, pp. 4828-4840
-
-
Gray, E.S.1
-
18
-
-
73949084963
-
Breadth of human immunodeficiency virus-specific neutralizing activity in sera: Clustering analysis and association with clinical variables
-
Doria-Rose, N. A. et al. Breadth of human immunodeficiency virus-specific neutralizing activity in sera: clustering analysis and association with clinical variables. J. Virol. 84, 1631-1636 (2010).
-
(2010)
J. Virol.
, vol.84
, pp. 1631-1636
-
-
Doria-Rose, N.A.1
-
19
-
-
67650453747
-
Human immunodeficiency virus type 1 elite neutralizers: Individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm
-
Simek, M. D. et al. Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm. J. Virol. 83, 7337-7348 (2009).
-
(2009)
J. Virol.
, vol.83
, pp. 7337-7348
-
-
Simek, M.D.1
-
20
-
-
0021839608
-
Endemic Lassa fever in Liberia IV Selection of optimally effective plasma for treatment by passive immunization
-
Jahrling, P. B., Frame, J. D., Rhoderick, J. B. & Monson, M. H. Endemic Lassa fever in Liberia. IV. Selection of optimally effective plasma for treatment by passive immunization. Trans. R. Soc. Trop. Med. Hyg. 79, 380-384 (1985).
-
(1985)
Trans. R. Soc. Trop. Med. Hyg.
, vol.79
, pp. 380-384
-
-
Jahrling, P.B.1
Frame, J.D.2
Rhoderick, J.B.3
Monson, M.H.4
-
21
-
-
84954245342
-
Immune history profoundly affects broadly protective B cell responses to influenza
-
Andrews, S. F. et al. Immune history profoundly affects broadly protective B cell responses to influenza. Sci. Transl Med. 7, 316ra192 (2015).
-
(2015)
Sci. Transl Med.
, vol.7
, pp. 316ra192
-
-
Andrews, S.F.1
-
22
-
-
84866495323
-
Human antibodies that neutralize HIV?1: Identification, structures, and B cell ontogenies
-
Kwong, P. D. & Mascola, J. R. Human antibodies that neutralize HIV?1: identification, structures, and B cell ontogenies. Immunity 37, 412-425 (2012).
-
(2012)
Immunity
, vol.37
, pp. 412-425
-
-
Kwong, P.D.1
Mascola, J.R.2
-
23
-
-
84929896699
-
Antibody responses to envelope glycoproteins in HIV?1 infection
-
Burton, D. R. & Mascola, J. R. Antibody responses to envelope glycoproteins in HIV?1 infection. Nat. Immunol. 16, 571-576 (2015).
-
(2015)
Nat. Immunol.
, vol.16
, pp. 571-576
-
-
Burton, D.R.1
Mascola, J.R.2
-
24
-
-
84883187027
-
Broadly neutralizing antibodies and the search for an HIV?1 vaccine: The end of the beginning
-
Kwong, P. D., Mascola, J. R. & Nabel, G. J. Broadly neutralizing antibodies and the search for an HIV?1 vaccine: the end of the beginning. Nat. Rev. Immunol. 13, 693-701 (2013).
-
(2013)
Nat. Rev. Immunol.
, vol.13
, pp. 693-701
-
-
Kwong, P.D.1
Mascola, J.R.2
Nabel, G.J.3
-
25
-
-
84969835812
-
Broadly neutralizing antibodies to HIV and their role in vaccine design
-
Burton, D. R. & Hangartner, L. Broadly neutralizing antibodies to HIV and their role in vaccine design. Annu. Rev. Immunol. 34, 635-659 (2016).
-
(2016)
Annu. Rev. Immunol.
, vol.34
, pp. 635-659
-
-
Burton, D.R.1
Hangartner, L.2
-
26
-
-
84894173514
-
Structural insights on the role of antibodies in HIV?1 vaccine and therapy
-
West, A. P. Jr et al. Structural insights on the role of antibodies in HIV?1 vaccine and therapy. Cell 156, 633-648 (2014).
-
(2014)
Cell
, vol.156
, pp. 633-648
-
-
West, A.P.1
-
27
-
-
84875551472
-
Broadly neutralizing antiviral antibodies
-
Corti, D. & Lanzavecchia, A. Broadly neutralizing antiviral antibodies. Annu. Rev. Immunol. 31, 705-742 (2013).
-
(2013)
Annu. Rev. Immunol.
, vol.31
, pp. 705-742
-
-
Corti, D.1
Lanzavecchia, A.2
-
28
-
-
84884238986
-
Immune history shapes specificity of pandemic H1N1 influenza antibody responses
-
Li, Y. et al. Immune history shapes specificity of pandemic H1N1 influenza antibody responses. J. Exp. Med. 210, 1493-1500 (2013).
-
(2013)
J. Exp. Med.
, vol.210
, pp. 1493-1500
-
-
Li, Y.1
-
29
-
-
84861872090
-
Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells
-
Li, G. M. et al. Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells. Proc. Natl Acad. Sci. USA 109, 9047-9052 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 9047-9052
-
-
Li, G.M.1
-
30
-
-
84979581546
-
Vaccine-induced antibodies that neutralize group 1 and group 2 influenza A viruses
-
Joyce, M. G. et al. Vaccine-induced antibodies that neutralize group 1 and group 2 influenza A viruses. Cell 166, 609-623 (2016).
-
(2016)
Cell
, vol.166
, pp. 609-623
-
-
Joyce, M.G.1
-
31
-
-
85054983006
-
Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans
-
Andrews, S. F. et al. Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans. Sci. Immunol. 2, eaan2676 (2017).
-
(2017)
Sci. Immunol.
, vol.2
, pp. eaan2676
-
-
Andrews, S.F.1
-
32
-
-
47049107589
-
Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor
-
Lee, J. E. et al. Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor. Nature 454, 177-182 (2008).
-
(2008)
Nature
, vol.454
, pp. 177-182
-
-
Lee, J.E.1
-
33
-
-
84863774072
-
Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses
-
Burton, D. R., Poignard, P., Stanfield, R. L. & Wilson, I. A. Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses. Science 337, 183-186 (2012).
-
(2012)
Science
, vol.337
, pp. 183-186
-
-
Burton, D.R.1
Poignard, P.2
Stanfield, R.L.3
Wilson, I.A.4
-
34
-
-
0030885594
-
A vaccine for HIV type 1: The antibody perspective
-
Burton, D. R. A vaccine for HIV type 1: the antibody perspective. Proc. Natl Acad. Sci. USA 94, 10018-10023 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 10018-10023
-
-
Burton, D.R.1
-
35
-
-
34948854718
-
Broad HIV?1 neutralization mediated by CD4?binding site antibodies
-
Li, Y. et al. Broad HIV?1 neutralization mediated by CD4?binding site antibodies. Nat. Med. 13, 1032-1034 (2007).
-
(2007)
Nat. Med.
, vol.13
, pp. 1032-1034
-
-
Li, Y.1
-
36
-
-
79958131570
-
Broadly cross-neutralizing antibodies in HIV?1 patients with undetectable viremia
-
Medina-Ramirez, M. et al. Broadly cross-neutralizing antibodies in HIV?1 patients with undetectable viremia. J. Virol. 85, 5804-5813 (2011).
-
(2011)
J. Virol.
, vol.85
, pp. 5804-5813
-
-
Medina-Ramirez, M.1
-
37
-
-
70349887757
-
Broad and potent neutralizing antibodies from an African donor reveal a new HIV?1 vaccine target
-
Walker, L. M. et al. Broad and potent neutralizing antibodies from an African donor reveal a new HIV?1 vaccine target. Science 326, 285-289 (2009).
-
(2009)
Science
, vol.326
, pp. 285-289
-
-
Walker, L.M.1
-
38
-
-
84861374644
-
PGV04, an HIV?1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4
-
Falkowska, E. et al. PGV04, an HIV?1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4. J. Virol. 86, 4394-4403 (2012).
-
(2012)
J. Virol.
, vol.86
, pp. 4394-4403
-
-
Falkowska, E.1
-
39
-
-
80053132436
-
Broad neutralization coverage of HIV by multiple highly potent antibodies
-
Walker, L. M. et al. Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature 477, 466-470 (2011).
-
(2011)
Nature
, vol.477
, pp. 466-470
-
-
Walker, L.M.1
-
40
-
-
84917705974
-
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
-
Sok, D. et al. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex. Proc. Natl Acad. Sci. USA 111, 17624-17629 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 17624-17629
-
-
Sok, D.1
-
41
-
-
84900517557
-
Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers
-
Falkowska, E. et al. Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers. Immunity 40, 657-668 (2014).
-
(2014)
Immunity
, vol.40
, pp. 657-668
-
-
Falkowska, E.1
-
42
-
-
80051670323
-
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins
-
Corti, D. et al. A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science 333, 850-856 (2011).
-
(2011)
Science
, vol.333
, pp. 850-856
-
-
Corti, D.1
-
43
-
-
84961282543
-
Development of broad-spectrum human monoclonal antibodies for rabies post-exposure prophylaxis
-
De Benedictis, P. et al. Development of broad-spectrum human monoclonal antibodies for rabies post-exposure prophylaxis. EMBO Mol. Med. 8, 407-421 (2016).
-
(2016)
EMBO Mol. Med.
, vol.8
, pp. 407-421
-
-
De Benedictis, P.1
-
44
-
-
85018766415
-
Recurrent potent human neutralizing antibodies to Zika virus in Brazil and Mexico
-
Robbiani, D. F. et al. Recurrent potent human neutralizing antibodies to Zika virus in Brazil and Mexico. Cell 169, 597-609. e11 (2017).
-
(2017)
Cell
, vol.169
, pp. 597e11-609e11
-
-
Robbiani, D.F.1
-
45
-
-
1342303482
-
Of mice and not men: Differences between mouse and human immunology
-
Mestas, J. & Hughes, C. C. Of mice and not men: differences between mouse and human immunology. J. Immunol. 172, 2731-2738 (2004).
-
(2004)
J. Immunol.
, vol.172
, pp. 2731-2738
-
-
Mestas, J.1
Hughes, C.C.2
-
46
-
-
80052938385
-
Analysis of a clonal lineage of HIV?1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors
-
Bonsignori, M. et al. Analysis of a clonal lineage of HIV?1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors. J. Virol. 85, 9998-10009 (2011).
-
(2011)
J. Virol.
, vol.85
, pp. 9998-10009
-
-
Bonsignori, M.1
-
47
-
-
84999836139
-
Identification of a CD4?binding-site antibody to HIV that evolved near-pan neutralization breadth
-
Huang, J. et al. Identification of a CD4?binding-site antibody to HIV that evolved near-pan neutralization breadth. Immunity 45, 1108-1121 (2016).
-
(2016)
Immunity
, vol.45
, pp. 1108-1121
-
-
Huang, J.1
-
48
-
-
84899991983
-
Developmental pathway for potent V1V2?directed HIV-neutralizing antibodies
-
Doria-Rose, N. A. et al. Developmental pathway for potent V1V2?directed HIV-neutralizing antibodies. Nature 509, 55-62 (2014).
-
(2014)
Nature
, vol.509
, pp. 55-62
-
-
Doria-Rose, N.A.1
-
49
-
-
73849116425
-
Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming
-
Kwakkenbos, M. J. et al. Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming. Nat. Med. 16, 123-128 (2010).
-
(2010)
Nat. Med.
, vol.16
, pp. 123-128
-
-
Kwakkenbos, M.J.1
-
50
-
-
84968627164
-
Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits
-
Robinson, J. E. et al. Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits. Nat. Commun. 7, 11544 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 11544
-
-
Robinson, J.E.1
-
51
-
-
84878349946
-
Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody
-
McLellan, J. S. et al. Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Science 340, 1113-1117 (2013).
-
(2013)
Science
, vol.340
, pp. 1113-1117
-
-
McLellan, J.S.1
-
52
-
-
84992677658
-
Cross-neutralizing and protective human antibody specificities to poxvirus infections
-
Gilchuk, I. et al. Cross-neutralizing and protective human antibody specificities to poxvirus infections. Cell 167, 684-694. e9 (2016).
-
(2016)
Cell
, vol.167
, pp. 684e9-694e9
-
-
Gilchuk, I.1
-
53
-
-
84939863145
-
Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus
-
Corti, D. et al. Prophylactic and postexposure efficacy of a potent human monoclonal antibody against MERS coronavirus. Proc. Natl Acad. Sci. USA 112, 10473-10478 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 10473-10478
-
-
Corti, D.1
-
54
-
-
84955572428
-
Cross-reactive and potent neutralizing antibody responses in human survivors of natural ebolavirus infection
-
Flyak, A. I. et al. Cross-reactive and potent neutralizing antibody responses in human survivors of natural ebolavirus infection. Cell 164, 392-405 (2016).
-
(2016)
Cell
, vol.164
, pp. 392-405
-
-
Flyak, A.I.1
-
55
-
-
84959359636
-
Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody
-
Corti, D. et al. Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody. Science 351, 1339-1342 (2016).
-
(2016)
Science
, vol.351
, pp. 1339-1342
-
-
Corti, D.1
-
56
-
-
84959351355
-
Structural and molecular basis for Ebola virus neutralization by protective human antibodies
-
Misasi, J. et al. Structural and molecular basis for Ebola virus neutralization by protective human antibodies. Science 351, 1343-1346 (2016).
-
(2016)
Science
, vol.351
, pp. 1343-1346
-
-
Misasi, J.1
-
57
-
-
0029839470
-
A novel strategy for generating monoclonal antibodies from single, isolated lymphocytes producing antibodies of defined specificities
-
Babcook, J. S., Leslie, K. B., Olsen, O. A., Salmon, R. A. & Schrader, J. W. A novel strategy for generating monoclonal antibodies from single, isolated lymphocytes producing antibodies of defined specificities. Proc. Natl Acad. Sci. USA 93, 7843-7848 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 7843-7848
-
-
Babcook, J.S.1
Leslie, K.B.2
Olsen, O.A.3
Salmon, R.A.4
Schrader, J.W.5
-
58
-
-
36849031722
-
Efficient generation of monoclonal antibodies from single human B cells by single cell RT?PCR and expression vector cloning
-
Tiller, T. et al. Efficient generation of monoclonal antibodies from single human B cells by single cell RT?PCR and expression vector cloning. J. Immunol. Methods 329, 112-124 (2008).
-
(2008)
J. Immunol. Methods
, vol.329
, pp. 112-124
-
-
Tiller, T.1
-
59
-
-
0041689676
-
Predominant autoantibody production by early human B cell precursors
-
Wardemann, H. et al. Predominant autoantibody production by early human B cell precursors. Science 301, 1374-1377 (2003).
-
(2003)
Science
, vol.301
, pp. 1374-1377
-
-
Wardemann, H.1
-
60
-
-
77954920017
-
Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV?1
-
This article presents the isolation of the prototype broadly neutralizing super-antibody to the CD4 binding site, VRC01
-
Wu, X. et al. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV?1. Science 329, 856-861 (2010). This article presents the isolation of the prototype broadly neutralizing super-antibody to the CD4 binding site, VRC01.
-
(2010)
Science
, vol.329
, pp. 856-861
-
-
Wu, X.1
-
61
-
-
77954943648
-
Structural basis for broad and potent neutralization of HIV?1 by antibody VRC01
-
Zhou, T. et al. Structural basis for broad and potent neutralization of HIV?1 by antibody VRC01. Science 329, 811-817 (2010).
-
(2010)
Science
, vol.329
, pp. 811-817
-
-
Zhou, T.1
-
62
-
-
80052925616
-
Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding
-
Scheid, J. F. et al. Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science 333, 1633-1637 (2011).
-
(2011)
Science
, vol.333
, pp. 1633-1637
-
-
Scheid, J.F.1
-
63
-
-
80052942203
-
Focused evolution of HIV?1 neutralizing antibodies revealed by structures and deep sequencing
-
Wu, X. et al. Focused evolution of HIV?1 neutralizing antibodies revealed by structures and deep sequencing. Science 333, 1593-1602 (2011).
-
(2011)
Science
, vol.333
, pp. 1593-1602
-
-
Wu, X.1
-
64
-
-
84960400876
-
Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak
-
Bornholdt, Z. A. et al. Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak. Science 351, 1078-1083 (2016).
-
(2016)
Science
, vol.351
, pp. 1078-1083
-
-
Bornholdt, Z.A.1
-
65
-
-
84908329318
-
Characteristics of memory B cells elicited by a highly efficacious HPV vaccine in subjects with no pre-existing immunity
-
Scherer, E. M. et al. Characteristics of memory B cells elicited by a highly efficacious HPV vaccine in subjects with no pre-existing immunity. PLoS Pathog. 10, e1004461 (2014).
-
(2014)
PLoS Pathog.
, vol.10
, pp. e1004461
-
-
Scherer, E.M.1
-
66
-
-
85019578866
-
Antibodies from a human survivor define sites of vulnerability for broad protection against ebolaviruses
-
Wec, A. Z. et al. Antibodies from a human survivor define sites of vulnerability for broad protection against ebolaviruses. Cell 169, 878-890. e15 (2017).
-
(2017)
Cell
, vol.169
, pp. 878e15-890e15
-
-
Wec, A.Z.1
-
67
-
-
85026907365
-
Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows
-
Sok, D. et al. Rapid elicitation of broadly neutralizing antibodies to HIV by immunization in cows. Nature 548, 108-111 (2017).
-
(2017)
Nature
, vol.548
, pp. 108-111
-
-
Sok, D.1
-
68
-
-
85019650530
-
Immunization-elicited broadly protective antibody reveals ebolavirus fusion loop as a site of vulnerability
-
Zhao, X. et al. Immunization-elicited broadly protective antibody reveals ebolavirus fusion loop as a site of vulnerability. Cell 169, 891-904. e15 (2017).
-
(2017)
Cell
, vol.169
, pp. 891e15-904e15
-
-
Zhao, X.1
-
69
-
-
0018749085
-
Characterization of a circulating subpopulation of spontaneous antitetanus toxoid antibody producing B cells following in vivo booster immunization
-
Stevens, R. H., Macy, E., Morrow, C. & Saxon, A. Characterization of a circulating subpopulation of spontaneous antitetanus toxoid antibody producing B cells following in vivo booster immunization. J. Immunol. 122, 2498-2504 (1979).
-
(1979)
J. Immunol.
, vol.122
, pp. 2498-2504
-
-
Stevens, R.H.1
Macy, E.2
Morrow, C.3
Saxon, A.4
-
70
-
-
44449118948
-
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
-
Wrammert, J. et al. Rapid cloning of high-affinity human monoclonal antibodies against influenza virus. Nature 453, 667-671 (2008).
-
(2008)
Nature
, vol.453
, pp. 667-671
-
-
Wrammert, J.1
-
71
-
-
84971449627
-
B Cell responses during secondary Dengue virus infection are dominated by highly cross-reactive, memory-derived plasmablasts
-
Priyamvada, L. et al. B Cell responses during secondary Dengue virus infection are dominated by highly cross-reactive, memory-derived plasmablasts. J. Virol. 90, 5574-5585 (2016).
-
(2016)
J. Virol.
, vol.90
, pp. 5574-5585
-
-
Priyamvada, L.1
-
72
-
-
84922947115
-
A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus
-
Dejnirattisai, W. et al. A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus. Nat. Immunol. 16, 170-177 (2015).
-
(2015)
Nat. Immunol.
, vol.16
, pp. 170-177
-
-
Dejnirattisai, W.1
-
73
-
-
85021092243
-
VP4-and VP7?specific antibodies mediate heterotypic immunity to rotavirus in humans
-
Nair, N. et al. VP4-and VP7?specific antibodies mediate heterotypic immunity to rotavirus in humans. Sci. Transl Med. 9, eaam5434 (2017).
-
(2017)
Sci. Transl Med.
, vol.9
, pp. eaam5434
-
-
Nair, N.1
-
74
-
-
84922152110
-
Vaccine-induced plasmablast responses in rhesus macaques: Phenotypic characterization and a source for generating antigen-specific monoclonal antibodies
-
Silveira, E. L. et al. Vaccine-induced plasmablast responses in rhesus macaques: phenotypic characterization and a source for generating antigen-specific monoclonal antibodies. J. Immunol. Methods 416, 69-83 (2015).
-
(2015)
J. Immunol. Methods
, vol.416
, pp. 69-83
-
-
Silveira, E.L.1
-
75
-
-
78651488739
-
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection
-
Wrammert, J. et al. Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection. J. Exp. Med. 208, 181-193 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 181-193
-
-
Wrammert, J.1
-
76
-
-
85042675338
-
Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors
-
Rogers, T. F. et al. Zika virus activates de novo and cross-reactive memory B cell responses in dengue-experienced donors. Sci. Immunol. 2, eaan6809 (2017).
-
(2017)
Sci. Immunol.
, vol.2
, pp. eaan6809
-
-
Rogers, T.F.1
-
77
-
-
84937107017
-
Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection
-
Pascal, K. E. et al. Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection. Proc. Natl Acad. Sci. USA 112, 8738-8743 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 8738-8743
-
-
Pascal, K.E.1
-
78
-
-
84973153410
-
Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo
-
Luke, T. et al. Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo. Sci. Transl Med. 8, 326ra21 (2016).
-
(2016)
Sci. Transl Med.
, vol.8
, pp. 326ra21
-
-
Luke, T.1
-
79
-
-
84914128755
-
DNA vaccine-derived human IgG produced in transchromosomal bovines protect in lethal models of hantavirus pulmonary syndrome
-
Hooper, J. W. et al. DNA vaccine-derived human IgG produced in transchromosomal bovines protect in lethal models of hantavirus pulmonary syndrome. Sci. Transl Med. 6, 264ra162 (2014).
-
(2014)
Sci. Transl Med.
, vol.6
, pp. 264ra162
-
-
Hooper, J.W.1
-
80
-
-
85021219038
-
Antibody preparations from human transchromosomic cows exhibit prophylactic and therapeutic efficacy against Venezuelan equine encephalitis virus
-
Gardner, C. L. et al. Antibody preparations from human transchromosomic cows exhibit prophylactic and therapeutic efficacy against Venezuelan equine encephalitis virus. J. Virol. 91, e00226-17 (2017).
-
(2017)
J. Virol.
, vol.91
, pp. e00226-e00317
-
-
Gardner, C.L.1
-
81
-
-
84964658344
-
Production of potent fully human polyclonal antibodies against Ebola Zaire virus in transchromosomal cattle
-
Dye, J. M. et al. Production of potent fully human polyclonal antibodies against Ebola Zaire virus in transchromosomal cattle. Sci. Rep. 6, 24897 (2016).
-
(2016)
Sci. Rep.
, vol.6
, pp. 24897
-
-
Dye, J.M.1
-
82
-
-
84997533781
-
Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice
-
Sapparapu, G. et al. Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice. Nature 540, 443-447 (2016).
-
(2016)
Nature
, vol.540
, pp. 443-447
-
-
Sapparapu, G.1
-
83
-
-
85006488816
-
Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
-
Wang, Q. et al. Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus. Sci. Transl Med. 8, 369ra179 (2016).
-
(2016)
Sci. Transl Med.
, vol.8
, pp. 369ra179
-
-
Wang, Q.1
-
84
-
-
84978153824
-
Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus
-
Priyamvada, L. et al. Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus. Proc. Natl Acad. Sci. USA 113, 7852-7857 (2016).
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. 7852-7857
-
-
Priyamvada, L.1
-
85
-
-
84976351583
-
Structural basis of potent Zika-dengue virus antibody cross-neutralization
-
Barba-Spaeth, G. et al. Structural basis of potent Zika-dengue virus antibody cross-neutralization. Nature 536, 48-53 (2016).
-
(2016)
Nature
, vol.536
, pp. 48-53
-
-
Barba-Spaeth, G.1
-
86
-
-
77956605864
-
The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity
-
Beltramello, M. et al. The human immune response to Dengue virus is dominated by highly cross-reactive antibodies endowed with neutralizing and enhancing activity. Cell Host Microbe 8, 271-283 (2010).
-
(2010)
Cell Host Microbe
, vol.8
, pp. 271-283
-
-
Beltramello, M.1
-
87
-
-
84887627657
-
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia
-
Shingai, M. et al. Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature 503, 277-280 (2013).
-
(2013)
Nature
, vol.503
, pp. 277-280
-
-
Shingai, M.1
-
88
-
-
66249098565
-
Combination therapy using chimeric monoclonal antibodies protects mice from lethal H5N1 infection and prevents formation of escape mutants
-
Prabakaran, M. et al. Combination therapy using chimeric monoclonal antibodies protects mice from lethal H5N1 infection and prevents formation of escape mutants. PLoS ONE 4, e5672 (2009).
-
(2009)
PLoS ONE
, vol.4
, pp. e5672
-
-
Prabakaran, M.1
-
89
-
-
85030792224
-
Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever
-
Mire, C. E. et al. Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever. Nat. Med. 23, 1146-1149 (2017).
-
(2017)
Nat. Med.
, vol.23
, pp. 1146-1149
-
-
Mire, C.E.1
-
90
-
-
85030571167
-
Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques
-
Magnani, D. M. et al. Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques. Sci. Transl Med. 9, eaan8184 (2017).
-
(2017)
Sci. Transl Med.
, vol.9
, pp. eaan8184
-
-
Magnani, D.M.1
-
91
-
-
85029757883
-
Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques
-
Xu, L. et al. Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques. Science 358, 85-90 (2017).
-
(2017)
Science
, vol.358
, pp. 85-90
-
-
Xu, L.1
-
92
-
-
85029755810
-
Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail
-
Julg, B. et al. Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail. Sci. Transl Med. 9, eaao4235 (2017).
-
(2017)
Sci. Transl Med.
, vol.9
, pp. eaao4235
-
-
Julg, B.1
-
93
-
-
85029651511
-
A human bispecific antibody against Zika virus with high therapeutic potential
-
Wang, J. et al. A human bi?specific antibody against Zika virus with high therapeutic potential. Cell 171, 229-241. e15 (2017).
-
(2017)
Cell
, vol.171
, pp. 229e15-241e15
-
-
Wang, J.1
-
94
-
-
0031683919
-
Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. the IMpact-RSV Study Group
-
[No authors listed. ] Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. The IMpact-RSV Study Group. Pediatrics 102, 531-537 (1998).
-
(1998)
Pediatrics
, vol.102
, pp. 531-537
-
-
-
95
-
-
85019187653
-
A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants
-
Zhu, Q. et al. A highly potent extended half-life antibody as a potential RSV vaccine surrogate for all infants. Sci. Transl Med. 9, eaaj1928 (2017).
-
(2017)
Sci. Transl Med.
, vol.9
, pp. eaaj1928
-
-
Zhu, Q.1
-
96
-
-
62049083943
-
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
-
Sui, J. et al. Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat. Struct. Mol. Biol. 16, 265-273 (2009).
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 265-273
-
-
Sui, J.1
-
97
-
-
84859206023
-
Ebola GP?specific monoclonal antibodies protect mice and Guinea pigs from lethal Ebola virus infection
-
Qiu, X. et al. Ebola GP?specific monoclonal antibodies protect mice and guinea pigs from lethal Ebola virus infection. PLoS Negl. Trop. Dis. 6, e1575 (2012).
-
(2012)
PLoS Negl. Trop. Dis.
, vol.6
, pp. e1575
-
-
Qiu, X.1
-
98
-
-
0034051595
-
Epitopes involved in antibody-mediated protection from Ebola virus
-
Wilson, J. A. et al. Epitopes involved in antibody-mediated protection from Ebola virus. Science 287, 1664-1666 (2000).
-
(2000)
Science
, vol.287
, pp. 1664-1666
-
-
Wilson, J.A.1
-
99
-
-
0032947286
-
Protection of Macaques against pathogenic simian/human immunodeficiency virus 89. 6PD by passive transfer of neutralizing antibodies
-
Mascola, J. R. et al. Protection of Macaques against pathogenic simian/human immunodeficiency virus 89. 6PD by passive transfer of neutralizing antibodies. J. Virol. 73, 4009-4018 (1999).
-
(1999)
J. Virol.
, vol.73
, pp. 4009-4018
-
-
Mascola, J.R.1
-
100
-
-
0033951746
-
Protection of macaques against vaginal transmission of a pathogenic HIV?1/SIV chimeric virus by passive infusion of neutralizing antibodies
-
Mascola, J. R. et al. Protection of macaques against vaginal transmission of a pathogenic HIV?1/SIV chimeric virus by passive infusion of neutralizing antibodies. Nat. Med. 6, 207-210 (2000).
-
(2000)
Nat. Med.
, vol.6
, pp. 207-210
-
-
Mascola, J.R.1
-
101
-
-
0034864776
-
Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro
-
Parren, P. W. et al. Antibody protects macaques against vaginal challenge with a pathogenic R5 simian/human immunodeficiency virus at serum levels giving complete neutralization in vitro. J. Virol. 75, 8340-8347 (2001).
-
(2001)
J. Virol.
, vol.75
, pp. 8340-8347
-
-
Parren, P.W.1
-
102
-
-
85029560996
-
The hemagglutinin A stem antibody MEDI8852 prevents and controls disease and limits transmission of pandemic influenza viruses
-
Paules, C. I. et al. The hemagglutinin A stem antibody MEDI8852 prevents and controls disease and limits transmission of pandemic influenza viruses. J. Infect. Dis. 216, 356-365 (2017).
-
(2017)
J. Infect. Dis.
, vol.216
, pp. 356-365
-
-
Paules, C.I.1
-
103
-
-
68349160853
-
Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
-
Hessell, A. J. et al. Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques. Nat. Med. 15, 951-954 (2009).
-
(2009)
Nat. Med.
, vol.15
, pp. 951-954
-
-
Hessell, A.J.1
-
104
-
-
67249131966
-
Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers
-
Hessell, A. J. et al. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Pathog. 5, e1000433 (2009).
-
(2009)
PLoS Pathog.
, vol.5
, pp. e1000433
-
-
Hessell, A.J.1
-
105
-
-
84907212727
-
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques
-
Shingai, M. et al. Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques. J. Exp. Med. 211, 2061-2074 (2014).
-
(2014)
J. Exp. Med.
, vol.211
, pp. 2061-2074
-
-
Shingai, M.1
-
106
-
-
85028951664
-
Broadly neutralizing antibodies targeting the HIV?1 envelope V2 apex confer protection against a clade C SHIV challenge
-
Julg, B. et al. Broadly neutralizing antibodies targeting the HIV?1 envelope V2 apex confer protection against a clade C SHIV challenge. Sci. Transl Med. 9, eaal1321 (2017).
-
(2017)
Sci. Transl Med.
, vol.9
, pp. eaal1321
-
-
Julg, B.1
-
107
-
-
84928552521
-
Vectored antibody gene delivery for the prevention or treatment of HIV infection
-
Deal, C. E. & Balazs, A. B. Vectored antibody gene delivery for the prevention or treatment of HIV infection. Curr. Opin. HIV AIDS 10, 190-197 (2015).
-
(2015)
Curr. Opin. HIV AIDS
, vol.10
, pp. 190-197
-
-
Deal, C.E.1
Balazs, A.B.2
-
108
-
-
68349150945
-
Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys
-
Johnson, P. R. et al. Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys. Nat. Med. 15, 901-906 (2009).
-
(2009)
Nat. Med.
, vol.15
, pp. 901-906
-
-
Johnson, P.R.1
-
109
-
-
84924375707
-
AAV-expressed eCD4?Ig provides durable protection from multiple SHIV challenges
-
Gardner, M. R. et al. AAV-expressed eCD4?Ig provides durable protection from multiple SHIV challenges. Nature 519, 87-91 (2015).
-
(2015)
Nature
, vol.519
, pp. 87-91
-
-
Gardner, M.R.1
-
110
-
-
84855466746
-
Antibody-based protection against HIV infection by vectored immunoprophylaxis
-
Balazs, A. B. et al. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature 481, 81-84 (2011).
-
(2011)
Nature
, vol.481
, pp. 81-84
-
-
Balazs, A.B.1
-
111
-
-
84929613728
-
Sustained delivery of a broadly neutralizing antibody in nonhuman primates confers long-term protection against simian/human immunodeficiency virus infection
-
Saunders, K. O. et al. Sustained delivery of a broadly neutralizing antibody in nonhuman primates confers long-term protection against simian/human immunodeficiency virus infection. J. Virol. 89, 5895-5903 (2015).
-
(2015)
J. Virol.
, vol.89
, pp. 5895-5903
-
-
Saunders, K.O.1
-
112
-
-
84938244572
-
Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy
-
Flingai, S. et al. Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy. Sci. Rep. 5, 12616 (2015).
-
(2015)
Sci. Rep.
, vol.5
, pp. 12616
-
-
Flingai, S.1
-
113
-
-
84885155143
-
Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV?1 envelope glycoprotein Fab
-
Muthumani, K. et al. Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV?1 envelope glycoprotein Fab. Hum. Vaccines Immunother. 9, 2253-2262 (2013).
-
(2013)
Hum. Vaccines Immunother.
, vol.9
, pp. 2253-2262
-
-
Muthumani, K.1
-
114
-
-
85014176711
-
Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV?1 challenge
-
Pardi, N. et al. Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV?1 challenge. Nat. Commun. 8, 14630 (2017).
-
(2017)
Nat. Commun.
, vol.8
, pp. 14630
-
-
Pardi, N.1
-
115
-
-
84942905508
-
Recurrent AAV2?related insertional mutagenesis in human hepatocellular carcinomas
-
Nault, J. C. et al. Recurrent AAV2?related insertional mutagenesis in human hepatocellular carcinomas. Nat. Genet. 47, 1187-1193 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 1187-1193
-
-
Nault, J.C.1
-
116
-
-
1942457251
-
Erythropoietin gene therapy leads to autoimmune anemia in macaques
-
Gao, G. et al. Erythropoietin gene therapy leads to autoimmune anemia in macaques. Blood 103, 3300-3302 (2004).
-
(2004)
Blood
, vol.103
, pp. 3300-3302
-
-
Gao, G.1
-
117
-
-
1642443440
-
Monoclonal antibodies produced by muscle after plasmid injection and electroporation
-
Tjelle, T. E. et al. Monoclonal antibodies produced by muscle after plasmid injection and electroporation. Mol. Ther. 9, 328-336 (2004).
-
(2004)
Mol. Ther.
, vol.9
, pp. 328-336
-
-
Tjelle, T.E.1
-
118
-
-
78649683045
-
Treatment of respiratory syncytial virus with palivizumab: A systematic review
-
Hu, J. & Robinson, J. L. Treatment of respiratory syncytial virus with palivizumab: a systematic review. World J. Pediatr. 6, 296-300 (2010).
-
(2010)
World J. Pediatr.
, vol.6
, pp. 296-300
-
-
Hu, J.1
Robinson, J.L.2
-
119
-
-
84887626950
-
Therapeutic efficacy of potent neutralizing HIV?1?specific monoclonal antibodies in SHIV-infected rhesus monkeys
-
Barouch, D. H. et al. Therapeutic efficacy of potent neutralizing HIV?1?specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature 503, 224-228 (2013).
-
(2013)
Nature
, vol.503
, pp. 224-228
-
-
Barouch, D.H.1
-
120
-
-
84885338257
-
HIV?1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice
-
Horwitz, J. A. et al. HIV?1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. Proc. Natl Acad. Sci. USA 110, 16538-16543 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 16538-16543
-
-
Horwitz, J.A.1
-
121
-
-
0033119374
-
Neutralizing antibodies have limited effects on the control of established HIV?1 infection in vivo
-
Poignard, P. et al. Neutralizing antibodies have limited effects on the control of established HIV?1 infection in vivo. Immunity 10, 431-438 (1999).
-
(1999)
Immunity
, vol.10
, pp. 431-438
-
-
Poignard, P.1
-
122
-
-
84928405730
-
Viraemia suppressed in HIV?1?infected humans by broadly neutralizing antibody 3BNC117
-
Caskey, M. et al. Viraemia suppressed in HIV?1?infected humans by broadly neutralizing antibody 3BNC117. Nature 522, 487-491 (2015).
-
(2015)
Nature
, vol.522
, pp. 487-491
-
-
Caskey, M.1
-
123
-
-
84976406858
-
HIV?1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption
-
Scheid, J. F. et al. HIV?1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption. Nature 535, 556-560 (2016).
-
(2016)
Nature
, vol.535
, pp. 556-560
-
-
Scheid, J.F.1
-
124
-
-
85009820387
-
Antibody 10-1074 suppresses viremia in HIV?1?infected individuals
-
Caskey, M. et al. Antibody 10-1074 suppresses viremia in HIV?1?infected individuals. Nat. Med. 23, 185-191 (2017).
-
(2017)
Nat. Med.
, vol.23
, pp. 185-191
-
-
Caskey, M.1
-
125
-
-
84954445565
-
Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV?1 infection
-
Lynch, R. M. et al. Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV?1 infection. Sci. Transl Med. 7, 319ra206 (2015).
-
(2015)
Sci. Transl Med.
, vol.7
, pp. 319ra206
-
-
Lynch, R.M.1
-
126
-
-
84997817411
-
Effect of HIV antibody VRC01 on viral rebound after treatment interruption
-
Bar, K. J. et al. Effect of HIV antibody VRC01 on viral rebound after treatment interruption. N. Engl. J. Med. 375, 2037-2050 (2016).
-
(2016)
N. Engl. J. Med.
, vol.375
, pp. 2037-2050
-
-
Bar, K.J.1
-
127
-
-
84966341056
-
HIV?1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV?1
-
Schoofs, T. et al. HIV?1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV?1. Science 352, 997-1001 (2016).
-
(2016)
Science
, vol.352
, pp. 997-1001
-
-
Schoofs, T.1
-
128
-
-
84964328690
-
Monoclonal antibody therapy for Junin virus infection
-
Zeitlin, L. et al. Monoclonal antibody therapy for Junin virus infection. Proc. Natl Acad. Sci. USA 113, 4458-4463 (2016).
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. 4458-4463
-
-
Zeitlin, L.1
-
129
-
-
84907263545
-
Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
-
Qiu, X. et al. Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature 514, 47-53 (2014).
-
(2014)
Nature
, vol.514
, pp. 47-53
-
-
Qiu, X.1
-
130
-
-
84996605499
-
Nanobodies as inhaled biotherapeutics for lung diseases
-
Van Heeke, G. et al. Nanobodies as inhaled biotherapeutics for lung diseases. Pharmacol. Ther. 169, 47-56 (2017).
-
(2017)
Pharmacol. Ther.
, vol.169
, pp. 47-56
-
-
Van Heeke, G.1
-
131
-
-
80155188633
-
Nanobodies specific for respiratory syncytial virus fusion protein protect against infection by inhibition of fusion
-
Schepens, B. et al. Nanobodies specific for respiratory syncytial virus fusion protein protect against infection by inhibition of fusion. J. Infect. Dis. 204, 1692-1701 (2011).
-
(2011)
J. Infect. Dis.
, vol.204
, pp. 1692-1701
-
-
Schepens, B.1
-
132
-
-
84957870173
-
Generation and characterization of ALX?0171, a potent novel therapeutic nanobody for the treatment of respiratory syncytial virus infection
-
Detalle, L. et al. Generation and characterization of ALX?0171, a potent novel therapeutic nanobody for the treatment of respiratory syncytial virus infection. Antimicrob. Agents Chemother. 60, 6-13 (2015).
-
(2015)
Antimicrob. Agents Chemother.
, vol.60
, pp. 6-13
-
-
Detalle, L.1
-
133
-
-
85012298983
-
Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state
-
Rossey, I. et al. Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state. Nat. Commun. 8, 14158 (2017).
-
(2017)
Nat. Commun.
, vol.8
, pp. 14158
-
-
Rossey, I.1
-
134
-
-
10744222698
-
Engineered human IgG antibodies with longer serum half-lives in primates
-
Hinton, P. R. et al. Engineered human IgG antibodies with longer serum half-lives in primates. J. Biol. Chem. 279, 6213-6216 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 6213-6216
-
-
Hinton, P.R.1
-
135
-
-
33747631571
-
Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn)
-
Dall'Acqua, W. F., Kiener, P. A. & Wu, H. Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn). J. Biol. Chem. 281, 23514-23524 (2006).
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 23514-23524
-
-
Dall'Acqua, W.F.1
Kiener, P.A.2
Wu, H.3
-
136
-
-
76349123565
-
Enhanced antibody half-life improves in vivo activity
-
Zalevsky, J. et al. Enhanced antibody half-life improves in vivo activity. Nat. Biotechnol. 28, 157-159 (2010).
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 157-159
-
-
Zalevsky, J.1
-
137
-
-
85009240311
-
Safety, tolerability, and pharmacokinetics of MEDI4893, an investigational, extended-half-life, anti-Staphylococcus aureus alpha-toxin human monoclonal antibody, in healthy adults
-
Yu, X. Q. et al. Safety, tolerability, and pharmacokinetics of MEDI4893, an investigational, extended-half-life, anti-Staphylococcus aureus alpha-toxin human monoclonal antibody, in healthy adults. Antimicrob. Agents Chemother. 61, e01020-16 (2017).
-
(2017)
Antimicrob. Agents Chemother.
, vol.61
, pp. e01016-e01020
-
-
Yu, X.Q.1
-
138
-
-
84907983318
-
Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
-
Ko, S. Y. et al. Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. Nature 514, 642-645 (2014).
-
(2014)
Nature
, vol.514
, pp. 642-645
-
-
Ko, S.Y.1
-
139
-
-
84966389751
-
A single injection of anti-HIV?1 antibodies protects against repeated SHIV challenges
-
Gautam, R. et al. A single injection of anti-HIV?1 antibodies protects against repeated SHIV challenges. Nature 533, 105-109 (2016).
-
(2016)
Nature
, vol.533
, pp. 105-109
-
-
Gautam, R.1
-
140
-
-
33645218704
-
Engineered antibody Fc variants with enhanced effector function
-
Lazar, G. A. et al. Engineered antibody Fc variants with enhanced effector function. Proc. Natl Acad. Sci. USA 103, 4005-4010 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 4005-4010
-
-
Lazar, G.A.1
-
141
-
-
48549105161
-
Molecular engineering and design of therapeutic antibodies
-
Presta, L. G. Molecular engineering and design of therapeutic antibodies. Curr. Opin. Immunol. 20, 460-470 (2008).
-
(2008)
Curr. Opin. Immunol.
, vol.20
, pp. 460-470
-
-
Presta, L.G.1
-
142
-
-
84862909342
-
Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies
-
Bowers, P. M. et al. Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies. Proc. Natl Acad. Sci. USA 108, 20455-20460 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 20455-20460
-
-
Bowers, P.M.1
-
143
-
-
0030994634
-
Yeast surface display for screening combinatorial polypeptide libraries
-
Boder, E. T. & Wittrup, K. D. Yeast surface display for screening combinatorial polypeptide libraries. Nat. Biotechnol. 15, 553-557 (1997).
-
(1997)
Nat. Biotechnol.
, vol.15
, pp. 553-557
-
-
Boder, E.T.1
Wittrup, K.D.2
-
144
-
-
0025226085
-
Phage antibodies: Filamentous phage displaying antibody variable domains
-
McCafferty, J., Griffiths, A. D., Winter, G. & Chiswell, D. J. Phage antibodies: filamentous phage displaying antibody variable domains. Nature 348, 552-554 (1990).
-
(1990)
Nature
, vol.348
, pp. 552-554
-
-
McCafferty, J.1
Griffiths, A.D.2
Winter, G.3
Chiswell, D.J.4
-
145
-
-
0024833055
-
Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda
-
Huse, W. D. et al. Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda. Science 246, 1275-1281 (1989).
-
(1989)
Science
, vol.246
, pp. 1275-1281
-
-
Huse, W.D.1
-
146
-
-
84900869380
-
Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery
-
Lee, E. C. et al. Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery. Nat. Biotechnol. 32, 356-363 (2014).
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 356-363
-
-
Lee, E.C.1
-
147
-
-
84898026231
-
Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice
-
Murphy, A. J. et al. Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice. Proc. Natl Acad. Sci. USA 111, 5153-5158 (2014).
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 5153-5158
-
-
Murphy, A.J.1
-
148
-
-
63749100579
-
A method for identification of HIV gp140 binding memory B cells in human blood
-
Scheid, J. F. et al. A method for identification of HIV gp140 binding memory B cells in human blood. J. Immunol. Methods 343, 65-67 (2009).
-
(2009)
J. Immunol. Methods
, vol.343
, pp. 65-67
-
-
Scheid, J.F.1
-
149
-
-
37549055446
-
Human monoclonal antibodies by immortalization of memory B cells
-
Lanzavecchia, A., Corti, D. & Sallusto, F. Human monoclonal antibodies by immortalization of memory B cells. Curr. Opin. Biotechnol. 18, 523-528 (2007).
-
(2007)
Curr. Opin. Biotechnol.
, vol.18
, pp. 523-528
-
-
Lanzavecchia, A.1
Corti, D.2
Sallusto, F.3
-
150
-
-
84884991510
-
Isolation of human monoclonal antibodies from peripheral blood B cells
-
Huang, J. et al. Isolation of human monoclonal antibodies from peripheral blood B cells. Nat. Protoc. 8, 1907-1915 (2013).
-
(2013)
Nat. Protoc.
, vol.8
, pp. 1907-1915
-
-
Huang, J.1
-
151
-
-
85019040760
-
A broadly neutralizing antibody targets the dynamic HIV envelope trimer apex via a long, rigidified, and anionic beta-hairpin structure
-
Lee, J. H. et al. A broadly neutralizing antibody targets the dynamic HIV envelope trimer apex via a long, rigidified, and anionic beta-hairpin structure. Immunity 46, 690-702 (2017).
-
(2017)
Immunity
, vol.46
, pp. 690-702
-
-
Lee, J.H.1
-
152
-
-
85010908338
-
Identification and specificity of broadly neutralizing antibodies against HIV
-
McCoy, L. E. & Burton, D. R. Identification and specificity of broadly neutralizing antibodies against HIV. Immunol. Rev. 275, 11-20 (2017).
-
(2017)
Immunol. Rev.
, vol.275
, pp. 11-20
-
-
McCoy, L.E.1
Burton, D.R.2
-
153
-
-
84866122029
-
Highly conserved protective epitopes on influenza B viruses
-
Dreyfus, C. et al. Highly conserved protective epitopes on influenza B viruses. Science 337, 1343-1348 (2012).
-
(2012)
Science
, vol.337
, pp. 1343-1348
-
-
Dreyfus, C.1
-
154
-
-
85019451451
-
Tackling influenza with broadly neutralizing antibodies
-
Corti, D. et al. Tackling influenza with broadly neutralizing antibodies. Curr. Opin. Virol. 24, 60-69 (2017).
-
(2017)
Curr. Opin. Virol.
, vol.24
, pp. 60-69
-
-
Corti, D.1
-
155
-
-
85021884782
-
Perspective on the structural and functional constraints for immune evasion: Insights from influenza virus
-
Wu, N. C. & Wilson, I. A. A. Perspective on the structural and functional constraints for immune evasion: insights from influenza virus. J. Mol. Biol. 429, 2694-2709 (2017).
-
(2017)
J. Mol. Biol.
, vol.429
, pp. 2694-2709
-
-
Wu, N.C.1
Wilson, I.A.A.2
-
156
-
-
85011295973
-
Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus
-
Wen, X. et al. Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus. Nat. Microbiol. 2, 16272 (2017).
-
(2017)
Nat. Microbiol.
, vol.2
, pp. 16272
-
-
Wen, X.1
|