Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth

Immunity

Volumn 45, Issue 5, 2016, Pages 1108-1121

  Huang, Jinghe ^a   Kang, Byong H ^a   Ishida, Elise ^a   Zhou, Tongqing ^a   Griesman, Trevor ^a   Sheng, Zizhang ^b   Wu, Fan ^a   Doria Rose, Nicole A ^a   Zhang, Baoshan ^a   McKee, Krisha ^a   O'Dell, Sijy ^a   Chuang, Gwo Yu ^a   Druz, Aliaksandr ^a   Georgiev, Ivelin S ^c,d,e   Schramm, Chaim A ^b   Zheng, Anqi ^a   Joyce, M Gordon ^a   Asokan, Mangaiarkarasi ^a   Ransier, Amy ^a   Darko, Sam ^a   Migueles, Stephen A ^a   Bailer, Robert T ^a   Louder, Mark K ^a   Alam, S Munir ^d   Parks, Robert ^d   Kelsoe, Garnett ^d   Von Holle, Tarra ^d   Haynes, Barton F ^d   Douek, Daniel C ^a   Hirsch, Vanessa ^a   Seaman, Michael S ^e   Shapiro, Lawrence ^a,b   Mascola, John R ^a   Kwong, Peter D ^a   Connors, Mark ^a   more..

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b Howard Hughes Medical Institute   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

antibody; CD4 binding site; envelope; HIV; immunotherapy; neutralizing; prophylaxis; resistance; structure; vaccine

Indexed keywords

12A 21; B LYMPHOCYTE RECEPTOR; CD4 ANTIGEN; GLYCAN; GLYCOPROTEIN GP 120; IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN M; MONOCLONAL ANTIBODY; N 6; UNCLASSIFIED DRUG; VRC 01; VRC 27; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; NEUTRALIZING ANTIBODY;

ARTICLE; DRUG PROTEIN BINDING; GLYCOSYLATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MEMORY CELL; NUCLEOTIDE SEQUENCE; PHYLOGENETIC TREE; PRIORITY JOURNAL; VIRUS NEUTRALIZATION; ANTIBODY COMBINING SITE; ANTIBODY SPECIFICITY; CD4+ T LYMPHOCYTE; CELL SEPARATION; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY;

ANTIBODIES, NEUTRALIZING; ANTIBODY SPECIFICITY; BINDING SITES, ANTIBODY; CD4-POSITIVE T-LYMPHOCYTES; CELL SEPARATION; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS;

EID: 84999836139     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.10.027     Document Type: Article

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