Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability

Cell

Volumn 169, Issue 5, 2017, Pages 891-904.e15

  Zhao, Xuelian ^a   Howell, Katie A ^b   He, Shihua ^c,d   Brannan, Jennifer M ^e   Wec, Anna Z ^f   Davidson, Edgar ^g   Turner, Hannah L ^h   Chiang, Chi I ^a   Lei, Lin ^a   Fels, J Maximilian ^f   Vu, Hong ^b   Shulenin, Sergey ^b   Turonis, Ashley N ^b   Kuehne, Ana I ^e   Liu, Guodong ^c,d   Ta, Mi ^g   Wang, Yimeng ^a   Sundling, Christopher ⁱ   Xiao, Yongli ^j   Spence, Jennifer S ^f   Doranz, Benjamin J ^g   Holtsberg, Frederick W ^b   Ward, Andrew B ^h   Chandran, Kartik ^f   Dye, John M ^e   Qiu, Xiangguo ^c,d   Li, Yuxing ^a,k   Aman, M Javad ^b   more..

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^b Integrated BioTherapeutics   (United States)

^c PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^d UNIVERSITY OF MANITOBA   (Canada)

^e UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^f ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^g Integral Molecular Inc   (United States)

^h SCRIPPS RESEARCH INSTITUTE   (United States)

ⁱ GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^j NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^k UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

FVM 04; NEUTRALIZING ANTIBODY; NEUTRALIZING ANTIBODY CA45; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; COMPLEMENTARITY DETERMINING REGION; EBOLA VACCINE; EPITOPE; IMMUNOGLOBULIN F(AB) FRAGMENT; VIRUS ANTIBODY;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; CLONE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; EBOLA HEMORRHAGIC FEVER; EBOLAVIRUS; ELECTRON MICROSCOPY; EPITOPE MAPPING; FEMALE; FETUS; GUINEA PIG; HUMAN; HUMAN CELL; IMMUNIZATION; MACACA FASCICULARIS; MALE; MEMORY CELL; MOLECULAR RECOGNITION; MOUSE; MUSTELA PUTORIUS FURO; NONHUMAN; NUCLEOTIDE SEQUENCE; POST EXPOSURE PROPHYLAXIS; PRIORITY JOURNAL; PROTECTION; RECEPTOR BINDING; VIRUS NEUTRALIZATION; AMINO ACID SEQUENCE; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; CROSS REACTION; IMMUNOLOGY; ISOLATION AND PURIFICATION; MOLECULAR MODEL; ULTRASTRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; COMPLEMENTARITY DETERMINING REGIONS; CROSS REACTIONS; EBOLA VACCINES; EBOLAVIRUS; EPITOPE MAPPING; EPITOPES, B-LYMPHOCYTE; FEMALE; FERRETS; GUINEA PIGS; HEMORRHAGIC FEVER, EBOLA; IMMUNOGLOBULIN FAB FRAGMENTS; MACACA FASCICULARIS; MALE; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR;

EID: 85019650530     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2017.04.038     Document Type: Article

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