Structural and molecular basis for Ebola virus neutralization by protective human antibodies

Science

Volumn 351, Issue 6279, 2016, Pages 1343-1346

  Misasi, John ^a,e,h   Gilman, Morgan S A ^b   Kanekiyo, Masaru ^a   Gui, Miao ^d   Cagigi, Alberto ^a   Mulangu, Sabue ^a   Corti, Davide ^f   Ledgerwood, Julie E ^a   Lanzavecchia, Antonio ^f,i   Cunningham, James ^e   Muyembe Tamfun, Jean Jacques ^g   Baxa, Ulrich ^c   Graham, Barney S ^a   Xiang, Ye ^d   Sullivan, Nancy J ^a   McLellan, Jason S ^b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^d Tsinghua University   (China)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^g National Laboratory of Public Health   (Democratic Republic Congo)

^h BOSTON CHILDREN S HOSPITAL   (United States)

ⁱ ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN; GLYCAN; HUMAN MONOCLONAL ANTIBODY; MAB100; MAB114; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; ENVELOPE GLYCOPROTEIN, EBOLA VIRUS; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; VIRUS ANTIBODY; VIRUS ENVELOPE PROTEIN;

ANTIBODY; MOLECULAR ANALYSIS; PRIMATE; PROTEIN; VACCINATION; VIRAL DISEASE; VIRUS;

ARTICLE; DRUG STRUCTURE; EBOLA HEMORRHAGIC FEVER; EBOLAVIRUS; NONHUMAN; PH; PRIORITY JOURNAL; VIRUS PARTICLE; CHEMISTRY; CRYOELECTRON MICROSCOPY; HEMORRHAGIC FEVER, EBOLA; HUMAN; IMMUNOLOGY; PROTEIN CONFORMATION; PROTEIN DEGRADATION; X RAY CRYSTALLOGRAPHY;

EBOLA VIRUS; PRIMATES;

ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CATHEPSINS; CRYOELECTRON MICROSCOPY; CRYSTALLOGRAPHY, X-RAY; EBOLAVIRUS; HEMORRHAGIC FEVER, EBOLA; HUMANS; PROTEIN CONFORMATION; PROTEOLYSIS; VIRAL ENVELOPE PROTEINS;

EID: 84959351355     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad6117     Document Type: Article

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