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Volumn 10, Issue 3, 2015, Pages 190-197

Vectored antibody gene delivery for the prevention or treatment of HIV infection

Author keywords

broadly neutralizing antibodies; HIV vaccine; immunotherapy; Keywords antibody gene transfer; vectored immunoprophylaxis

Indexed keywords

NEUTRALIZING ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY;

EID: 84928552521     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0000000000000145     Document Type: Review
Times cited : (28)

References (88)
  • 1
    • 9044241681 scopus 로고    scopus 로고
    • Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1
    • Trkola A, Purtscher M, Muster T, et al. Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1. J Virol 1996; 70:1100-1108.
    • (1996) J Virol , vol.70 , pp. 1100-1108
    • Trkola, A.1    Purtscher, M.2    Muster, T.3
  • 2
    • 0027985431 scopus 로고
    • Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody
    • Burton DR, Pyati J, Koduri R, et al. Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody. Science 1994; 266:1024-1027.
    • (1994) Science , vol.266 , pp. 1024-1027
    • Burton, D.R.1    Pyati, J.2    Koduri, R.3
  • 3
    • 0028235930 scopus 로고
    • Cross-neutralizing activity against divergent human immunodeficiency virus type 1 isolates induced by the gp41 sequence ELDKWAS
    • Muster T, Guinea R, Trkola A, et al. Cross-neutralizing activity against divergent human immunodeficiency virus type 1 isolates induced by the gp41 sequence ELDKWAS. J Virol 1994; 68:4031-4034.
    • (1994) J Virol , vol.68 , pp. 4031-4034
    • Muster, T.1    Guinea, R.2    Trkola, A.3
  • 4
    • 70349887757 scopus 로고    scopus 로고
    • Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
    • Walker LM, Phogat SK, Chan-Hui P-Y, et al. Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target. Science 2009; 326:285-289.
    • (2009) Science , vol.326 , pp. 285-289
    • Walker, L.M.1    Phogat, S.K.2    Chan-Hui, P.-Y.3
  • 5
    • 80053132436 scopus 로고    scopus 로고
    • Broad neutralization coverage of HIV by multiple highly potent antibodies
    • Walker LM, Huber M, Doores KJ, et al. Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature 2011; 477:466-470.
    • (2011) Nature , vol.477 , pp. 466-470
    • Walker, L.M.1    Huber, M.2    Doores, K.J.3
  • 6
    • 77954920017 scopus 로고    scopus 로고
    • Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1
    • Wu X, Yang Z-Y, Li Y, et al. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science 2010; 329:856-861.
    • (2010) Science , vol.329 , pp. 856-861
    • Wu, X.1    Yang, Z.-Y.2    Li, Y.3
  • 7
    • 80052942203 scopus 로고    scopus 로고
    • Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing
    • Wu X, Zhou T, Zhu J, et al. Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing. Science 2011; 333:1593-1602.
    • (2011) Science , vol.333 , pp. 1593-1602
    • Wu, X.1    Zhou, T.2    Zhu, J.3
  • 8
    • 80052925616 scopus 로고    scopus 로고
    • Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding
    • Scheid JF, Mouquet H, Ueberheide B, et al. Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science 2011; 333:1633-1637.
    • (2011) Science , vol.333 , pp. 1633-1637
    • Scheid, J.F.1    Mouquet, H.2    Ueberheide, B.3
  • 9
    • 82755184131 scopus 로고    scopus 로고
    • Increasing the potency and breadth of an HIV antibody by using structure-based rational design
    • Diskin R, Scheid JF, Marcovecchio PM, et al. Increasing the potency and breadth of an HIV antibody by using structure-based rational design. Science 2011; 334:1289-1293.
    • (2011) Science , vol.334 , pp. 1289-1293
    • Diskin, R.1    Scheid, J.F.2    Marcovecchio, P.M.3
  • 10
    • 84921607768 scopus 로고    scopus 로고
    • Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface
    • Huang J, Kang BH, Pancera M, et al. Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface. Nature 2014; 515:138-142.
    • (2014) Nature , vol.515 , pp. 138-142
    • Huang, J.1    Kang, B.H.2    Pancera, M.3
  • 11
    • 84917705974 scopus 로고    scopus 로고
    • Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
    • Sok D, van Gils MJ, Pauthner M, et al. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex. Proc Natl Acad Sci USA 2014; 111:17624-17629.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 17624-17629
    • Sok, D.1    Van Gils, M.J.2    Pauthner, M.3
  • 12
    • 84855466746 scopus 로고    scopus 로고
    • Antibody-based protection against HIV infection by vectored immunoprophylaxis
    • Balazs AB, Chen J, Hong CM, et al. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature 2011; 481:81-84.
    • (2011) Nature , vol.481 , pp. 81-84
    • Balazs, A.B.1    Chen, J.2    Hong, C.M.3
  • 13
    • 68349150945 scopus 로고    scopus 로고
    • Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys
    • Johnson PR, Schnepp BC, Zhang J, et al. Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys. Nat Med 2009; 15:901-906.
    • (2009) Nat Med , vol.15 , pp. 901-906
    • Johnson, P.R.1    Schnepp, B.C.2    Zhang, J.3
  • 14
    • 0036340378 scopus 로고    scopus 로고
    • Generation of neutralizing activity against human immunodeficiency virus type 1 in serum by antibody gene transfer
    • Lewis AD, Chen R, Montefiori DC, et al. Generation of neutralizing activity against human immunodeficiency virus type 1 in serum by antibody gene transfer. J Virol 2002; 76:8769-8775.
    • (2002) J Virol , vol.76 , pp. 8769-8775
    • Lewis, A.D.1    Chen, R.2    Montefiori, D.C.3
  • 15
    • 78651236211 scopus 로고    scopus 로고
    • Dimeric 2G12 as a potent protection against HIV-1
    • Luo XM, Lei MYY, Feidi RA, et al. Dimeric 2G12 as a potent protection against HIV-1. PLoS Pathog 2010; 6:e1001225.
    • (2010) PLoS Pathog , vol.6 , pp. e1001225
    • Luo, X.M.1    Lei, M.Y.Y.2    Feidi, R.A.3
  • 16
    • 84869232528 scopus 로고    scopus 로고
    • Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo
    • Moldt B, Rakasz EG, Schultz N, et al. Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo. Proc Natl Acad Sci U S A 2012; 109:18921-18925.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 18921-18925
    • Moldt, B.1    Rakasz, E.G.2    Schultz, N.3
  • 17
    • 84904497424 scopus 로고    scopus 로고
    • Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor
    • Pegu A, Yang Z-Y, Boyington JC, et al. Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor. Sci Transl Med 2014; 6:243ra88.
    • (2014) Sci Transl Med , vol.6 , pp. 243ra88
    • Pegu, A.1    Yang, Z.-Y.2    Boyington, J.C.3
  • 18
    • 84896120124 scopus 로고    scopus 로고
    • Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission
    • Balazs AB, Ouyang Y, Hong CM, et al. Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission. Nat Med 2014; 20:296-300.
    • (2014) Nat Med , vol.20 , pp. 296-300
    • Balazs, A.B.1    Ouyang, Y.2    Hong, C.M.3
  • 19
    • 84885338257 scopus 로고    scopus 로고
    • HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice
    • Horwitz JA, Halper-Stromberg A, Mouquet H, et al. HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. Proc Natl Acad Sci USA 2013; 110:16538-16543.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 16538-16543
    • Horwitz, J.A.1    Halper-Stromberg, A.2    Mouquet, H.3
  • 20
    • 2442689092 scopus 로고    scopus 로고
    • Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies
    • Haigwood NL, Montefiori DC, Sutton WF, et al. Passive immunotherapy in simian immunodeficiency virus-infected macaques accelerates the development of neutralizing antibodies. J Virol 2004; 78:5983-5995.
    • (2004) J Virol , vol.78 , pp. 5983-5995
    • Haigwood, N.L.1    Montefiori, D.C.2    Sutton, W.F.3
  • 21
    • 84887627657 scopus 로고    scopus 로고
    • Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia
    • Shingai M, Nishimura Y, Klein F, et al. Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature 2013; 503:277-280.
    • (2013) Nature , vol.503 , pp. 277-280
    • Shingai, M.1    Nishimura, Y.2    Klein, F.3
  • 22
    • 84887626950 scopus 로고    scopus 로고
    • Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
    • Barouch DH, Whitney JB, Moldt B, et al. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature 2013; 503:244-248.
    • (2013) Nature , vol.503 , pp. 244-248
    • Barouch, D.H.1    Whitney, J.B.2    Moldt, B.3
  • 23
    • 20944446452 scopus 로고    scopus 로고
    • Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies
    • Trkola A, Kuster H, Rusert P, et al. Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies. Nat Med 2005; 11:615-622.
    • (2005) Nat Med , vol.11 , pp. 615-622
    • Trkola, A.1    Kuster, H.2    Rusert, P.3
  • 24
    • 35148864699 scopus 로고    scopus 로고
    • Adjunctive passive immunotherapy in human immunodeficiency virus type 1-infected individuals treated with antiviral therapy during acute and early infection
    • Mehandru S, Vcelar B, Wrin T, et al. Adjunctive passive immunotherapy in human immunodeficiency virus type 1-infected individuals treated with antiviral therapy during acute and early infection. J Virol 2007; 81:11016-11031.
    • (2007) J Virol , vol.81 , pp. 11016-11031
    • Mehandru, S.1    Vcelar, B.2    Wrin, T.3
  • 25
    • 77957820631 scopus 로고    scopus 로고
    • Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques
    • Ng CT, Jaworski JP, Jayaraman P, et al. Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques. Nat Med 2010; 16:1117-1119.
    • (2010) Nat Med , vol.16 , pp. 1117-1119
    • Ng, C.T.1    Jaworski, J.P.2    Jayaraman, P.3
  • 26
    • 84907379431 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice
    • Halper-Stromberg A, Lu C-L, Klein F, et al. Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice. Cell 2014; 158:989-999.
    • (2014) Cell , vol.158 , pp. 989-999
    • Halper-Stromberg, A.1    Lu, C.-L.2    Klein, F.3
  • 27
    • 84906968862 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir
    • Chun T-W, Murray D, Justement JS, et al. Broadly neutralizing antibodies suppress HIV in the persistent viral reservoir. Proc Natl Acad Sci USA 2014; 111:13151-13156.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 13151-13156
    • Chun, T.-W.1    Murray, D.2    Justement, J.S.3
  • 28
    • 84870562234 scopus 로고    scopus 로고
    • HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
    • Klein F, Halper-Stromberg A, Horwitz JA, et al. HIV therapy by a combination of broadly neutralizing antibodies in humanized mice. Nature 2012; 492:118-122.
    • (2012) Nature , vol.492 , pp. 118-122
    • Klein, F.1    Halper-Stromberg, A.2    Horwitz, J.A.3
  • 29
    • 58149399396 scopus 로고    scopus 로고
    • Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies
    • Doria-Rose NA, Klein RM, Manion MM, et al. Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies. J Virol 2009; 83:188-199.
    • (2009) J Virol , vol.83 , pp. 188-199
    • Doria-Rose, N.A.1    Klein, R.M.2    Manion, M.M.3
  • 30
    • 79955389756 scopus 로고    scopus 로고
    • The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4 T cell decline and high viral load during acute infection
    • Gray ES, Madiga MC, Hermanus T, et al. The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4 T cell decline and high viral load during acute infection. J Virol 2011; 85:4828-4840.
    • (2011) J Virol , vol.85 , pp. 4828-4840
    • Gray, E.S.1    Madiga, M.C.2    Hermanus, T.3
  • 31
    • 79551518897 scopus 로고    scopus 로고
    • Characteristics of the earliest crossneutralizing antibody response to HIV-1
    • Mikell I, Sather DN, Kalams SA, et al. Characteristics of the earliest crossneutralizing antibody response to HIV-1. PLoS Pathog 2011; 7:e1001251.
    • (2011) PLoS Pathog , vol.7 , pp. e1001251
    • Mikell, I.1    Sather, D.N.2    Kalams, S.A.3
  • 32
    • 84866495323 scopus 로고    scopus 로고
    • Human antibodies that neutralize HIV-1: Identification, structures, and B cell ontogenies
    • Kwong PD, Mascola JR. Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies. Immunity 2012; 37:412-425.
    • (2012) Immunity , vol.37 , pp. 412-425
    • Kwong, P.D.1    Mascola, J.R.2
  • 33
    • 83455254775 scopus 로고    scopus 로고
    • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9
    • McLellan JS, Pancera M, Carrico C, et al. Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature 2011; 480:336-343.
    • (2011) Nature , vol.480 , pp. 336-343
    • McLellan, J.S.1    Pancera, M.2    Carrico, C.3
  • 34
    • 77954912140 scopus 로고    scopus 로고
    • Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1
    • Pejchal R, Walker LM, Stanfield RL, et al. Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1. Proc Natl Acad Sci USA 2010; 107:11483-11488.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 11483-11488
    • Pejchal, R.1    Walker, L.M.2    Stanfield, R.L.3
  • 35
    • 84876797103 scopus 로고    scopus 로고
    • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
    • Liao H-X, Lynch R, Zhou T, et al. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature 2013; 496:469-476.
    • (2013) Nature , vol.496 , pp. 469-476
    • Liao, H.-X.1    Lynch, R.2    Zhou, T.3
  • 36
    • 84869155712 scopus 로고    scopus 로고
    • Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape
    • Moore PL, Gray ES, Wibmer CK, et al. Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape. Nat Med 2012; 18:1688-1692.
    • (2012) Nat Med , vol.18 , pp. 1688-1692
    • Moore, P.L.1    Gray, E.S.2    Wibmer, C.K.3
  • 38
    • 84860014826 scopus 로고    scopus 로고
    • Unraveling the divergent results of preexposure prophylaxis trials for HIV prevention
    • van der Straten A, Van Damme L, Haberer JE, Bangsberg DR. Unraveling the divergent results of preexposure prophylaxis trials for HIV prevention. AIDS 2012; 26:F13-F19.
    • (2012) AIDS , vol.26 , pp. F13-F19
    • Van Der Straten, A.1    Van Damme, L.2    Haberer, J.E.3    Bangsberg, D.R.4
  • 39
    • 76349123565 scopus 로고    scopus 로고
    • Enhanced antibody half-life improves in vivo activity
    • Zalevsky J, Chamberlain AK, Horton HM, et al. Enhanced antibody half-life improves in vivo activity. Nat Biotechnol 2010; 28:157-159.
    • (2010) Nat Biotechnol , vol.28 , pp. 157-159
    • Zalevsky, J.1    Chamberlain, A.K.2    Horton, H.M.3
  • 40
    • 84907983318 scopus 로고    scopus 로고
    • Enhanced neonatal Fc receptor function improves protection against primate SHIV infection
    • Ko S-Y, Pegu A, Rudicell RS, et al. Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. Nature 2014; 514:642-645.
    • (2014) Nature , vol.514 , pp. 642-645
    • Ko, S.-Y.1    Pegu, A.2    Rudicell, R.S.3
  • 41
    • 84885155143 scopus 로고    scopus 로고
    • Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab
    • Muthumani K, Flingai S, Wise M, et al. Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab. Hum Vaccin Immunother 2013; 9:2253-2262.
    • (2013) Hum Vaccin Immunother , vol.9 , pp. 2253-2262
    • Muthumani, K.1    Flingai, S.2    Wise, M.3
  • 42
    • 84878941170 scopus 로고    scopus 로고
    • New developments in lentiviral vector design, production and purification
    • Segura MM, Mangion M, Gaillet B, Garnier A. New developments in lentiviral vector design, production and purification. Expert Opin Biol Ther 2013; 13:987-1011.
    • (2013) Expert Opin Biol Ther , vol.13 , pp. 987-1011
    • Segura, M.M.1    Mangion, M.2    Gaillet, B.3    Garnier, A.4
  • 43
    • 61849122809 scopus 로고    scopus 로고
    • Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes
    • Luo XM, Maarschalk E, O'Connell RM, et al. Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes. Blood 2009; 113:1422-1431.
    • (2009) Blood , vol.113 , pp. 1422-1431
    • Luo, X.M.1    Maarschalk, E.2    O'connell, R.M.3
  • 44
    • 77953311689 scopus 로고    scopus 로고
    • Inhibition of in vivo HIV infection in humanized mice by gene therapy of human hematopoietic stem cells with a lentiviral vector encoding a broadly neutralizing anti-HIV antibody
    • Joseph A, Zheng JH, Chen K, et al. Inhibition of in vivo HIV infection in humanized mice by gene therapy of human hematopoietic stem cells with a lentiviral vector encoding a broadly neutralizing anti-HIV antibody. J Virol 2010; 84:6645-6653.
    • (2010) J Virol , vol.84 , pp. 6645-6653
    • Joseph, A.1    Zheng, J.H.2    Chen, K.3
  • 45
    • 84870510055 scopus 로고    scopus 로고
    • Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice
    • Hur EM, Patel SN, Shimizu S, et al. Inhibitory effect of HIV-specific neutralizing IgA on mucosal transmission of HIV in humanized mice. Blood 2012; 120:4571-4582.
    • (2012) Blood , vol.120 , pp. 4571-4582
    • Hur, E.M.1    Patel, S.N.2    Shimizu, S.3
  • 46
    • 33746909909 scopus 로고    scopus 로고
    • Evidence of multiyear factor IX expression by AAV-mediated gene transfer to skeletal muscle in an individual with severe hemophilia B
    • Jiang H, Pierce GF, Ozelo MC, et al. Evidence of multiyear factor IX expression by AAV-mediated gene transfer to skeletal muscle in an individual with severe hemophilia B. Mol Ther 2006; 14:452-455.
    • (2006) Mol Ther , vol.14 , pp. 452-455
    • Jiang, H.1    Pierce, G.F.2    Ozelo, M.C.3
  • 47
    • 84866899464 scopus 로고    scopus 로고
    • Endgame: Glybera finally recommended for approval as the first gene therapy drug in the European Union
    • Yla-Herttuala S. Endgame: glybera finally recommended for approval as the first gene therapy drug in the European Union. Mol Ther 2012; 20:1831-1832.
    • (2012) Mol Ther , vol.20 , pp. 1831-1832
    • Yla-Herttuala, S.1
  • 48
    • 84911383748 scopus 로고    scopus 로고
    • Long-term safety and efficacy of factor IX gene therapy in hemophilia B
    • Nathwani AC, Reiss UM, Tuddenham EGD, et al. Long-term safety and efficacy of factor IX gene therapy in hemophilia B. N Engl J Med 2014; 371:1994-2004.
    • (2014) N Engl J Med , vol.371 , pp. 1994-2004
    • Nathwani, A.C.1    Reiss, U.M.2    Tuddenham, E.G.D.3
  • 49
    • 84855161388 scopus 로고    scopus 로고
    • Adenovirus-Associated Virus Vector-Mediated Gene Transfer in Hemophilia B
    • Nathwani AC, Tuddenham EGD, Rangarajan S, et al. Adenovirus-Associated Virus Vector-Mediated Gene Transfer in Hemophilia B. N Engl J Med 2011; 365:2357-2365.
    • (2011) N Engl J Med , vol.365 , pp. 2357-2365
    • Nathwani, A.C.1    Tuddenham, E.G.D.2    Rangarajan, S.3
  • 50
    • 0034572459 scopus 로고    scopus 로고
    • Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors
    • Chao H, Liu Y, Rabinowitz J, et al. Several log increase in therapeutic transgene delivery by distinct adeno-associated viral serotype vectors. Mol Ther 2000; 2:619-623.
    • (2000) Mol Ther , vol.2 , pp. 619-623
    • Chao, H.1    Liu, Y.2    Rabinowitz, J.3
  • 51
    • 21244491577 scopus 로고    scopus 로고
    • AAV hybrid serotypes: Improved vectors for gene delivery
    • Choi VW, McCarty DM, Samulski RJ. AAV hybrid serotypes: improved vectors for gene delivery. Curr Gene Ther 2005; 5:299-310.
    • (2005) Curr Gene Ther , vol.5 , pp. 299-310
    • Choi, V.W.1    McCarty, D.M.2    Samulski, R.J.3
  • 52
    • 77954976233 scopus 로고    scopus 로고
    • Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: Implications for gene therapy using AAV vectors
    • Boutin S, Monteilhet V, Veron P, et al. Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors. Hum Gene Ther 2010; 21:704-712.
    • (2010) Hum Gene Ther , vol.21 , pp. 704-712
    • Boutin, S.1    Monteilhet, V.2    Veron, P.3
  • 53
    • 0014355039 scopus 로고
    • Epidemiology of adenovirusassociated virus infection in a nursery population
    • Blacklow NR, Hoggan MD, Kapikian AZ, et al. Epidemiology of adenovirusassociated virus infection in a nursery population. Am J Epidemiol 1968; 88:368-378.
    • (1968) Am J Epidemiol , vol.88 , pp. 368-378
    • Blacklow, N.R.1    Hoggan, M.D.2    Kapikian, A.Z.3
  • 54
    • 80052496589 scopus 로고    scopus 로고
    • Impact of preexisting immunity on gene transfer to nonhuman primate liver with adeno-associated virus 8 vectors
    • Wang L, Calcedo R, Bell P, et al. Impact of preexisting immunity on gene transfer to nonhuman primate liver with adeno-associated virus 8 vectors. Hum Gene Ther 2011; 22:1389-1401.
    • (2011) Hum Gene Ther , vol.22 , pp. 1389-1401
    • Wang, L.1    Calcedo, R.2    Bell, P.3
  • 55
    • 0037015049 scopus 로고    scopus 로고
    • Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy
    • Gao G-P, Alvira MR, Wang L, et al. Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. Proc Natl Acad Sci USA 2002; 99:11854-11859.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11854-11859
    • Gao, G.-P.1    Alvira, M.R.2    Wang, L.3
  • 56
    • 84862599159 scopus 로고    scopus 로고
    • Enhancing the clinical potential of AAV vectors by capsid engineering to evade pre-existing immunity
    • Bartel M, Schaffer D, Bü ning H. Enhancing the clinical potential of AAV vectors by capsid engineering to evade pre-existing immunity. Front Microbiol 2011; 2:204.
    • (2011) Front Microbiol , vol.2 , pp. 204
    • Bartel, M.1    Schaffer, D.2    Bü Ning, H.3
  • 57
    • 32344438754 scopus 로고    scopus 로고
    • Directed evolution of adenoassociated virus yields enhanced gene delivery vectors
    • Maheshri N, Koerber JT, Kaspar BK, Schaffer DV. Directed evolution of adenoassociated virus yields enhanced gene delivery vectors. Nat Biotechnol 2006; 24:198-204.
    • (2006) Nat Biotechnol , vol.24 , pp. 198-204
    • Maheshri, N.1    Koerber, J.T.2    Kaspar, B.K.3    Schaffer, D.V.4
  • 58
    • 74049085498 scopus 로고    scopus 로고
    • Effect of genome size on AAV vector packaging
    • Wu Z, Yang H, Colosi P. Effect of genome size on AAV vector packaging. Mol Ther 2010; 18:80-86.
    • (2010) Mol Ther , vol.18 , pp. 80-86
    • Wu, Z.1    Yang, H.2    Colosi, P.3
  • 59
    • 0029849257 scopus 로고    scopus 로고
    • Quantitative analysis of the packaging capacity of recombinant adeno-associated virus
    • Dong JY, Fan PD, Frizzell RA. Quantitative analysis of the packaging capacity of recombinant adeno-associated virus. Hum Gene Ther 1996; 7:2101-2112.
    • (1996) Hum Gene Ther , vol.7 , pp. 2101-2112
    • Dong, J.Y.1    Fan, P.D.2    Frizzell, R.A.3
  • 60
    • 33947410764 scopus 로고    scopus 로고
    • Self-complementary recombinant adenoassociated viral vectors: Packaging capacity and the role of rep proteins in vector purity
    • Wu J, Zhao W, Zhong L, et al. Self-complementary recombinant adenoassociated viral vectors: packaging capacity and the role of rep proteins in vector purity. Hum Gene Ther 2007; 18:171-182.
    • (2007) Hum Gene Ther , vol.18 , pp. 171-182
    • Wu, J.1    Zhao, W.2    Zhong, L.3
  • 61
    • 0034882826 scopus 로고    scopus 로고
    • Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis
    • McCarty DM, Monahan PE, Samulski RJ. Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis. Gene Ther 2001; 8:1248-1254.
    • (2001) Gene Ther , vol.8 , pp. 1248-1254
    • McCarty, D.M.1    Monahan, P.E.2    Samulski, R.J.3
  • 62
    • 22744444388 scopus 로고    scopus 로고
    • Stable antibody expression at therapeutic levels using the 2A peptide
    • Fang J, Qian J-J, Yi S, et al. Stable antibody expression at therapeutic levels using the 2A peptide. Nat Biotechnol 2005; 23:584-590.
    • (2005) Nat Biotechnol , vol.23 , pp. 584-590
    • Fang, J.1    Qian, J.-J.2    Yi, S.3
  • 63
    • 34249289748 scopus 로고    scopus 로고
    • An antibody delivery system for regulated expression of therapeutic levels of monoclonal antibodies in vivo
    • Fang J, Yi S, Simmons A, et al. An antibody delivery system for regulated expression of therapeutic levels of monoclonal antibodies in vivo. Mol Ther 2007; 15:1153-1159.
    • (2007) Mol Ther , vol.15 , pp. 1153-1159
    • Fang, J.1    Yi, S.2    Simmons, A.3
  • 64
    • 84859715471 scopus 로고    scopus 로고
    • ScFv antibody: Principles and clinical application
    • Ahmad ZA, Yeap SK, Ali AM, et al. scFv antibody: principles and clinical application. Clin Dev Immunol 2012; 2012:1-15.
    • (2012) Clin Dev Immunol , vol.2012 , pp. 1-15
    • Ahmad, Z.A.1    Yeap, S.K.2    Ali, A.M.3
  • 66
    • 84898540554 scopus 로고    scopus 로고
    • Adeno-associated virus delivery of broadly neutralizing antibodies
    • Schnepp BC, Johnson PR. Adeno-associated virus delivery of broadly neutralizing antibodies. Curr Opin HIV AIDS 2014; 9:250-256.
    • (2014) Curr Opin HIV AIDS , vol.9 , pp. 250-256
    • Schnepp, B.C.1    Johnson, P.R.2
  • 67
    • 84891827301 scopus 로고    scopus 로고
    • AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells
    • Mays LE, Wang L, Lin J, et al. AAV8 induces tolerance in murine muscle as a result of poor APC transduction, T cell exhaustion, and minimal MHCI upregulation on target cells. Mol Ther 2014; 22:28-41.
    • (2014) Mol Ther , vol.22 , pp. 28-41
    • Mays, L.E.1    Wang, L.2    Lin, J.3
  • 68
    • 79958812814 scopus 로고    scopus 로고
    • Humanized Rag1-/- gc-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes
    • Akkina R, Berges BK, Palmer BE, et al. Humanized Rag1-/- gc-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes. PLoS One 2011; 6:e20169.
    • (2011) PLoS One , vol.6 , pp. e20169
    • Akkina, R.1    Berges, B.K.2    Palmer, B.E.3
  • 69
    • 44449141907 scopus 로고    scopus 로고
    • Functional and phenotypic characterization of the humanized BLT mouse model
    • Wege AK, Melkus MW, Denton PW, et al. Functional and phenotypic characterization of the humanized BLT mouse model. Curr Top Microbiol Immunol 2008; 324:149-165.
    • (2008) Curr Top Microbiol Immunol , vol.324 , pp. 149-165
    • Wege, A.K.1    Melkus, M.W.2    Denton, P.W.3
  • 70
    • 38849136442 scopus 로고    scopus 로고
    • Antiretroviral preexposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice
    • Denton PW, Estes JD, Sun Z, et al. Antiretroviral preexposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med 2008; 5:e16.
    • (2008) PLoS Med , vol.5 , pp. e16
    • Denton, P.W.1    Estes, J.D.2    Sun, Z.3
  • 71
    • 84855902980 scopus 로고    scopus 로고
    • Determinants of per-coital-act HIV-1 infectivity among African HIV-1-serodiscordant couples
    • Hughes JP, Baeten JM, Lingappa JR, et al. Determinants of per-coital-act HIV-1 infectivity among African HIV-1-serodiscordant couples. J Infect Dis 2012; 205:358-365.
    • (2012) J Infect Dis , vol.205 , pp. 358-365
    • Hughes, J.P.1    Baeten, J.M.2    Lingappa, J.R.3
  • 72
    • 0345569681 scopus 로고    scopus 로고
    • Inhibiting sexual transmission of HIV-1 infection
    • Shattock RJ, Moore JP. Inhibiting sexual transmission of HIV-1 infection. Nat Rev Micro 2003; 1:25-34.
    • (2003) Nat Rev Micro , vol.1 , pp. 25-34
    • Shattock, R.J.1    Moore, J.P.2
  • 73
    • 0033119374 scopus 로고    scopus 로고
    • Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo
    • Poignard P, Sabbe R, Picchio GR, et al. Neutralizing antibodies have limited effects on the control of established HIV-1 infection in vivo. Immunity 1999; 10:431-438.
    • (1999) Immunity , vol.10 , pp. 431-438
    • Poignard, P.1    Sabbe, R.2    Picchio, G.R.3
  • 74
    • 84893815335 scopus 로고    scopus 로고
    • Targeted cytotoxic therapy kills persisting HIV infected cells during ART
    • Denton PW, Long JM, Wietgrefe SW, et al. Targeted cytotoxic therapy kills persisting HIV infected cells during ART. PLoS Pathog 2014; 10:e1003872.
    • (2014) PLoS Pathog , vol.10 , pp. e1003872
    • Denton, P.W.1    Long, J.M.2    Wietgrefe, S.W.3
  • 75
    • 80054780343 scopus 로고    scopus 로고
    • H3N2 influenza infection elicits more cross-reactive and less clonally expanded antihemagglutinin antibodies than influenza vaccination
    • Moody MA, Zhang R, Walter EB, et al. H3N2 influenza infection elicits more cross-reactive and less clonally expanded antihemagglutinin antibodies than influenza vaccination. PLoS One 2011; 6:e25797.
    • (2011) PLoS One , vol.6 , pp. e25797
    • Moody, M.A.1    Zhang, R.2    Walter, E.B.3
  • 76
    • 68349150945 scopus 로고    scopus 로고
    • Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys
    • Johnson PR, Schnepp BC, Zhang J, et al. Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys. Nat Med 2009; 15:901-906.
    • (2009) Nat Med , vol.15 , pp. 901-906
    • Johnson, P.R.1    Schnepp, B.C.2    Zhang, J.3
  • 77
    • 0019193474 scopus 로고
    • Immune deposits in extraglomerular vessels: Their correlation with circulating immune complexes
    • Burden RP, Cotton RE, Wallington TB, Reeves WG. Immune deposits in extraglomerular vessels: Their correlation with circulating immune complexes. Clin Exp Immunol 1980; 42:483-489.
    • (1980) Clin Exp Immunol , vol.42 , pp. 483-489
    • Burden, R.P.1    Cotton, R.E.2    Wallington, T.B.3    Reeves, W.G.4
  • 78
    • 84874562109 scopus 로고    scopus 로고
    • Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies
    • Yang G, Holl TM, Liu Y, et al. Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. J Exp Med 2013; 210:241-256.
    • (2013) J Exp Med , vol.210 , pp. 241-256
    • Yang, G.1    Holl, T.M.2    Liu, Y.3
  • 79
    • 21344434534 scopus 로고    scopus 로고
    • Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies
    • Haynes BF, Fleming J, St Clair EW, et al. Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. Science 2005; 308:1906-1908.
    • (2005) Science , vol.308 , pp. 1906-1908
    • Haynes, B.F.1    Fleming, J.2    St Clair, E.W.3
  • 80
    • 0032080680 scopus 로고    scopus 로고
    • Phase i study of a human monoclonal antibody directed against the CD4-binding site of HIV type 1 glycoprotein 120
    • Cavacini LA, Samore MH, Gambertoglio J, et al. Phase I study of a human monoclonal antibody directed against the CD4-binding site of HIV type 1 glycoprotein 120. AIDS Res Hum Retroviruses 1998; 14:545-550.
    • (1998) AIDS Res Hum Retroviruses , vol.14 , pp. 545-550
    • Cavacini, L.A.1    Samore, M.H.2    Gambertoglio, J.3
  • 81
    • 0026462782 scopus 로고
    • Characterization of the cDNA of a broadly reactive neutralizing human antigp120 monoclonal antibody
    • Marasco WA, Bagley J, Zani C, et al. Characterization of the cDNA of a broadly reactive neutralizing human antigp120 monoclonal antibody. J Clin Invest 1992; 90:1467-1478.
    • (1992) J Clin Invest , vol.90 , pp. 1467-1478
    • Marasco, W.A.1    Bagley, J.2    Zani, C.3
  • 82
    • 0037169214 scopus 로고    scopus 로고
    • A phase i trial with two human monoclonal antibodies (hMAb 2F5, 2G12) against HIV-1
    • Armbruster C, Stiegler GM, Vcelar BA, et al. A phase I trial with two human monoclonal antibodies (hMAb 2F5, 2G12) against HIV-1. AIDS 2002; 16:227-233.
    • (2002) AIDS , vol.16 , pp. 227-233
    • Armbruster, C.1    Stiegler, G.M.2    Vcelar, B.A.3
  • 83
    • 0027378573 scopus 로고
    • A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1
    • Muster T, Steindl F, Purtscher M, et al. A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1. J Virol 1993; 67:6642-6647.
    • (1993) J Virol , vol.67 , pp. 6642-6647
    • Muster, T.1    Steindl, F.2    Purtscher, M.3
  • 84
    • 0028865465 scopus 로고
    • Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG
    • Trkola A, Pomales AB, Yuan H, et al. Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG. J Virol 1995; 69:6609-6617.
    • (1995) J Virol , vol.69 , pp. 6609-6617
    • Trkola, A.1    Pomales, A.B.2    Yuan, H.3
  • 85
    • 33646723290 scopus 로고    scopus 로고
    • Anti-V3 humanized antibody KD-247 effectively suppresses ex vivo generation of human immunodeficiency virus type 1 and affords sterile protection of monkeys against a heterologous simian/human immunodeficiency virus infection
    • Eda Y, Murakami T, Ami Y, et al. Anti-V3 humanized antibody KD-247 effectively suppresses ex vivo generation of human immunodeficiency virus type 1 and affords sterile protection of monkeys against a heterologous simian/human immunodeficiency virus infection. J Virol 2006; 80:5563-5570.
    • (2006) J Virol , vol.80 , pp. 5563-5570
    • Eda, Y.1    Murakami, T.2    Ami, Y.3
  • 86
    • 34447091994 scopus 로고    scopus 로고
    • Preclinical and clinical safety of monoclonal antibodies
    • Tabrizi MA, Roskos LK. Preclinical and clinical safety of monoclonal antibodies. Drug Discov Today 2007; 12:540-547.
    • (2007) Drug Discov Today , vol.12 , pp. 540-547
    • Tabrizi, M.A.1    Roskos, L.K.2
  • 87
    • 0033855859 scopus 로고    scopus 로고
    • Clinical trials of antibody therapy
    • Glennie MJ, Johnson PW. Clinical trials of antibody therapy. Immunol Today 2000; 21:403-410.
    • (2000) Immunol Today , vol.21 , pp. 403-410
    • Glennie, M.J.1    Johnson, P.W.2
  • 88
    • 17644378667 scopus 로고    scopus 로고
    • Immunogenicity of engineered antibodies
    • Hwang WYK, Foote J. Immunogenicity of engineered antibodies. Methods 2005; 36:3-10.
    • (2005) Methods , vol.36 , pp. 3-10
    • Hwang, W.Y.K.1    Foote, J.2


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