-
1
-
-
80051670323
-
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins
-
D. Corti, J. Voss, S. J. Gamblin, G. Codoni, A. Macagno, D. Jarrossay, S. G. Vachieri, D. Pinna, A. Minola, F. Vanzetta, C. Silacci, B. M. Fernandez-Rodriguez, G. Agatic, S. Bianchi, I. Giacchetto-Sasselli, L. Calder, F. Sallusto, P. Collins, L. F. Haire, N. Temperton, J. P. M. Langedijk, J. J. Skehel, A. Lanzavecchia, A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science 333, 850–856 (2011).
-
(2011)
Science
, vol.333
, pp. 850-856
-
-
Corti, D.1
Voss, J.2
Gamblin, S.J.3
Codoni, G.4
Macagno, A.5
Jarrossay, D.6
Vachieri, S.G.7
Pinna, D.8
Minola, A.9
Vanzetta, F.10
Silacci, C.11
Fernandez-Rodriguez, B.M.12
Agatic, G.13
Bianchi, S.14
Giacchetto-Sasselli, I.15
Calder, L.16
Sallusto, F.17
Collins, P.18
Haire, L.F.19
Temperton, N.20
Langedijk, J.P.M.21
Skehel, J.J.22
Lanzavecchia, A.23
more..
-
2
-
-
84866122029
-
Highly conserved protective epitopes on influenza B viruses
-
C. Dreyfus, N. S. Laursen, T. Kwaks, D. Zuijdgeest, R. Khayat, D. C. Ekiert, J. H. Lee, Z. Metlagel, M. V. Bujny, M. Jongeneelen, R. van der Vlugt, M. Lamrani, H. J. W. M. Korse, E. Geelen, Ö. Sahin, M. Sieuwerts, J. P. J. Brakenhoff, R. Vogels, O. T. W. Li, L. L. M. Poon, M. Peiris, W. Koudstaal, A. B. Ward, I. A. Wilson, J. Goudsmit, R. H. E. Friesen, Highly conserved protective epitopes on influenza B viruses. Science 337, 1343–1348 (2012).
-
(2012)
Science
, vol.337
, pp. 1343-1348
-
-
Dreyfus, C.1
Laursen, N.S.2
Kwaks, T.3
Zuijdgeest, D.4
Khayat, R.5
Ekiert, D.C.6
Lee, J.H.7
Metlagel, Z.8
Bujny, M.V.9
Jongeneelen, M.10
Van Der Vlugt, R.11
Lamrani, M.12
Korse, H.J.W.M.13
Geelen, E.14
Sahin, Ö.15
Sieuwerts, M.16
Brakenhoff, J.P.J.17
Vogels, R.18
Li, O.T.W.19
Poon, L.L.M.20
Peiris, M.21
Koudstaal, W.22
Ward, A.B.23
Wilson, I.A.24
Goudsmit, J.25
Friesen, R.H.E.26
more..
-
3
-
-
58049198443
-
+ memory B cells
-
+ memory B cells. PLOS ONE 3, e3942 (2008).
-
(2008)
PLOS ONE
, vol.3
-
-
Throsby, M.1
Van Den Brink, E.2
Jongeneelen, M.3
Poon, L.L.M.4
Alard, P.5
Cornelissen, L.6
Bakker, A.7
Cox, F.8
Van Deventer, E.9
Guan, Y.10
Cinatl, J.11
Ter Meulen, J.12
Lasters, I.13
Carsetti, R.14
Peiris, M.15
De Kruif, J.16
Goudsmit, J.17
-
4
-
-
0027471177
-
A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains
-
Y. Okuno, Y. Isegawa, F. Sasao, S. Ueda, A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains. J. Virol. 67, 2552–2558 (1993).
-
(1993)
J. Virol.
, vol.67
, pp. 2552-2558
-
-
Okuno, Y.1
Isegawa, Y.2
Sasao, F.3
Ueda, S.4
-
5
-
-
62049083943
-
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses
-
J. Sui, W. C. Hwang, S. Perez, G. Wei, D. Aird, L.-M. Chen, E. Santelli, B. Stec, G. Cadwell, M. Ali, H. Wan, A. Murakami, A. Yammanuru, T. Han, N. J. Cox, L. A. Bankston, R. O. Donis, R. C. Liddington, W. A. Marasco, Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat. Struct. Mol. Biol. 16, 265–273 (2009).
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 265-273
-
-
Sui, J.1
Hwang, W.C.2
Perez, S.3
Wei, G.4
Aird, D.5
Chen, L.-M.6
Santelli, E.7
Stec, B.8
Cadwell, G.9
Ali, M.10
Wan, H.11
Murakami, A.12
Yammanuru, A.13
Han, T.14
Cox, N.J.15
Bankston, L.A.16
Donis, R.O.17
Liddington, R.C.18
Marasco, W.A.19
-
6
-
-
84941023600
-
Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection
-
H. M. Yassine, J. C. Boyington, P. M. McTamney, C.-J. Wei, M. Kanekiyo, W.-P. Kong, J. R. Gallagher, L. Wang, Y. Zhang, M. G. Joyce, D. Lingwood, S. M. Moin, H. Andersen, Y. Okuno, S. S. Rao, A. K. Harris, P. D. Kwong, J. R. Mascola, G. J. Nabel, B. S. Graham, Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection. Nat. Med. 21, 1065–1070 (2015).
-
(2015)
Nat. Med.
, vol.21
, pp. 1065-1070
-
-
Yassine, H.M.1
Boyington, J.C.2
McTamney, P.M.3
Wei, C.-J.4
Kanekiyo, M.5
Kong, W.-P.6
Gallagher, J.R.7
Wang, L.8
Zhang, Y.9
Joyce, M.G.10
Lingwood, D.11
Moin, S.M.12
Andersen, H.13
Okuno, Y.14
Rao, S.S.15
Harris, A.K.16
Kwong, P.D.17
Mascola, J.R.18
Nabel, G.J.19
Graham, B.S.20
more..
-
7
-
-
84941873935
-
A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen
-
A. Impagliazzo, F. Milder, H. Kuipers, M. V. Wagner, X. Zhu, R. M. B. Hoffman, R. van Meersbergen, J. Huizingh, P. Wanningen, J. Verspuij, M. de Man, Z. Ding, A. Apetri, B. Kükrer, E. Sneekes-Vriese, D. Tomkiewicz, N. S. Laursen, P. S. Lee, A. Zakrzewska, L. Dekking, J. Tolboom, L. Tettero, S. van Meerten, W. Yu, W. Koudstaal, J. Goudsmit, A. B. Ward, W. Meijberg, I. A. Wilson, K. Radošević, A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen. Science 349, 1301–1306 (2015).
-
(2015)
Science
, vol.349
, pp. 1301-1306
-
-
Impagliazzo, A.1
Milder, F.2
Kuipers, H.3
Wagner, M.V.4
Zhu, X.5
Hoffman, R.M.B.6
Van Meersbergen, R.7
Huizingh, J.8
Wanningen, P.9
Verspuij, J.10
De Man, M.11
Ding, Z.12
Apetri, A.13
Kükrer, B.14
Sneekes-Vriese, E.15
Tomkiewicz, D.16
Laursen, N.S.17
Lee, P.S.18
Zakrzewska, A.19
Dekking, L.20
Tolboom, J.21
Tettero, L.22
Van Meerten, S.23
Yu, W.24
Koudstaal, W.25
Goudsmit, J.26
Ward, A.B.27
Meijberg, W.28
Wilson, I.A.29
Radošević, K.30
more..
-
8
-
-
84931573106
-
Vaccination with soluble headless hemagglutinin protects mice from challenge with divergent influenza viruses
-
T. J. Wohlbold, R. Nachbagauer, I. Margine, G. S. Tan, A. Hirsh, F. Krammer, Vaccination with soluble headless hemagglutinin protects mice from challenge with divergent influenza viruses. Vaccine 33, 3314–3321 (2015).
-
(2015)
Vaccine
, vol.33
, pp. 3314-3321
-
-
Wohlbold, T.J.1
Nachbagauer, R.2
Margine, I.3
Tan, G.S.4
Hirsh, A.5
Krammer, F.6
-
9
-
-
84961114525
-
Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets
-
R. Nachbagauer, M. S. Miller, R. Hai, A. B. Ryder, J. K. Rose, P. Palese, A. García-Sastre, F. Krammer, R. A. Albrecht, Hemagglutinin stalk immunity reduces influenza virus replication and transmission in ferrets. J. Virol. 90, 3268–3273 (2016).
-
(2016)
J. Virol.
, vol.90
, pp. 3268-3273
-
-
Nachbagauer, R.1
Miller, M.S.2
Hai, R.3
Ryder, A.B.4
Rose, J.K.5
Palese, P.6
García-Sastre, A.7
Krammer, F.8
Albrecht, R.A.9
-
10
-
-
84979011884
-
Globular head-displayed conserved influenza H1 hemagglutinin stalk epitopes confer protection against heterologous H1N1 virus
-
M. Klausberger, R. Tscheliessnig, S. Neff, R. Nachbagauer, T. J. Wohlbold, M. Wilde, D. Palmberger, F. Krammer, A. Jungbauer, R. Grabherr, Globular head-displayed conserved influenza H1 hemagglutinin stalk epitopes confer protection against heterologous H1N1 virus. PLOS ONE 11, e0153579 (2016).
-
(2016)
PLOS ONE
, vol.11
-
-
Klausberger, M.1
Tscheliessnig, R.2
Neff, S.3
Nachbagauer, R.4
Wohlbold, T.J.5
Wilde, M.6
Palmberger, D.7
Krammer, F.8
Jungbauer, A.9
Grabherr, R.10
-
11
-
-
84960448072
-
Stalking influenza by vaccination with pre-fusion headless HA mini-stem
-
S. A. Valkenburg, V. V. A. Mallajosyula, O. T. W. Li, A. W. H. Chin, G. Carnell, N. Temperton, R. Varadarajan, L. L. M. Poon, Stalking influenza by vaccination with pre-fusion headless HA mini-stem. Sci. Rep. 6, 22666 (2016).
-
(2016)
Sci. Rep.
, vol.6
, pp. 22666
-
-
Valkenburg, S.A.1
Mallajosyula, V.V.A.2
Li, O.T.W.3
Chin, A.W.H.4
Carnell, G.5
Temperton, N.6
Varadarajan, R.7
Poon, L.L.M.8
-
12
-
-
78651488739
-
Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection
-
J. Wrammert, D. Koutsonanos, G.-M. Li, S. Edupuganti, J. Sui, M. Morrissey, M. McCausland, I. Skountzou, M. Hornig, W. I. Lipkin, A. Mehta, B. Razavi, C. Del Rio, N.-Y. Zheng, J.-H. Lee, M. Huang, Z. Ali, K. Kaur, S. Andrews, R. R. Amara, Y. Wang, S. R. Das, C. D. O’Donnell, J. W. Yewdell, K. Subbarao, W. A. Marasco, M. J. Mulligan, R. Compans, R. Ahmed, P. C. Wilson, Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection. J. Exp. Med. 208, 181–193 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 181-193
-
-
Wrammert, J.1
Koutsonanos, D.2
Li, G.-M.3
Edupuganti, S.4
Sui, J.5
Morrissey, M.6
McCausland, M.7
Skountzou, I.8
Hornig, M.9
Lipkin, W.I.10
Mehta, A.11
Razavi, B.12
Del Rio, C.13
Zheng, N.-Y.14
Lee, J.-H.15
Huang, M.16
Ali, Z.17
Kaur, K.18
Andrews, S.19
Amara, R.R.20
Wang, Y.21
Das, S.R.22
O’Donnell, C.D.23
Yewdell, J.W.24
Subbarao, K.25
Marasco, W.A.26
Mulligan, M.J.27
Compans, R.28
Ahmed, R.29
Wilson, P.C.30
more..
-
13
-
-
84864824020
-
Pandemic H1N1 influenza infection and vaccination in humans induces cross-protective antibodies that target the hemagglutinin stem
-
C. A. Thomson, Y. Wang, L. M. Jackson, M. Olson, W. Wang, A. Liavonchanka, L. Keleta, V. Silva, S. Diederich, R. B. Jones, J. Gubbay, J. Pasick, M. Petric, F. Jean, V. G. Allen, E. G. Brown, J. M. Rini, J. W. Schrader, Pandemic H1N1 influenza infection and vaccination in humans induces cross-protective antibodies that target the hemagglutinin stem. Front. Immunol. 3, 87 (2012).
-
(2012)
Front. Immunol.
, vol.3
, pp. 87
-
-
Thomson, C.A.1
Wang, Y.2
Jackson, L.M.3
Olson, M.4
Wang, W.5
Liavonchanka, A.6
Keleta, L.7
Silva, V.8
Diederich, S.9
Jones, R.B.10
Gubbay, J.11
Pasick, J.12
Petric, M.13
Jean, F.14
Allen, V.G.15
Brown, E.G.16
Rini, J.M.17
Schrader, J.W.18
-
14
-
-
84861872090
-
Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells
-
G.-M. Li, C. Chiu, J. Wrammert, M. McCausland, S. F. Andrews, N.-Y. Zheng, J.-H. Lee, M. Huang, X. Qu, S. Edupuganti, M. Mulligan, S. R. Das, J. W. Yewdell, A. K. Mehta, P. C. Wilson, R. Ahmed, Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells. Proc. Natl. Acad. Sci. U.S.A. 109, 9047–9052 (2012).
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 9047-9052
-
-
Li, G.-M.1
Chiu, C.2
Wrammert, J.3
McCausland, M.4
Andrews, S.F.5
Zheng, N.-Y.6
Lee, J.-H.7
Huang, M.8
Qu, X.9
Edupuganti, S.10
Mulligan, M.11
Das, S.R.12
Yewdell, J.W.13
Mehta, A.K.14
Wilson, P.C.15
Ahmed, R.16
-
15
-
-
84936803233
-
H5N1 vaccine-elicited memory B cells are genetically constrained by the IGHV locus in the recognition of a neutralizing epitope in the hemagglutinin stem
-
A. K. Wheatley, J. R. R. Whittle, D. Lingwood, M. Kanekiyo, H. M. Yassine, S. S. Ma, S. R. Narpala, M. S. Prabhakaran, R. A. Matus-Nicodemos, R. T. Bailer, G. J. Nabel, B. S. Graham, J. E. Ledgerwood, R. A. Koup, A. B. McDermott, H5N1 vaccine-elicited memory B cells are genetically constrained by the IGHV locus in the recognition of a neutralizing epitope in the hemagglutinin stem. J. Immunol. 195, 602–610 (2015).
-
(2015)
J. Immunol.
, vol.195
, pp. 602-610
-
-
Wheatley, A.K.1
Whittle, J.R.R.2
Lingwood, D.3
Kanekiyo, M.4
Yassine, H.M.5
Ma, S.S.6
Narpala, S.R.7
Prabhakaran, M.S.8
Matus-Nicodemos, R.A.9
Bailer, R.T.10
Nabel, G.J.11
Graham, B.S.12
Ledgerwood, J.E.13
Koup, R.A.14
McDermott, A.B.15
-
16
-
-
84896917279
-
Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages
-
J. R. R. Whittle, A. K. Wheatley, L. Wu, D. Lingwood, M. Kanekiyo, S. S. Ma, S. R. Narpala, H. M. Yassine, G. M. Frank, J. W. Yewdell, J. E. Ledgerwood, C.-J. Wei, A. B. McDermott, B. S. Graham, R. A. Koup, G. J. Nabel, Flow cytometry reveals that H5N1 vaccination elicits cross-reactive stem-directed antibodies from multiple Ig heavy-chain lineages. J. Virol. 88, 4047–4057 (2014).
-
(2014)
J. Virol.
, vol.88
, pp. 4047-4057
-
-
Whittle, J.R.R.1
Wheatley, A.K.2
Wu, L.3
Lingwood, D.4
Kanekiyo, M.5
Ma, S.S.6
Narpala, S.R.7
Yassine, H.M.8
Frank, G.M.9
Yewdell, J.W.10
Ledgerwood, J.E.11
Wei, C.-J.12
McDermott, A.B.13
Graham, B.S.14
Koup, R.A.15
Nabel, G.J.16
-
17
-
-
64849114224
-
Antibody recognition of a highly conserved influenza virus epitope
-
D. C. Ekiert, G. Bhabha, M.-A. Elsliger, R. H. E. Friesen, M. Jongeneelen, M. Throsby, J. Goudsmit, I. A. Wilson, Antibody recognition of a highly conserved influenza virus epitope. Science 324, 246–251 (2009).
-
(2009)
Science
, vol.324
, pp. 246-251
-
-
Ekiert, D.C.1
Bhabha, G.2
Elsliger, M.-A.3
Friesen, R.H.E.4
Jongeneelen, M.5
Throsby, M.6
Goudsmit, J.7
Wilson, I.A.8
-
18
-
-
84922225958
-
Rapid development of broadly influenza neutralizing antibodies through redundant mutations
-
L. Pappas, M. Foglierini, L. Piccoli, N. L. Kallewaard, F. Turrini, C. Silacci, B. Fernandez-Rodriguez, G. Agatic, I. Giacchetto-Sasselli, G. Pellicciotta, F. Sallusto, Q. Zhu, E. Vicenzi, D. Corti, A. Lanzavecchia, Rapid development of broadly influenza neutralizing antibodies through redundant mutations. Nature 516, 418–422 (2014).
-
(2014)
Nature
, vol.516
, pp. 418-422
-
-
Pappas, L.1
Foglierini, M.2
Piccoli, L.3
Kallewaard, N.L.4
Turrini, F.5
Silacci, C.6
Fernandez-Rodriguez, B.7
Agatic, G.8
Giacchetto-Sasselli, I.9
Pellicciotta, G.10
Sallusto, F.11
Zhu, Q.12
Vicenzi, E.13
Corti, D.14
Lanzavecchia, A.15
-
19
-
-
84866949036
-
Structural and genetic basis for development of broadly neutralizing influenza antibodies
-
D. Lingwood, P. M. McTamney, H. M. Yassine, J. R. R. Whittle, X. Guo, J. C. Boyington, C.-J. Wei, G. J. Nabel, Structural and genetic basis for development of broadly neutralizing influenza antibodies. Nature 489, 566–570 (2012).
-
(2012)
Nature
, vol.489
, pp. 566-570
-
-
Lingwood, D.1
McTamney, P.M.2
Yassine, H.M.3
Whittle, J.R.R.4
Guo, X.5
Boyington, J.C.6
Wei, C.-J.7
Nabel, G.J.8
-
20
-
-
84901687604
-
Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses
-
Y. Avnir, A. S. Tallarico, Q. Zhu, A. S. Bennett, G. Connelly, J. Sheehan, J. Sui, A. Fahmy, C.-Y. Huang, G. Cadwell, L. A. Bankston, A. T. McGuire, L. Stamatatos, G. Wagner, R. C. Liddington, W. A. Marasco, Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses. PLOS Pathog. 10, e1004103 (2014).
-
(2014)
PLOS Pathog
, vol.10
, pp. e1004103
-
-
Avnir, Y.1
Tallarico, A.S.2
Zhu, Q.3
Bennett, A.S.4
Connelly, G.5
Sheehan, J.6
Sui, J.7
Fahmy, A.8
Huang, C.-Y.9
Cadwell, G.10
Bankston, L.A.11
McGuire, A.T.12
Stamatatos, L.13
Wagner, G.14
Liddington, R.C.15
Marasco, W.A.16
-
21
-
-
80051635697
-
A highly conserved neutralizing epitope on group 2 influenza A viruses
-
D. C. Ekiert, R. H. E. Friesen, G. Bhabha, T. Kwaks, M. Jongeneelen, W. Yu, C. Ophorst, F. Cox, H. J. W. M. Korse, B. Brandenburg, R. Vogels, J. P. J. Brakenhoff, R. Kompier, M. H. Koldijk, L. A. H. M. Cornelissen, L. L. M. Poon, M. Peiris, W. Koudstaal, I. A. Wilson, J. Goudsmit, A highly conserved neutralizing epitope on group 2 influenza A viruses. Science 333, 843–850 (2011).
-
(2011)
Science
, vol.333
, pp. 843-850
-
-
Ekiert, D.C.1
Friesen, R.H.E.2
Bhabha, G.3
Kwaks, T.4
Jongeneelen, M.5
Yu, W.6
Ophorst, C.7
Cox, F.8
Korse, H.J.W.M.9
Brandenburg, B.10
Vogels, R.11
Brakenhoff, J.P.J.12
Kompier, R.13
Koldijk, M.H.14
Cornelissen, L.A.H.M.15
Poon, L.L.M.16
Peiris, M.17
Koudstaal, W.18
Wilson, I.A.19
Goudsmit, J.20
more..
-
22
-
-
84924034216
-
Preexisting human antibodies neutralize recently emerged H7N9 influenza strains
-
C. J. Henry Dunand, P. E. Leon, K. Kaur, G. S. Tan, N.-Y. Zheng, S. Andrews, M. Huang, X. Qu, Y. Huang, M. Salgado-Ferrer, I. Y. Ho, W. Taylor, R. Hai, J. Wrammert, R. Ahmed, A. García-Sastre, P. Palese, F. Krammer, P. C. Wilson, Preexisting human antibodies neutralize recently emerged H7N9 influenza strains. J. Clin. Invest. 125, 1255–1268 (2015).
-
(2015)
J. Clin. Invest.
, vol.125
, pp. 1255-1268
-
-
Henry Dunand, C.J.1
Leon, P.E.2
Kaur, K.3
Tan, G.S.4
Zheng, N.-Y.5
Andrews, S.6
Huang, M.7
Qu, X.8
Huang, Y.9
Salgado-Ferrer, M.10
Ho, I.Y.11
Taylor, W.12
Hai, R.13
Wrammert, J.14
Ahmed, R.15
García-Sastre, A.16
Palese, P.17
Krammer, F.18
Wilson, P.C.19
-
23
-
-
84937684824
-
A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus
-
Y. Wu, M. Cho, D. Shore, M. Song, J. Choi, T. Jiang, Y.-Q. Deng, M. Bourgeois, L. Almli, H. Yang, L.-M. Chen, Y. Shi, J. Qi, A. Li, K. S. Yi, M. Chang, J. S. Bae, H. Lee, J. Shin, J. Stevens, S. Hong, C.-F. Qin, G. F. Gao, S. J. Chang, R. O. Donis, A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus. Nat. Commun. 6, 7708 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 7708
-
-
Wu, Y.1
Cho, M.2
Shore, D.3
Song, M.4
Choi, J.5
Jiang, T.6
Deng, Y.-Q.7
Bourgeois, M.8
Almli, L.9
Yang, H.10
Chen, L.-M.11
Shi, Y.12
Qi, J.13
Li, A.14
Yi, K.S.15
Chang, M.16
Bae, J.S.17
Lee, H.18
Shin, J.19
Stevens, J.20
Hong, S.21
Qin, C.-F.22
Gao, G.F.23
Chang, S.J.24
Donis, R.O.25
more..
-
24
-
-
84979581546
-
Vaccine-induced antibodies that neutralize group 1 and group 2 influenza A viruses
-
NISC Comparative Sequencing Program
-
M. G. Joyce, A. K. Wheatley, P. V. Thomas, G.-Y. Chuang, C. Soto, R. T. Bailer, A. Druz, I. S. Georgiev, R. A. Gillespie, M. Kanekiyo, W.-P. Kong, K. Leung, S. N. Narpala, M. S. Prabhakaran, E. S. Yang, B. Zhang, Y. Zhang, M. Asokan, J. C. Boyington, T. Bylund, S. Darko, C. R. Lees, A. Ransier, C.-H. Shen, L. Wang, J. R. Whittle, X. Wu, H. M. Yassine, C. Santos, Y. Matsuoka, Y. Tsybovsky, U. Baxa; NISC Comparative Sequencing Program, J. C. Mullikin, K. Subbarao, D. C. Douek, B. S. Graham, R. A. Koup, J. E. Ledgerwood, M. Roederer, L. Shapiro, P. D. Kwong, J. R. Mascola, A. B. McDermott, Vaccine-induced antibodies that neutralize group 1 and group 2 influenza A viruses. Cell 166, 609–623 (2016).
-
(2016)
Cell
, vol.166
, pp. 609-623
-
-
Joyce, M.G.1
Wheatley, A.K.2
Thomas, P.V.3
Chuang, G.-Y.4
Soto, C.5
Bailer, R.T.6
Druz, A.7
Georgiev, I.S.8
Gillespie, R.A.9
Kanekiyo, M.10
Kong, W.-P.11
Leung, K.12
Narpala, S.N.13
Prabhakaran, M.S.14
Yang, E.S.15
Zhang, B.16
Zhang, Y.17
Asokan, M.18
Boyington, J.C.19
Bylund, T.20
Darko, S.21
Lees, C.R.22
Ransier, A.23
Shen, C.-H.24
Wang, L.25
Whittle, J.R.26
Wu, X.27
Yassine, H.M.28
Santos, C.29
Matsuoka, Y.30
Tsybovsky, Y.31
Baxa, U.32
Mullikin, J.C.33
Subbarao, K.34
Douek, D.C.35
Graham, B.S.36
Koup, R.A.37
Ledgerwood, J.E.38
Roederer, M.39
Shapiro, L.40
Kwong, P.D.41
Mascola, J.R.42
McDermott, A.B.43
more..
-
25
-
-
84979713667
-
Structure and function analysis of an antibody recognizing all influenza A subtypes
-
N. L. Kallewaard, D. Corti, P. J. Collins, U. Neu, J. M. McAuliffe, E. Benjamin, L. Wachter-Rosati, F. J. Palmer-Hill, A. Q. Yuan, P. A. Walker, M. K. Vorlaender, S. Bianchi, B. Guarino, A. De Marco, F. Vanzetta, G. Agatic, M. Foglierini, D. Pinna, B. Fernandez-Rodriguez, A. Fruehwirth, C. Silacci, R. W. Ogrodowicz, S. R. Martin, F. Sallusto, J. A. Suzich, A. Lanzavecchia, Q. Zhu, S. J. Gamblin, J. J. Skehel, Structure and function analysis of an antibody recognizing all influenza A subtypes. Cell 166, 596–608 (2016).
-
(2016)
Cell
, vol.166
, pp. 596-608
-
-
Kallewaard, N.L.1
Corti, D.2
Collins, P.J.3
Neu, U.4
McAuliffe, J.M.5
Benjamin, E.6
Wachter-Rosati, L.7
Palmer-Hill, F.J.8
Yuan, A.Q.9
Walker, P.A.10
Vorlaender, M.K.11
Bianchi, S.12
Guarino, B.13
De Marco, A.14
Vanzetta, F.15
Agatic, G.16
Foglierini, M.17
Pinna, D.18
Fernandez-Rodriguez, B.19
Fruehwirth, A.20
Silacci, C.21
Ogrodowicz, R.W.22
Martin, S.R.23
Sallusto, F.24
Suzich, J.A.25
Lanzavecchia, A.26
Zhu, Q.27
Gamblin, S.J.28
Skehel, J.J.29
more..
-
26
-
-
84880191764
-
Prime-boost interval matters: A randomized phase 1 study to identify the minimum interval necessary to observe the H5 DNA influenza vaccine priming effect
-
J. E. Ledgerwood, K. Zephir, Z. Hu, C.-J. Wei, L. Chang, M. E. Enama, C. S. Hendel, S. Sitar, R. T. Bailer, R. A. Koup, J. R. Mascola, G. J. Nabel, B. S. Graham; VRC 310 Study Team, Prime-boost interval matters: A randomized phase 1 study to identify the minimum interval necessary to observe the H5 DNA influenza vaccine priming effect. J. Infect. Dis. 208, 418–422 (2013).
-
(2013)
J. Infect. Dis.
, vol.208
, pp. 418-422
-
-
Ledgerwood, J.E.1
Zephir, K.2
Hu, Z.3
Wei, C.-J.4
Chang, L.5
Enama, M.E.6
Hendel, C.S.7
Sitar, S.8
Bailer, R.T.9
Koup, R.A.10
Mascola, J.R.11
Nabel, G.J.12
Graham, B.S.13
-
27
-
-
85041507182
-
An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial
-
A. D. DeZure, E. E. Coates, Z. Hu, G. V. Yamshchikov, K. L. Zephir, M. E. Enama, S. H. Plummer, I. J. Gordon, F. Kaltovich, S. Andrews, A. McDermott, M. C. Crank, R. A. Koup, R. M. Schwartz, R. T. Bailer, X. Sun, J. R. Mascola, T. M. Tumpey, B. S. Graham, J. E. Ledgerwood, An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial. npj Vaccines 2, 15 (2017).
-
(2017)
Npj Vaccines
, vol.2
, pp. 15
-
-
DeZure, A.D.1
Coates, E.E.2
Hu, Z.3
Yamshchikov, G.V.4
Zephir, K.L.5
Enama, M.E.6
Plummer, S.H.7
Gordon, I.J.8
Kaltovich, F.9
Andrews, S.10
McDermott, A.11
Crank, M.C.12
Koup, R.A.13
Schwartz, R.M.14
Bailer, R.T.15
Sun, X.16
Mascola, J.R.17
Tumpey, T.M.18
Graham, B.S.19
Ledgerwood, J.E.20
more..
-
28
-
-
84893797938
-
Broadly neutralizing hemagglutinin stalk–specific antibodies require FcR interactions for protection against influenza virus in vivo
-
D. J. DiLillo, G. S. Tan, P. Palese, J. V. Ravetch, Broadly neutralizing hemagglutinin stalk–specific antibodies require FcR interactions for protection against influenza virus in vivo. Nat. Med. 20, 143–151 (2014).
-
(2014)
Nat. Med.
, vol.20
, pp. 143-151
-
-
DiLillo, D.J.1
Tan, G.S.2
Palese, P.3
Ravetch, J.V.4
-
29
-
-
84956934982
-
Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection
-
D. J. DiLillo, P. Palese, P. C. Wilson, J. V. Ravetch, Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection. J. Clin. Invest. 126, 605–610 (2016).
-
(2016)
J. Clin. Invest.
, vol.126
, pp. 605-610
-
-
DiLillo, D.J.1
Palese, P.2
Wilson, P.C.3
Ravetch, J.V.4
-
30
-
-
84954245342
-
Immune history profoundly affects broadly protective B cell responses to influenza
-
S. F. Andrews, Y. Huang, K. Kaur, L. I. Popova, I. Y. Ho, N. T. Pauli, C. J. Henry Dunand, W. M. Taylor, S. Lim, M. Huang, X. Qu, J.-H. Lee, M. Salgado-Ferrer, F. Krammer, P. Palese, J. Wrammert, R. Ahmed, P. C. Wilson, Immune history profoundly affects broadly protective B cell responses to influenza. Sci. Transl. Med. 7, 316ra192 (2015).
-
(2015)
Sci. Transl. Med.
, vol.7
, pp. 316ra192
-
-
Andrews, S.F.1
Huang, Y.2
Kaur, K.3
Popova, L.I.4
Ho, I.Y.5
Pauli, N.T.6
Henry Dunand, C.J.7
Taylor, W.M.8
Lim, S.9
Huang, M.10
Qu, X.11
Lee, J.-H.12
Salgado-Ferrer, M.13
Krammer, F.14
Palese, P.15
Wrammert, J.16
Ahmed, R.17
Wilson, P.C.18
-
31
-
-
84973488141
-
Both neutralizing and non-neutralizing human H7N9 influenza vaccine-induced monoclonal antibodies confer protection
-
C. J. Henry Dunand, P. E. Leon, M. Huang, A. Choi, V. Chromikova, I. Y. Ho, G. S. Tan, J. Cruz, A. Hirsh, N.-Y. Zheng, C. E. Mullarkey, F. A. Ennis, M. Terajima, J. J. Treanor, D. J. Topham, K. Subbarao, P. Palese, F. Krammer, P. C. Wilson, Both neutralizing and non-neutralizing human H7N9 influenza vaccine-induced monoclonal antibodies confer protection. Cell Host Microbe 19, 800–813 (2016).
-
(2016)
Cell Host Microbe
, vol.19
, pp. 800-813
-
-
Henry Dunand, C.J.1
Leon, P.E.2
Huang, M.3
Choi, A.4
Chromikova, V.5
Ho, I.Y.6
Tan, G.S.7
Cruz, J.8
Hirsh, A.9
Zheng, N.-Y.10
Mullarkey, C.E.11
Ennis, F.A.12
Terajima, M.13
Treanor, J.J.14
Topham, D.J.15
Subbarao, K.16
Palese, P.17
Krammer, F.18
Wilson, P.C.19
-
32
-
-
84964632488
-
H7N9 influenza virus neutralizing antibodies that possess few somatic mutations
-
N. J. Thornburg, H. Zhang, S. Bangaru, G. Sapparapu, N. Kose, R. M. Lampley, R. G. Bombardi, Y. Yu, S. Graham, A. Branchizio, S. M. Yoder, M. T. Rock, C. B. Creech, K. M. Edwards, D. Lee, S. Li, I. A. Wilson, A. García-Sastre, R. A. Albrecht, J. E. Crowe Jr., H7N9 influenza virus neutralizing antibodies that possess few somatic mutations. J. Clin. Invest. 126, 1482–1494 (2016).
-
(2016)
J. Clin. Invest.
, vol.126
, pp. 1482-1494
-
-
Thornburg, N.J.1
Zhang, H.2
Bangaru, S.3
Sapparapu, G.4
Kose, N.5
Lampley, R.M.6
Bombardi, R.G.7
Yu, Y.8
Graham, S.9
Branchizio, A.10
Yoder, S.M.11
Rock, M.T.12
Creech, C.B.13
Edwards, K.M.14
Lee, D.15
Li, S.16
Wilson, I.A.17
García-Sastre, A.18
Albrecht, R.A.19
Crowe, J.E.20
more..
-
33
-
-
84880427552
-
An in vivo human-plasmablast enrichment technique allows rapid identification of therapeutic influenza A antibodies
-
G. Nakamura, N. Chai, S. Park, N. Chiang, Z. Lin, H. Chiu, R. Fong, D. Yan, J. Kim, J. Zhang, W. P. Lee, A. Estevez, M. Coons, M. Xu, P. Lupardus, M. Balazs, L. R. Swem, An in vivo human-plasmablast enrichment technique allows rapid identification of therapeutic influenza A antibodies. Cell Host Microbe 14, 93–103 (2013).
-
(2013)
Cell Host Microbe
, vol.14
, pp. 93-103
-
-
Nakamura, G.1
Chai, N.2
Park, S.3
Chiang, N.4
Lin, Z.5
Chiu, H.6
Fong, R.7
Yan, D.8
Kim, J.9
Zhang, J.10
Lee, W.P.11
Estevez, A.12
Coons, M.13
Xu, M.14
Lupardus, P.15
Balazs, M.16
Swem, L.R.17
-
34
-
-
84930083052
-
Viral receptor-binding site antibodies with diverse germline origins
-
A. G. Schmidt, M. D. Therkelsen, S. Stewart, T. B. Kepler, H.-X. Liao, M. A. Moody, B. F. Haynes, S. C. Harrison, Viral receptor-binding site antibodies with diverse germline origins. Cell 161, 1026–1034 (2015).
-
(2015)
Cell
, vol.161
, pp. 1026-1034
-
-
Schmidt, A.G.1
Therkelsen, M.D.2
Stewart, S.3
Kepler, T.B.4
Liao, H.-X.5
Moody, M.A.6
Haynes, B.F.7
Harrison, S.C.8
-
35
-
-
84864612944
-
Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China
-
J. Lessler, S. Riley, J. M. Read, S. Wang, H. Zhu, G. J. D. Smith, Y. Guan, C. Q. Jiang, D. A. T. Cummings, Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China. PLOS Pathog. 8, e1002802 (2012).
-
(2012)
PLOS Pathog
, vol.8
-
-
Lessler, J.1
Riley, S.2
Read, J.M.3
Wang, S.4
Zhu, H.5
Smith, G.J.D.6
Guan, Y.7
Jiang, C.Q.8
Cummings, D.A.T.9
-
36
-
-
84883856356
-
Neutralizing antibodies against previously encountered influenza virus strains increase over time: A longitudinal analysis
-
M. S. Miller, T. J. Gardner, F. Krammer, L. C. Aguado, D. Tortorella, C. F. Basler, P. Palese, Neutralizing antibodies against previously encountered influenza virus strains increase over time: A longitudinal analysis. Sci. Transl. Med. 5, 198ra107 (2013).
-
(2013)
Sci. Transl. Med.
, vol.5
, pp. 198ra107
-
-
Miller, M.S.1
Gardner, T.J.2
Krammer, F.3
Aguado, L.C.4
Tortorella, D.5
Basler, C.F.6
Palese, P.7
-
37
-
-
84994518871
-
Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting
-
K. M. Gostic, M. Ambrose, M. Worobey, J. O. Lloyd-Smith, Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting. Science 354, 722–726 (2016).
-
(2016)
Science
, vol.354
, pp. 722-726
-
-
Gostic, K.M.1
Ambrose, M.2
Worobey, M.3
Lloyd-Smith, J.O.4
-
38
-
-
84892615764
-
Mechanisms of hemagglutinin targeted influenza virus neutralization
-
B. Brandenburg, W. Koudstaal, J. Goudsmit, V. Klaren, C. Tang, M. V. Bujny, H. J. W. M. Korse, T. Kwaks, J. J. Otterstrom, J. Juraszek, A. M. van Oijen, R. Vogels, R. H. E. Friesen, Mechanisms of hemagglutinin targeted influenza virus neutralization. PLOS ONE 8, e80034 (2013).
-
(2013)
PLOS ONE
, vol.8
-
-
Brandenburg, B.1
Koudstaal, W.2
Goudsmit, J.3
Klaren, V.4
Tang, C.5
Bujny, M.V.6
Korse, H.J.W.M.7
Kwaks, T.8
Otterstrom, J.J.9
Juraszek, J.10
Van Oijen, A.M.11
Vogels, R.12
Friesen, R.H.E.13
-
39
-
-
81855182191
-
DNA priming and influenza vaccine immunogenicity: Two phase 1 open label randomised clinical trials
-
J. E. Ledgerwood, C.-J. Wei, Z. Hu, I. J. Gordon, M. E. Enama, C. S. Hendel, P. M. McTamney, M. B. Pearce, H. M. Yassine, J. C. Boyington, R. Bailer, T. M. Tumpey, R. A. Koup, J. R. Mascola, G. J. Nabel, B. S. Graham; VRC 306 Study Team, DNA priming and influenza vaccine immunogenicity: Two phase 1 open label randomised clinical trials. Lancet Infect. Dis. 11, 916–924 (2011).
-
(2011)
Lancet Infect. Dis.
, vol.11
, pp. 916-924
-
-
Ledgerwood, J.E.1
Wei, C.-J.2
Hu, Z.3
Gordon, I.J.4
Enama, M.E.5
Hendel, C.S.6
McTamney, P.M.7
Pearce, M.B.8
Yassine, H.M.9
Boyington, J.C.10
Bailer, R.11
Tumpey, T.M.12
Koup, R.A.13
Mascola, J.R.14
Nabel, G.J.15
Graham, B.S.16
-
40
-
-
36849031722
-
Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning
-
T. Tiller, E. Meffre, S. Yurasov, M. Tsuiji, M. C. Nussenzweig, H. Wardemann, Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning. J. Immunol. Methods 329, 112–124 (2008).
-
(2008)
J. Immunol. Methods
, vol.329
, pp. 112-124
-
-
Tiller, T.1
Meffre, E.2
Yurasov, S.3
Tsuiji, M.4
Nussenzweig, M.C.5
Wardemann, H.6
-
41
-
-
48449094247
-
IMGT/V-QUEST: The highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
-
X. Brochet, M.-P. Lefranc, V. Giudicelli, IMGT/V-QUEST: The highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucleic Acids Res. 36, W503–W508 (2008).
-
(2008)
Nucleic Acids Res
, vol.36
, pp. W503-W508
-
-
Brochet, X.1
Lefranc, M.-P.2
Giudicelli, V.3
-
42
-
-
0034705225
-
A DNA transfection system for generation of influenza A virus from eight plasmids
-
E. Hoffmann, G. Neumann, Y. Kawaoka, G. Hobom, R. G. Webster, A DNA transfection system for generation of influenza A virus from eight plasmids. Proc. Natl. Acad. Sci. U.S.A. 97, 6108–6113 (2000).
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 6108-6113
-
-
Hoffmann, E.1
Neumann, G.2
Kawaoka, Y.3
Hobom, G.4
Webster, R.G.5
-
44
-
-
25644458666
-
Automated electron microscope tomography using robust prediction of specimen movements
-
D. N. Mastronarde, Automated electron microscope tomography using robust prediction of specimen movements. J. Struct. Biol. 152, 36–51 (2005).
-
(2005)
J. Struct. Biol.
, vol.152
, pp. 36-51
-
-
Mastronarde, D.N.1
-
45
-
-
33845332754
-
EMAN2: An extensible image processing suite for electron microscopy
-
G. Tang, L. Peng, P. R. Baldwin, D. S. Mann, W. Jiang, I. Rees, S. J. Ludtke, EMAN2: An extensible image processing suite for electron microscopy. J. Struct. Biol. 157, 38–46 (2007).
-
(2007)
J. Struct. Biol.
, vol.157
, pp. 38-46
-
-
Tang, G.1
Peng, L.2
Baldwin, P.R.3
Mann, D.S.4
Jiang, W.5
Rees, I.6
Ludtke, S.J.7
-
46
-
-
84868444740
-
Relion: Implementation of a Bayesian approach to cryo-EM structure determination
-
S. H. W. Scheres, RELION: Implementation of a Bayesian approach to cryo-EM structure determination. J. Struct. Biol. 180, 519–530 (2012).
-
(2012)
J. Struct. Biol.
, vol.180
, pp. 519-530
-
-
Scheres, S.H.W.1
-
47
-
-
34547886820
-
Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity
-
Z.-Y. Yang, C.-J. Wei, W.-P. Kong, L. Wu, L. Xu, D. F. Smith, G. J. Nabel, Immunization by avian H5 influenza hemagglutinin mutants with altered receptor binding specificity. Science 317, 825–828 (2007).
-
(2007)
Science
, vol.317
, pp. 825-828
-
-
Yang, Z.-Y.1
Wei, C.-J.2
Kong, W.-P.3
Wu, L.4
Xu, L.5
Smith, D.F.6
Nabel, G.J.7
-
48
-
-
0029993858
-
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector
-
L. Naldini, U. Blömer, F. H. Gage, D. Trono, I. M. Verma, Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc. Natl. Acad. Sci. U.S.A. 93, 11382–11388 (1996).
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 11382-11388
-
-
Naldini, L.1
Blömer, U.2
Gage, F.H.3
Trono, D.4
Verma, I.M.5
-
49
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Z. Otwinowski, W. Minor, Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307–326 (1997).
-
(1997)
Methods Enzymol
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
50
-
-
77949535720
-
Features and development of Coot
-
P. Emsley, B. Lohkamp, W. G. Scott, K. Cowtan, Features and development of Coot. Acta Crystallogr. D Biol. Crystallogr. 66, 486–501 (2010).
-
(2010)
Acta Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 486-501
-
-
Emsley, P.1
Lohkamp, B.2
Scott, W.G.3
Cowtan, K.4
-
51
-
-
76449098262
-
Phenix: A comprehensive Python-based system for macromolecular structure solution
-
P. D. Adams, P. V. Afonine, G. Bunkóczi, V. B. Chen, I. W. Davis, N. Echols, J. J. Headd, L.-W. Hung, G. J. Kapral, R. W. Grosse-Kunstleve, A. J. McCoy, N. W. Moriarty, R. Oeffner, R. J. Read, D. C. Richardson, J. S. Richardson, T. C. Terwilliger, P. H. Zwart, PHENIX: A comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr. D Biol. Crystallogr. 66, 213–221 (2010).
-
(2010)
Acta Crystallogr. D Biol. Crystallogr.
, vol.66
, pp. 213-221
-
-
Adams, P.D.1
Afonine, P.V.2
Bunkóczi, G.3
Chen, V.B.4
Davis, I.W.5
Echols, N.6
Headd, J.J.7
Hung, L.-W.8
Kapral, G.J.9
Grosse-Kunstleve, R.W.10
McCoy, A.J.11
Moriarty, N.W.12
Oeffner, R.13
Read, R.J.14
Richardson, D.C.15
Richardson, J.S.16
Terwilliger, T.C.17
Zwart, P.H.18
-
52
-
-
4444221565
-
UCSF Chimera—A visualization system for exploratory research and analysis
-
E. F. Pettersen, T. D. Goddard, C. C. Huang, G. S. Couch, D. M. Greenblatt, E. C. Meng, T. E. Ferrin, UCSF Chimera—A visualization system for exploratory research and analysis. J. Comput. Chem. 25, 1605–1612 (2004).
-
(2004)
J. Comput. Chem.
, vol.25
, pp. 1605-1612
-
-
Pettersen, E.F.1
Goddard, T.D.2
Huang, C.C.3
Couch, G.S.4
Greenblatt, D.M.5
Meng, E.C.6
Ferrin, T.E.7
-
53
-
-
85022158148
-
MEGA7: Molecular evolutionary genetics analysis version 7.0 for bigger datasets
-
S. Kumar, G. Stecher, K. Tamura, MEGA7: Molecular evolutionary genetics analysis version 7.0 for bigger datasets. Mol. Biol. Evol. 33, 1870–1874 (2016).
-
(2016)
Mol. Biol. Evol.
, vol.33
, pp. 1870-1874
-
-
Kumar, S.1
Stecher, G.2
Tamura, K.3
|