Esterase-Catalyzed Siderophore Hydrolysis Activates an Enterobactin-Ciprofloxacin Conjugate and Confers Targeted Antibacterial Activity

Journal of the American Chemical Society

Volumn 140, Issue 15, 2018, Pages 5193-5201

  Neumann, Wilma ^a   Sassone Corsi, Martina ^b   Raffatellu, Manuela ^b,c   Nolan, Elizabeth M ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; ESCHERICHIA COLI; GENES; HYDROLASES; HYDROLYSIS; MACHINERY;

ALKYL LINKERS; ANTI-BACTERIAL ACTIVITY; BROAD SPECTRUM ANTIBIOTICS; ESSENTIAL NUTRIENTS; GRAM-NEGATIVE BACTERIA; MICROBIAL ENZYMES; PROCESSING STEPS; VALUABLE CHEMICALS;

ANTIBIOTICS;

ALKYL GROUP; ANTIBIOTIC AGENT; CATECHOL DERIVATIVE; CIPROFLOXACIN; ENTEROCHELIN; ESTERASE; GYRASE INHIBITOR; HYDROLASE; PROTEIN IROD; SIDEROPHORE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GENE; CATALYSIS; CYTOPLASM; DRUG CONJUGATION; DRUG STRUCTURE; DRUG TARGETING; ESCHERICHIA COLI; GENE CLUSTER; GENE EXPRESSION; HYDROLYSIS; IROA GENE; NONHUMAN; STRUCTURE ANALYSIS; UROPATHOGENIC ESCHERICHIA COLI; BIOCATALYSIS; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECT; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BIOCATALYSIS; CIPROFLOXACIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROBACTIN; ESCHERICHIA COLI; ESTERASES; HYDROLYSIS; MICROBIAL SENSITIVITY TESTS; MOLECULAR CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85045521012     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.8b01042     Document Type: Article

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