Probing linker design in citric acid-ciprofloxacin conjugates

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 16, 2014, Pages 4499-4505

  Milner, Stephen J ^a   Snelling, Anna M ^c   Kerr, Kevin G ^a,b,d   Abd El Aziz, Ahmad ^a   Thomas, Gavin H ^a   Hubbard, Roderick E ^a,e   Routledge, Anne ^a   Duhme Klair, Anne Kathrin ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b HARROGATE DISTRICT HOSPITAL   (United Kingdom)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

^d UNIVERSITY OF HULL   (United Kingdom)

^e Vernalis PLC   (United Kingdom)

Author keywords

Antibiotic; Citrate; Computational modelling; Siderophore

Indexed keywords

1,4 DIMETHYL 2 [[[2 [4 [1 CYCLOPROPYL 6 FLUORO 3 (METHOXYCARBONYL) 4 OXO 1,4 DIHYDROQUINOLIN 7 YL]PIPERAZIN 1 YL]H 2 OXOETHYL]CARBAMOYL]METHYL] 2 HYDROXYBUTANEDIOATE; 1,4 DIMETHYL 2 [[[5 [4 [1 CYCLOPROPYL 6 FLUORO 3 (METHOXYCARBONYL) 4 OXO 1,4 DIHYDROQUINOLIN 7 YL]PIPERAZIN 1 YL] 5 OXOPENTYL]CARBAMOYL]METHYL] 2 HYDROXYBUTANEDIOATE; 2 [[[2 [4 (3 CARBOXY 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLIN 7 YL)PIPERAZIN 1 YL] 2 OXOETHYL]CARBAMOYL]METHYL] 2 HYDROXYBUTANEDIOIC ACID; 5 [[(TERT BUTOXY)CARBONYL]AMINO]PENTANOIC ACID; CIPROFLOXACIN; CIPROFLOXACIN DERIVATIVE; CITRIC ACID; DNA TOPOISOMERASE (ATP HYDROLYSING); METHYL 7 [4 [5 [[(TERT BUTOXY)CARBONYL]AMINO]PENTANOYL]PIPERAZIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; SIDEROPHORE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; GYRASE INHIBITOR;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY; ENZYME ASSAY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HYDROLYSIS; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; NONHUMAN; PROCESS OPTIMIZATION; BACTERIA; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; BACTERIA; CIPROFLOXACIN; CITRIC ACID; DNA GYRASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE II INHIBITORS;

EID: 84906220907     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.04.009     Document Type: Article

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