Fluoroquinolone-gyrase-DNA complexes two modes of drug binding

Journal of Biological Chemistry

Volumn 289, Issue 18, 2014, Pages 12300-12312

  Mustaev, Arkady ^a   Malik, Muhammad ^a   Zhao, Xilin ^a   Kurepina, Natalia ^a   Luan, Gan ^a   Oppegard, Lisa M ^b   Hiasa, Hiroshi ^b   Marks, Kevin R ^c   Kerns, Robert J ^c   Berger, James M ^d,e   Drlica, Karl ^a  

^a PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS;

CIPROFLOXACIN; CYSTEINE SUBSTITUTIONS; DRUG BINDING; X RAY CRYSTAL STRUCTURES;

BINDING ENERGY;

CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE (ATP HYDROLYSING) A; DNA TOPOISOMERASE (ATP HYDROLYSING) B; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ARTICLE; BACTERIOSTASIS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA PROTEIN COMPLEX; DNA REPLICATION; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ESCHERICHIA COLI; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; RESIDUE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANTIBIOTIC ACTION; BACTERIA; BACTERIUM; CLEAVED COMPLEXES; CROSS-LINKING; DNA TOPOISOMERASE; ENZYME INHIBITORS; ESCHERICHIA COLI; MYCOBACTERIUM SMEGMATIS; RESISTANCE MUTATIONS;

ANTI-BACTERIAL AGENTS; CIPROFLOXACIN; CRYSTALLOGRAPHY, X-RAY; DNA GYRASE; DNA TOPOISOMERASES, TYPE II; DNA, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FLUOROQUINOLONES; MACROMOLECULAR SUBSTANCES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; MYCOBACTERIUM SMEGMATIS; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; TOPOISOMERASE II INHIBITORS;

EID: 84898945462     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.529164     Document Type: Article

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