Synthesis and antibacterial activity of catecholate-ciprofloxacin conjugates

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 15, 2014, Pages 4049-4060

  Fardeau, Sylvain ^a   Dassonville Klimpt, Alexandra ^a   Audic, Nicolas ^b   Sasaki, André ^a,b   Pillon, Marine ^a   Baudrin, Emmanuel ^a   Mullié, Catherine ^a   Sonnet, Pascal ^a  

^a UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^b Pharmamens   (France)

Author keywords

Antibacterial; Iron chelator ciprofloxacin conjugate; Pseudomonas; Siderophore; Trojan horse strategy

Indexed keywords

1 CYCLOPROPYL 6 FLUORO 7 [4 (2 METHOXY 2 OXOETHYL)PIPERAZIN 1 YL] 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 7 [4 (2,3 DIHYDROXYBENZOYL)PIPERAZIN 1 YL] 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; 2,3 BIS(BENZYLOXY)BENZOIC ACID; 2,3 BIS(BENZYLOXY)BENZOYL FLUORIDE; 4 (3 AMINOPROPYL) 4 [(TERT BUTYLDIMETHYLSILYLOXY)METHYL]; 5 [2,3 BIS(BENZYLOXY)BENZAMIDO] 2,2 BIS[3 [2,3 BIS(BENZYLOXY)BENZAMIDO]PROPYL] PENTANOIC ACID; 5 [2,3 BIS(BENZYLOXY)BENZAMIDO] 2,2 BIS[3 [2,3 BIS(BENZYLOXY)BENZAMIDO]PROPYL] PENTYL 2 CHLOROACETATE; 5 [2,3 BIS(BENZYLOXY)BENZAMIDO] 2,2 BIS[3 [2,3 BIS(BENZYLOXY)BENZAMIDO]PROPYL]PENTYL 3 CHLOROPROPANOATE; 7 [4 (CARBOXYMETHYL)PIPERAZIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLIC ACID; BENZYL 1 CYCLOPROPYL 6 FLUORO 4 OXO 7 (PIPERAZIN 1 YL) 1,4 DIHYDRO QUINOLINE 3 CARBOXYLATE; CATECHOLATE CIPROFLOXACIN CONJUGATE; CIPROFLOXACIN; ENTEROCHELIN; IRON; METHYL 2,3 BIS(BENZYLOXY)BENZOATE; MONOCATECHOLATE CIPROFLOXACIN CONJUGATE; PIPERAZINE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; CATECHOL DERIVATIVE; IRON CHELATING AGENT; SIDEROPHORE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IRON TRANSPORT; NONHUMAN; PSEUDOMONAS AERUGINOSA; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ERYTHROCYTE; HEMOLYSIS; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

BACTERIA (MICROORGANISMS); EQUIDAE; NEGIBACTERIA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

ANTI-BACTERIAL AGENTS; CATECHOLS; CIPROFLOXACIN; ERYTHROCYTES; HEMOLYSIS; HUMANS; IRON CHELATING AGENTS; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS AERUGINOSA; SIDEROPHORES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84905103472     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.05.067     Document Type: Article

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