A Synthetic Dual Drug Sideromycin Induces Gram-Negative Bacteria to Commit Suicide with a Gram-Positive Antibiotic

Journal of Medicinal Chemistry

Volumn 61, Issue 9, 2018, Pages 3845-3854

  Liu, Rui ^a   Miller, Patricia A ^a   Vakulenko, Sergei B ^a   Stewart, Nichole K ^a   Boggess, William C ^a   Miller, Marvin J ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [[[[2 [4 [4 [5 (ACETAMIDOMETHYL) 2 OXOOXAZOLIDIN 3 YL] 2 FLUOROPHENYL]PIPERAZIN 1 YL] 2 OXOETHYL]CARBAMOYL]OXY]METHYL] 7 (2 AMINO 2 PHENYLACETAMIDO) 8 OXO 5 THIA 1 AZABICYCLO[4.2.0]OCT 2 ENE 2 CARBOXYLIC ACID; 3 [[[[2 [4 [4 [5 (ACETAMIDOMETHYL) 2 OXOOXAZOLIDIN 3 YL] 2 FLUOROPHENYL]PIPERAZIN 1 YL] 2 OXOETHYL]CARBAMOYL]OXY]METHYL] 7 [2 [2 [N [4 (2,3 DIHYDROXYBENZAMIDO)ACETAMIDO] 2 PHENYLACERAMIDO] 8 OXO 5 THIA 1 AZABICYCLO[4.2.0]OCT 2 ENE 2 CARBOXYLIC ACID; ANTIBIOTIC AGENT; BETA LACTAMASE; CEPHALOSPORIN; EPEREZOLID; N [2 [[2 [4 [4 [5 (ACETAMIDOMETHYL) 2 OXOOXAZOLIDIN 3 YL] 2 FLUOROPHENYL]PIPERAZIN 1 YL] 2 OXOETHYL]AMINO] 2 OXOETHYL] N [4 (2,3 DIHYDROXYBENZAMIDO]]BUTYL 2,3 DIHYDROXYBENZAMIDE; OXAZOLIDINONE DERIVATIVE; SIDEROMYCIN; SIDEROPHORE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; DRUG; FERROUS ION; PEPTIDE; SIDEROMYCINS;

ACINETOBACTER BAUMANNII; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIUM ISOLATE; CONJUGATE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; PSEUDOMONAS AERUGINOSA; DRUG EFFECT; ENZYMOLOGY; GRAM POSITIVE BACTERIUM; METABOLISM; MICROBIAL SENSITIVITY TEST;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; FERROUS COMPOUNDS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; PEPTIDES; SYNTHETIC DRUGS;

EID: 85045531904     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.8b00218     Document Type: Article

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