Is drug release necessary for antimicrobial activity of siderophore-drug conjugates? Syntheses and biological studies of the naturally occurring salmycin "trojan Horse" antibiotics and synthetic desferridanoxamine- antibiotic conjugates

BioMetals

Volumn 22, Issue 4, 2009, Pages 633-648

  Wencewicz, Timothy A ^a   Möllmann, Ute ^b   Long, Timothy E ^a   Miller, Marvin J ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b HANS KNÖLL INSTITUTE   (Germany)

Author keywords

"Trojan Horse"; Antibiotics; Danoxamine; Drug delivery; Iron transport; Resistance; Salmycins; Siderophores

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; CIPROFLOXACIN; DANOXAMINE; DESFERRIDANOXAMINE; DESFERRISALMYCIN; DESFERRISALMYCIN B; EPIDESFERRISALMYCIN B; GRISEIN; IRON; LORACARBEF; PYOVERDINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SALMYCIN; SIDEROPHORE; TETRA O BENZYLDANOXAMINE; TRICLOSAN; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; BACTERIAL STRAIN; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG INHIBITION; DRUG RELEASE; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IRON TRANSPORT; MICROBIAL GROWTH; MYCOBACTERIUM; NONHUMAN; REVIEW;

ANTI-BACTERIAL AGENTS; BACTERIA; DEFEROXAMINE; DRUG DELIVERY SYSTEMS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; SIDEROPHORES;

EQUIDAE; FUNGI;

EID: 67651247598     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10534-009-9218-3     Document Type: Review

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