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Volumn 4, Issue SEP, 2017, Pages

Interleukin-13 in asthma and other eosinophilic disorders

Author keywords

Asthma; Chemokines; Eosinophilic disorders; Eosinophils; Interleukin 13

Indexed keywords


EID: 85045515816     PISSN: None     EISSN: 2296858X     Source Type: Journal    
DOI: 10.3389/fmed.2017.00139     Document Type: Article
Times cited : (107)

References (125)
  • 1
    • 84873408369 scopus 로고    scopus 로고
    • Targeting eosinophils in allergy, inflammation and beyond
    • Fulkerson PC, Rothenberg ME. Targeting eosinophils in allergy, inflammation and beyond. Nat Rev Drug Discov (2013) 12(2):117-29. doi:10.1038/nrd3838
    • (2013) Nat Rev Drug Discov , vol.12 , Issue.2 , pp. 117-129
    • Fulkerson, P.C.1    Rothenberg, M.E.2
  • 2
    • 0037775352 scopus 로고    scopus 로고
    • IL-13 effector functions
    • Wynn TA. IL-13 effector functions. Annu Rev Immunol (2003) 21:425-56. doi:10.1146/annurev.immunol.21.120601.141142
    • (2003) Annu Rev Immunol , vol.21 , pp. 425-456
    • Wynn, T.A.1
  • 3
    • 79151471617 scopus 로고    scopus 로고
    • Eosinophils in innate immunity: an evolving story
    • Shamri R, Xenakis JJ, Spencer LA. Eosinophils in innate immunity: an evolving story. Cell Tissue Res (2011) 343(1):57-83. doi:10.1007/s00441-010-1049-6
    • (2011) Cell Tissue Res , vol.343 , Issue.1 , pp. 57-83
    • Shamri, R.1    Xenakis, J.J.2    Spencer, L.A.3
  • 4
    • 84979210565 scopus 로고    scopus 로고
    • The eosinophil in infection
    • Ravin KA, Loy M. The eosinophil in infection. Clin Rev Allergy Immunol (2016) 50(2):214-27. doi:10.1007/s12016-015-8525-4
    • (2016) Clin Rev Allergy Immunol , vol.50 , Issue.2 , pp. 214-227
    • Ravin, K.A.1    Loy, M.2
  • 6
    • 84868608435 scopus 로고    scopus 로고
    • The expanding role(s) of eosinophils in health and disease
    • Jacobsen EA, Helmers RA, Lee JJ, Lee NA. The expanding role(s) of eosinophils in health and disease. Blood (2012) 120(19):3882-90. doi:10.1182/blood-2012-06-330845
    • (2012) Blood , vol.120 , Issue.19 , pp. 3882-3890
    • Jacobsen, E.A.1    Helmers, R.A.2    Lee, J.J.3    Lee, N.A.4
  • 7
    • 0001370370 scopus 로고
    • A clinical and pathological study of fatal cases of status asthmaticus
    • Houston JC, De Navasquez S, Trounce JR. A clinical and pathological study of fatal cases of status asthmaticus. Thorax (1953) 8(3):207-13. doi:10.1136/thx.8.3.207
    • (1953) Thorax , vol.8 , Issue.3 , pp. 207-213
    • Houston, J.C.1    De Navasquez, S.2    Trounce, J.R.3
  • 8
    • 0026075046 scopus 로고
    • Glucocorticoids inhibit eosinophil responses to granulocyte-macrophage colony-stimulating factor
    • Lamas AM, Leon OG, Schleimer RP. Glucocorticoids inhibit eosinophil responses to granulocyte-macrophage colony-stimulating factor. J Immunol (1991) 147(1):254-9
    • (1991) J Immunol , vol.147 , Issue.1 , pp. 254-259
    • Lamas, A.M.1    Leon, O.G.2    Schleimer, R.P.3
  • 9
    • 0030771945 scopus 로고    scopus 로고
    • Human eosinophils
    • Weller PF. Human eosinophils. J Allergy Clin Immunol (1997) 100(3):283-7. doi:10.1016/S0091-6749(97)70237-9
    • (1997) J Allergy Clin Immunol , vol.100 , Issue.3 , pp. 283-287
    • Weller, P.F.1
  • 10
    • 0027464685 scopus 로고
    • Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses
    • Minty A, Chalon P, Derocq JM, Dumont X, Guillemot JC, Kaghad M, et al. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature (1993) 362(6417):248-50. doi:10.1038/362248a0
    • (1993) Nature , vol.362 , Issue.6417 , pp. 248-250
    • Minty, A.1    Chalon, P.2    Derocq, J.M.3    Dumont, X.4    Guillemot, J.C.5    Kaghad, M.6
  • 11
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest (1999) 103(6):779-88. doi:10.1172/JCI5909
    • (1999) J Clin Invest , vol.103 , Issue.6 , pp. 779-788
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3    Chen, Q.4    Geba, G.P.5    Wang, J.6
  • 12
    • 0032545213 scopus 로고    scopus 로고
    • Interleukin-13: central mediator of allergic asthma
    • Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, et al. Interleukin-13: central mediator of allergic asthma. Science (1998) 282(5397):2258-61. doi:10.1126/science.282.5397.2258
    • (1998) Science , vol.282 , Issue.5397 , pp. 2258-2261
    • Wills-Karp, M.1    Luyimbazi, J.2    Xu, X.3    Schofield, B.4    Neben, T.Y.5    Karp, C.L.6
  • 13
    • 77951817855 scopus 로고    scopus 로고
    • Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    • Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TK, et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature (2010) 464(7293):1367-70. doi:10.1038/nature08900
    • (2010) Nature , vol.464 , Issue.7293 , pp. 1367-1370
    • Neill, D.R.1    Wong, S.H.2    Bellosi, A.3    Flynn, R.J.4    Daly, M.5    Langford, T.K.6
  • 14
    • 33646196946 scopus 로고    scopus 로고
    • Regulation of Th2 differentiation and Il4 locus accessibility
    • Ansel KM, Djuretic I, Tanasa B, Rao A. Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol (2006) 24:607-56. doi:10.1146/annurev.immunol.23.021704.115821
    • (2006) Annu Rev Immunol , vol.24 , pp. 607-656
    • Ansel, K.M.1    Djuretic, I.2    Tanasa, B.3    Rao, A.4
  • 15
    • 77950261975 scopus 로고    scopus 로고
    • How are T(H)2-type immune responses initiated and amplified?
    • Paul WE, Zhu J. How are T(H)2-type immune responses initiated and amplified? Nat Rev Immunol (2010) 10(4):225-35. doi:10.1038/nri2735
    • (2010) Nat Rev Immunol , vol.10 , Issue.4 , pp. 225-235
    • Paul, W.E.1    Zhu, J.2
  • 16
    • 45549122275 scopus 로고    scopus 로고
    • IL-13 as a therapeutic target for respiratory disease
    • Kasaian MT, Miller DK. IL-13 as a therapeutic target for respiratory disease. Biochem Pharmacol (2008) 76(2):147-55. doi:10.1016/j.bcp.2008.04.002
    • (2008) Biochem Pharmacol , vol.76 , Issue.2 , pp. 147-155
    • Kasaian, M.T.1    Miller, D.K.2
  • 17
    • 84903626965 scopus 로고    scopus 로고
    • Endogenously expressed IL-13RI±2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts
    • Chandriani S, DePianto DJ, N'Diaye EN, Abbas AR, Jackman J, Bevers J, et al. Endogenously expressed IL-13RI±2 attenuates IL-13-mediated responses but does not activate signaling in human lung fibroblasts. J Immunol (2014) 193(1):111-9. doi:10.4049/jimmunol.1301761
    • (2014) J Immunol , vol.193 , Issue.1 , pp. 111-119
    • Chandriani, S.1    DePianto, D.J.2    N'Diaye, E.N.3    Abbas, A.R.4    Jackman, J.5    Bevers, J.6
  • 18
    • 84908121772 scopus 로고    scopus 로고
    • TNF-a/IL-17 synergy inhibits IL-13 bioactivity via IL-13RI±2 induction
    • Badalyan V, Thompson R, Addo K, Borthwick LA, Fisher AJ, Ort T, et al. TNF-a/IL-17 synergy inhibits IL-13 bioactivity via IL-13RI±2 induction. J Allergy Clin Immunol (2014) 134(4):975-8.e5. doi:10.1016/j.jaci.2014.05.019
    • (2014) J Allergy Clin Immunol , vol.134 , Issue.4 , pp. 975.e5-978.e5
    • Badalyan, V.1    Thompson, R.2    Addo, K.3    Borthwick, L.A.4    Fisher, A.J.5    Ort, T.6
  • 19
    • 84876049040 scopus 로고    scopus 로고
    • Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo
    • Wen T, Besse JA, Mingler MK, Fulkerson PC, Rothenberg ME. Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo. Proc Natl Acad Sci U S A (2013) 110(15):6067-72. doi:10.1073/pnas.1220572110
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.15 , pp. 6067-6072
    • Wen, T.1    Besse, J.A.2    Mingler, M.K.3    Fulkerson, P.C.4    Rothenberg, M.E.5
  • 20
    • 84878249836 scopus 로고    scopus 로고
    • α(M)β(2) integrin-mediated adhesion and motility of IL-5-stimulated eosinophils on periostin
    • Johansson MW, Annis DS, Mosher DF. α(M)β(2) integrin-mediated adhesion and motility of IL-5-stimulated eosinophils on periostin. Am J Respir Cell Mol Biol (2013) 48(4):503-10. doi:10.1165/rcmb.2012-0150OC
    • (2013) Am J Respir Cell Mol Biol , vol.48 , Issue.4 , pp. 503-510
    • Johansson, M.W.1    Annis, D.S.2    Mosher, D.F.3
  • 21
    • 0028963908 scopus 로고
    • Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung
    • Rothenberg ME, Luster AD, Lilly CM, Drazen JM, Leder P. Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung. J Exp Med (1995) 181(3):1211-6. doi:10.1084/jem.181.3.1211
    • (1995) J Exp Med , vol.181 , Issue.3 , pp. 1211-1216
    • Rothenberg, M.E.1    Luster, A.D.2    Lilly, C.M.3    Drazen, J.M.4    Leder, P.5
  • 22
    • 0034769498 scopus 로고    scopus 로고
    • IL-13 induces eosinophil recruitment into the lung by an IL-5-and eotaxin-dependent mechanism
    • Pope SM, Brandt EB, Mishra A, Hogan SP, Zimmermann N, Matthaei KI, et al. IL-13 induces eosinophil recruitment into the lung by an IL-5-and eotaxin-dependent mechanism. J Allergy Clin Immunol (2001) 108(4):594-601. doi:10.1067/mai.2001.118600
    • (2001) J Allergy Clin Immunol , vol.108 , Issue.4 , pp. 594-601
    • Pope, S.M.1    Brandt, E.B.2    Mishra, A.3    Hogan, S.P.4    Zimmermann, N.5    Matthaei, K.I.6
  • 23
    • 33750811888 scopus 로고    scopus 로고
    • A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation
    • Fulkerson PC, Fischetti CA, McBride ML, Hassman LM, Hogan SP, Rothenberg ME. A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Proc Natl Acad Sci U S A (2006) 103(44):16418-23. doi:10.1073/pnas.0607863103
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.44 , pp. 16418-16423
    • Fulkerson, P.C.1    Fischetti, C.A.2    McBride, M.L.3    Hassman, L.M.4    Hogan, S.P.5    Rothenberg, M.E.6
  • 24
    • 0037013924 scopus 로고    scopus 로고
    • Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo
    • Yu C, Cantor AB, Yang H, Browne C, Wells RA, Fujiwara Y, et al. Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med (2002) 195(11):1387-95. doi:10.1084/jem.20020656
    • (2002) J Exp Med , vol.195 , Issue.11 , pp. 1387-1395
    • Yu, C.1    Cantor, A.B.2    Yang, H.3    Browne, C.4    Wells, R.A.5    Fujiwara, Y.6
  • 25
    • 4544274172 scopus 로고    scopus 로고
    • A critical role for eosinophils in allergic airways remodeling
    • Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, et al. A critical role for eosinophils in allergic airways remodeling. Science (2004) 305(5691):1776-9. doi:10.1126/science.1100283
    • (2004) Science , vol.305 , Issue.5691 , pp. 1776-1779
    • Humbles, A.A.1    Lloyd, C.M.2    McMillan, S.J.3    Friend, D.S.4    Xanthou, G.5    McKenna, E.E.6
  • 26
    • 4544304222 scopus 로고    scopus 로고
    • Defining a link with asthma in mice congenitally deficient in eosinophils
    • Lee JJ, Dimina D, Macias MP, Ochkur SI, McGarry MP, O'Neill KR, et al. Defining a link with asthma in mice congenitally deficient in eosinophils. Science (2004) 305(5691):1773-6. doi:10.1126/science.1099472
    • (2004) Science , vol.305 , Issue.5691 , pp. 1773-1776
    • Lee, J.J.1    Dimina, D.2    Macias, M.P.3    Ochkur, S.I.4    McGarry, M.P.5    O'Neill, K.R.6
  • 27
    • 84881187383 scopus 로고    scopus 로고
    • Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation
    • Kano G, Almanan M, Bochner BS, Zimmermann N. Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation. J Allergy Clin Immunol (2013) 132(2):437-45. doi:10.1016/j.jaci.2013.03.024
    • (2013) J Allergy Clin Immunol , vol.132 , Issue.2 , pp. 437-445
    • Kano, G.1    Almanan, M.2    Bochner, B.S.3    Zimmermann, N.4
  • 28
    • 84924187758 scopus 로고    scopus 로고
    • Biologic therapies targeting eosinophils: current status and future prospects
    • Legrand F, Klion AD. Biologic therapies targeting eosinophils: current status and future prospects. J Allergy Clin Immunol Pract (2015) 3(2):167-74. doi:10.1016/j.jaip.2015.01.013
    • (2015) J Allergy Clin Immunol Pract , vol.3 , Issue.2 , pp. 167-174
    • Legrand, F.1    Klion, A.D.2
  • 29
    • 85010902369 scopus 로고    scopus 로고
    • Asthma guidelines: the global initiative for asthma in relation to national guidelines
    • Becker AB, Abrams EM. Asthma guidelines: the global initiative for asthma in relation to national guidelines. Curr Opin Allergy Clin Immunol (2017) 17(2):99-103. doi:10.1097/ACI.0000000000000346
    • (2017) Curr Opin Allergy Clin Immunol , vol.17 , Issue.2 , pp. 99-103
    • Becker, A.B.1    Abrams, E.M.2
  • 30
    • 33747756534 scopus 로고    scopus 로고
    • Asthma: defining of the persistent adult phenotypes
    • Wenzel SE. Asthma: defining of the persistent adult phenotypes. Lancet (2006) 368(9537):804-13. doi:10.1016/S0140-6736(06)69290-8
    • (2006) Lancet , vol.368 , Issue.9537 , pp. 804-813
    • Wenzel, S.E.1
  • 31
    • 79959363586 scopus 로고    scopus 로고
    • Human asthma phenotypes: from the clinic, to cytokines, and back again
    • Bhakta NR, Woodruff PG. Human asthma phenotypes: from the clinic, to cytokines, and back again. Immunol Rev (2011) 242(1):220-32. doi:10.1111/j.1600-065X.2011.01032.x
    • (2011) Immunol Rev , vol.242 , Issue.1 , pp. 220-232
    • Bhakta, N.R.1    Woodruff, P.G.2
  • 33
    • 0037202790 scopus 로고    scopus 로고
    • Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    • Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet (2002) 360(9347):1715-21. doi:10.1016/S0140-6736(02)11679-5
    • (2002) Lancet , vol.360 , Issue.9347 , pp. 1715-1721
    • Green, R.H.1    Brightling, C.E.2    McKenna, S.3    Hargadon, B.4    Parker, D.5    Bradding, P.6
  • 35
    • 84873136114 scopus 로고    scopus 로고
    • Eosinophils as diagnostic tools in chronic lung disease
    • Eltboli O, Brightling CE. Eosinophils as diagnostic tools in chronic lung disease. Expert Rev Respir Med (2013) 7(1):33-42. doi:10.1586/ers.12.81
    • (2013) Expert Rev Respir Med , vol.7 , Issue.1 , pp. 33-42
    • Eltboli, O.1    Brightling, C.E.2
  • 36
    • 0016864288 scopus 로고
    • Total eosinophil counts in the management of bronchial asthma
    • Horn BR, Robin ED, Theodore J, Van Kessel A. Total eosinophil counts in the management of bronchial asthma. N Engl J Med (1975) 292(22):1152-5. doi:10.1056/NEJM197505292922204
    • (1975) N Engl J Med , vol.292 , Issue.22 , pp. 1152-1155
    • Horn, B.R.1    Robin, E.D.2    Theodore, J.3    Van Kessel, A.4
  • 37
    • 0023212275 scopus 로고
    • Peripheral blood eosinophil counts and bronchial responsiveness
    • Taylor KJ, Luksza AR. Peripheral blood eosinophil counts and bronchial responsiveness. Thorax (1987) 42(6):452-6. doi:10.1136/thx.42.6.452
    • (1987) Thorax , vol.42 , Issue.6 , pp. 452-456
    • Taylor, K.J.1    Luksza, A.R.2
  • 38
    • 0025818686 scopus 로고
    • Increased chemokinetic and chemotactic responses of eosinophils in asthmatic patients
    • Griffin E, Håkansson L, Formgren H, Jörgensen K, Venge P. Increased chemokinetic and chemotactic responses of eosinophils in asthmatic patients. Allergy (1991) 46(4):255-65. doi:10.1111/j.1398-9995.1991.tb00583.x
    • (1991) Allergy , vol.46 , Issue.4 , pp. 255-265
    • Griffin, E.1    Håkansson, L.2    Formgren, H.3    Jörgensen, K.4    Venge, P.5
  • 39
    • 0028325257 scopus 로고
    • Relationship of plasma epinephrine and circulating eosinophils to nocturnal asthma
    • Bates ME, Clayton M, Calhoun W, Jarjour N, Schrader L, Geiger K, et al. Relationship of plasma epinephrine and circulating eosinophils to nocturnal asthma. Am J Respir Crit Care Med (1994) 149(3 Pt 1):667-72. doi:10.1164/ajrccm.149.3.8118634
    • (1994) Am J Respir Crit Care Med , vol.149 , Issue.3 , pp. 667-672
    • Bates, M.E.1    Clayton, M.2    Calhoun, W.3    Jarjour, N.4    Schrader, L.5    Geiger, K.6
  • 40
    • 0029164515 scopus 로고
    • Peripheral eosinophil counts as a marker of disease activity in intrinsic and extrinsic asthma
    • Ulrik CS. Peripheral eosinophil counts as a marker of disease activity in intrinsic and extrinsic asthma. Clin Exp Allergy (1995) 25(9):820-7. doi:10.1111/j.1365-2222.1995.tb00024.x
    • (1995) Clin Exp Allergy , vol.25 , Issue.9 , pp. 820-827
    • Ulrik, C.S.1
  • 41
    • 0032841666 scopus 로고    scopus 로고
    • The effect of corticosteroid therapy on blood eosinophils and eosinophilic cationic protein in patients with acute and chronic asthma
    • Marouf R, Khadadah ME, Onadeko BO, Mustafa HT, Khamis A, Ezeamuzie CE, et al. The effect of corticosteroid therapy on blood eosinophils and eosinophilic cationic protein in patients with acute and chronic asthma. J Asthma (1999) 36(7):555-64. doi:10.3109/02770909909087292
    • (1999) J Asthma , vol.36 , Issue.7 , pp. 555-564
    • Marouf, R.1    Khadadah, M.E.2    Onadeko, B.O.3    Mustafa, H.T.4    Khamis, A.5    Ezeamuzie, C.E.6
  • 42
    • 0035129132 scopus 로고    scopus 로고
    • The relation between peripheral blood leukocyte counts and respiratory symptoms, atopy, lung function, and airway responsiveness in adults
    • Lewis SA, Pavord ID, Stringer JR, Knox AJ, Weiss ST, Britton JR. The relation between peripheral blood leukocyte counts and respiratory symptoms, atopy, lung function, and airway responsiveness in adults. Chest (2001) 119(1):105-14. doi:10.1378/chest.119.1.105
    • (2001) Chest , vol.119 , Issue.1 , pp. 105-114
    • Lewis, S.A.1    Pavord, I.D.2    Stringer, J.R.3    Knox, A.J.4    Weiss, S.T.5    Britton, J.R.6
  • 43
    • 84902985671 scopus 로고    scopus 로고
    • High blood eosinophil count is associated with more frequent asthma attacks in asthma patients
    • Tran TN, Khatry DB, Ke X, Ward CK, Gossage D. High blood eosinophil count is associated with more frequent asthma attacks in asthma patients. Ann Allergy Asthma Immunol (2014) 113(1):19-24. doi:10.1016/j.anai.2014.04.011
    • (2014) Ann Allergy Asthma Immunol , vol.113 , Issue.1 , pp. 19-24
    • Tran, T.N.1    Khatry, D.B.2    Ke, X.3    Ward, C.K.4    Gossage, D.5
  • 44
    • 84865696394 scopus 로고    scopus 로고
    • Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients
    • Jia G, Erickson RW, Choy DF, Mosesova S, Wu LC, Solberg OD, et al. Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol (2012) 130(3):647-54.e10. doi:10.1016/j.jaci.2012.06.025
    • (2012) J Allergy Clin Immunol , vol.130 , Issue.3 , pp. 647.e10-654.e10
    • Jia, G.1    Erickson, R.W.2    Choy, D.F.3    Mosesova, S.4    Wu, L.C.5    Solberg, O.D.6
  • 45
    • 84906226684 scopus 로고    scopus 로고
    • Full blood count parameters for the detection of asthma inflammatory phenotypes
    • Zhang XY, Simpson JL, Powell H, Yang IA, Upham JW, Reynolds PN, et al. Full blood count parameters for the detection of asthma inflammatory phenotypes. Clin Exp Allergy (2014) 44(9):1137-45. doi:10.1111/cea.12345
    • (2014) Clin Exp Allergy , vol.44 , Issue.9 , pp. 1137-1145
    • Zhang, X.Y.1    Simpson, J.L.2    Powell, H.3    Yang, I.A.4    Upham, J.W.5    Reynolds, P.N.6
  • 46
    • 0032875377 scopus 로고    scopus 로고
    • Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    • Wenzel SE, Schwartz LB, Langmack EL, Halliday JL, Trudeau JB, Gibbs RL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med (1999) 160(3):1001-8. doi:10.1164/ajrccm.160.3.9812110
    • (1999) Am J Respir Crit Care Med , vol.160 , Issue.3 , pp. 1001-1008
    • Wenzel, S.E.1    Schwartz, L.B.2    Langmack, E.L.3    Halliday, J.L.4    Trudeau, J.B.5    Gibbs, R.L.6
  • 47
    • 84940733208 scopus 로고    scopus 로고
    • Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies
    • Hanania NA, Noonan M, Corren J, Korenblat P, Zheng Y, Fischer SK, et al. Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies. Thorax (2015) 70(8):748-56. doi:10.1136/thoraxjnl-2014-206719
    • (2015) Thorax , vol.70 , Issue.8 , pp. 748-756
    • Hanania, N.A.1    Noonan, M.2    Corren, J.3    Korenblat, P.4    Zheng, Y.5    Fischer, S.K.6
  • 48
    • 84941182925 scopus 로고    scopus 로고
    • Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial
    • Brightling CE, Chanez P, Leigh R, O'Byrne PM, Korn S, She D, et al. Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial. Lancet Respir Med (2015) 3(9):692-701. doi:10.1016/S2213-2600(15)00197-6
    • (2015) Lancet Respir Med , vol.3 , Issue.9 , pp. 692-701
    • Brightling, C.E.1    Chanez, P.2    Leigh, R.3    O'Byrne, P.M.4    Korn, S.5    She, D.6
  • 50
    • 84879401471 scopus 로고    scopus 로고
    • Dupilumab in persistent asthma with elevated eosinophil levels
    • Wenzel S, Ford L, Pearlman D, Spector S, Sher L, Skobieranda F, et al. Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med (2013) 368(26):2455-66. doi:10.1056/NEJMoa1304048
    • (2013) N Engl J Med , vol.368 , Issue.26 , pp. 2455-2466
    • Wenzel, S.1    Ford, L.2    Pearlman, D.3    Spector, S.4    Sher, L.5    Skobieranda, F.6
  • 51
    • 84892490403 scopus 로고    scopus 로고
    • Noninvasive biomarkers that predict treatment benefit from biologic therapies in asthma
    • Arron JR, Choy DF, Scheerens H, Matthews JG. Noninvasive biomarkers that predict treatment benefit from biologic therapies in asthma. Ann Am Thorac Soc (2013) 10(Suppl):S206-13. doi:10.1513/AnnalsATS.201303-047AW
    • (2013) Ann Am Thorac Soc , vol.10 , pp. S206-S213
    • Arron, J.R.1    Choy, D.F.2    Scheerens, H.3    Matthews, J.G.4
  • 52
    • 0030923641 scopus 로고    scopus 로고
    • Interleukin-13 but not interleukin-4 prolongs eosinophil survival and induces eosinophil chemotaxis
    • Horie S, Okubo Y, Hossain M, Sato E, Nomura H, Koyama S, et al. Interleukin-13 but not interleukin-4 prolongs eosinophil survival and induces eosinophil chemotaxis. Intern Med (1997) 36(3):179-85
    • (1997) Intern Med , vol.36 , Issue.3 , pp. 179-185
    • Horie, S.1    Okubo, Y.2    Hossain, M.3    Sato, E.4    Nomura, H.5    Koyama, S.6
  • 53
    • 0030586671 scopus 로고    scopus 로고
    • Activation of human eosinophils by IL-13 Induction of CD69 surface antigen, its relationship to messenger RNA expression, and promotion of cellular viability
    • Luttmann W, Knoechel B, Foerster M, Matthys H, Virchow JC, Kroegel C. Activation of human eosinophils by IL-13. Induction of CD69 surface antigen, its relationship to messenger RNA expression, and promotion of cellular viability. J Immunol (1996) 157(4):1678-83
    • (1996) J Immunol , vol.157 , Issue.4 , pp. 1678-1683
    • Luttmann, W.1    Knoechel, B.2    Foerster, M.3    Matthys, H.4    Virchow, J.C.5    Kroegel, C.6
  • 54
    • 0028815074 scopus 로고
    • IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells
    • Bochner BS, Klunk DA, Sterbinsky SA, Coffman RL, Schleimer RP. IL-13 selectively induces vascular cell adhesion molecule-1 expression in human endothelial cells. J Immunol (1995) 154(2):799-803
    • (1995) J Immunol , vol.154 , Issue.2 , pp. 799-803
    • Bochner, B.S.1    Klunk, D.A.2    Sterbinsky, S.A.3    Coffman, R.L.4    Schleimer, R.P.5
  • 55
    • 33645059692 scopus 로고    scopus 로고
    • Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients
    • Truyen E, Coteur L, Dilissen E, Overbergh L, Dupont LJ, Ceuppens JL, et al. Evaluation of airway inflammation by quantitative Th1/Th2 cytokine mRNA measurement in sputum of asthma patients. Thorax (2006) 61(3):202-8. doi:10.1136/thx.2005.052399
    • (2006) Thorax , vol.61 , Issue.3 , pp. 202-208
    • Truyen, E.1    Coteur, L.2    Dilissen, E.3    Overbergh, L.4    Dupont, L.J.5    Ceuppens, J.L.6
  • 57
    • 7944237374 scopus 로고    scopus 로고
    • Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis
    • Berry MA, Parker D, Neale N, Woodman L, Morgan A, Monk P, et al. Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis. J Allergy Clin Immunol (2004) 114(5):1106-9. doi:10.1016/j.jaci.2004.08.032
    • (2004) J Allergy Clin Immunol , vol.114 , Issue.5 , pp. 1106-1109
    • Berry, M.A.1    Parker, D.2    Neale, N.3    Woodman, L.4    Morgan, A.5    Monk, P.6
  • 58
    • 84959038001 scopus 로고    scopus 로고
    • Bioanalytical challenges and improved detection of circulating levels of IL-13
    • Cai F, Hornauer H, Peng K, Schofield CA, Scheerens H, Morimoto AM. Bioanalytical challenges and improved detection of circulating levels of IL-13. Bioanalysis (2016) 8(4):323-32. doi:10.4155/bio.15.254
    • (2016) Bioanalysis , vol.8 , Issue.4 , pp. 323-332
    • Cai, F.1    Hornauer, H.2    Peng, K.3    Schofield, C.A.4    Scheerens, H.5    Morimoto, A.M.6
  • 59
    • 84919391929 scopus 로고    scopus 로고
    • Eosinophil cytokines, chemokines, and growth factors: emerging roles in immunity
    • Davoine F, Lacy P. Eosinophil cytokines, chemokines, and growth factors: emerging roles in immunity. Front Immunol (2014) 5:570. doi:10.3389/fimmu.2014.00570
    • (2014) Front Immunol , vol.5 , pp. 570
    • Davoine, F.1    Lacy, P.2
  • 60
    • 0023358395 scopus 로고
    • Comparative toxicity of purified human eosinophil granule proteins for newborn larvae of Trichinella spiralis
    • Hamann KJ, Barker RL, Loegering DA, Gleich GJ. Comparative toxicity of purified human eosinophil granule proteins for newborn larvae of Trichinella spiralis. J Parasitol (1987) 73(3):523-9. doi:10.2307/3282130
    • (1987) J Parasitol , vol.73 , Issue.3 , pp. 523-529
    • Hamann, K.J.1    Barker, R.L.2    Loegering, D.A.3    Gleich, G.J.4
  • 61
    • 84892757972 scopus 로고    scopus 로고
    • Primary lysis of eosinophils in severe desquamative asthma
    • Persson C. Primary lysis of eosinophils in severe desquamative asthma. Clin Exp Allergy (2014) 44(2):173-83. doi:10.1111/cea.12255
    • (2014) Clin Exp Allergy , vol.44 , Issue.2 , pp. 173-183
    • Persson, C.1
  • 62
    • 0028230969 scopus 로고
    • Vesicular transport of peroxidase in human eosinophilic myelocytes
    • Dvorak AM, Estrella P, Ishizaka T. Vesicular transport of peroxidase in human eosinophilic myelocytes. Clin Exp Allergy (1994) 24(1):10-8. doi:10.1111/j.1365-2222.1994.tb00910.x
    • (1994) Clin Exp Allergy , vol.24 , Issue.1 , pp. 10-18
    • Dvorak, A.M.1    Estrella, P.2    Ishizaka, T.3
  • 63
    • 77953963471 scopus 로고    scopus 로고
    • Eosinophil protein in airway macrophages: a novel biomarker of eosinophilic inflammation in patients with asthma
    • Kulkarni NS, Hollins F, Sutcliffe A, Saunders R, Shah S, Siddiqui S, et al. Eosinophil protein in airway macrophages: a novel biomarker of eosinophilic inflammation in patients with asthma. J Allergy Clin Immunol (2010) 126(1):61-9.e3. doi:10.1016/j.jaci.2010.03.026
    • (2010) J Allergy Clin Immunol , vol.126 , Issue.1 , pp. 61.e3-69.e3
    • Kulkarni, N.S.1    Hollins, F.2    Sutcliffe, A.3    Saunders, R.4    Shah, S.5    Siddiqui, S.6
  • 64
    • 51349135381 scopus 로고    scopus 로고
    • Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense
    • Yousefi S, Gold JA, Andina N, Lee JJ, Kelly AM, Kozlowski E, et al. Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense. Nat Med (2008) 14(9):949-53. doi:10.1038/nm.1855
    • (2008) Nat Med , vol.14 , Issue.9 , pp. 949-953
    • Yousefi, S.1    Gold, J.A.2    Andina, N.3    Lee, J.J.4    Kelly, A.M.5    Kozlowski, E.6
  • 65
    • 84877622192 scopus 로고    scopus 로고
    • Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans
    • Ueki S, Melo RC, Ghiran I, Spencer LA, Dvorak AM, Weller PF. Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans. Blood (2013) 121(11):2074-83. doi:10.1182/blood-2012-05-432088
    • (2013) Blood , vol.121 , Issue.11 , pp. 2074-2083
    • Ueki, S.1    Melo, R.C.2    Ghiran, I.3    Spencer, L.A.4    Dvorak, A.M.5    Weller, P.F.6
  • 66
    • 33644846176 scopus 로고    scopus 로고
    • Circulating eosinophils in asthma, allergic rhinitis, and atopic dermatitis lack morphological signs of degranulation
    • Malm-Erjefält M, Greiff L, Ankerst J, Andersson M, Wallengren J, Cardell LO, et al. Circulating eosinophils in asthma, allergic rhinitis, and atopic dermatitis lack morphological signs of degranulation. Clin Exp Allergy (2005) 35(10):1334-40. doi:10.1111/j.1365-2222.2005.02335.x
    • (2005) Clin Exp Allergy , vol.35 , Issue.10 , pp. 1334-1340
    • Malm-Erjefält, M.1    Greiff, L.2    Ankerst, J.3    Andersson, M.4    Wallengren, J.5    Cardell, L.O.6
  • 67
    • 0033785104 scopus 로고    scopus 로고
    • Piecemeal degranulation of peripheral blood eosinophils: a study of allergic subjects during and out of the pollen season
    • Karawajczyk M, Sevéus L, Garcia R, Björnsson E, Peterson CG, Roomans GM, et al. Piecemeal degranulation of peripheral blood eosinophils: a study of allergic subjects during and out of the pollen season. Am J Respir Cell Mol Biol (2000) 23(4):521-9. doi:10.1165/ajrcmb.23.4.4025
    • (2000) Am J Respir Cell Mol Biol , vol.23 , Issue.4 , pp. 521-529
    • Karawajczyk, M.1    Sevéus, L.2    Garcia, R.3    Björnsson, E.4    Peterson, C.G.5    Roomans, G.M.6
  • 68
    • 84880290541 scopus 로고    scopus 로고
    • Morphological changes in eosinophils are reliable markers of the severity of an acute asthma exacerbation in children
    • Muniz-Junqueira MI, Barbosa-Marques SM, Junqueira LF. Morphological changes in eosinophils are reliable markers of the severity of an acute asthma exacerbation in children. Allergy (2013) 68(7):911-20. doi:10.1111/all.12176
    • (2013) Allergy , vol.68 , Issue.7 , pp. 911-920
    • Muniz-Junqueira, M.I.1    Barbosa-Marques, S.M.2    Junqueira, L.F.3
  • 69
    • 63849087415 scopus 로고    scopus 로고
    • Serum eosinophil granule proteins predict asthma risk in allergic rhinitis
    • Nielsen LP, Peterson CG, Dahl R. Serum eosinophil granule proteins predict asthma risk in allergic rhinitis. Allergy (2009) 64(5):733-7. doi:10.1111/j.1398-9995.2008.01869.x
    • (2009) Allergy , vol.64 , Issue.5 , pp. 733-737
    • Nielsen, L.P.1    Peterson, C.G.2    Dahl, R.3
  • 70
    • 84989808988 scopus 로고    scopus 로고
    • Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials
    • Hanania NA, Korenblat P, Chapman KR, Bateman ED, Kopecky P, Paggiaro P, et al. Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials. Lancet Respir Med (2016) 4(10):781-96. doi:10.1016/S2213-2600(16)30265-X
    • (2016) Lancet Respir Med , vol.4 , Issue.10 , pp. 781-796
    • Hanania, N.A.1    Korenblat, P.2    Chapman, K.R.3    Bateman, E.D.4    Kopecky, P.5    Paggiaro, P.6
  • 71
    • 84873389433 scopus 로고    scopus 로고
    • A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma
    • Piper E, Brightling C, Niven R, Oh C, Faggioni R, Poon K, et al. A phase II placebo-controlled study of tralokinumab in moderate-to-severe asthma. Eur Respir J (2013) 41(2):330-8. doi:10.1183/09031936.00223411
    • (2013) Eur Respir J , vol.41 , Issue.2 , pp. 330-338
    • Piper, E.1    Brightling, C.2    Niven, R.3    Oh, C.4    Faggioni, R.5    Poon, K.6
  • 72
    • 84964573673 scopus 로고    scopus 로고
    • Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial
    • Wenzel S, Castro M, Corren J, Maspero J, Wang L, Zhang B, et al. Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial. Lancet (2016) 388(10039):31-44. doi:10.1016/S0140-6736(16)30307-5
    • (2016) Lancet , vol.388 , pp. 31-44
    • Wenzel, S.1    Castro, M.2    Corren, J.3    Maspero, J.4    Wang, L.5    Zhang, B.6
  • 73
    • 84999885019 scopus 로고    scopus 로고
    • A mathematical modeling approach to understanding the effect of anti-interleukin therapy on eosinophils
    • Karelina T, Voronova V, Demin O, Colice G, Agoram BM. A mathematical modeling approach to understanding the effect of anti-interleukin therapy on eosinophils. CPT Pharmacometrics Syst Pharmacol (2016) 5(11):608-16. doi:10.1002/psp4.12129
    • (2016) CPT Pharmacometrics Syst Pharmacol , vol.5 , Issue.11 , pp. 608-616
    • Karelina, T.1    Voronova, V.2    Demin, O.3    Colice, G.4    Agoram, B.M.5
  • 74
    • 0037438409 scopus 로고    scopus 로고
    • Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway
    • Flood-Page PT, Menzies-Gow AN, Kay AB, Robinson DS. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med (2003) 167(2):199-204. doi:10.1164/rccm.200208-789OC
    • (2003) Am J Respir Crit Care Med , vol.167 , Issue.2 , pp. 199-204
    • Flood-Page, P.T.1    Menzies-Gow, A.N.2    Kay, A.B.3    Robinson, D.S.4
  • 75
    • 61849086181 scopus 로고    scopus 로고
    • Mepolizumab and exacerbations of refractory eosinophilic asthma
    • Haldar P, Brightling CE, Hargadon B, Gupta S, Monteiro W, Sousa A, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med (2009) 360(10):973-84. doi:10.1056/NEJMoa0808991
    • (2009) N Engl J Med , vol.360 , Issue.10 , pp. 973-984
    • Haldar, P.1    Brightling, C.E.2    Hargadon, B.3    Gupta, S.4    Monteiro, W.5    Sousa, A.6
  • 76
    • 84875635019 scopus 로고    scopus 로고
    • The international study of asthma and allergies in childhood (ISAAC) phase three: a global synthesis
    • Mallol J, Crane J, von Mutius E, Odhiambo J, Keil U, Stewart A, et al. The international study of asthma and allergies in childhood (ISAAC) phase three: a global synthesis. Allergol Immunopathol (2013) 41(2):73-85. doi:10.1016/j.aller.2012.03.001
    • (2013) Allergol Immunopathol , vol.41 , Issue.2 , pp. 73-85
    • Mallol, J.1    Crane, J.2    von Mutius, E.3    Odhiambo, J.4    Keil, U.5    Stewart, A.6
  • 78
    • 0017172058 scopus 로고
    • The structure of normal skin and the morphology of atopic eczema
    • Mihm MC, Soter NA, Dvorak HF, Austen KF. The structure of normal skin and the morphology of atopic eczema. J Invest Dermatol (1976) 67(3):305-12. doi:10.1111/1523-1747.ep12514346
    • (1976) J Invest Dermatol , vol.67 , Issue.3 , pp. 305-312
    • Mihm, M.C.1    Soter, N.A.2    Dvorak, H.F.3    Austen, K.F.4
  • 79
    • 0035175482 scopus 로고    scopus 로고
    • Tissue eosinophilia in acute and chronic atopic dermatitis: a morphometric approach using quantitative image analysis of immunostaining
    • Kiehl P, Falkenberg K, Vogelbruch M, Kapp A. Tissue eosinophilia in acute and chronic atopic dermatitis: a morphometric approach using quantitative image analysis of immunostaining. Br J Dermatol (2001) 145(5):720-9. doi:10.1046/j.1365-2133.2001.04456.x
    • (2001) Br J Dermatol , vol.145 , Issue.5 , pp. 720-729
    • Kiehl, P.1    Falkenberg, K.2    Vogelbruch, M.3    Kapp, A.4
  • 81
    • 0037057645 scopus 로고    scopus 로고
    • Endogenous antimicrobial peptides and skin infections in atopic dermatitis
    • Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med (2002) 347(15):1151-60. doi:10.1056/NEJMoa021481
    • (2002) N Engl J Med , vol.347 , Issue.15 , pp. 1151-1160
    • Ong, P.Y.1    Ohtake, T.2    Brandt, C.3    Strickland, I.4    Boguniewicz, M.5    Ganz, T.6
  • 82
    • 49549108250 scopus 로고    scopus 로고
    • Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation
    • Howell MD, Fairchild HR, Kim BE, Bin L, Boguniewicz M, Redzic JS, et al. Th2 cytokines act on S100/A11 to downregulate keratinocyte differentiation. J Invest Dermatol (2008) 128(9):2248-58. doi:10.1038/jid.2008.74
    • (2008) J Invest Dermatol , vol.128 , Issue.9 , pp. 2248-2258
    • Howell, M.D.1    Fairchild, H.R.2    Kim, B.E.3    Bin, L.4    Boguniewicz, M.5    Redzic, J.S.6
  • 83
    • 0041331649 scopus 로고    scopus 로고
    • Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes
    • Nomura I, Goleva E, Howell MD, Hamid QA, Ong PY, Hall CF, et al. Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol (2003) 171(6):3262-9. doi:10.4049/jimmunol.171.6.3262
    • (2003) J Immunol , vol.171 , Issue.6 , pp. 3262-3269
    • Nomura, I.1    Goleva, E.2    Howell, M.D.3    Hamid, Q.A.4    Ong, P.Y.5    Hall, C.F.6
  • 84
    • 2142770371 scopus 로고    scopus 로고
    • Relative importance of IL-4 and IL-13 in lesional skin of atopic dermatitis
    • Tazawa T, Sugiura H, Sugiura Y, Uehara M. Relative importance of IL-4 and IL-13 in lesional skin of atopic dermatitis. Arch Dermatol Res (2004) 295(11):459-64. doi:10.1007/s00403-004-0455-6
    • (2004) Arch Dermatol Res , vol.295 , Issue.11 , pp. 459-464
    • Tazawa, T.1    Sugiura, H.2    Sugiura, Y.3    Uehara, M.4
  • 85
    • 79251582522 scopus 로고    scopus 로고
    • Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways
    • Choy DF, Modrek B, Abbas AR, Kummerfeld S, Clark HF, Wu LC, et al. Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways. J Immunol (2011) 186(3):1861-9. doi:10.4049/jimmunol.1002568
    • (2011) J Immunol , vol.186 , Issue.3 , pp. 1861-1869
    • Choy, D.F.1    Modrek, B.2    Abbas, A.R.3    Kummerfeld, S.4    Clark, H.F.5    Wu, L.C.6
  • 87
    • 14344264857 scopus 로고    scopus 로고
    • CD4(+)IL-13(+) cells in peripheral blood well correlates with the severity of atopic dermatitis in children
    • La Grutta S, Richiusa P, Pizzolanti G, Mattina A, Pajno GB, Citarrella R, et al. CD4(+)IL-13(+) cells in peripheral blood well correlates with the severity of atopic dermatitis in children. Allergy (2005) 60(3):391-5. doi:10.1111/j.1398-9995.2005.00733.x
    • (2005) Allergy , vol.60 , Issue.3 , pp. 391-395
    • La Grutta, S.1    Richiusa, P.2    Pizzolanti, G.3    Mattina, A.4    Pajno, G.B.5    Citarrella, R.6
  • 88
    • 5444252845 scopus 로고    scopus 로고
    • Keratinocytes in atopic dermatitis: inflammatory signals
    • Esche C, de Benedetto A, Beck LA. Keratinocytes in atopic dermatitis: inflammatory signals. Curr Allergy Asthma Rep (2004) 4(4):276-84. doi:10.1007/s11882-004-0071-8
    • (2004) Curr Allergy Asthma Rep , vol.4 , Issue.4 , pp. 276-284
    • Esche, C.1    de Benedetto, A.2    Beck, L.A.3
  • 89
    • 59949089656 scopus 로고    scopus 로고
    • Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling
    • Zheng T, Oh MH, Oh SY, Schroeder JT, Glick AB, Zhu Z. Transgenic expression of interleukin-13 in the skin induces a pruritic dermatitis and skin remodeling. J Invest Dermatol (2009) 129(3):742-51. doi:10.1038/jid.2008.295
    • (2009) J Invest Dermatol , vol.129 , Issue.3 , pp. 742-751
    • Zheng, T.1    Oh, M.H.2    Oh, S.Y.3    Schroeder, J.T.4    Glick, A.B.5    Zhu, Z.6
  • 90
    • 77951890216 scopus 로고    scopus 로고
    • IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation
    • Sehra S, Yao Y, Howell MD, Nguyen ET, Kansas GS, Leung DY, et al. IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation. J Immunol (2010) 184(6):3186-90. doi:10.4049/jimmunol.0901860
    • (2010) J Immunol , vol.184 , Issue.6 , pp. 3186-3190
    • Sehra, S.1    Yao, Y.2    Howell, M.D.3    Nguyen, E.T.4    Kansas, G.S.5    Leung, D.Y.6
  • 91
    • 59449093989 scopus 로고    scopus 로고
    • Topical delivery of interleukin-13 antisense oligonucleotides with cationic elastic liposome for the treatment of atopic dermatitis
    • Kim ST, Lee KM, Park HJ, Jin SE, Ahn WS, Kim CK. Topical delivery of interleukin-13 antisense oligonucleotides with cationic elastic liposome for the treatment of atopic dermatitis. J Gene Med (2009) 11(1):26-37. doi:10.1002/jgm.1268
    • (2009) J Gene Med , vol.11 , Issue.1 , pp. 26-37
    • Kim, S.T.1    Lee, K.M.2    Park, H.J.3    Jin, S.E.4    Ahn, W.S.5    Kim, C.K.6
  • 92
    • 63149192686 scopus 로고    scopus 로고
    • Profiling the dysregulated genes of keratinocytes in atopic dermatitis patients: cDNA microarray and interactomic analyses
    • Lü ZR, Park D, Lee KA, Ryu JW, Bhak J, Shi L, et al. Profiling the dysregulated genes of keratinocytes in atopic dermatitis patients: cDNA microarray and interactomic analyses. J Dermatol Sci (2009) 54(2):126-9. doi:10.1016/j.jdermsci.2008.12.006
    • (2009) J Dermatol Sci , vol.54 , Issue.2 , pp. 126-129
    • Lü, Z.R.1    Park, D.2    Lee, K.A.3    Ryu, J.W.4    Bhak, J.5    Shi, L.6
  • 93
    • 0035845855 scopus 로고    scopus 로고
    • Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes: involvement of STAT6, ERK and p38 MAPK pathways
    • David M, Ford D, Bertoglio J, Maizel AL, Pierre J. Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes: involvement of STAT6, ERK and p38 MAPK pathways. Oncogene (2001) 20(46):6660-8. doi:10.1038/sj.onc.1204629
    • (2001) Oncogene , vol.20 , Issue.46 , pp. 6660-6668
    • David, M.1    Ford, D.2    Bertoglio, J.3    Maizel, A.L.4    Pierre, J.5
  • 94
    • 78650672614 scopus 로고    scopus 로고
    • IL-13Ra2 has a protective role in a mouse model of cutaneous inflammation
    • Sivaprasad U, Warrier MR, Gibson AM, Chen W, Tabata Y, Bass SA, et al. IL-13Ra2 has a protective role in a mouse model of cutaneous inflammation. J Immunol (2010) 185(11):6802-8. doi:10.4049/jimmunol.1002118
    • (2010) J Immunol , vol.185 , Issue.11 , pp. 6802-6808
    • Sivaprasad, U.1    Warrier, M.R.2    Gibson, A.M.3    Chen, W.4    Tabata, Y.5    Bass, S.A.6
  • 95
    • 84971641180 scopus 로고    scopus 로고
    • Dupilumab therapy provides clinically meaningful improvement in patient-reported outcomes (PROs): a phase IIb, randomized, placebo-controlled, clinical trial in adult patients with moderate to severe atopic dermatitis (AD)
    • Simpson EL, Gadkari A, Worm M, Soong W, Blauvelt A, Eckert L, et al. Dupilumab therapy provides clinically meaningful improvement in patient-reported outcomes (PROs): a phase IIb, randomized, placebo-controlled, clinical trial in adult patients with moderate to severe atopic dermatitis (AD). J Am Acad Dermatol (2016) 75(3):506-15. doi:10.1016/j.jaad.2016.04.054
    • (2016) J Am Acad Dermatol , vol.75 , Issue.3 , pp. 506-515
    • Simpson, E.L.1    Gadkari, A.2    Worm, M.3    Soong, W.4    Blauvelt, A.5    Eckert, L.6
  • 96
    • 84858257955 scopus 로고    scopus 로고
    • Eosinophilic esophagitis: rapidly emerging disorder
    • Straumann A. Eosinophilic esophagitis: rapidly emerging disorder. Swiss Med Wkly (2012) 142:w13513. doi:10.4414/smw.2012.13513
    • (2012) Swiss Med Wkly , vol.142
    • Straumann, A.1
  • 97
    • 84899799927 scopus 로고    scopus 로고
    • Epidemiology of eosinophilic esophagitis
    • Dellon ES. Epidemiology of eosinophilic esophagitis. Gastroenterol Clin North Am (2014) 43(2):201-18. doi:10.1016/j.gtc.2014.02.002
    • (2014) Gastroenterol Clin North Am , vol.43 , Issue.2 , pp. 201-218
    • Dellon, E.S.1
  • 98
    • 84877580898 scopus 로고    scopus 로고
    • ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE)
    • quiz 693
    • Dellon ES, Gonsalves N, Hirano I, Furuta GT, Liacouras CA, Katzka DA, et al. ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). Am J Gastroenterol (2013) 108(5):679-92; quiz 693. doi:10.1038/ajg.2013.71
    • (2013) Am J Gastroenterol , vol.108 , Issue.5 , pp. 679-692
    • Dellon, E.S.1    Gonsalves, N.2    Hirano, I.3    Furuta, G.T.4    Liacouras, C.A.5    Katzka, D.A.6
  • 99
    • 84899933707 scopus 로고    scopus 로고
    • Histopathologic features of eosinophilic esophagitis and eosinophilic gastrointestinal diseases
    • Collins MH. Histopathologic features of eosinophilic esophagitis and eosinophilic gastrointestinal diseases. Gastroenterol Clin North Am (2014) 43(2):257-68. doi:10.1016/j.gtc.2014.02.007
    • (2014) Gastroenterol Clin North Am , vol.43 , Issue.2 , pp. 257-268
    • Collins, M.H.1
  • 100
    • 79951939344 scopus 로고    scopus 로고
    • Understanding eosinophilic esophagitis: the cellular and molecular mechanisms of an emerging disease
    • Mulder DJ, Justinich CJ. Understanding eosinophilic esophagitis: the cellular and molecular mechanisms of an emerging disease. Mucosal Immunol (2011) 4(2):139-47. doi:10.1038/mi.2010.88
    • (2011) Mucosal Immunol , vol.4 , Issue.2 , pp. 139-147
    • Mulder, D.J.1    Justinich, C.J.2
  • 101
    • 77951639698 scopus 로고    scopus 로고
    • Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis
    • Blanchard C, Stucke EM, Burwinkel K, Caldwell JM, Collins MH, Ahrens A, et al. Coordinate interaction between IL-13 and epithelial differentiation cluster genes in eosinophilic esophagitis. J Immunol (2010) 184(7):4033-41. doi:10.4049/jimmunol.0903069
    • (2010) J Immunol , vol.184 , Issue.7 , pp. 4033-4041
    • Blanchard, C.1    Stucke, E.M.2    Burwinkel, K.3    Caldwell, J.M.4    Collins, M.H.5    Ahrens, A.6
  • 102
    • 32444443951 scopus 로고    scopus 로고
    • Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis
    • Blanchard C, Wang N, Stringer KF, Mishra A, Fulkerson PC, Abonia JP, et al. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J Clin Invest (2006) 116(2):536-47. doi:10.1172/JCI26679
    • (2006) J Clin Invest , vol.116 , Issue.2 , pp. 536-547
    • Blanchard, C.1    Wang, N.2    Stringer, K.F.3    Mishra, A.4    Fulkerson, P.C.5    Abonia, J.P.6
  • 104
    • 84905587526 scopus 로고    scopus 로고
    • Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease
    • Kottyan LC, Davis BP, Sherrill JD, Liu K, Rochman M, Kaufman K, et al. Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease. Nat Genet (2014) 46(8):895-900. doi:10.1038/ng.3033
    • (2014) Nat Genet , vol.46 , Issue.8 , pp. 895-900
    • Kottyan, L.C.1    Davis, B.P.2    Sherrill, J.D.3    Liu, K.4    Rochman, M.5    Kaufman, K.6
  • 105
    • 84990832667 scopus 로고    scopus 로고
    • Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment
    • Davis BP, Stucke EM, Khorki ME, Litosh VA, Rymer JK, Rochman M, et al. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI Insight (2016) 1(4):e86355. doi:10.1172/jci.insight.86355
    • (2016) JCI Insight , vol.1 , Issue.4
    • Davis, B.P.1    Stucke, E.M.2    Khorki, M.E.3    Litosh, V.A.4    Rymer, J.K.5    Rochman, M.6
  • 106
    • 84870301114 scopus 로고    scopus 로고
    • Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation
    • Choy DF, Hsu DK, Seshasayee D, Fung MA, Modrusan Z, Martin F, et al. Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation. J Allergy Clin Immunol (2012) 130(6):1335-43.e5. doi:10.1016/j.jaci.2012.06.044
    • (2012) J Allergy Clin Immunol , vol.130 , Issue.6 , pp. 1335.e5-1343.e5
    • Choy, D.F.1    Hsu, D.K.2    Seshasayee, D.3    Fung, M.A.4    Modrusan, Z.5    Martin, F.6
  • 107
    • 84877028770 scopus 로고    scopus 로고
    • Expression microarray analysis identifies novel epithelial-derived protein markers in eosinophilic esophagitis
    • Matoso A, Mukkada VA, Lu S, Monahan R, Cleveland K, Noble L, et al. Expression microarray analysis identifies novel epithelial-derived protein markers in eosinophilic esophagitis. Mod Pathol (2013) 26(5):665-76. doi:10.1038/modpathol.2013.41
    • (2013) Mod Pathol , vol.26 , Issue.5 , pp. 665-676
    • Matoso, A.1    Mukkada, V.A.2    Lu, S.3    Monahan, R.4    Cleveland, K.5    Noble, L.6
  • 108
    • 84908022585 scopus 로고    scopus 로고
    • Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing
    • Sherrill JD, Kiran KC, Blanchard C, Stucke EM, Kemme KA, Collins MH, et al. Analysis and expansion of the eosinophilic esophagitis transcriptome by RNA sequencing. Genes Immun (2014) 15(6):361-9. doi:10.1038/gene.2014.27
    • (2014) Genes Immun , vol.15 , Issue.6 , pp. 361-369
    • Sherrill, J.D.1    Kiran, K.C.2    Blanchard, C.3    Stucke, E.M.4    Kemme, K.A.5    Collins, M.H.6
  • 109
    • 84932606854 scopus 로고    scopus 로고
    • Neurotrophic tyrosine kinase receptor 1 is a direct transcriptional and epigenetic target of IL-13 involved in allergic inflammation
    • Rochman M, Kartashov AV, Caldwell JM, Collins MH, Stucke EM, Kc K, et al. Neurotrophic tyrosine kinase receptor 1 is a direct transcriptional and epigenetic target of IL-13 involved in allergic inflammation. Mucosal Immunol (2015) 8(4):785-98. doi:10.1038/mi.2014.109
    • (2015) Mucosal Immunol , vol.8 , Issue.4 , pp. 785-798
    • Rochman, M.1    Kartashov, A.V.2    Caldwell, J.M.3    Collins, M.H.4    Stucke, E.M.5    Kc, K.6
  • 110
    • 84922379477 scopus 로고    scopus 로고
    • Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis
    • Rothenberg ME, Wen T, Greenberg A, Alpan O, Enav B, Hirano I, et al. Intravenous anti-IL-13 mAb QAX576 for the treatment of eosinophilic esophagitis. J Allergy Clin Immunol (2015) 135(2):500-7. doi:10.1016/j.jaci.2014.07.049
    • (2015) J Allergy Clin Immunol , vol.135 , Issue.2 , pp. 500-507
    • Rothenberg, M.E.1    Wen, T.2    Greenberg, A.3    Alpan, O.4    Enav, B.5    Hirano, I.6
  • 113
    • 34447542269 scopus 로고    scopus 로고
    • European position paper on rhinosinusitis and nasal polyps 2007
    • Fokkens W, Lund V, Mullol J; European Position Paper on Rhinosinusitis, Nasal Polyps group. European position paper on rhinosinusitis and nasal polyps 2007. Rhinol Suppl (2007) 20:1-136
    • (2007) Rhinol Suppl , vol.20 , pp. 1-136
    • Fokkens, W.1    Lund, V.2    Mullol, J.3
  • 114
    • 13244284700 scopus 로고    scopus 로고
    • Prevalence of nasal polyposis in France: a cross-sectional, case-control study
    • Klossek JM, Neukirch F, Pribil C, Jankowski R, Serrano E, Chanal I, et al. Prevalence of nasal polyposis in France: a cross-sectional, case-control study. Allergy (2005) 60(2):233-7. doi:10.1111/j.1398-9995.2005.00688.x
    • (2005) Allergy , vol.60 , Issue.2 , pp. 233-237
    • Klossek, J.M.1    Neukirch, F.2    Pribil, C.3    Jankowski, R.4    Serrano, E.5    Chanal, I.6
  • 115
    • 0037489646 scopus 로고    scopus 로고
    • Prevalence of nasal polyps in adults: the Skövde population-based study
    • Johansson L, Akerlund A, Holmberg K, Melén I, Bende M. Prevalence of nasal polyps in adults: the Skövde population-based study. Ann Otol Rhinol Laryngol (2003) 112(7):625-9. doi:10.1177/000348940311200709
    • (2003) Ann Otol Rhinol Laryngol , vol.112 , Issue.7 , pp. 625-629
    • Johansson, L.1    Akerlund, A.2    Holmberg, K.3    Melén, I.4    Bende, M.5
  • 116
    • 84921058786 scopus 로고    scopus 로고
    • Prevalence of nasal polyps and its risk factors: Korean National Health and Nutrition Examination Survey 2009-2011
    • We J, Lee WH, Tan KL, Wee JH, Rhee CS, Lee CH, et al. Prevalence of nasal polyps and its risk factors: Korean National Health and Nutrition Examination Survey 2009-2011. Am J Rhinol Allergy (2015) 29(1):e24-8. doi:10.2500/ajra.2015.29.4131
    • (2015) Am J Rhinol Allergy , vol.29 , Issue.1 , pp. e24-e28
    • We, J.1    Lee, W.H.2    Tan, K.L.3    Wee, J.H.4    Rhee, C.S.5    Lee, C.H.6
  • 117
    • 84878538890 scopus 로고    scopus 로고
    • Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology
    • Akdis CA, Bachert C, Cingi C, Dykewicz MS, Hellings PW, Naclerio RM, et al. Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol (2013) 131(6):1479-90. doi:10.1016/j.jaci.2013.02.036
    • (2013) J Allergy Clin Immunol , vol.131 , Issue.6 , pp. 1479-1490
    • Akdis, C.A.1    Bachert, C.2    Cingi, C.3    Dykewicz, M.S.4    Hellings, P.W.5    Naclerio, R.M.6
  • 118
    • 84899629396 scopus 로고    scopus 로고
    • Interleukin-4 and interleukin-13 compromise the sinonasal epithelial barrier and perturb intercellular junction protein expression
    • Wise SK, Laury AM, Katz EH, Den Beste KA, Parkos CA, Nusrat A. Interleukin-4 and interleukin-13 compromise the sinonasal epithelial barrier and perturb intercellular junction protein expression. Int Forum Allergy Rhinol (2014) 4(5):361-70. doi:10.1002/alr.21298
    • (2014) Int Forum Allergy Rhinol , vol.4 , Issue.5 , pp. 361-370
    • Wise, S.K.1    Laury, A.M.2    Katz, E.H.3    Den Beste, K.A.4    Parkos, C.A.5    Nusrat, A.6
  • 119
    • 42449114052 scopus 로고    scopus 로고
    • Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells
    • Ramanathan M, Lee WK, Spannhake EW, Lane AP. Th2 cytokines associated with chronic rhinosinusitis with polyps down-regulate the antimicrobial immune function of human sinonasal epithelial cells. Am J Rhinol (2008) 22(2):115-21. doi:10.2500/ajr.2008.22.3136
    • (2008) Am J Rhinol , vol.22 , Issue.2 , pp. 115-121
    • Ramanathan, M.1    Lee, W.K.2    Spannhake, E.W.3    Lane, A.P.4
  • 120
    • 0031407184 scopus 로고    scopus 로고
    • Increased eotaxin-mRNA expression in non-atopic and atopic nasal polyps: comparison to RANTES and MCP-3 expression
    • Bartels J, Maune S, Meyer JE, Kulke R, Schlüter C, Röwert J, et al. Increased eotaxin-mRNA expression in non-atopic and atopic nasal polyps: comparison to RANTES and MCP-3 expression. Rhinology (1997) 35(4):171-4
    • (1997) Rhinology , vol.35 , Issue.4 , pp. 171-174
    • Bartels, J.1    Maune, S.2    Meyer, J.E.3    Kulke, R.4    Schlüter, C.5    Röwert, J.6
  • 121
    • 0035038554 scopus 로고    scopus 로고
    • Total and specific IgE in nasal polyps is related to local eosinophilic inflammation
    • Bachert C, Gevaert P, Holtappels G, Johansson SG, van Cauwenberge P. Total and specific IgE in nasal polyps is related to local eosinophilic inflammation. J Allergy Clin Immunol (2001) 107(4):607-14. doi:10.1067/mai.2001.112374
    • (2001) J Allergy Clin Immunol , vol.107 , Issue.4 , pp. 607-614
    • Bachert, C.1    Gevaert, P.2    Holtappels, G.3    Johansson, S.G.4    van Cauwenberge, P.5
  • 122
    • 0033178937 scopus 로고    scopus 로고
    • Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia
    • Jahnsen FL, Haye R, Gran E, Brandtzaeg P, Johansen FE. Glucocorticosteroids inhibit mRNA expression for eotaxin, eotaxin-2, and monocyte-chemotactic protein-4 in human airway inflammation with eosinophilia. J Immunol (1999) 163(3):1545-51
    • (1999) J Immunol , vol.163 , Issue.3 , pp. 1545-1551
    • Jahnsen, F.L.1    Haye, R.2    Gran, E.3    Brandtzaeg, P.4    Johansen, F.E.5
  • 123
    • 35148876928 scopus 로고    scopus 로고
    • IL-4 and TNF-alpha increased the secretion of eotaxin from cultured fibroblasts of nasal polyps with eosinophil infiltration
    • Yoshifuku K, Matsune S, Ohori J, Sagara Y, Fukuiwa T, Kurono Y. IL-4 and TNF-alpha increased the secretion of eotaxin from cultured fibroblasts of nasal polyps with eosinophil infiltration. Rhinology (2007) 45(3):235-41
    • (2007) Rhinology , vol.45 , Issue.3 , pp. 235-241
    • Yoshifuku, K.1    Matsune, S.2    Ohori, J.3    Sagara, Y.4    Fukuiwa, T.5    Kurono, Y.6
  • 124
    • 84971298280 scopus 로고    scopus 로고
    • Transcriptome analysis reveals distinct gene expression profiles in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps
    • Wang W, Gao Z, Wang H, Li T, He W, Lv W, et al. Transcriptome analysis reveals distinct gene expression profiles in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps. Sci Rep (2016) 6:26604. doi:10.1038/srep26604
    • (2016) Sci Rep , vol.6 , pp. 26604
    • Wang, W.1    Gao, Z.2    Wang, H.3    Li, T.4    He, W.5    Lv, W.6
  • 125
    • 84957790502 scopus 로고    scopus 로고
    • Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial
    • Bachert C, Mannent L, Naclerio RM, Mullol J, Ferguson BJ, Gevaert P, et al. Effect of subcutaneous dupilumab on nasal polyp burden in patients with chronic sinusitis and nasal polyposis: a randomized clinical trial. JAMA (2016) 315(5):469-79. doi:10.1001/jama.2015.19330
    • (2016) JAMA , vol.315 , Issue.5 , pp. 469-479
    • Bachert, C.1    Mannent, L.2    Naclerio, R.M.3    Mullol, J.4    Ferguson, B.J.5    Gevaert, P.6


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