Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: Role for reactive oxygen species-enhanced MEK/ERK activation

Journal of Allergy and Clinical Immunology

Volumn 132, Issue 2, 2013, Pages 437-445

  Kano, Gen ^a   Almanan, Maha ^a   Bochner, Bruce S ^b   Zimmermann, Nives ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cell death; Eosinophils; signaling

Indexed keywords

CASPASE; INTERLEUKIN 5; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; REACTIVE OXYGEN METABOLITE; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN 8; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL STRUCTURE; CONTROLLED STUDY; CROSS LINKING; ENZYME PHOSPHORYLATION; EOSINOPHIL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; UPREGULATION; WESTERN BLOTTING;

7-AMINOACTINOMYCIN D; 7AAD; C-JUN N-TERMINAL KINASE; CELL DEATH; DIPHENYLENEIODONIUM; DPI; DUAL-SPECIFICITY PHOSPHATASE; DUSP; EOSINOPHIL PEROXIDASE; EOSINOPHILS; EPX; ERK; EXTRACELLULAR SIGNAL-REGULATED KINASE; H(2)O(2); HORSERADISH PEROXIDASE; HRP; HYDROGEN PEROXIDE; JNK; MAPK; MAPK-ERK KINASE; MEK; MITOGEN-ACTIVATED PROTEIN KINASE; NAN(3); PARAFORMALDEHYDE; PFA; REACTIVE OXYGEN SPECIES; ROS; SIALIC ACID-BINDING IMMUNOGLOBULIN-LIKE LECTIN; SIGLEC; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; SIGNALING; SODIUM AZIDE; STAT;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; APOPTOSIS; CELL DEATH; CELLS, CULTURED; ENZYME ACTIVATION; EOSINOPHILS; HUMANS; INTERLEUKIN-5; LECTINS; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES;

EID: 84881187383     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2013.03.024     Document Type: Article

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