Cytokine modulation of atopic dermatitis filaggrin skin expression

Journal of Allergy and Clinical Immunology

Volumn 120, Issue 1, 2007, Pages 150-155

  Howell, Michael D ^a   Kim, Byung Eui ^a,b   Gao, Peisong ^c   Grant, Audrey V ^c   Boguniewicz, Mark ^a   DeBenedetto, Anna ^d   Schneider, Lynda ^e   Beck, Lisa A ^d   Barnes, Kathleen C ^c   Leung, Donald Y M ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b Inje University College of Medicine   (South Korea)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Atopic dermatitis; filaggrin; skin barrier

Indexed keywords

FILAGGRIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 13; INTERLEUKIN 4;

ADULT; ARTICLE; ATOPIC DERMATITIS; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; GENE MUTATION; HETEROZYGOSITY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SKIN BIOPSY;

ADULT; DERMATITIS, ATOPIC; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-13; INTERLEUKIN-4; INTERMEDIATE FILAMENT PROTEINS; KERATINOCYTES; SKIN;

EID: 34250828434     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2007.04.031     Document Type: Article

References (24)

1. Leung D.Y., and Bieber T. Atopic dermatitis. Lancet 361 (2003) 151-160
2. Homey B., Steinhoff M., Ruzicka T., and Leung D.Y. Cytokines and chemokines orchestrate atopic skin inflammation. J Allergy Clin Immunol 118 (2006) 178-189
3. Warner J.O. A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months' treatment and 18 months' posttreatment follow-up. J Allergy Clin Immunol 108 (2001) 929-937
4. Bowcock A.M., and Cookson W.O. The genetics of psoriasis, psoriatic arthritis and atopic dermatitis. Hum Mol Genet (2004) 13 Spec No 1:R43-R55
5. Spergel J.M., Mizoguchi E., Brewer J.P., Martin T.R., Bhan A.K., and Geha R.S. Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest 101 (1998) 1614-1622
6. Candi E., Schmidt R., and Melino G. The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol 6 (2005) 328-340
7. Palmer C.N., Irvine A.D., Terron-Kwiatkowski A., Zhao Y., Liao H., Lee S.P., et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 38 (2006) 441-446
8. Weidinger S., Illig T., Baurecht H., Irvine A.D., Rodriguez E., Diaz-Lacava A., et al. Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. J Allergy Clin Immunol 118 (2006) 214-219
9. Marenholz I., Nickel R., Ruschendorf F., Schulz F., Esparza-Gordillo J., Kerscher T., et al. Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march. J Allergy Clin Immunol 118 (2006) 866-871
10. Ong P.Y., Ohtake T., Brandt C., Strickland I., Boguniewicz M., Ganz T., et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 347 (2002) 1151-1160
11. Fiset P.O., Leung D.Y., and Hamid Q. Immunopathology of atopic dermatitis. J Allergy Clin Immunol 118 (2006) 287-290
12. Howell M.D., Gallo R.L., Boguniewicz M., Jones J.F., Wong C., Streib J.E., et al. Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. Immunity 24 (2006) 341-348
13. Hamid Q., Boguniewicz M., and Leung D.Y. Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest 94 (1994) 870-876
14. Howell M.D., Novak N., Bieber T., Pastore S., Girolomoni G., Boguniewicz M., et al. Interleukin-10 downregulates anti-microbial peptide expression in atopic dermatitis. J Invest Dermatol 125 (2005) 738-745
15. Tukey J. Exploratory data analysis (1977), Addison Wesley, Reading (NY)
16. Wenzel J., Scheler M., Proelss J., Bieber T., and Tuting T. Type I interferon-associated cytotoxic inflammation in lichen planus. J Cutan Pathol 33 (2006) 672-678
17. Nomura I., Goleva E., Howell M.D., Hamid Q.A., Ong P.Y., Hall C.F., et al. Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol 171 (2003) 3262-3269
18. Boguniewicz M., and Leung D.Y. Atopic dermatitis. J Allergy Clin Immunol 117 (2006) S475-S480
19. Leung D.Y., Boguniewicz M., Howell M.D., Nomura I., and Hamid Q.A. New insights into atopic dermatitis. J Clin Invest 113 (2004) 651-657
20. Laouini D., Kawamoto S., Yalcindag A., Bryce P., Mizoguchi E., Oettgen H., et al. Epicutaneous sensitization with superantigen induces allergic skin inflammation. J Allergy Clin Immunol 112 (2003) 981-987
21. Gustafsson D., Sjoberg O., and Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis: a prospective follow-up to 7 years of age. Allergy 55 (2000) 240-245
22. Illi S., von Mutius E., Lau S., Nickel R., Gruber C., Niggemann B., et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol 113 (2004) 925-931
23. Howell M.D., Boguniewicz M., Pastore S., Novak N., Bieber T., Girolomoni G., et al. Mechanism of HBD-3 deficiency in atopic dermatitis. Clin Immunol 121 (2006) 332-338
24. Aalto-Korte K. Improvement of skin barrier function during treatment of atopic dermatitis. J Am Acad Dermatol 33 (1995) 969-972