Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors

International Journal of Cancer

Volumn 143, Issue 4, 2018, Pages 886-896

  Pan, Pan ^a   Oshima, Kiyoko ^b   Huang, Yi Wen ^a   Agle, Kimberle A ^a   Drobyski, William R ^a   Chen, Xiao ^a   Zhang, Jianying ^c   Yearsley, Martha M ^c   Yu, Jianhua ^d   Wang, Li Shu ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

butyrate; colon cancer; epigenetics; FFAR2; HDAC

Indexed keywords

AZOXYMETHANE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEXTRAN SULFATE; FREE FATTY ACID RECEPTOR 2; G PROTEIN COUPLED RECEPTOR; HISTONE; HISTONE DEACETYLASE; SECRETED FRIZZLED RELATED PROTEIN 1; SUPPRESSOR OF CYTOKINE SIGNALING 1; UNCLASSIFIED DRUG; FFAR2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CARCINOGENESIS; COLON ADENOCARCINOMA; COLON ADENOMA; COLON CANCER; COLONIC LAMINA PROPRIA; CONTROLLED STUDY; DKK3 GENE; EPIGENETIC DYSREGULATION; GENE; GENE EXPRESSION; GENETIC DISORDER; HISTONE MODIFICATION; INFLAMMATION; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SFRP1 GENE; SIGNAL TRANSDUCTION; SOCS1 GENE; ADENOCARCINOMA; ADENOMA; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; COLITIS; COLON TUMOR; DISEASE EXACERBATION; EXPERIMENTAL NEOPLASM; GENETIC EPIGENESIS; GENETICS; HOMEOSTASIS; METABOLISM; NEUTROPHIL; PATHOLOGY; TRANSGENIC MOUSE;

ADENOCARCINOMA; ADENOMA; ANIMALS; AZOXYMETHANE; COLITIS; COLONIC NEOPLASMS; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DEXTRAN SULFATE; DISEASE PROGRESSION; EPIGENESIS, GENETIC; HISTONE DEACETYLASES; HOMEOSTASIS; INFLAMMATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEOPLASMS, EXPERIMENTAL; NEUTROPHILS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 85044521158     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.31366     Document Type: Article

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