Analysis of the DNA methylation level of cancer-related genes in colorectal cancer and the surrounding normal mucosa

Clinical Epigenetics

Volumn 9, Issue 1, 2017, Pages

  Sugai, Tamotsu ^a   Yoshida, Masakazu ^a   Eizuka, Makoto ^a   Uesugii, Noriyuki ^a   Habano, Wataru ^a   Otsuka, Kouki ^a   Sasaki, Akira ^a   Yamamoto, Eiichiro ^b   Matsumoto, Takayuki ^a   Suzuki, Hiromu ^b  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

Colorectal cancer; Crypt isolation; DNA methylation; Microsatellite instability; Normal mucosa

Indexed keywords

DNA; DKK2 PROTEIN, HUMAN; MEMBRANE PROTEIN; MICRORNA; MIRN34 MICRORNA, HUMAN; SFRP1 PROTEIN, HUMAN; SFRP2 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ADULT; AGED; ANATOMICAL VARIATION; ARTICLE; ASCENDING COLON; CANCER LOCALIZATION; CANCER RISK; CARCINOGENESIS; CDKN2A GENE; CECUM; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; DESCENDING COLON; DKK2 GENE; DKK3 GENE; DNA METHYLATION; EPIGENETICS; FEMALE; GENE FREQUENCY; GENE LOCATION; GENETIC IDENTIFICATION; HUMAN; HUMAN TISSUE; IGFBP7 GENE; INTESTINE CRYPT; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MIR34B GENE; MIR34C GENE; MLH1 GENE; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; PYROSEQUENCING; RASSF1A GENE; RECTUM; RECTUM MUCOSA; SFRP1 GENE; SFRP2 GENE; SFRP5 GENE; SIGMOID; TRANSVERSE COLON; CHEMISTRY; COLORECTAL TUMOR; CPG ISLAND; DNA SEQUENCE; GENE REGULATORY NETWORK; GENETIC EPIGENESIS; GENETICS; MIDDLE AGED; MUCOSA; PROCEDURES; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; COLORECTAL NEOPLASMS; CPG ISLANDS; DNA METHYLATION; EPIGENESIS, GENETIC; GENE REGULATORY NETWORKS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICRORNAS; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUCOUS MEMBRANE; SEQUENCE ANALYSIS, DNA;

EID: 85019575186     PISSN: 18687075     EISSN: 18687083     Source Type: Journal    
DOI: 10.1186/s13148-017-0352-4     Document Type: Article

References (40)

1. Vogelstein B, Fearon ER, Hamilton SR, Kern SE, Preisinger AC, Leppert M, et al. Genetic alterations during colorectal tumor development. N Eng J Med. 1988;319:525–32.
2. Jass JR, Whitehall VL, Young J, Leggett BA. Emerging concepts in colorectal neoplasia. Gastroenterology. 2002;123:862–76.
3. Ogino S, Goel A. Molecular classification and correlates in colorectal cancer. J Mol Diagn. 2008;10:13–27.
4. Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature. 1997;386:623–7.
5. Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012;487(7407):330–7.
6. Kaneda A, Yagi K. Two groups of DNA methylation markers to classify colorectal cancer into three epigenotypes. Cancer Sci. 2011;102:18–24.
7. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa JP. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A. 1999;96:8681–6.
8. Shen L, Toyota M, Kondo Y, Lin E, Zhang L, Guo Y, et al. Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc Natl Acad Sci U S A. 2007;104:18654–9.
9. Guinney J, Dienstmann R, Wang X, de Reyniès A, Schlicker A, Soneson C, et al. The consensus molecular subtypes of colorectal cancer. Nat Med. 2015;21:1350–6.
10. Müller MF, Ibrahim AE, Arends MJ. Molecular pathological classification of colorectal cancer. Virchows Arch. 2016;469:125–34.
11. Dienstmann R, Vermeulen L, Guinney J, Kopetz S, Tejpar S, Tabernero J. Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer. Nat Rev Cancer. 2017;17:79–92.
12. Takahashi Y, Sugai T, Habano W, Ishida K, Eizuka M, Otsuka K, et al. Molecular differences in the microsatellite stable phenotype between left-sided and right-sided colorectal cancer. Int J Cancer. 2016;139:2493–501.
13. Sugai T, Habano W, Jiao Y-F, Tsukahara M, Takeda Y, Otsuka K, et al. Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas. J Mol Diagn. 2006;8:193–201.
14. Hawthorn L, Lan L, Mojica W. Evidence for field effect cancerization in colorectal cancer. Genomics. 2014;103:211–21.
15. Park SK, Song CS, Yang HJ, Jung YS, Choi KY, Koo DH, et al. Field cancerization in sporadic colon cancer. Gut Liver. 2016;10(5):773–80.
16. Baba Y, Ishimoto T, Kurashige J, Iwatsuki M, Sakamoto Y, Yoshida N, et al. Epigenetic field cancerization in gastrointestinal cancers. Cancer Lett. 2016;375:360–6.
17. Belshaw NJ, Pal N, Tapp HS, Dainty JR, Lewis MP, et al. Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosa. Carcinogenesis. 2010;31:1158–63.
18. Subramaniam MM, Loh M, Chan JY, Liem N, Lim PL, Peng YW, et al. The topography of DNA methylation in the non-neoplastic colonic mucosa surrounding colorectal cancers. Mol Carcinog. 2014;53:98–108.
19. Kawakami K, Ruszkiewicz A, Bennett G, Moore J, Grieu F, Watanabe G, et al. DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer. Br J Cancer. 2006;94:593–8.
20. Kaz AM, Wong CJ, Dzieciatkowski S, Luo Y, Schoen RE, Grady WM. Patterns of DNA methylation in the normal colon vary by anatomical location, gender, and age. Epigenetics. 2014;9:492–502.
21. Ramírez N, Bandrés E, Navarro A, Pons A, Jansa S, Moreno I, et al. Epigenetic events in normal colonic mucosa surrounding colorectal cancer lesions. Eur J Cancer. 2008;44:2689–95.
22. Qi J, Zhu YQ, Luo J, Tao WH. Hypermethylation and expression regulation of secreted frizzled-related protein genes in colorectal tumor. World J Gastroenterol. 2006;12:7113–7.
23. Kim MS, Lee J, Sidransky D. DNA methylation markers in colorectal cancer. Cancer Metastasis Rev. 2010;29:181–206.
24. Kalimutho M, Di Cecilia S, Del Vecchio Blanco G, Roviello F, Sileri P, et al. Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer. Br J Cancer. 2011;104:1770–8.
25. Abouzeid HE, Kassem AM, Abdel Wahab AH, El-mezayen HA, Sharad H, Abdel Rahman S. Promoter hypermethylation of RASSF1A, MGMT, and HIC-1 genes in benign and malignant colorectal tumors. Tumour Biol. 2011;32:1055.
26. Sahnane N, Magnoli F, Bernasconi B, Tibiletti MG, Romualdi C, Pedroni M, AIFEG, et al. Aberrant DNA methylation profiles of inherited and sporadic colorectal cancer. Clin Epigenetics. 2015;7:131.
27. Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, et al. IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype. Carcinogenesis. 2010;31:342–9.
28. Kaz A, Kim YH, Dzieciatkowski S, Lynch H, Watson P, Kay Washington M, et al. Evidence for the role of aberrant DNA methylation in the pathogenesis of Lynch syndrome adenomas. Int J Cancer. 2007;120:1922–9.
29. Nakagawa H, Nuovo GJ, Zervos EE, Martin Jr EW, Salovaara R, Aaltonen LA, et al. Age-related hypermethylation of the 5′ region of MLH1 in normal colonic mucosa is associated with microsatellite-unstable colorectal cancer development. Cancer Res. 2001;61:6991–5.
30. Toyota M, Issa JP. CpG island methylator phenotypes in aging and cancer. Semin Cancer Biol. 1999;9:349–57.
31. Japanese Society for Cancer of the Colon and Rectum. Japanese Classification of Colorectal Carcinoma, second English edition. Tokyo: Kanehara Co; 2009. p. 30–63.
32. Habano W, Sugai T, Nakamura S, Yoshida T. A novel method for gene analysis of colorectal carcinomas using a crypt isolation technique. Lab Invest. 1996;74:933–40.
33. Boland CR, Thibodeau SN, Hamilton SR, Sidransky D, Eshleman JR, Burt RW, et al. National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 1998;58:5248–57.
34. Yamamoto E, Suzuki H, Yamano HO, Maruyama R, Nojima M, Kamimae S, et al. Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG island methylator phenotype. Am J Pathol. 2012;181:1847–61.
35. Menigatti M, Truninger K, Gebbers JO, Marbet U, Marra G, Schär P. Normal colorectal mucosa exhibits sex- and segment-specific susceptibility to DNA methylation at the hMLH1 and MGMT promoters. Oncogene. 2009;28:899–909.
36. Worthley DL, Whitehall VL, Buttenshaw RL, Irahara N, Greco SA, Ramsnes I, et al. DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer. Oncogene. 2010;29:1653–62.
37. Moretto R, Cremolini C, Rossini D, Pietrantonio F, Battaglin F, Mennitto A, et al. Location of primary tumor and benefit from anti-epidermal growth factor receptor monoclonal antibodies in patients with RAS and BRAF wild-type metastatic colorectal cancer. Oncologist. 2016;21:988–94.
38. Shen L, Kondo Y, Rosner GL, Xiao L, Hernandez NS, Vilaythong J, Houlihan PS, Krouse RS, Prasad AR, Einspahr JG, Buckmeier J, Alberts DS, Hamilton SR, Issa JP. MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst. 2005;97:1330–8.
39. Zhang D, Bai Y, Ge Q, Qiao Y, Wang Y, Chen Z, et al. Microarray-based molecular margin methylation pattern analysis in colorectal carcinoma. Anal Biochem. 2006;355:117–24.
40. Patai AV, Valcz G, Hollósi P, Kalmár A, Péterfia B, Patai A, et al. Comprehensive DNA methylation analysis reveals a common ten-gene methylation signature in colorectal adenomas and carcinomas. PLoS One. 2015;10:e0133836. doi:10.1371/journal.pone.0133836.