Mechanism of suppressors of cytokine signaling 1 inhibition of epithelial-mesenchymal transition signaling through ROS regulation in colon cancer cells: Suppression of Src leading to thioredoxin up-regulation

Oncotarget

Volumn 7, Issue 38, 2016, Pages 62559-62571

  Jung, Sung Hoon ^a   Kim, Su Min ^a   Lee, Choong Eun ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

EMT signaling; Reactive oxygen species; Src; Suppressors of cytokine signaling; Thioredoxin

Indexed keywords

JANUS KINASE; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; SUPPRESSOR OF CYTOKINE SIGNALING 1; THIOREDOXIN; TRANSCRIPTION FACTOR NRF2; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; VIMENTIN; ANTIOXIDANT; HYDROGEN PEROXIDE; NFE2L2 PROTEIN, HUMAN; SNAI1 PROTEIN, HUMAN; SOCS1 PROTEIN, HUMAN; TXN PROTEIN, HUMAN;

ARTICLE; CANCER CELL; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME REPRESSION; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; COLON TUMOR; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HCT 116 CELL LINE; METABOLISM; NUCLEOCYTOPLASMIC TRANSPORT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTIOXIDANTS; CELL LINE, TUMOR; COLONIC NEOPLASMS; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; HCT116 CELLS; HUMANS; HYDROGEN PEROXIDE; NF-E2-RELATED FACTOR 2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SNAIL FAMILY TRANSCRIPTION FACTORS; SRC-FAMILY KINASES; SUPPRESSOR OF CYTOKINE SIGNALING 1 PROTEIN; THIOREDOXINS; TRANSFECTION; UP-REGULATION; VIMENTIN;

EID: 84991746875     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.11537     Document Type: Article

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