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Volumn 17, Issue 9, 2016, Pages 1025-1036

Targeting natural killer cells in cancer immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOMODULATING AGENT; INTERLEUKIN 15; NATURAL KILLER CELL RECEPTOR; NECTIN 2; TRANSCRIPTION FACTOR LHX3; CYTOKINE; EOMES PROTEIN, HUMAN; EOMES PROTEIN, MOUSE; HYBRID PROTEIN; IMMUNOLOGICAL ADJUVANT; T BOX TRANSCRIPTION FACTOR; TUMOR ANTIGEN;

EID: 84983343680     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3518     Document Type: Review
Times cited : (860)

References (144)
  • 2
    • 34548201160 scopus 로고    scopus 로고
    • Developmental pathways that generate natural-killer-cell diversity in mice and humans
    • Huntington, N.D., Vosshenrich, C.A., & Di Santo, J.P. Developmental pathways that generate natural-killer-cell diversity in mice and humans. Nat. Rev. Immunol. 7, 703-714 (2007
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 703-714
    • Huntington, N.D.1    Vosshenrich, C.A.2    Di Santo, J.P.3
  • 4
    • 84927691776 scopus 로고    scopus 로고
    • DNAM-1 expression marks an alternative program of NK cell maturation
    • Martinet, L. et al. DNAM-1 expression marks an alternative program of NK cell maturation. Cell Rep. 11, 85-97 (2015
    • (2015) Cell Rep , vol.11 , pp. 85-97
    • Martinet, L.1
  • 5
    • 84897965554 scopus 로고    scopus 로고
    • Tissue-resident natural killer cells and their potential diversity
    • Sojka, D.K., Tian, Z., & Yokoyama, W.M. Tissue-resident natural killer cells and their potential diversity. Semin. Immunol. 26, 127-131 (2014
    • (2014) Semin. Immunol , vol.26 , pp. 127-131
    • Sojka, D.K.1    Tian, Z.2    Yokoyama, W.M.3
  • 6
    • 84901259365 scopus 로고    scopus 로고
    • Cutting edge: Salivary gland NK cells develop independently of Nfil3 in steady-state
    • Cortez, V.S., Fuchs, A., Cella, M., Gilfillan, S., & Colonna, M. Cutting edge: Salivary gland NK cells develop independently of Nfil3 in steady-state. J. Immunol. 192, 4487-4491 (2014
    • (2014) J. Immunol , vol.192 , pp. 4487-4491
    • Cortez, V.S.1    Fuchs, A.2    Cella, M.3    Gilfillan, S.4    Colonna, M.5
  • 7
    • 84924529960 scopus 로고    scopus 로고
    • Cutting edge: Identification and characterization of human intrahepatic CD49a+ NK cells
    • Marquardt, N. et al. Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells. J. Immunol. 194, 2467-2471 (2015
    • (2015) J. Immunol , vol.194 , pp. 2467-2471
    • Marquardt, N.1
  • 8
    • 84872977452 scopus 로고    scopus 로고
    • Innate lymphoid cells-A proposal for uniform nomenclature
    • Spits, H. et al. Innate lymphoid cells-A proposal for uniform nomenclature. Nat. Rev. Immunol. 13, 145-149 (2013
    • (2013) Nat. Rev. Immunol , vol.13 , pp. 145-149
    • Spits, H.1
  • 9
    • 33745567831 scopus 로고    scopus 로고
    • Self-Tolerance of natural killer cells
    • Raulet, D.H., & Vance, R.E. Self-Tolerance of natural killer cells. Nat. Rev. Immunol. 6, 520-531 (2006
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 520-531
    • Raulet, D.H.1    Vance, R.E.2
  • 10
    • 84920828341 scopus 로고    scopus 로고
    • Utilizing cytokines to function-enable human NK cells for the immunotherapy of cancer
    • Romee, R., Leong, J.W., & Fehniger, T.A. Utilizing cytokines to function-enable human NK cells for the immunotherapy of cancer. Scientifica (Cairo) 2014, 205796 (2014
    • (2014) Scientifica (Cairo) , vol.2014 , pp. 205796
    • Romee, R.1    Leong, J.W.2    Fehniger, T.A.3
  • 11
    • 84944457504 scopus 로고    scopus 로고
    • Toll-like receptor 3 regulates NK cell responses to cytokines and controls experimental metastasis
    • Guillerey, C. et al. Toll-like receptor 3 regulates NK cell responses to cytokines and controls experimental metastasis. OncoImmunology 4, e1027468 (2015
    • (2015) OncoImmunology , vol.4 , pp. e1027468
    • Guillerey, C.1
  • 12
    • 33845199637 scopus 로고    scopus 로고
    • Perforin-mediated target-cell death and immune homeostasis
    • Voskoboinik, I., Smyth, M.J., & Trapani, J.A. Perforin-mediated target-cell death and immune homeostasis. Nat. Rev. Immunol. 6, 940-952 (2006
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 940-952
    • Voskoboinik, I.1    Smyth, M.J.2    Trapani, J.A.3
  • 13
    • 84899627559 scopus 로고    scopus 로고
    • Positive and negative regulation by NK cells in cancer
    • Sungur, C.M., & Murphy, W.J. Positive and negative regulation by NK cells in cancer. Crit. Rev. Oncog. 19, 57-66 (2014
    • (2014) Crit. Rev. Oncog , vol.19 , pp. 57-66
    • Sungur, C.M.1    Murphy, W.J.2
  • 14
    • 84885458655 scopus 로고    scopus 로고
    • P53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells
    • Iannello, A., Thompson, T.W., Ardolino, M., Lowe, S.W., & Raulet, D.H. p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells. J. Exp. Med. 210, 2057-2069 (2013
    • (2013) J. Exp. Med , vol.210 , pp. 2057-2069
    • Iannello, A.1    Thompson, T.W.2    Ardolino, M.3    Lowe, S.W.4    Raulet, D.H.5
  • 16
    • 84901857205 scopus 로고    scopus 로고
    • Effect of tumor cells and tumor microenvironment on NK-cell function
    • Vitale, M., Cantoni, C., Pietra, G., Mingari, M.C., & Moretta, L. Effect of tumor cells and tumor microenvironment on NK-cell function. Eur. J. Immunol. 44, 1582-1592 (2014
    • (2014) Eur. J. Immunol , vol.44 , pp. 1582-1592
    • Vitale, M.1    Cantoni, C.2    Pietra, G.3    Mingari, M.C.4    Moretta, L.5
  • 18
    • 26844464792 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-β-dependent manner
    • Ghiringhelli, F. et al. CD4+CD25+ regulatory T cells inhibit natural killer cell functions in a transforming growth factor-β-dependent manner. J. Exp. Med. 202, 1075-1085 (2005
    • (2005) J. Exp. Med , vol.202 , pp. 1075-1085
    • Ghiringhelli, F.1
  • 19
    • 31144468294 scopus 로고    scopus 로고
    • CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer
    • Smyth, M.J. et al. CD4+CD25+ T regulatory cells suppress NK cell-mediated immunotherapy of cancer. J. Immunol. 176, 1582-1587 (2006
    • (2006) J. Immunol , vol.176 , pp. 1582-1587
    • Smyth, M.J.1
  • 20
    • 84883422236 scopus 로고    scopus 로고
    • Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors
    • Beavis, P.A. et al. Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors. Proc. Natl. Acad. Sci. USA 110, 14711-14716 (2013
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 14711-14716
    • Beavis, P.A.1
  • 21
    • 84904254163 scopus 로고    scopus 로고
    • Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor
    • Mittal, D. et al. Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor. Cancer Res. 74, 3652-3658 (2014
    • (2014) Cancer Res , vol.74 , pp. 3652-3658
    • Mittal, D.1
  • 22
    • 80053069818 scopus 로고    scopus 로고
    • IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection
    • Stacey, M.A., Marsden, M., Wang, E.C., Wilkinson, G.W., & Humphreys, I.R. IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection. J. Immunol. 187, 2944-2952 (2011
    • (2011) J. Immunol , vol.187 , pp. 2944-2952
    • Stacey, M.A.1    Marsden, M.2    Wang, E.C.3    Wilkinson, G.W.4    Humphreys, I.R.5
  • 23
    • 11044220305 scopus 로고    scopus 로고
    • IL-10 stimulatory effects on human NK cells explored by gene profile analysis
    • Mocellin, S. et al. IL-10 stimulatory effects on human NK cells explored by gene profile analysis. Genes Immun. 5, 621-630 (2004
    • (2004) Genes Immun , vol.5 , pp. 621-630
    • Mocellin, S.1
  • 24
    • 84959134520 scopus 로고    scopus 로고
    • TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway
    • ra19
    • Viel, S. et al. TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway. Sci. Signal. 9, ra19 (2016
    • (2016) Sci. Signal , vol.9
    • Viel, S.1
  • 25
    • 84867529636 scopus 로고    scopus 로고
    • Melanoma cells inhibit NK cell functions
    • author reply 5430
    • Sconocchia, G. et al. Melanoma cells inhibit NK cell functions. Cancer Res. 72, 5428-5429 author reply 5430 (2012
    • (2012) Cancer Res , vol.72 , pp. 5428-5429
    • Sconocchia, G.1
  • 26
    • 0037086131 scopus 로고    scopus 로고
    • Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
    • Ruggeri, L. et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295, 2097-2100 (2002
    • (2002) Science , vol.295 , pp. 2097-2100
    • Ruggeri, L.1
  • 27
    • 83455220035 scopus 로고    scopus 로고
    • IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect
    • Benson, D.M. Jr. et al. IPH2101, a novel anti-inhibitory KIR antibody, and lenalidomide combine to enhance the natural killer cell versus multiple myeloma effect. Blood 118, 6387-6391 (2011
    • (2011) Blood , vol.118 , pp. 6387-6391
    • Benson, D.M.1
  • 29
    • 78649968328 scopus 로고    scopus 로고
    • Genotypes of NK cell KIR receptors, their ligands, and Fc? Receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy
    • Delgado, D.C. et al. Genotypes of NK cell KIR receptors, their ligands, and Fc? receptors in the response of neuroblastoma patients to Hu14.18-IL2 immunotherapy. Cancer Res. 70, 9554-9561 (2010
    • (2010) Cancer Res , vol.70 , pp. 9554-9561
    • Delgado, D.C.1
  • 30
    • 84880923269 scopus 로고    scopus 로고
    • Intratumoral treatment of smaller mouse neuroblastoma tumors with a recombinant protein consisting of IL-2 linked to the hu14.18 antibody increases intratumoral CD8+ T and NK cells and improves survival
    • Yang, R.K. et al. Intratumoral treatment of smaller mouse neuroblastoma tumors with a recombinant protein consisting of IL-2 linked to the hu14.18 antibody increases intratumoral CD8+ T and NK cells and improves survival. Cancer Immunol. Immunother. 62, 1303-1313 (2013
    • (2013) Cancer Immunol. Immunother , vol.62 , pp. 1303-1313
    • Yang, R.K.1
  • 31
    • 84937010762 scopus 로고    scopus 로고
    • CAR-engineered NK cells targeting wild-Type EGFR and EGFRvIII enhance killing of glioblastoma and patient-derived glioblastoma stem cells
    • Han, J. et al. CAR-engineered NK cells targeting wild-Type EGFR and EGFRvIII enhance killing of glioblastoma and patient-derived glioblastoma stem cells. Sci. Rep. 5, 11483 (2015
    • (2015) Sci. Rep , vol.5 , pp. 11483
    • Han, J.1
  • 32
    • 84968761575 scopus 로고    scopus 로고
    • ErbB2/HER2-specific NK cells for targeted therapy of glioblastoma
    • djv375
    • Zhang, C. et al. ErbB2/HER2-specific NK cells for targeted therapy of glioblastoma. J. Natl. Cancer Inst. 108, djv375 (2015
    • (2015) J. Natl. Cancer Inst , vol.108
    • Zhang, C.1
  • 33
    • 84962787338 scopus 로고    scopus 로고
    • Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival
    • Genßler, S. et al. Dual targeting of glioblastoma with chimeric antigen receptor-engineered natural killer cells overcomes heterogeneity of target antigen expression and enhances antitumor activity and survival. OncoImmunology 5, e1119354 (2015
    • (2015) OncoImmunology , vol.5 , pp. e1119354
    • Genßler, S.1
  • 34
    • 84962844515 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC
    • Besse, B. et al. Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC. OncoImmunology 5, e1071008 (2015
    • (2015) OncoImmunology , vol.5 , pp. e1071008
    • Besse, B.1
  • 35
    • 84887052348 scopus 로고    scopus 로고
    • Treatment of patients with advanced cancer with the natural killer cell line NK-92
    • Tonn, T. et al. Treatment of patients with advanced cancer with the natural killer cell line NK-92. Cytotherapy 15, 1563-1570 (2013
    • (2013) Cytotherapy , vol.15 , pp. 1563-1570
    • Tonn, T.1
  • 36
    • 84955312560 scopus 로고    scopus 로고
    • Selection and expansion of natural killer cells for NK cell-based immunotherapy
    • Becker, P.S. et al. Selection and expansion of natural killer cells for NK cell-based immunotherapy. Cancer Immunol. Immunother. 65, 477-484 (2016
    • (2016) Cancer Immunol. Immunother , vol.65 , pp. 477-484
    • Becker, P.S.1
  • 37
    • 84897965451 scopus 로고    scopus 로고
    • Clinical utility of natural killer cells in cancer therapy and transplantation
    • Knorr, D.A., Bachanova, V., Verneris, M.R., & Miller, J.S. Clinical utility of natural killer cells in cancer therapy and transplantation. Semin. Immunol. 26, 161-172 (2014
    • (2014) Semin. Immunol , vol.26 , pp. 161-172
    • Knorr, D.A.1    Bachanova, V.2    Verneris, M.R.3    Miller, J.S.4
  • 38
    • 84899989272 scopus 로고    scopus 로고
    • Lymphocyte subset recovery and outcome after autologous hematopoietic stem cell transplantation for plasma cell myeloma
    • Rueff, J., Medinger, M., Heim, D., Passweg, J., & Stern, M. Lymphocyte subset recovery and outcome after autologous hematopoietic stem cell transplantation for plasma cell myeloma. Biol. Blood Marrow Transplant. 20, 896-899 (2014
    • (2014) Biol. Blood Marrow Transplant , vol.20 , pp. 896-899
    • Rueff, J.1    Medinger, M.2    Heim, D.3    Passweg, J.4    Stern, M.5
  • 39
    • 44649124773 scopus 로고    scopus 로고
    • Early lymphocyte recovery predicts superior survival after autologous stem cell transplantation in non-Hodgkin lymphoma: A prospective study
    • Porrata, L.F. et al. Early lymphocyte recovery predicts superior survival after autologous stem cell transplantation in non-Hodgkin lymphoma: a prospective study. Biol. Blood Marrow Transplant. 14, 807-816 (2008
    • (2008) Biol. Blood Marrow Transplant , vol.14 , pp. 807-816
    • Porrata, L.F.1
  • 40
    • 84939815682 scopus 로고    scopus 로고
    • Phase i clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer
    • Sakamoto, N. et al. Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer. J. Transl. Med. 13, 277 (2015).
    • (2015) J. Transl. Med , vol.13 , pp. 277
    • Sakamoto, N.1
  • 41
    • 80053465574 scopus 로고    scopus 로고
    • Adoptive transfer of autologous natural killer cells leads to high levels of circulating natural killer cells but does not mediate tumor regression
    • Parkhurst, M.R., Riley, J.P., Dudley, M.E., & Rosenberg, S.A. Adoptive transfer of autologous natural killer cells leads to high levels of circulating natural killer cells but does not mediate tumor regression. Clin. Cancer Res. 17, 6287-6297 (2011
    • (2011) Clin. Cancer Res , vol.17 , pp. 6287-6297
    • Parkhurst, M.R.1    Riley, J.P.2    Dudley, M.E.3    Rosenberg, S.A.4
  • 42
    • 80053208226 scopus 로고    scopus 로고
    • Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients
    • Curti, A. et al. Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients. Blood 118, 3273-3279 (2011
    • (2011) Blood , vol.118 , pp. 3273-3279
    • Curti, A.1
  • 43
    • 20144388509 scopus 로고    scopus 로고
    • Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
    • Miller, J.S. et al. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer. Blood 105, 3051-3057 (2005
    • (2005) Blood , vol.105 , pp. 3051-3057
    • Miller, J.S.1
  • 44
    • 77949898005 scopus 로고    scopus 로고
    • NKAML: A pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia
    • Rubnitz, J.E. et al. NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia. J. Clin. Oncol. 28, 955-959 (2010
    • (2010) J. Clin. Oncol , vol.28 , pp. 955-959
    • Rubnitz, J.E.1
  • 45
    • 84921805688 scopus 로고    scopus 로고
    • Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following T-cell-depleted stem cell transplantation
    • Shah, N.N. et al. Acute GVHD in patients receiving IL-15/4-1BBL activated NK cells following T-cell-depleted stem cell transplantation. Blood 125, 784-792 (2015
    • (2015) Blood , vol.125 , pp. 784-792
    • Shah, N.N.1
  • 46
    • 1542359024 scopus 로고    scopus 로고
    • The beneficial role of inhibitory KIR genes of HLA class i NK epitopes in haploidentically mismatched stem cell allografts may be masked by residual donor-Alloreactive T cells causing GVHD
    • Bishara, A. et al. The beneficial role of inhibitory KIR genes of HLA class I NK epitopes in haploidentically mismatched stem cell allografts may be masked by residual donor-Alloreactive T cells causing GVHD. Tissue Antigens 63, 204-211 (2004
    • (2004) Tissue Antigens , vol.63 , pp. 204-211
    • Bishara, A.1
  • 47
    • 0037111776 scopus 로고    scopus 로고
    • Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants Killer immunoglobulin-like receptor
    • Davies, S.M. et al. Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor. Blood 100, 3825-3827 (2002
    • (2002) Blood , vol.100 , pp. 3825-3827
    • Davies, S.M.1
  • 48
    • 84924750926 scopus 로고    scopus 로고
    • Going viral: Chimeric antigen receptor T-cell therapy for hematological malignancies
    • Gill, S., & June, C.H. Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies. Immunol. Rev. 263, 68-89 (2015
    • (2015) Immunol. Rev , vol.263 , pp. 68-89
    • Gill, S.1    June, C.H.2
  • 49
    • 84902590288 scopus 로고    scopus 로고
    • Are natural killer cells superior CAR drivers?
    • Klingemann, H. Are natural killer cells superior CAR drivers?. OncoImmunology 3, e28147 (2014
    • (2014) OncoImmunology , vol.3 , pp. e28147
    • Klingemann, H.1
  • 50
    • 84926457446 scopus 로고    scopus 로고
    • Advantages and applications of CAR-expressing natural killer cells
    • Glienke, W. et al. Advantages and applications of CAR-expressing natural killer cells. Front. Pharmacol. 6, 21 (2015
    • (2015) Front. Pharmacol , vol.6 , pp. 21
    • Glienke, W.1
  • 51
    • 84925079009 scopus 로고    scopus 로고
    • Challenges of cancer therapy with natural killer cells
    • Klingemann, H. Challenges of cancer therapy with natural killer cells. Cytotherapy 17, 245-249 (2015
    • (2015) Cytotherapy , vol.17 , pp. 245-249
    • Klingemann, H.1
  • 52
    • 84977497147 scopus 로고    scopus 로고
    • CD19-CAR engineered NK-92 cells are sufficient to overcome NK cell resistance in B-cell malignancies
    • Romanski, A. et al. CD19-CAR engineered NK-92 cells are sufficient to overcome NK cell resistance in B-cell malignancies. J. Cell. Mol. Med. 20, 1287-1294 (2016
    • (2016) J. Cell. Mol. Med , vol.20 , pp. 1287-1294
    • Romanski, A.1
  • 53
    • 84922257867 scopus 로고    scopus 로고
    • Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor
    • Schönfeld, K. et al. Selective inhibition of tumor growth by clonal NK cells expressing an ErbB2/HER2-specific chimeric antigen receptor. Mol. Ther. 23, 330-338 (2015).
    • (2015) Mol. Ther , vol.23 , pp. 330-338
    • Schönfeld, K.1
  • 54
    • 84895832116 scopus 로고    scopus 로고
    • Preactivation with IL-12 IL-15, and IL-18 induces CD25 and a functional high-Affinity IL-2 receptor on human cytokine-induced memory-like natural killer cells
    • Leong, J.W. et al. Preactivation with IL-12, IL-15, and IL-18 induces CD25 and a functional high-Affinity IL-2 receptor on human cytokine-induced memory-like natural killer cells. Biol. Blood Marrow Transplant. 20, 463-473 (2014
    • (2014) Biol. Blood Marrow Transplant , vol.20 , pp. 463-473
    • Leong, J.W.1
  • 55
    • 10744220588 scopus 로고    scopus 로고
    • IL-2-based immunotherapy after autologous transplantation for lymphoma and breast cancer induces immune activation and cytokine release: A phase I/II trial
    • Burns, L.J. et al. IL-2-based immunotherapy after autologous transplantation for lymphoma and breast cancer induces immune activation and cytokine release: a phase I/II trial. Bone Marrow Transplant. 32, 177-186 (2003
    • (2003) Bone Marrow Transplant , vol.32 , pp. 177-186
    • Burns, L.J.1
  • 56
    • 84902682889 scopus 로고    scopus 로고
    • Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein
    • Bachanova, V. et al. Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein. Blood 123, 3855-3863 (2014).
    • (2014) Blood , vol.123 , pp. 3855-3863
    • Bachanova, V.1
  • 57
    • 84857786741 scopus 로고    scopus 로고
    • A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer
    • Steele, N. et al. A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer. Br. J. Cancer 106, 793-798 (2012
    • (2012) Br. J. Cancer , vol.106 , pp. 793-798
    • Steele, N.1
  • 58
    • 84911021644 scopus 로고    scopus 로고
    • Interleukin-15 in the treatment of cancer
    • Waldmann, T.A. Interleukin-15 in the treatment of cancer. Expert Rev. Clin. Immunol. 10, 1689-1701 (2014
    • (2014) Expert Rev. Clin. Immunol , vol.10 , pp. 1689-1701
    • Waldmann, T.A.1
  • 59
    • 77952479517 scopus 로고    scopus 로고
    • Interleukin-15 affects patient survival through natural killer cell recovery after autologous hematopoietic stem cell transplantation for non-Hodgkin lymphomas
    • Porrata, L.F. et al. Interleukin-15 affects patient survival through natural killer cell recovery after autologous hematopoietic stem cell transplantation for non-Hodgkin lymphomas. Clin. Dev. Immunol. 2010, 914945 (2010
    • (2010) Clin. Dev. Immunol , pp. 914945
    • Porrata, L.F.1
  • 60
    • 84920577302 scopus 로고    scopus 로고
    • Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer
    • Conlon, K.C. et al. Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer. J. Clin. Oncol. 33, 74-82 (2015).
    • (2015) J. Clin. Oncol , vol.33 , pp. 74-82
    • Conlon, K.C.1
  • 61
    • 84942551827 scopus 로고    scopus 로고
    • A phase I/II trial of interleukin-15-stimulated natural killer cell infusion after haplo-identical stem cell transplantation for pediatric refractory solid tumors
    • Pérez-Martínez, A. et al. A phase I/II trial of interleukin-15-stimulated natural killer cell infusion after haplo-identical stem cell transplantation for pediatric refractory solid tumors. Cytotherapy 17, 1594-1603 (2015
    • (2015) Cytotherapy , vol.17 , pp. 1594-1603
    • Pérez-Martínez, A.1
  • 62
    • 84971667832 scopus 로고    scopus 로고
    • IL-15 superagonist/IL-15R?Sushi-Fc fusion complex (IL-15SA/IL-15R?Su-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-Tumor activity against murine breast and colon carcinomas
    • Kim, P.S. et al. IL-15 superagonist/IL-15R?Sushi-Fc fusion complex (IL-15SA/IL-15R?Su-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-Tumor activity against murine breast and colon carcinomas. Oncotarget 7, 16130-16145 (2016
    • (2016) Oncotarget , vol.7 , pp. 16130-16145
    • Kim, P.S.1
  • 63
    • 84866541747 scopus 로고    scopus 로고
    • Expression of IL-15 in NK cells results in rapid enrichment and selective cytotoxicity of gene-modified effectors that carry a tumor-specific antigen receptor
    • Sahm, C., Schönfeld, K., & Wels, W.S. Expression of IL-15 in NK cells results in rapid enrichment and selective cytotoxicity of gene-modified effectors that carry a tumor-specific antigen receptor. Cancer Immunol. Immunother. 61, 1451-1461 (2012
    • (2012) Cancer Immunol. Immunother , vol.61 , pp. 1451-1461
    • Sahm, C.1    Schönfeld, K.2    Wels, W.S.3
  • 64
    • 84905989882 scopus 로고    scopus 로고
    • Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15
    • Imamura, M. et al. Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15. Blood 124, 1081-1088 (2014
    • (2014) Blood , vol.124 , pp. 1081-1088
    • Imamura, M.1
  • 65
    • 84874296249 scopus 로고    scopus 로고
    • Novel immune modulators used in hematology: Impact on NK cells
    • Krieg, S., & Ullrich, E. Novel immune modulators used in hematology: impact on NK cells. Front. Immunol. 3, 388 (2013
    • (2013) Front. Immunol , vol.3 , pp. 388
    • Krieg, S.1    Ullrich, E.2
  • 66
    • 0035412366 scopus 로고    scopus 로고
    • Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma
    • Davies, F.E. et al. Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma. Blood 98, 210-216 (2001
    • (2001) Blood , vol.98 , pp. 210-216
    • Davies, F.E.1
  • 67
    • 4043134677 scopus 로고    scopus 로고
    • Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects
    • Borg, C. et al. Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects. J. Clin. Invest. 114, 379-388 (2004
    • (2004) J. Clin. Invest , vol.114 , pp. 379-388
    • Borg, C.1
  • 68
    • 84962734942 scopus 로고    scopus 로고
    • Repression of GSK3 restores NK cell cytotoxicity in AML patients
    • Parameswaran, R. et al. Repression of GSK3 restores NK cell cytotoxicity in AML patients. Nat. Commun. 7, 11154 (2016).
    • (2016) Nat. Commun , vol.7 , pp. 11154
    • Parameswaran, R.1
  • 69
    • 79955413027 scopus 로고    scopus 로고
    • Azacytidine impairs NK cell reactivity while decitabine augments NK cell responsiveness toward stimulation
    • Schmiedel, B.J. et al. Azacytidine impairs NK cell reactivity while decitabine augments NK cell responsiveness toward stimulation. Int. J. Cancer 128, 2911-2922 (2011
    • (2011) Int. J. Cancer , vol.128 , pp. 2911-2922
    • Schmiedel, B.J.1
  • 70
    • 84856490854 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression
    • Rossi, L.E. et al. Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression. J. Leukoc. Biol. 91, 321-331 (2012
    • (2012) J. Leukoc. Biol , vol.91 , pp. 321-331
    • Rossi, L.E.1
  • 71
    • 84870897858 scopus 로고    scopus 로고
    • Sensitizing primary acute lymphoblastic leukemia to natural killer cell recognition by induction of NKG2D ligands
    • Jardine, L. et al. Sensitizing primary acute lymphoblastic leukemia to natural killer cell recognition by induction of NKG2D ligands. Leuk. Lymphoma 54, 167-173 (2013
    • (2013) Leuk. Lymphoma , vol.54 , pp. 167-173
    • Jardine, L.1
  • 72
    • 66349096076 scopus 로고    scopus 로고
    • Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity
    • Wang, X. et al. Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity. Haematologica 94, 470-478 (2009
    • (2009) Haematologica , vol.94 , pp. 470-478
    • Wang, X.1
  • 73
    • 67650355477 scopus 로고    scopus 로고
    • Bortezomib treatment and regulatory T-cell depletion enhance the antitumor effects of adoptively infused NK cells
    • Lundqvist, A., Yokoyama, H., Smith, A., Berg, M., & Childs, R. Bortezomib treatment and regulatory T-cell depletion enhance the antitumor effects of adoptively infused NK cells. Blood 113, 6120-6127 (2009
    • (2009) Blood , vol.113 , pp. 6120-6127
    • Lundqvist, A.1    Yokoyama, H.2    Smith, A.3    Berg, M.4    Childs, R.5
  • 74
    • 84904725488 scopus 로고    scopus 로고
    • The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells
    • Marçais, A. et al. The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat. Immunol. 15, 749-757 (2014
    • (2014) Nat. Immunol , vol.15 , pp. 749-757
    • Marçais, A.1
  • 75
    • 77951614830 scopus 로고    scopus 로고
    • Monoclonal antibodies: Versatile platforms for cancer immunotherapy
    • Weiner, L.M., Surana, R., & Wang, S. Monoclonal antibodies: versatile platforms for cancer immunotherapy. Nat. Rev. Immunol. 10, 317-327 (2010
    • (2010) Nat. Rev. Immunol , vol.10 , pp. 317-327
    • Weiner, L.M.1    Surana, R.2    Wang, S.3
  • 76
    • 84958523290 scopus 로고    scopus 로고
    • Fc receptor-dependent mechanisms of monoclonal antibody therapy of cancer
    • Bakema, J.E., & Van Egmond, M. Fc receptor-dependent mechanisms of monoclonal antibody therapy of cancer. Curr. Top. Microbiol. Immunol. 382, 373-392 (2014
    • (2014) Curr. Top. Microbiol. Immunol , vol.382 , pp. 373-392
    • Bakema, J.E.1    Van Egmond, M.2
  • 77
    • 0642373290 scopus 로고    scopus 로고
    • Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma
    • Weng, W.K., & Levy, R. Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J. Clin. Oncol. 21, 3940-3947 (2003
    • (2003) J. Clin. Oncol , vol.21 , pp. 3940-3947
    • Weng, W.K.1    Levy, R.2
  • 78
    • 84864131126 scopus 로고    scopus 로고
    • Fc gamma receptor polymorphisms as predictive markers of Cetuximab efficacy in epidermal growth factor receptor downstream-mutated metastatic colorectal cancer
    • Rodríguez, J. et al. Fc gamma receptor polymorphisms as predictive markers of Cetuximab efficacy in epidermal growth factor receptor downstream-mutated metastatic colorectal cancer. Eur. J. Cancer 48, 1774-1780 (2012
    • (2012) Eur. J. Cancer , vol.48 , pp. 1774-1780
    • Rodríguez, J.1
  • 79
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    • Clynes, R.A., Towers, T.L., Presta, L.G., & Ravetch, J.V. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat. Med. 6, 443-446 (2000
    • (2000) Nat. Med , vol.6 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 80
    • 11144353984 scopus 로고    scopus 로고
    • Phase i studies of interleukin (IL)-2 and rituximab in B-cell non-Hodgkins lymphoma: IL-2 mediated natural killer cell expansion correlations with clinical response
    • Gluck, W.L. et al. Phase I studies of interleukin (IL)-2 and rituximab in B-cell non-Hodgkins lymphoma: IL-2 mediated natural killer cell expansion correlations with clinical response. Clin. Cancer Res. 10, 2253-2264 (2004
    • (2004) Clin. Cancer Res , vol.10 , pp. 2253-2264
    • Gluck, W.L.1
  • 81
    • 84879703012 scopus 로고    scopus 로고
    • NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17
    • Romee, R. et al. NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17). Blood 121, 3599-3608 (2013
    • (2013) Blood , vol.121 , pp. 3599-3608
    • Romee, R.1
  • 82
    • 84878784248 scopus 로고    scopus 로고
    • Matrix metalloproteinases inhibition promotes the polyfunctionality of human natural killer cells in therapeutic antibody-based anti-Tumour immunotherapy
    • Zhou, Q., Gil-Krzewska, A., Peruzzi, G., & Borrego, F. Matrix metalloproteinases inhibition promotes the polyfunctionality of human natural killer cells in therapeutic antibody-based anti-Tumour immunotherapy. Clin. Exp. Immunol. 173, 131-139 (2013
    • (2013) Clin. Exp. Immunol , vol.173 , pp. 131-139
    • Zhou, Q.1    Gil-Krzewska, A.2    Peruzzi, G.3    Borrego, F.4
  • 83
    • 33750622479 scopus 로고    scopus 로고
    • Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab
    • Bowles, J.A. et al. Anti-CD20 monoclonal antibody with enhanced affinity for CD16 activates NK cells at lower concentrations and more effectively than rituximab. Blood 108, 2648-2654 (2006
    • (2006) Blood , vol.108 , pp. 2648-2654
    • Bowles, J.A.1
  • 84
    • 84874837435 scopus 로고    scopus 로고
    • GA201 (RG7160): A novel, humanized, glycoengineered anti-EGFR antibody with enhanced ADCC and superior in vivo efficacy compared with cetuximab
    • Gerdes, C.A. et al. GA201 (RG7160): a novel, humanized, glycoengineered anti-EGFR antibody with enhanced ADCC and superior in vivo efficacy compared with cetuximab. Clin. Cancer Res. 19, 1126-1138 (2013
    • (2013) Clin. Cancer Res , vol.19 , pp. 1126-1138
    • Gerdes, C.A.1
  • 85
    • 84878765992 scopus 로고    scopus 로고
    • IL-2-or IL-15-Activated NK cells enhance cetuximab-mediated activity against triple-negative breast cancer in xenografts and in breast cancer patients
    • Roberti, M.P. et al. IL-2-or IL-15-Activated NK cells enhance cetuximab-mediated activity against triple-negative breast cancer in xenografts and in breast cancer patients. Breast Cancer Res. Treat. 136, 659-671 (2012
    • (2012) Breast Cancer Res. Treat , vol.136 , pp. 659-671
    • Roberti, M.P.1
  • 86
    • 37249026830 scopus 로고    scopus 로고
    • NK cells stimulated with IL-15 or CpG ODN enhance rituximab-dependent cellular cytotoxicity against B-cell lymphoma
    • Moga, E. et al. NK cells stimulated with IL-15 or CpG ODN enhance rituximab-dependent cellular cytotoxicity against B-cell lymphoma. Exp. Hematol. 36, 69-77 (2008
    • (2008) Exp. Hematol , vol.36 , pp. 69-77
    • Moga, E.1
  • 87
    • 51649123319 scopus 로고    scopus 로고
    • Lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-Treated CD20+ tumor cells
    • Wu, L. et al. lenalidomide enhances natural killer cell and monocyte-mediated antibody-dependent cellular cytotoxicity of rituximab-Treated CD20+ tumor cells. Clin. Cancer Res. 14, 4650-4657 (2008
    • (2008) Clin. Cancer Res , vol.14 , pp. 4650-4657
    • Wu, L.1
  • 88
    • 84871389574 scopus 로고    scopus 로고
    • Bispecific and trispecific killer cell engagers directly activate human NK cells through CD16 signaling and induce cytotoxicity and cytokine production
    • Gleason, M.K. et al. Bispecific and trispecific killer cell engagers directly activate human NK cells through CD16 signaling and induce cytotoxicity and cytokine production. Mol. Cancer Ther. 11, 2674-2684 (2012
    • (2012) Mol. Cancer Ther , vol.11 , pp. 2674-2684
    • Gleason, M.K.1
  • 89
    • 0030974954 scopus 로고    scopus 로고
    • Treatment of refractory Hodgkins disease with an anti-CD16/CD30 bispecific antibody
    • Hartmann, F. et al. Treatment of refractory Hodgkins disease with an anti-CD16/CD30 bispecific antibody. Blood 89, 2042-2047 (1997
    • (1997) Blood , vol.89 , pp. 2042-2047
    • Hartmann, F.1
  • 90
    • 11144238604 scopus 로고    scopus 로고
    • Bispecific minibodies targeting HER2/neu and CD16 exhibit improved tumor lysis when placed in a divalent tumor antigen binding format
    • Shahied, L.S. et al. Bispecific minibodies targeting HER2/neu and CD16 exhibit improved tumor lysis when placed in a divalent tumor antigen binding format. J. Biol. Chem. 279, 53907-53914 (2004
    • (2004) J. Biol. Chem , vol.279 , pp. 53907-53914
    • Shahied, L.S.1
  • 91
    • 84881169028 scopus 로고    scopus 로고
    • Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16 x 33 bispecific killer cell engager and ADAM17 inhibition
    • Wiernik, A. et al. Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16 x 33 bispecific killer cell engager and ADAM17 inhibition. Clin. Cancer Res. 19, 3844-3855 (2013
    • (2013) Clin. Cancer Res , vol.19 , pp. 3844-3855
    • Wiernik, A.1
  • 92
    • 84975839987 scopus 로고    scopus 로고
    • Heterodimeric bispecific single chain variable fragments (scFv) killer engagers (BiKEs) enhance NK-cell activity against CD133+ colorectal cancer cells
    • Schmohl, J.U., Gleason, M.K., Dougherty, P.R., Miller, J.S., & Vallera, D.A. Heterodimeric bispecific single chain variable fragments (scFv) killer engagers (BiKEs) enhance NK-cell activity against CD133+ colorectal cancer cells. Target. Oncol. (2015).
    • (2015) Target. Oncol
    • Schmohl, J.U.1    Gleason, M.K.2    Dougherty, P.R.3    Miller, J.S.4    Vallera, D.A.5
  • 93
    • 84978396441 scopus 로고    scopus 로고
    • IL15 trispecific killer engagers (TriKE) make natural killer cells specific to cd33+ targets while also inducing persistence, in vivo expansion, and enhanced function
    • Vallera, D.A. et al. IL15 trispecific killer engagers (TriKE) make natural killer cells specific to cd33+ targets while also inducing persistence, in vivo expansion, and enhanced function. Clin. Cancer Res. (2016).
    • (2016) Clin. Cancer Res
    • Vallera, D.A.1
  • 94
    • 79958705571 scopus 로고    scopus 로고
    • Bi-specific aptamers mediating tumor cell lysis
    • Boltz, A. et al. Bi-specific aptamers mediating tumor cell lysis. J. Biol. Chem. 286, 21896-21905 (2011
    • (2011) J. Biol. Chem , vol.286 , pp. 21896-21905
    • Boltz, A.1
  • 95
    • 84859644562 scopus 로고    scopus 로고
    • Fusion proteins between ligands for NKG2D and CD20-directed single-chain variable fragments sensitize lymphoma cells for natural killer cell-mediated lysis and enhance antibody-dependent cellular cytotoxicity
    • Kellner, C. et al. Fusion proteins between ligands for NKG2D and CD20-directed single-chain variable fragments sensitize lymphoma cells for natural killer cell-mediated lysis and enhance antibody-dependent cellular cytotoxicity. Leukemia 26, 830-834 (2012
    • (2012) Leukemia , vol.26 , pp. 830-834
    • Kellner, C.1
  • 96
    • 33344477900 scopus 로고    scopus 로고
    • A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo
    • von Strandmann, E.P. et al. A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo. Blood 107, 1955-1962 (2006
    • (2006) Blood , vol.107 , pp. 1955-1962
    • Von Strandmann, E.P.1
  • 97
    • 0037126310 scopus 로고    scopus 로고
    • Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation
    • Groh, V., Wu, J., Yee, C., & Spies, T. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 419, 734-738 (2002
    • (2002) Nature , vol.419 , pp. 734-738
    • Groh, V.1    Wu, J.2    Yee, C.3    Spies, T.4
  • 98
    • 84927658788 scopus 로고    scopus 로고
    • Antitumor immunity A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection
    • Deng, W. et al. Antitumor immunity. A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection. Science 348, 136-139 (2015).
    • (2015) Science , vol.348 , pp. 136-139
    • Deng, W.1
  • 99
    • 84961879643 scopus 로고    scopus 로고
    • NKG2D receptor and its ligands in host defense
    • Lanier, L.L. NKG2D receptor and its ligands in host defense. Cancer Immunol. Res. 3, 575-582 (2015
    • (2015) Cancer Immunol. Res , vol.3 , pp. 575-582
    • Lanier, L.L.1
  • 101
    • 79958118266 scopus 로고    scopus 로고
    • Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors
    • Delahaye, N.F. et al. Alternatively spliced NKp30 isoforms affect the prognosis of gastrointestinal stromal tumors. Nat. Med. 17, 700-707 (2011
    • (2011) Nat. Med , vol.17 , pp. 700-707
    • Delahaye, N.F.1
  • 102
    • 84928253171 scopus 로고    scopus 로고
    • Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients
    • Semeraro, M. et al. Clinical impact of the NKp30/B7-H6 axis in high-risk neuroblastoma patients. Sci. Transl. Med. 7, 283ra55 (2015
    • (2015) Sci. Transl. Med , vol.7 , pp. 283ra55
    • Semeraro, M.1
  • 103
    • 63449129623 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: A role for NKG2D ligands and IL-15Ralpha
    • Viaud, S. et al. Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Ralpha. PLoS One 4, e4942 (2009
    • (2009) PLoS One , vol.4 , pp. e4942
    • Viaud, S.1
  • 104
    • 84929001442 scopus 로고    scopus 로고
    • Immunosurveillance and therapy of multiple myeloma are CD226 dependent
    • Guillerey, C. et al. Immunosurveillance and therapy of multiple myeloma are CD226 dependent. J. Clin. Invest. 125, 2077-2089 (2015
    • (2015) J. Clin. Invest , vol.125 , pp. 2077-2089
    • Guillerey, C.1
  • 105
    • 76249116438 scopus 로고    scopus 로고
    • DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases
    • Chan, C.J. et al. DNAM-1/CD155 interactions promote cytokine and NK cell-mediated suppression of poorly immunogenic melanoma metastases. J. Immunol. 184, 902-911 (2010
    • (2010) J. Immunol , vol.184 , pp. 902-911
    • Chan, C.J.1
  • 106
    • 84952932933 scopus 로고    scopus 로고
    • Rationale for anti-CD137 cancer immunotherapy
    • Makkouk, A., Chester, C., & Kohrt, H.E. Rationale for anti-CD137 cancer immunotherapy. Eur. J. Cancer 54, 112-119 (2016
    • (2016) Eur. J. Cancer , vol.54 , pp. 112-119
    • Makkouk, A.1    Chester, C.2    Kohrt, H.E.3
  • 107
    • 77951042495 scopus 로고    scopus 로고
    • CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells
    • Baessler, T. et al. CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells. Blood 115, 3058-3069 (2010
    • (2010) Blood , vol.115 , pp. 3058-3069
    • Baessler, T.1
  • 108
    • 79952124960 scopus 로고    scopus 로고
    • CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies
    • Kohrt, H.E. et al. CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies. Blood 117, 2423-2432 (2011
    • (2011) Blood , vol.117 , pp. 2423-2432
    • Kohrt, H.E.1
  • 109
    • 84902137525 scopus 로고    scopus 로고
    • Targeting CD137 enhances the efficacy of cetuximab
    • Kohrt, H.E. et al. Targeting CD137 enhances the efficacy of cetuximab. J. Clin. Invest. 124, 2668-2682 (2014).
    • (2014) J. Clin. Invest , vol.124 , pp. 2668-2682
    • Kohrt, H.E.1
  • 110
    • 84940378016 scopus 로고    scopus 로고
    • Agonists of co-stimulation in cancer immunotherapy directed against CD137, OX40, GITR, CD27, CD28, and ICOS
    • Sanmamed, M.F. et al. Agonists of co-stimulation in cancer immunotherapy directed against CD137, OX40, GITR, CD27, CD28, and ICOS. Semin. Oncol. 42, 640-655 (2015
    • (2015) Semin. Oncol , vol.42 , pp. 640-655
    • Sanmamed, M.F.1
  • 111
    • 69249108787 scopus 로고    scopus 로고
    • Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells
    • Romagné, F. et al. Preclinical characterization of 1-7F9, a novel human anti-KIR receptor therapeutic antibody that augments natural killer-mediated killing of tumor cells. Blood 114, 2667-2677 (2009
    • (2009) Blood , vol.114 , pp. 2667-2677
    • Romagné, F.1
  • 112
    • 84869819029 scopus 로고    scopus 로고
    • A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma
    • Benson, D.M. Jr. et al. A phase 1 trial of the anti-KIR antibody IPH2101 in patients with relapsed/refractory multiple myeloma. Blood 120, 4324-4333 (2012
    • (2012) Blood , vol.120 , pp. 4324-4333
    • Benson, D.M.1
  • 113
    • 84869856060 scopus 로고    scopus 로고
    • A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission
    • Vey, N. et al. A phase 1 trial of the anti-inhibitory KIR mAb IPH2101 for AML in complete remission. Blood 120, 4317-4323 (2012).
    • (2012) Blood , vol.120 , pp. 4317-4323
    • Vey, N.1
  • 114
    • 84901712243 scopus 로고    scopus 로고
    • A phase II trial of pan-KIR2D blockade with IPH2101 in smoldering multiple myeloma
    • Korde, N. et al. A phase II trial of pan-KIR2D blockade with IPH2101 in smoldering multiple myeloma. Haematologica 99, e81-e83 (2014
    • (2014) Haematologica , vol.99 , pp. e81-e83
    • Korde, N.1
  • 115
    • 84894030202 scopus 로고    scopus 로고
    • Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies
    • Kohrt, H.E. et al. Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies. Blood 123, 678-686 (2014
    • (2014) Blood , vol.123 , pp. 678-686
    • Kohrt, H.E.1
  • 116
    • 84911415636 scopus 로고    scopus 로고
    • And immunological significance of HLA-E in stem cell transplantation and cancer
    • Wieten, L., Mahaweni, N.M., Voorter, C.E., Bos, G.M., & Tilanus, M.G. Clinical and immunological significance of HLA-E in stem cell transplantation and cancer. Tissue Antigens 84, 523-535 (2014
    • (2014) Tissue Antigens , vol.84 , pp. 523-535
    • Wieten, L.1    Mahaweni, N.M.2    Voorter, C.E.3    Bos, G.M.4    Clinical, G.T.M.5
  • 117
    • 67349221158 scopus 로고    scopus 로고
    • HLA-E upregulation on IFN-?-Activated AML blasts impairs CD94/NKG2A-dependent NK cytolysis after haplo-mismatched hematopoietic SCT
    • Nguyen, S. et al. HLA-E upregulation on IFN-?-Activated AML blasts impairs CD94/NKG2A-dependent NK cytolysis after haplo-mismatched hematopoietic SCT. Bone Marrow Transplant. 43, 693-699 (2009
    • (2009) Bone Marrow Transplant , vol.43 , pp. 693-699
    • Nguyen, S.1
  • 118
    • 84925743331 scopus 로고    scopus 로고
    • Balancing natural killer cell activation through paired receptors
    • Martinet, L., & Smyth, M.J. Balancing natural killer cell activation through paired receptors. Nat. Rev. Immunol. 15, 243-254 (2015
    • (2015) Nat. Rev. Immunol , vol.15 , pp. 243-254
    • Martinet, L.1    Smyth, M.J.2
  • 119
    • 84899099175 scopus 로고    scopus 로고
    • The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions
    • Chan, C.J. et al. The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions. Nat. Immunol. 15, 431-438 (2014
    • (2014) Nat. Immunol , vol.15 , pp. 431-438
    • Chan, C.J.1
  • 120
    • 84962449276 scopus 로고    scopus 로고
    • Suppression of metastases using a new lymphocyte checkpoint target for cancer immunotherapy
    • Blake, S.J. et al. Suppression of metastases using a new lymphocyte checkpoint target for cancer immunotherapy. Cancer Discov. 6, 446-459 (2016).
    • (2016) Cancer Discov , vol.6 , pp. 446-459
    • Blake, S.J.1
  • 121
    • 84925625990 scopus 로고    scopus 로고
    • On being less tolerant: Enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation
    • Lesokhin, A.M., Callahan, M.K., Postow, M.A., & Wolchok, J.D. On being less tolerant: enhanced cancer immunosurveillance enabled by targeting checkpoints and agonists of T cell activation. Sci. Transl. Med. 7, 280sr1 (2015
    • (2015) Sci. Transl. Med , vol.7 , pp. 280sr1
    • Lesokhin, A.M.1    Callahan, M.K.2    Postow, M.A.3    Wolchok, J.D.4
  • 122
    • 84899515283 scopus 로고    scopus 로고
    • CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-? Production in response to mature dendritic cells
    • Stojanovic, A., Fiegler, N., Brunner-Weinzierl, M., & Cerwenka, A. CTLA-4 is expressed by activated mouse NK cells and inhibits NK Cell IFN-? production in response to mature dendritic cells. J. Immunol. 192, 4184-4191 (2014
    • (2014) J. Immunol , vol.192 , pp. 4184-4191
    • Stojanovic, A.1    Fiegler, N.2    Brunner-Weinzierl, M.3    Cerwenka, A.4
  • 123
    • 84943194758 scopus 로고    scopus 로고
    • The PD-1/B7-H1 pathway modulates the natural killer cells versus mouse glioma stem cells
    • Huang, B.Y. et al. The PD-1/B7-H1 pathway modulates the natural killer cells versus mouse glioma stem cells. PLoS One 10, e0134715 (2015
    • (2015) PLoS One , vol.10 , pp. e0134715
    • Huang, B.Y.1
  • 124
    • 84891373595 scopus 로고    scopus 로고
    • Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: A single group, open-label, phase 2 trial
    • Westin, J.R. et al. Safety and activity of PD1 blockade by pidilizumab in combination with rituximab in patients with relapsed follicular lymphoma: a single group, open-label, phase 2 trial. Lancet Oncol. 15, 69-77 (2014
    • (2014) Lancet Oncol , vol.15 , pp. 69-77
    • Westin, J.R.1
  • 125
    • 84908397938 scopus 로고    scopus 로고
    • Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade
    • da Silva, I.P. et al. Reversal of NK-cell exhaustion in advanced melanoma by Tim-3 blockade. Cancer Immunol. Res. 2, 410-422 (2014
    • (2014) Cancer Immunol. Res , vol.2 , pp. 410-422
    • Da Silva, I.P.1
  • 126
    • 84948461194 scopus 로고    scopus 로고
    • Increased Tim-3 expression in peripheral NK cells predicts a poorer prognosis and Tim-3 blockade improves NK cell-mediated cytotoxicity in human lung adenocarcinoma
    • Xu, L. et al. Increased Tim-3 expression in peripheral NK cells predicts a poorer prognosis and Tim-3 blockade improves NK cell-mediated cytotoxicity in human lung adenocarcinoma. Int. Immunopharmacol. 29, 635-641 (2015
    • (2015) Int. Immunopharmacol , vol.29 , pp. 635-641
    • Xu, L.1
  • 127
    • 84939245512 scopus 로고    scopus 로고
    • The clinical significance of abnormal Tim-3 expression on NK cells from patients with gastric cancer
    • Wang, Z. et al. The clinical significance of abnormal Tim-3 expression on NK cells from patients with gastric cancer. Immunol. Invest. 44, 578-589 (2015
    • (2015) Immunol. Invest , vol.44 , pp. 578-589
    • Wang, Z.1
  • 128
    • 84928209254 scopus 로고    scopus 로고
    • Role of donor activating KIR-HLA ligand-mediated NK cell education status in control of malignancy in hematopoietic cell transplant recipients
    • Nowak, J. et al. role of donor activating KIR-HLA ligand-mediated NK cell education status in control of malignancy in hematopoietic cell transplant recipients. Biol. Blood Marrow Transplant. 21, 829-839 (2015
    • (2015) Biol. Blood Marrow Transplant , vol.21 , pp. 829-839
    • Nowak, J.1
  • 129
    • 84865960648 scopus 로고    scopus 로고
    • Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment
    • Tarek, N. et al. Unlicensed NK cells target neuroblastoma following anti-GD2 antibody treatment. J. Clin. Invest. 122, 3260-3270 (2012
    • (2012) J. Clin. Invest , vol.122 , pp. 3260-3270
    • Tarek, N.1
  • 132
    • 84958534134 scopus 로고    scopus 로고
    • Probing human NK cell biology using human immune system (HIS) mice
    • Li, Y., & Di Santo, J.P. Probing human NK cell biology using human immune system (HIS) mice. Curr. Top. Microbiol. Immunol. 395, 191-208 (2016
    • (2016) Curr. Top. Microbiol. Immunol , vol.395 , pp. 191-208
    • Li, Y.1    Di Santo, J.P.2
  • 133
    • 84897954522 scopus 로고    scopus 로고
    • The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
    • Paolino, M. et al. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature 507, 508-512 (2014).
    • (2014) Nature , vol.507 , pp. 508-512
    • Paolino, M.1
  • 134
    • 84881614850 scopus 로고    scopus 로고
    • CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance
    • Putz, E.M. et al. CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance. Cell Rep. 4, 437-444 (2013
    • (2013) Cell Rep , vol.4 , pp. 437-444
    • Putz, E.M.1
  • 135
    • 84969760211 scopus 로고    scopus 로고
    • CIS is a potent checkpoint in NK cell-mediated tumor immunity
    • Delconte, R.B. et al. CIS is a potent checkpoint in NK cell-mediated tumor immunity. Nat. Immunol. 17, 816-824 (2016).
    • (2016) Nat. Immunol , vol.17 , pp. 816-824
    • Delconte, R.B.1
  • 136
    • 77957970532 scopus 로고    scopus 로고
    • Role of chemokines in the biology of natural killer cells
    • Maghazachi, A.A. Role of chemokines in the biology of natural killer cells. Curr. Top. Microbiol. Immunol. 341, 37-58 (2010
    • (2010) Curr. Top. Microbiol. Immunol , vol.341 , pp. 37-58
    • Maghazachi, A.A.1
  • 137
    • 84899658350 scopus 로고    scopus 로고
    • The pathophysiological role of chemokines in the regulation of NK cell tissue homing
    • Bernardini, G., & Santoni, A. The pathophysiological role of chemokines in the regulation of NK cell tissue homing. Crit. Rev. Oncog. 19, 77-90 (2014
    • (2014) Crit. Rev. Oncog , vol.19 , pp. 77-90
    • Bernardini, G.1    Santoni, A.2
  • 138
    • 84905455228 scopus 로고    scopus 로고
    • Targeting cancer-derived adenosine: New therapeutic approaches
    • Young, A., Mittal, D., Stagg, J., & Smyth, M.J. Targeting cancer-derived adenosine: new therapeutic approaches. Cancer Discov. 4, 879-888 (2014
    • (2014) Cancer Discov , vol.4 , pp. 879-888
    • Young, A.1    Mittal, D.2    Stagg, J.3    Smyth, M.J.4
  • 139
    • 84899464260 scopus 로고    scopus 로고
    • The unconventional expression of IL-15 and its role in NK cell homeostasis
    • Huntington, N.D. The unconventional expression of IL-15 and its role in NK cell homeostasis. Immunol. Cell Biol. 92, 210-213 (2014
    • (2014) Immunol. Cell Biol , vol.92 , pp. 210-213
    • Huntington, N.D.1
  • 140
    • 84958841305 scopus 로고    scopus 로고
    • The helix-loop-helix protein ID2 governs NK cell fate by tuning their sensitivity to interleukin-15
    • Delconte, R.B. et al. The helix-loop-helix protein ID2 governs NK cell fate by tuning their sensitivity to interleukin-15. Immunity 44, 103-115 (2016
    • (2016) Immunity , vol.44 , pp. 103-115
    • Delconte, R.B.1
  • 141
    • 70449597272 scopus 로고    scopus 로고
    • The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
    • Stanietsky, N. et al. The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity. Proc. Natl. Acad. Sci. USA 106, 17858-17863 (2009
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 17858-17863
    • Stanietsky, N.1
  • 142
    • 84881498985 scopus 로고    scopus 로고
    • Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR
    • Stanietsky, N. et al. Mouse TIGIT inhibits NK-cell cytotoxicity upon interaction with PVR. Eur. J. Immunol. 43, 2138-2150 (2013
    • (2013) Eur. J. Immunol , vol.43 , pp. 2138-2150
    • Stanietsky, N.1
  • 143
    • 1642394991 scopus 로고    scopus 로고
    • Cutting edge: CD96 (tactile) promotes NK cell-Target cell adhesion by interacting with the poliovirus receptor (CD155
    • Fuchs, A., Cella, M., Giurisato, E., Shaw, A.S., & Colonna, M. Cutting edge: CD96 (tactile) promotes NK cell-Target cell adhesion by interacting with the poliovirus receptor (CD155). J. Immunol. 172, 3994-3998 (2004
    • (2004) J. Immunol , vol.172 , pp. 3994-3998
    • Fuchs, A.1    Cella, M.2    Giurisato, E.3    Shaw, A.S.4    Colonna, M.5
  • 144
    • 84926433030 scopus 로고    scopus 로고
    • Improving the safety of cell therapy products by suicide gene transfer
    • Jones, B.S., Lamb, L.S., Goldman, F., & Di Stasi, A. Improving the safety of cell therapy products by suicide gene transfer. Front. Pharmacol. 5, 254 (2014
    • (2014) Front. Pharmacol , vol.5 , pp. 254
    • Jones, B.S.1    Lamb, L.S.2    Goldman, F.3    Di Stasi, A.4


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