Disease modeling using 3D organoids derived from human induced pluripotent stem cells

International Journal of Molecular Sciences

Volumn 19, Issue 4, 2018, Pages

  Ho, Beatrice Xuan ^a,b   Pek, Nicole Min Qian ^a   Soh, Boon Seng ^a,b  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

3D organoids; CRISPR Cas 9; Disease modeling; Drug screening; Genome editing; Hereditary diseases; Human induced pluripotent stem cells; Infectious diseases; Microenvironment; Neurodevelopmental disorders

Indexed keywords

BIOLOGICAL MARKER; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR;

ACTION POTENTIAL; ALAGILLE SYNDROME; AUTISM; CELL DIFFERENTIATION; COLORECTAL CANCER; COMMUNICABLE DISEASE; CRISPR CAS SYSTEM; CYSTIC FIBROSIS; DISEASE SIMULATION; DRUG RESPONSE; DRUG SCREENING; EXTRACELLULAR MATRIX; FATTY LIVER; GENE EDITING; GENETIC DISORDER; HUMAN; INDUCED PLURIPOTENT STEM CELL; INFLAMMATORY BOWEL DISEASE; MESENCHYMAL STEM CELL; MICROCEPHALY; MICROENVIRONMENT; NECROTIZING ENTEROCOLITIS; NERVOUS SYSTEM MALFORMATION; NEURAL STEM CELL; NONHUMAN; ORGANOID; OVARY CANCER; PROSTATE CANCER; PROTEIN EXPRESSION; REGENERATIVE MEDICINE; REVIEW; VASCULAR SMOOTH MUSCLE CELL; VASCULARIZATION; ZIKA FEVER; ANTIBODY SPECIFICITY; BIOLOGICAL MODEL; CYTOLOGY; DISEASES;

DISEASE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MODELS, BIOLOGICAL; ORGAN SPECIFICITY; ORGANOIDS;

EID: 85044439361     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms19040936     Document Type: Review

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