Concise review: Organoids are a powerful tool for the study of liver disease and personalized treatment design in humans and animals

Stem Cells Translational Medicine

Volumn 5, Issue 3, 2016, Pages 325-330

  Nantasanti, Sathidpak ^a,b,c   de Bruin, Alain ^b,d   Rothuizen, Jan ^a   Penning, Louis C ^a   Schotanus, Baukje A ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c KASETSART UNIVERSITY   (Thailand)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Adult stem cell culture; Applications; Liver; Organoids

Indexed keywords

BIOLOGICAL MARKER;

ANIMAL DISEASE; CYTOPLASM; DISEASE COURSE; DISEASE MODEL; HUMAN; LIVER CELL; LIVER CELL CARCINOMA; LIVER DISEASE; MEDICAL RESEARCH; NONHUMAN; PERSONALIZED MEDICINE; REVIEW; STEM CELL CULTURE; STEM CELL TRANSPLANTATION; VIRUS HEPATITIS; ADULT; ANIMAL; CELL CULTURE TECHNIQUE; CYTOLOGY; LIVER; METABOLISM; STEM CELL;

ADULT; ANIMALS; CELL CULTURE TECHNIQUES; HUMANS; LIVER; ORGANOIDS; STEM CELL TRANSPLANTATION; STEM CELLS;

EID: 84959421061     PISSN: 21576564     EISSN: 21576580     Source Type: Journal    
DOI: 10.5966/sctm.2015-0152     Document Type: Review

References (48)

1. Fox IJ, Chowdhury JR, Kaufman SS et al. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation. N Engl J Med 1998; 338: 1422-1426.
2. Horslen SP, McCowan TC, Goertzen TC et al. Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder. Pediatrics 2003; 111: 1262-1267.
3. Fitzpatrick E, Mitry RR, Dhawan A. Human hepatocyte transplantation: State of the art. J Intern Med 2009; 266: 339-357.
4. Handa K, Matsubara K, Fukumitsu K et al. Assembly of human organs from stem cells to study liver disease. Am J Pathol 2014; 184: 348-357.
5. Stéphenne X, Najimi M, Sokal EM. Hepatocyte cryopreservation: Is it time to change the strategy? World J Gastroenterol 2010; 16: 1-14.
6. Snykers S, DeKock J, RogiersV et al. In vitro differentiation of embryonic and adult stem cells into hepatocytes: State of the art. STEM CELLS 2009; 27: 577-605.
7. Ma H, Morey R, O'Neil RC et al. Abnormalities in human pluripotent cells due to reprogramming mechanisms. Nature 2014; 511: 177-183.
8. Lu WY, Bird TG, Boulter L et al. Hepatic progenitor cells of biliary origin with liver repopulation capacity. Nat Cell Biol 2015; 17: 971-983.
9. Scheers I, Maerckx C, Khuu DN et al. Adultderived human liver progenitor cells in longterm culture maintain appropriate gatekeeper mechanisms against transformation. Cell Transplant 2012; 21: 2241-2255.
10. Pampaloni F, Reynaud EG, Stelzer EH. The third dimension bridges the gap between cell culture and live tissue. Nat Rev Mol Cell Biol 2007; 8: 839-845.
11. Huch M, Dorrell C, Boj SF et al. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature 2013; 494: 247-250.
12. Huch M, Gehart H, van Boxtel R et al. Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell 2015; 160: 299-312.
13. Nantasanti S, Spee B, KruitwagenHSet al. Disease modeling and gene therapy of copper storage disease in canine hepatic organoids. Stem Cell Rep 2015; 5: 895-907.
14. Zeisel MB, Fofana I, Fafi-Kremer S et al. Hepatitis C virus entry into hepatocytes: Molecular mechanisms and targets for antiviral therapies. J Hepatol 2011; 54: 566-576.
15. Catanese MT, Dorner M. Advances in experimental systems to study hepatitis C virus in vitro and in vivo. Virology 2015; 479-480: 221-233.
16. Galle PR, Hagelstein J, Kommerell B et al. In vitro experimental infection of primary human hepatocytes with hepatitis B virus. Gastroenterology 1994; 106: 664-673.
17. Andrus L, Marukian S, Jones CT et al. Expression of paramyxovirus V proteins promotes replication and spread of hepatitis C virus in cultures of primary human fetal liver cells. Hepatology 2011; 54: 1901-1912.
18. Yang D, Zuo C, Wang X et al. Complete replication of hepatitis B virus and hepatitis C virus in a newly developed hepatoma cell line. Proc Natl Acad Sci USA 2014; 111: E1264-E1273.
19. Zhang T, Lin RT, Li Y et al. Hepatitis C virus inhibits intracellular interferon alpha expression in human hepatic cell lines. Hepatology 2005; 42: 819-827.
20. Thursz M, Yee L, Khakoo S. Understanding the host genetics of chronic hepatitis B and C. Semin Liver Dis 2011; 31: 115-127.
21. Wu X, Robotham JM, Lee E et al. Productive hepatitis C virus infection of stem cellderived hepatocytes reveals a critical transition to viral permissiveness during differentiation. PLoS Pathog 2012; 8: e1002617.
22. Than NN, Newsome PN. A concise review of non-alcoholic fatty liver disease. Atherosclerosis 2015; 239: 192-202.
23. Rosso N, Chavez-Tapia NC, TiribelliC et al. Translational approaches: From fatty liver to non-alcoholic steatohepatitis. World J Gastroenterol 2014; 20: 9038-9049.
24. Sun C, Fan JG, Qiao L. Potential epigenetic mechanism in non-alcoholic fatty liver disease. Int J Mol Sci 2015; 16: 5161-5179.
25. Ricchi M, Odoardi MR, Carulli L et al. Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J Gastroenterol Hepatol 2009; 24: 830- 840.
26. Dekkers R, Vijftigschild LA, VonkAMet al. A bioassay using intestinal organoids to measure CFTR modulators in human plasma. J Cyst Fibros 2015; 14: 178-181.
27. Dekkers JF, Wiegerinck CL, de Jonge HR et al. A functional CFTR assay using primary cystic fibrosis intestinal organoids. Nat Med 2013; 19: 939-945.
28. Schwank G, Koo BK, Sasselli V et al. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell 2013; 13: 653-658.
29. Dekkers JF, van der Ent CK, Beekman JM. Novel opportunities for CFTR-targeting drug development using organoids. Rare Dis 2013; 1: e27112.
30. Ikpa PT, Bijvelds MJ, de Jonge HR. Cystic fibrosis: Toward personalized therapies. Int J Biochem Cell Biol 2014; 52: 192-200.
31. El-Serag HB, Rudolph KL. Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology 2007; 132: 2557- 2576.
32. Boj SF, HwangCI, Baker LA et al. Organoid models of human and mouse ductal pancreatic cancer. Cell 2015; 160: 324-338.
33. van de Wetering M, Francies HE, Francis JM et al. Prospective derivation of a living organoid biobank of colorectal cancer patients. Cell 2015; 161: 933-945.
34. Huch M, Bonfanti P, Boj SF et al. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis. EMBO J 2013; 32: 2708-2721.
35. Schwartz RE, Fleming HE, KhetaniSR et al. Pluripotent stem cell-derived hepatocyte-like cells. Biotechnol Adv 2014; 32: 504-513.
36. Asonuma K, Gilbert JC, Stein JE et al. Quantitation of transplanted hepatic mass necessary to cure the Gunn rat model of hyperbilirubinemia. J Pediatr Surg 1992; 27: 298-301.
37. Ijzer J, Schotanus BA, Vander Borght S et al. Characterisation of the hepatic progenitor cell compartment in normal liver and in hepatitis: An immunohistochemical comparison between dog and man. Vet J 2010; 184: 308-314.
38. Arends B, Spee B, Schotanus BA et al. In vitro differentiation of liver progenitor cells derived from healthy dog livers. Stem Cells Dev 2009; 18: 351-358.
39. Oda D, Lee SP, Hayashi A. Long-term culture and partial characterization of dog gallbladder epithelial cells. Lab Invest 1991; 64: 682-692.
40. Boomkens SY, Spee B, Ijzer J et al. The establishment and characterization of the first canine hepatocellular carcinoma cell line, which resembles human oncogenic expression patterns. Comp Hepatol 2004; 3: 9.
41. Boomkens SY, Penning LC, Egberink HF et al. Hepatitis with special reference to dogs. Areview on the pathogenesis and infectious etiologies, including unpublished results of recent own studies. Vet Q 2004; 26: 107-114.
42. ArmstrongPJ, BlanchardG. Hepatic lipidosis in cats. Vet Clin North Am Small AnimPract 2009; 39: 599-616.
43. Collison KS, Zaidi MZ, Saleh SM et al. Nutrigenomics of hepatic steatosis in a feline model: Effect of monosodium glutamate, fructose, and trans-fat feeding. Genes Nutr 2012; 7: 265-280.
44. Callahan Clark JE, Haddad JL, Brown DC et al. Feline cholangitis: A necropsy study of 44. cats (1986-2008). J Feline Med Surg 2011; 13: 570-576.
45. Boomkens SY, Kusters JG, Hoffmann G et al. Detection of Helicobacter pylori in bile of cats. FEMS Immunol Med Microbiol 2004; 42: 307-311.
46. Riccardo F, Aurisicchio L, Impellizeri JA et al. The importance of comparative oncology in translational medicine. Cancer Immunol Immunother 2015; 64: 137-148.
47. Lee JS, Shin J, Park HM et al. Liver extracellular matrix providing dual functions of two-dimensional substrate coating and threedimensional injectable hydrogel platform for liver tissue engineering. Biomacromolecules 2014; 15: 206-218.
48. KooBK, Stange DE, Sato T et al. Controlled gene expression in primary Lgr5 organoid cultures. Nat Methods 2011; 9: 81-83.