Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

Gut

Volumn 66, Issue 3, 2017, Pages 473-486

  Hohwieler, Meike ^a   Illing, Anett ^a   Hermann, Patrick C ^a   Mayer, Tobias ^a   Stockmann, Marianne ^a   Perkhofer, Lukas ^a   Eiseler, Tim ^a   Antony, Justin S ^b   Müller, Martin ^a   Renz, Susanne ^a   Kuo, Chao Chung ^c   Lin, Qiong ^c   Sendler, Matthias ^d   Breunig, Markus ^a   Kleiderman, Susanne M ^a   Lechel, André ^a   Zenker, Martin ^e   Leichsenring, Michael ^a   Rosendahl, Jonas ^f   Zenke, Martin ^c   Sainz, Bruno ^g   Mayerle, Julia ^d   Costa, Ivan G ^c   Seufferlein, Thomas ^a   Kormann, Michael ^b   Wagner, Martin ^a   Liebau, Stefan ^b   Kleger, Alexander ^a   more..

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d UNIVERSITY OF GREIFSWALD   (Germany)

^e UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

^f MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^g UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

cystic fibrosis; Pancreas; stem cells

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; MESSENGER RNA;

ACINAR CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOASSAY; CFTR GENE; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE MODEL; FETUS; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; ORGANOGENESIS; ORTHOTOPIC TRANSPLANTATION; PANCREAS DEVELOPMENT; PHENOTYPE; PLURIPOTENT STEM CELL; PROTEIN EXPRESSION; ANIMAL; CYTOLOGY; CYTOPLASM; GENE EXPRESSION PROFILING; GENE THERAPY; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PANCREAS; PANCREATIC DUCT; TRANSPLANTATION;

ACINAR CELLS; ANIMALS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENETIC THERAPY; HUMANS; MICE; ORGANOIDS; PANCREAS; PANCREATIC DUCTS; PHENOTYPE; PLURIPOTENT STEM CELLS; RNA, MESSENGER;

EID: 84987917122     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2016-312423     Document Type: Article

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