High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain

Cell Stem Cell

Volumn 21, Issue 2, 2017, Pages 274-283.e5

  Zhou, Ting ^a   Tan, Lei ^a   Cederquist, Gustav Y ^b,c   Fan, Yujie ^a   Hartley, Brigham J ^d   Mukherjee, Suranjit ^a   Tomishima, Mark ^b,c   Brennand, Kristen J ^d   Zhang, Qisheng ^e   Schwartz, Robert E ^a   Evans, Todd ^a   Studer, Lorenz ^b,c   Chen, Shuibing ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b The Center for Stem Cell Biology   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e UNC Hamner Institute for Drug Safety Sciences   (United States)

Author keywords

high content chemical screen; human cortical neuron progenitor cells; human forebrain organoids; human pluripotent stem cells; Zika virus

Indexed keywords

AMODIAQUINE; AMODIAQUINE DIHYDROCHLORIDE DIHYDRATE; ANTIVIRUS AGENT; HIPPEASTRINE HYDROBROMIDE; UNCLASSIFIED DRUG; AMARYLLIDACEAE ALKALOID; HIPPEASTRINE;

ADOLESCENT; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CHILD; CONTROLLED STUDY; CYTOPLASM; DRUG SCREENING; FEMALE; FOREBRAIN; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NEURAL STEM CELL; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; SCHOOL CHILD; YOUNG ADULT; ZIKA FEVER; ANIMAL; BRAIN; CELL LINE; DRUG EFFECTS; FETUS; INDUCED PLURIPOTENT STEM CELL; METABOLISM; ORGANOID; PATHOLOGY; PHYSIOLOGY; PRECLINICAL STUDY; PROCEDURES; SCID MOUSE; VIROLOGY; ZIKA VIRUS;

ADOLESCENT; AMARYLLIDACEAE ALKALOIDS; AMODIAQUINE; ANIMALS; ANTIVIRAL AGENTS; BRAIN; CELL LINE; CHILD; DRUG EVALUATION, PRECLINICAL; FEMALE; FETUS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE, SCID; NEURAL STEM CELLS; ORGANOIDS; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 85025475900     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2017.06.017     Document Type: Article

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