Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges

Proceedings of the National Academy of Sciences of the United States of America

Volumn 115, Issue 3, 2018, Pages E488-E497

  Piasecka, Barbara ^a   Duffy, Darragh ^a,b   Urrutia, Alejandra ^a,b,c   Quach, Hélène ^a,d   Patin, Etienne ^a,d   Posseme, Céline ^a   Bergstedt, Jacob ^a,e   Charbit, Bruno ^a   Rouilly, Vincent ^a   MacPherson, Cameron R ^a   Hasan, Milena ^a   Albaud, Benoit ^f   Gentien, David ^f   Fellay, Jacques ^g,h   Albert, Matthew L ^a,b,c   Quintana Murci, Lluis ^a,d  

^a INSTITUT PASTEUR   (France)

^b INSTITUT PASTEUR   (France)

^c GENENTECH INC   (United States)

^d CNRS   (France)

^e LUND UNIVERSITY   (Sweden)

^f INSTITUT CURIE   (France)

^g PSL RESEARCH UNIVERSITY   (France)

^h EPFL   (Switzerland)

Author keywords

Age; Gene expression; Genetics; Human immune variation; Sex

Indexed keywords

ADULT; AGE; AGED; ARTICLE; AUTOIMMUNE DISEASE; AUTOINFLAMMATORY DISEASE; CANDIDA ALBICANS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL POPULATION; COHORT ANALYSIS; DISEASE ASSOCIATION; ESCHERICHIA COLI; EXPRESSION QUANTITATIVE TRAIT LOCUS; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE MAPPING; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HEREDITY; HUMAN; HUMAN EXPERIMENT; IMMUNE RESPONSE GENE; IMMUNOSTIMULATION; INFECTION RISK; MALE; MICROBIAL GENETICS; MONOCYTE; MYCOBACTERIUM BOVIS BCG; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SEX; STAPHYLOCOCCUS AUREUS; AGING; BACTERIUM; FUNGUS; GENE EXPRESSION REGULATION; GENETIC VARIATION; GENOTYPE; IMMUNOLOGY; INFLUENZA A VIRUS; MIDDLE AGED; QUANTITATIVE TRAIT LOCUS; YOUNG ADULT;

ENTEROTOXIN; ENTEROTOXIN B, STAPHYLOCOCCAL;

ADULT; AGED; AGING; BACTERIA; COHORT STUDIES; ENTEROTOXINS; FEMALE; FUNGI; GENE EXPRESSION REGULATION; GENETIC VARIATION; GENOTYPE; HUMANS; INFLUENZA A VIRUS; MALE; MIDDLE AGED; QUANTITATIVE TRAIT LOCI; YOUNG ADULT;

EID: 85042117261     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1714765115     Document Type: Article

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