메뉴 건너뛰기




Volumn 47, Issue 3, 2015, Pages 267-271

Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy

(32)  Liu, Hong a,b,c,d   Irwanto, Astrid e,f   Fu, Xi'an b,d   Yu, Gongqi b,d   Yu, Yongxiang b,d   Sun, Yonghu b,d   Wang, Chuan b,d   Wang, Zhenzhen b,d   Okada, Yukinori g,h   Low, Huiqi e   Li, Yi e   Liany, Herty e   Chen, Mingfei b,d   Bao, Fangfang b,d   Li, Jinghui b,d   You, Jiabao b,d   Zhang, Qilin c   Liu, Jian b,d   Chu, Tongsheng b,d   Andiappan, Anand Kumar i   more..


Author keywords

[No Author keywords available]

Indexed keywords

BATF3 PROTEIN; CCDC88B PROTEIN; HLA DRB1 ANTIGEN; PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; UNCLASSIFIED DRUG;

EID: 84924041476     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3212     Document Type: Article
Times cited : (100)

References (50)
  • 2
    • 84884399962 scopus 로고    scopus 로고
    • Global leprosy: Update on the 2012 situation
    • World Health Organization. Global leprosy: update on the 2012 situation. Wkly. Epidemiol. Rec. 88, 365-379 (2013).
    • (2013) Wkly. Epidemiol. Rec. , vol.88 , pp. 365-379
    • World Health Organization1
  • 3
    • 84868492064 scopus 로고    scopus 로고
    • Identification of IL18RAP/IL18R1 and IL12B as leprosy risk genes demonstrates shared pathogenesis between inflammation and infectious diseases
    • Liu, H. et al. Identification of IL18RAP/IL18R1 and IL12B as leprosy risk genes demonstrates shared pathogenesis between inflammation and infectious diseases. Am. J. Hum. Genet. 91, 935-941 (2012).
    • (2012) Am. J. Hum. Genet. , vol.91 , pp. 935-941
    • Liu, H.1
  • 4
    • 84885761541 scopus 로고    scopus 로고
    • An association study of TOLL and CARD with leprosy susceptibility in Chinese population
    • Liu, H. et al. An association study of TOLL and CARD with leprosy susceptibility in Chinese population. Hum. Mol. Genet. 22, 4430-4437 (2013).
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 4430-4437
    • Liu, H.1
  • 5
    • 0025129171 scopus 로고
    • Human leukocyte antigen and leprosy: Study in northern Louisiana and review
    • Todd, J.R., West, B.C. & McDonald, J.C. Human leukocyte antigen and leprosy: study in northern Louisiana and review. Rev. Infect. Dis. 12, 63-74 (1990).
    • (1990) Rev. Infect. Dis. , vol.12 , pp. 63-74
    • Todd, J.R.1    West, B.C.2    McDonald, J.C.3
  • 6
    • 0035065541 scopus 로고    scopus 로고
    • A major susceptibility locus for leprosy in India maps to chromosome 10p13
    • Siddiqui, M.R. et al. A major susceptibility locus for leprosy in India maps to chromosome 10p13. Nat. Genet. 27, 439-441 (2001).
    • (2001) Nat. Genet. , vol.27 , pp. 439-441
    • Siddiqui, M.R.1
  • 7
    • 10744220764 scopus 로고    scopus 로고
    • Susceptibility to leprosy is associated with PARK2 and PACRG
    • Mira, M.T. et al. Susceptibility to leprosy is associated with PARK2 and PACRG. Nature 427, 636-640 (2004).
    • (2004) Nature , vol.427 , pp. 636-640
    • Mira, M.T.1
  • 8
    • 34047143696 scopus 로고    scopus 로고
    • Stepwise replication identifies a low-producing lymphotoxin-α allele as a major risk factor for early-onset leprosy
    • Alcaïs, A. et al. Stepwise replication identifies a low-producing lymphotoxin-± allele as a major risk factor for early-onset leprosy. Nat. Genet. 39, 517-522 (2007).
    • (2007) Nat. Genet. , vol.39 , pp. 517-522
    • Alcaïs, A.1
  • 9
    • 82255179222 scopus 로고    scopus 로고
    • Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy
    • Zhang, F. et al. Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. Nat. Genet. 43, 1247-1251 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 1247-1251
    • Zhang, F.1
  • 10
    • 74049127960 scopus 로고    scopus 로고
    • Genomewide association study of leprosy
    • Zhang, F.R. et al. Genomewide association study of leprosy. N. Engl. J. Med. 361, 2609-2618 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2609-2618
    • Zhang, F.R.1
  • 11
    • 77957654090 scopus 로고    scopus 로고
    • Leprosy and the adaptation of human Toll-like receptor 1
    • Wong, S.H. et al. Leprosy and the adaptation of human Toll-like receptor 1. PLoS Pathog. 6, e1000979 (2010).
    • (2010) PLoS Pathog. , vol.6 , pp. e1000979
    • Wong, S.H.1
  • 12
    • 0027362134 scopus 로고
    • Study of HLA class II alleles by PCR oligotyping in leprosy patients from north India
    • Rani, R., Fernandez-Vina, M.A., Zaheer, S.A., Beena, K.R. & Stastny, P. Study of HLA class II alleles by PCR oligotyping in leprosy patients from north India. Tissue Antigens 42, 133-137 (1993).
    • (1993) Tissue Antigens , vol.42 , pp. 133-137
    • Rani, R.1    Fernandez-Vina, M.A.2    Zaheer, S.A.3    Beena, K.R.4    Stastny, P.5
  • 13
    • 34250017362 scopus 로고    scopus 로고
    • HLA-DRB1∗04 and DRB1∗10 are associated with resistance and susceptibility, respectively, in Brazilian and Vietnamese leprosy patients
    • Vanderborght, P.R. et al. HLA-DRB1∗04 and DRB1∗10 are associated with resistance and susceptibility, respectively, in Brazilian and Vietnamese leprosy patients. Genes Immun. 8, 320-324 (2007).
    • (2007) Genes Immun. , vol.8 , pp. 320-324
    • Vanderborght, P.R.1
  • 14
    • 0022350837 scopus 로고
    • Leprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand
    • Schauf, V. et al. Leprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand. Tissue Antigens 26, 243-247 (1985).
    • (1985) Tissue Antigens , vol.26 , pp. 243-247
    • Schauf, V.1
  • 15
    • 84885018609 scopus 로고    scopus 로고
    • Systematic identification of trans eQTLs as putative drivers of known disease associations
    • Westra, H.J. et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat. Genet. 45, 1238-1243 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1238-1243
    • Westra, H.J.1
  • 16
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff, L.A. et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl. Acad. Sci. USA 106, 9362-9367 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1
  • 17
    • 79953208931 scopus 로고    scopus 로고
    • Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
    • Mells, G.F. et al. Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis. Nat. Genet. 43, 329-332 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 329-332
    • Mells, G.F.1
  • 18
    • 84868031310 scopus 로고    scopus 로고
    • A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1
    • Fischer, A. et al. A novel sarcoidosis risk locus for Europeans on chromosome 11q13.1. Am. J. Respir. Crit. Care Med. 186, 877-885 (2012).
    • (2012) Am. J. Respir. Crit. Care Med. , vol.186 , pp. 877-885
    • Fischer, A.1
  • 19
    • 84859224216 scopus 로고    scopus 로고
    • A meta-analysis and genome-wide association study of platelet count and mean platelet volume in African Americans
    • Qayyum, R. et al. A meta-analysis and genome-wide association study of platelet count and mean platelet volume in African Americans. PLoS Genet. 8, e1002491 (2012).
    • (2012) PLoS Genet. , vol.8 , pp. e1002491
    • Qayyum, R.1
  • 20
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • Jostins, L. et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491, 119-124 (2012).
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1
  • 21
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke, A. et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat. Genet. 42, 1118-1125 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 1118-1125
    • Franke, A.1
  • 22
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett, J.C. et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40, 955-962 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 955-962
    • Barrett, J.C.1
  • 23
    • 77950243833 scopus 로고    scopus 로고
    • Multiple common variants for celiac disease influencing immune gene expression
    • Dubois, P.C. et al. Multiple common variants for celiac disease influencing immune gene expression. Nat. Genet. 42, 295-302 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 295-302
    • Dubois, P.C.1
  • 24
    • 41349103493 scopus 로고    scopus 로고
    • Newly identified genetic risk variants for celiac disease related to the immune response
    • Hunt, K.A. et al. Newly identified genetic risk variants for celiac disease related to the immune response. Nat. Genet. 40, 395-402 (2008).
    • (2008) Nat. Genet. , vol.40 , pp. 395-402
    • Hunt, K.A.1
  • 25
    • 84868195423 scopus 로고    scopus 로고
    • Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population
    • Hirota, T. et al. Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. Nat. Genet. 44, 1222-1226 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 1222-1226
    • Hirota, T.1
  • 26
    • 69449097214 scopus 로고    scopus 로고
    • Crohn's disease as an immune deficiency?
    • Coulombe, F. & Behr, M.A. Crohn's disease as an immune deficiency? Lancet 374, 769-770 (2009).
    • (2009) Lancet , vol.374 , pp. 769-770
    • Coulombe, F.1    Behr, M.A.2
  • 27
    • 69549121823 scopus 로고    scopus 로고
    • Revisiting Crohn's disease as a primary immunodeficiency of macrophages
    • Casanova, J.L. & Abel, L. Revisiting Crohn's disease as a primary immunodeficiency of macrophages. J. Exp. Med. 206, 1839-1843 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 1839-1843
    • Casanova, J.L.1    Abel, L.2
  • 28
    • 63449119636 scopus 로고    scopus 로고
    • Where are all the Mycobacterium avium subspecies paratuberculosis in patients with Crohn's disease?
    • Pierce, E.S. Where are all the Mycobacterium avium subspecies paratuberculosis in patients with Crohn's disease? PLoS Pathog. 5, e1000234 (2009).
    • (2009) PLoS Pathog. , vol.5 , pp. e1000234
    • Pierce, E.S.1
  • 29
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: A tool set for whole-genome association and populationbased linkage analyses
    • Purcell, S. et al. PLINK: a tool set for whole-genome association and populationbased linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 559-575
    • Purcell, S.1
  • 30
    • 84856478855 scopus 로고    scopus 로고
    • A linear complexity phasing method for thousands of genomes
    • Delaneau, O., Marchini, J. & Zagury, J.F. A linear complexity phasing method for thousands of genomes. Nat. Methods 9, 179-181 (2012).
    • (2012) Nat. Methods , vol.9 , pp. 179-181
    • Delaneau, O.1    Marchini, J.2    Zagury, J.F.3
  • 31
    • 84871952176 scopus 로고    scopus 로고
    • Improved whole-chromosome phasing for disease and population genetic studies
    • Delaneau, O., Zagury, J.F. & Marchini, J. Improved whole-chromosome phasing for disease and population genetic studies. Nat. Methods 10, 5-6 (2013).
    • (2013) Nat. Methods , vol.10 , pp. 5-6
    • Delaneau, O.1    Zagury, J.F.2    Marchini, J.3
  • 32
    • 84863845193 scopus 로고    scopus 로고
    • Genotype imputation with thousands of genomes
    • Howie, B., Marchini, J. & Stephens, M. Genotype imputation with thousands of genomes. G3 1, 457-470 (2011).
    • (2011) G3 , vol.1 , pp. 457-470
    • Howie, B.1    Marchini, J.2    Stephens, M.3
  • 33
    • 67651222400 scopus 로고    scopus 로고
    • A flexible and accurate genotype imputation method for the next generation of genome-wide association studies
    • Howie, B.N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009).
    • (2009) PLoS Genet. , vol.5 , pp. e1000529
    • Howie, B.N.1    Donnelly, P.2    Marchini, J.3
  • 34
    • 34347344976 scopus 로고    scopus 로고
    • A new multipoint method for genome-wide association studies by imputation of genotypes
    • Marchini, J., Howie, B., Myers, S., McVean, G. & Donnelly, P. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat. Genet. 39, 906-913 (2007).
    • (2007) Nat. Genet. , vol.39 , pp. 906-913
    • Marchini, J.1    Howie, B.2    Myers, S.3    McVean, G.4    Donnelly, P.5
  • 35
    • 77951751034 scopus 로고    scopus 로고
    • Meta-analysis and imputation refines the association of 15q25 with smoking quantity
    • Liu, J.Z. et al. Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat. Genet. 42, 436-440 (2010).
    • (2010) Nat. Genet. , vol.42 , pp. 436-440
    • Liu, J.Z.1
  • 36
    • 71149105110 scopus 로고    scopus 로고
    • Genetic structure of the Han Chinese population revealed by genomewide SNP variation
    • Chen, J. et al. Genetic structure of the Han Chinese population revealed by genomewide SNP variation. Am. J. Hum. Genet. 85, 775-785 (2009).
    • (2009) Am. J. Hum. Genet. , vol.85 , pp. 775-785
    • Chen, J.1
  • 37
    • 77956586071 scopus 로고    scopus 로고
    • LocusZoom: Regional visualization of genome-wide association scan results
    • Pruim, R.J. et al. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 26, 2336-2337 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 2336-2337
    • Pruim, R.J.1
  • 38
    • 0035071957 scopus 로고    scopus 로고
    • A new statistical method for haplotype reconstruction from population data
    • Stephens, M., Smith, N.J. & Donnelly, P. A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 68, 978-989 (2001).
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 978-989
    • Stephens, M.1    Smith, N.J.2    Donnelly, P.3
  • 39
    • 13844270527 scopus 로고    scopus 로고
    • Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation
    • Stephens, M. & Scheet, P. Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. Am. J. Hum. Genet. 76, 449-462 (2005).
    • (2005) Am. J. Hum. Genet. , vol.76 , pp. 449-462
    • Stephens, M.1    Scheet, P.2
  • 40
    • 33749137515 scopus 로고    scopus 로고
    • A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC
    • de Bakker, P.I. et al. A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat. Genet. 38, 1166-1172 (2006).
    • (2006) Nat. Genet. , vol.38 , pp. 1166-1172
    • De Bakker, P.I.1
  • 41
    • 35348817330 scopus 로고    scopus 로고
    • Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering
    • Browning, S.R. & Browning, B.L. Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. Am. J. Hum. Genet. 81, 1084-1097 (2007).
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 1084-1097
    • Browning, S.R.1    Browning, B.L.2
  • 42
    • 78650084232 scopus 로고    scopus 로고
    • The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
    • Pereyra, F. et al. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science 330, 1551-1557 (2010).
    • (2010) Science , vol.330 , pp. 1551-1557
    • Pereyra, F.1
  • 43
    • 70350043898 scopus 로고    scopus 로고
    • High-resolution, high-throughput HLA genotyping by nextgeneration sequencing
    • Bentley, G. et al. High-resolution, high-throughput HLA genotyping by nextgeneration sequencing. Tissue Antigens 74, 393-403 (2009).
    • (2009) Tissue Antigens , vol.74 , pp. 393-403
    • Bentley, G.1
  • 44
    • 84862776511 scopus 로고    scopus 로고
    • Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis
    • Raychaudhuri, S. et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat. Genet. 44, 291-296 (2012).
    • (2012) Nat. Genet. , vol.44 , pp. 291-296
    • Raychaudhuri, S.1
  • 45
    • 79851502150 scopus 로고    scopus 로고
    • Proteins encoded in genomic regions associated with immunemediated disease physically interact and suggest underlying biology
    • Rossin, E.J. et al. Proteins encoded in genomic regions associated with immunemediated disease physically interact and suggest underlying biology. PLoS Genet. 7, e1001273 (2011).
    • (2011) PLoS Genet. , vol.7 , pp. e1001273
    • Rossin, E.J.1
  • 46
    • 77957342306 scopus 로고    scopus 로고
    • Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits
    • Segrè, A.V. et al. Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet. 6, e1001058 (2010).
    • (2010) PLoS Genet. , vol.6 , pp. e1001058
    • Segrè, A.V.1
  • 47
    • 84894288992 scopus 로고    scopus 로고
    • Genetics of rheumatoid arthritis contributes to biology and drug discovery
    • Okada, Y. et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506, 376-381 (2014).
    • (2014) Nature , vol.506 , pp. 376-381
    • Okada, Y.1
  • 48
    • 77957232748 scopus 로고    scopus 로고
    • Genevar: A database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies
    • Yang, T.P. et al. Genevar: a database and Java application for the analysis and visualization of SNP-gene associations in eQTL studies. Bioinformatics 26, 2474-2476 (2010).
    • (2010) Bioinformatics , vol.26 , pp. 2474-2476
    • Yang, T.P.1
  • 49
    • 67651205715 scopus 로고    scopus 로고
    • Identifying relationships among genomic disease regions: Predicting genes at pathogenic SNP associations and rare deletions
    • Raychaudhuri, S. et al. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet. 5, e1000534 (2009).
    • (2009) PLoS Genet. , vol.5 , pp. e1000534
    • Raychaudhuri, S.1
  • 50
    • 58349111875 scopus 로고    scopus 로고
    • AmiGO: Online access to ontology and annotation data
    • Carbon, S. et al. AmiGO: online access to ontology and annotation data. Bioinformatics 25, 288-289 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 288-289
    • Carbon, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.