-
1
-
-
33750204720
-
Genetic studies on mutant enzymes in maize III control of gene action in the synthesis of pH 7.5 esterase
-
Schwartz D. Genetic studies on mutant enzymes in maize. III. Control of gene action in the synthesis of pH 7.5 esterase. Genetics 47, 1609-1615 (1962
-
(1962)
Genetics
, vol.47
, pp. 1609-1615
-
-
Schwartz, D.1
-
2
-
-
0035400051
-
Genetical genomics: The added value from segregation
-
Jansen R. C. & Nap J. P. Genetical genomics: the added value from segregation. Trends Genet. 17, 388-391 (2001
-
(2001)
Trends Genet
, vol.17
, pp. 388-391
-
-
Jansen, R.C.1
Nap, J.P.2
-
3
-
-
0037177625
-
Genetic dissection of transcriptional regulation in budding yeast
-
Brem R. B., Yvert G., Clinton R. & Kruglyak L. Genetic dissection of transcriptional regulation in budding yeast. Science 296, 752-755 (2002
-
(2002)
Science
, vol.296
, pp. 752-755
-
-
Brem, R.B.1
Yvert, G.2
Clinton, R.3
Kruglyak, L.4
-
4
-
-
0037456823
-
Genetics of gene expression surveyed in maize mouse and man
-
Schadt E. E., et al. Genetics of gene expression surveyed in maize mouse and man. Nature 422, 297-302 (2003
-
(2003)
Nature
, vol.422
, pp. 297-302
-
-
Schadt, E.E.1
-
5
-
-
0028285005
-
Quantitative trait loci underlying gene product variation: A novel perspective for analyzing regulation of genome expression
-
Damerval C., Maurice A., Josse J. M. & de Vienne D. Quantitative trait loci underlying gene product variation: a novel perspective for analyzing regulation of genome expression. Genetics 137, 289-301 (1994
-
(1994)
Genetics
, vol.137
, pp. 289-301
-
-
Damerval, C.1
Maurice, A.2
Josse, J.M.3
De Vienne, D.4
-
6
-
-
55449112185
-
Genome-wide associations of gene expression variation in humans
-
Stranger B. E., et al. Genome-wide associations of gene expression variation in humans. PLoS Genet. 1, e78 (2005
-
(2005)
Plos Genet
, vol.1
, pp. e78
-
-
Stranger, B.E.1
-
7
-
-
34548738566
-
Population genomics of human gene expression
-
Stranger B. E., et al. Population genomics of human gene expression. Nature Genet. 39, 1217-1224 (2007
-
(2007)
Nature Genet
, vol.39
, pp. 1217-1224
-
-
Stranger, B.E.1
-
8
-
-
69949176863
-
Common regulatory variation impacts gene expression in a cell type-dependent manner
-
Dimas A. S., et al. Common regulatory variation impacts gene expression in a cell type-dependent manner. Science 325, 1246-1250 (2009
-
(2009)
Science
, vol.325
, pp. 1246-1250
-
-
Dimas, A.S.1
-
9
-
-
4043128071
-
Genetic analysis of genome-wide variation in human gene expression
-
Morley M., et al. Genetic analysis of genome-wide variation in human gene expression. Nature 430, 743-747 (2004
-
(2004)
Nature
, vol.430
, pp. 743-747
-
-
Morley, M.1
-
10
-
-
41349095280
-
Genetics of gene expression and its effect on disease
-
Emilsson V., et al. Genetics of gene expression and its effect on disease. Nature 452, 423-428 (2008
-
(2008)
Nature
, vol.452
, pp. 423-428
-
-
Emilsson, V.1
-
11
-
-
27644482314
-
Mapping determinants of human gene expression by regional and genome-wide association
-
Cheung V. G., et al. Mapping determinants of human gene expression by regional and genome-wide association. Nature 437, 1365-1369 (2005
-
(2005)
Nature
, vol.437
, pp. 1365-1369
-
-
Cheung, V.G.1
-
12
-
-
33846978695
-
Relative impact of nucleotide and copy number variation on gene expression phenotypes
-
Stranger B. E., et al. Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science 315, 848-853 (2007
-
(2007)
Science
, vol.315
, pp. 848-853
-
-
Stranger, B.E.1
-
13
-
-
33750204290
-
Genetics of global gene expression
-
Rockman M. V. & Kruglyak L. Genetics of global gene expression. Nature Rev. Genet. 7, 862-872 (2006
-
(2006)
Nature Rev. Genet
, vol.7
, pp. 862-872
-
-
Rockman, M.V.1
Kruglyak, L.2
-
14
-
-
84862524625
-
Functional genomic architecture of predisposition to voluntary exercise in mice: Expression QTL in the brain
-
Kelly S. A., Nehrenberg D. L., Hua K., Garland T. & Pomp D. Functional genomic architecture of predisposition to voluntary exercise in mice: expression QTL in the brain. Genetics 191, 643-654 (2012
-
(2012)
Genetics
, vol.191
, pp. 643-654
-
-
Kelly, S.A.1
Nehrenberg, D.L.2
Hua, K.3
Garland, T.4
Pomp, D.5
-
15
-
-
84908627915
-
Genetic influences on brain gene expression in rats selected for tameness and aggression
-
Heyne H. O., et al. Genetic influences on brain gene expression in rats selected for tameness and aggression. Genetics 198, 1277-1290 (2014
-
(2014)
Genetics
, vol.198
, pp. 1277-1290
-
-
Heyne, H.O.1
-
16
-
-
84868036620
-
Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages
-
Orozco L. D., et al. Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell 151, 658-670 (2012
-
(2012)
Cell
, vol.151
, pp. 658-670
-
-
Orozco, L.D.1
-
17
-
-
20144377218
-
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
-
Hubner N., et al. Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease. Nature Genet. 37, 243-253 (2005
-
(2005)
Nature Genet
, vol.37
, pp. 243-253
-
-
Hubner, N.1
-
18
-
-
79957658264
-
Genetic analysis of complex traits in the emerging collaborative cross
-
Aylor D. L., et al. Genetic analysis of complex traits in the emerging collaborative cross. Genome Res. 21, 1213-1222 (2011
-
(2011)
Genome Res
, vol.21
, pp. 1213-1222
-
-
Aylor, D.L.1
-
19
-
-
40749105508
-
Variations in DNA elucidate molecular networks that cause disease
-
Chen Y., et al. Variations in DNA elucidate molecular networks that cause disease. Nature 452, 429-435 (2008
-
(2008)
Nature
, vol.452
, pp. 429-435
-
-
Chen, Y.1
-
20
-
-
22844446947
-
An integrative genomics approach to infer causal associations between gene expression and disease
-
Schadt E. E., et al. An integrative genomics approach to infer causal associations between gene expression and disease. Nature Genet. 37, 710-717 (2005
-
(2005)
Nature Genet
, vol.37
, pp. 710-717
-
-
Schadt, E.E.1
-
21
-
-
84870693546
-
Genomic variation and its impact on gene expression in Drosophila melanogaster
-
Massouras A., et al. Genomic variation and its impact on gene expression in Drosophila melanogaster. PLoS Genet. 8, e1003055 (2012
-
(2012)
Plos Genet
, vol.8
, pp. e1003055
-
-
Massouras, A.1
-
22
-
-
84901611017
-
Genetic dissection of the drosophila melanogaster female head transcriptome reveals widespread allelic heterogeneity
-
King E. G., Sanderson B. J., McNeil C. L., Long A. D. & Macdonald S. J. Genetic dissection of the Drosophila melanogaster female head transcriptome reveals widespread allelic heterogeneity. PLoS Genet. 10, e1004322 (2014
-
(2014)
Plos Genet
, vol.10
, pp. e1004322
-
-
King, E.G.1
Sanderson, B.J.2
McNeil, C.L.3
Long, A.D.4
MacDonald, S.J.5
-
23
-
-
34249055193
-
Global eqtl mapping reveals the complex genetic architecture of transcript-level variation in arabidopsis
-
West M. A., et al. Global eQTL mapping reveals the complex genetic architecture of transcript-level variation in Arabidopsis. Genetics 175, 1441-1450 (2006
-
(2006)
Genetics
, vol.175
, pp. 1441-1450
-
-
West, M.A.1
-
24
-
-
70450180852
-
Paternal dominance of trans-eQTL influences gene expression patterns in maize hybrids
-
Swanson-Wagner R. A., et al. Paternal dominance of trans-eQTL influences gene expression patterns in maize hybrids. Science 326, 1118-1120 (2009
-
(2009)
Science
, vol.326
, pp. 1118-1120
-
-
Swanson-Wagner, R.A.1
-
25
-
-
59149100506
-
System-wide molecular evidence for phenotypic buffering in arabidopsis
-
Fu, J., et al. System-wide molecular evidence for phenotypic buffering in Arabidopsis. Nature Genet. 41, 166-167 (2009
-
(2009)
Nature Genet
, vol.41
, pp. 166-167
-
-
Fu, J.1
-
26
-
-
33846818896
-
Regulatory network construction in Arabidopsis by using genome-wide gene expression quantitative trait loci
-
Keurentjes J. J., et al. Regulatory network construction in Arabidopsis by using genome-wide gene expression quantitative trait loci. Proc. Natl Acad. Sci. 104, 1708-1713 (2007
-
(2007)
Proc. Natl Acad. Sci
, vol.104
, pp. 1708-1713
-
-
Keurentjes, J.J.1
-
27
-
-
84858843257
-
Expression variation in connected recombinant populations of arabidopsis thaliana highlights distinct transcriptome architectures
-
Cubillos F. A., et al. Expression variation in connected recombinant populations of Arabidopsis thaliana highlights distinct transcriptome architectures. BMC Genomics 13, 117 (2012
-
(2012)
BMC Genomics
, vol.13
, pp. 117
-
-
Cubillos, F.A.1
-
28
-
-
84890685736
-
RNA sequencing reveals the complex regulatory network in the maize kernel
-
Fu, J., et al. RNA sequencing reveals the complex regulatory network in the maize kernel. Nature Commun. 4, 2832 (2013
-
(2013)
Nature Commun
, vol.4
, pp. 2832
-
-
Fu, J.1
-
29
-
-
79959675162
-
Genome-wide expression quantitative trait loci (eqtl) analysis in maize
-
Holloway B., Luck S., Beatty M., Rafalski J. A. & Li, B. Genome-wide expression quantitative trait loci (eQTL) analysis in maize. BMC Genomics 12, 336 (2011
-
(2011)
BMC Genomics
, vol.12
, pp. 336
-
-
Holloway, B.1
Luck, S.2
Beatty, M.3
Rafalski, J.A.4
Li, B.5
-
30
-
-
84886561316
-
Expression quantitative trait locus mapping across water availability environments reveals contrasting associations with genomic features in arabidopsis
-
Lowry D. B., et al. Expression quantitative trait locus mapping across water availability environments reveals contrasting associations with genomic features in Arabidopsis. Plant Cell 25, 3266-3279 (2013
-
(2013)
Plant Cell
, vol.25
, pp. 3266-3279
-
-
Lowry, D.B.1
-
31
-
-
77957942349
-
Selection at linked sites shapes heritable phenotypic variation in C. Elegans
-
Rockman M. V., Skrovanek S. S. & Kruglyak L. Selection at linked sites shapes heritable phenotypic variation in C. elegans. Science 330, 372-376 (2010
-
(2010)
Science
, vol.330
, pp. 372-376
-
-
Rockman, M.V.1
Skrovanek, S.S.2
Kruglyak, L.3
-
32
-
-
33845976693
-
Mapping determinants of gene expression plasticity by genetical genomics in C. Elegans
-
Li Y., et al. Mapping determinants of gene expression plasticity by genetical genomics in C. elegans. PLoS Genet. 2, e222 (2006
-
(2006)
Plos Genet
, vol.2
, pp. e222
-
-
Li, Y.1
-
33
-
-
0042856391
-
Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors
-
Yvert G., et al. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nature Genet. 35, 57-64 (2003
-
(2003)
Nature Genet
, vol.35
, pp. 57-64
-
-
Yvert, G.1
-
34
-
-
84865822182
-
Systematic localization of common disease-associated variation in regulatory DNA
-
Maurano M. T., et al. Systematic localization of common disease-associated variation in regulatory DNA. Science 337, 1190-1195 (2012
-
(2012)
Science
, vol.337
, pp. 1190-1195
-
-
Maurano, M.T.1
-
35
-
-
77956494602
-
The genetic basis of evolutionary change in gene expression levels
-
Emerson J. J. & Li, W. H. The genetic basis of evolutionary change in gene expression levels. Phil. Trans. R. Soc. B 365, 2581-2590 (2010
-
(2010)
Phil. Trans. R. Soc. B
, vol.365
, pp. 2581-2590
-
-
Emerson, J.J.1
Li, W.H.2
-
37
-
-
84901056381
-
Determining causality and consequence of expression quantitative trait loci
-
Battle A. & Montgomery S. B. Determining causality and consequence of expression quantitative trait loci. Hum. Genet. 133, 727-735 (2014
-
(2014)
Hum. Genet
, vol.133
, pp. 727-735
-
-
Battle, A.1
Montgomery, S.B.2
-
38
-
-
84857192201
-
Cellular genomics for complex traits
-
Dermitzakis E. T. Cellular genomics for complex traits. Nature Rev. Genet. 13, 215-220 (2012
-
(2012)
Nature Rev. Genet
, vol.13
, pp. 215-220
-
-
Dermitzakis, E.T.1
-
39
-
-
84878497307
-
Global properties and functional complexity of human gene regulatory variation
-
Gaffney D. J. Global properties and functional complexity of human gene regulatory variation. PLoS Genet. 9, e1003501 (2013
-
(2013)
Plos Genet
, vol.9
, pp. e1003501
-
-
Gaffney, D.J.1
-
40
-
-
84890546613
-
Systems genetics approaches to understand complex traits
-
Civelek M. & Lusis A. J. Systems genetics approaches to understand complex traits. Nature Rev. Genet. 15, 34-48 (2014
-
(2014)
Nature Rev. Genet
, vol.15
, pp. 34-48
-
-
Civelek, M.1
Lusis, A.J.2
-
42
-
-
3042722019
-
Evolutionary changes in cis and trans gene regulation
-
Wittkopp P. J., Haerum B. K. & Clark A. G. Evolutionary changes in cis and trans gene regulation. Nature 430, 85-88 (2004
-
(2004)
Nature
, vol.430
, pp. 85-88
-
-
Wittkopp, P.J.1
Haerum, B.K.2
Clark, A.G.3
-
43
-
-
77950458649
-
Transcriptome genetics using second generation sequencing in a caucasian population
-
Montgomery S. B., et al. Transcriptome genetics using second generation sequencing in a Caucasian population. Nature 464, 773-777 (2010
-
(2010)
Nature
, vol.464
, pp. 773-777
-
-
Montgomery, S.B.1
-
44
-
-
77950460661
-
Understanding mechanisms underlying human gene expression variation with RNA sequencing
-
Pickrell J. K., et al. Understanding mechanisms underlying human gene expression variation with RNA sequencing. Nature 464, 768-772 (2010
-
(2010)
Nature
, vol.464
, pp. 768-772
-
-
Pickrell, J.K.1
-
45
-
-
19844366096
-
Cis-acting expression quantitative trait loci in mice
-
Doss S., Schadt E. E., Drake T. A. & Lusis A. J. Cis-acting expression quantitative trait loci in mice. Genome Res. 15, 681-691 (2005
-
(2005)
Genome Res
, vol.15
, pp. 681-691
-
-
Doss, S.1
Schadt, E.E.2
Drake, T.A.3
Lusis, A.J.4
-
46
-
-
0037119584
-
Allelic variation in human gene expression
-
Yan H., Yuan W., Velculescu V. E., Vogelstein B. & Kinzler K. W. Allelic variation in human gene expression. Science 297, 1143 (2002
-
(2002)
Science
, vol.297
, pp. 1143
-
-
Yan, H.1
Yuan, W.2
Velculescu, V.E.3
Vogelstein, B.4
Kinzler, K.W.5
-
47
-
-
84891685308
-
Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals
-
Battle A., et al. Characterizing the genetic basis of transcriptome diversity through RNA-sequencing of 922 individuals. Genome Res. 24, 14-24 (2014
-
(2014)
Genome Res
, vol.24
, pp. 14-24
-
-
Battle, A.1
-
48
-
-
40149096663
-
The evolution of gene expression QTL in Saccharomyces cerevisiae
-
Ronald J. & Akey J. M. The evolution of gene expression QTL in Saccharomyces cerevisiae. PLoS ONE 2, e678 (2007
-
(2007)
Plos One
, vol.2
, pp. e678
-
-
Ronald, J.1
Akey, J.M.2
-
49
-
-
34548719076
-
Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes
-
Göring H. H., et al. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nature Genet. 39, 1208-1216 (2007
-
(2007)
Nature Genet
, vol.39
, pp. 1208-1216
-
-
Göring, H.H.1
-
50
-
-
43249129715
-
Gene-environment interaction in yeast gene expression
-
Smith E. N. & Kruglyak L. Gene-environment interaction in yeast gene expression. PLoS Biol. 6, e83 (2008
-
(2008)
Plos Biol
, vol.6
, pp. e83
-
-
Smith, E.N.1
Kruglyak, L.2
-
51
-
-
84924081178
-
Natural genetic variation impacts expression levels of coding non-coding and antisense transcripts in fission yeast
-
Clement-Ziza M., et al. Natural genetic variation impacts expression levels of coding non-coding and antisense transcripts in fission yeast. Mol. Syst. Biol. 10, 764 (2014
-
(2014)
Mol. Syst. Biol
, vol.10
, pp. 764
-
-
Clement-Ziza, M.1
-
52
-
-
84874682007
-
Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans
-
Langley S. R., et al. Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans. Cardiovasc. Res. 97, 653-665 (2013
-
(2013)
Cardiovasc. Res
, vol.97
, pp. 653-665
-
-
Langley, S.R.1
-
53
-
-
20144383240
-
Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics
-
Bystrykh L., et al. Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nature Genet. 37, 225-232 (2005
-
(2005)
Nature Genet
, vol.37
, pp. 225-232
-
-
Bystrykh, L.1
-
54
-
-
20144386111
-
Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
-
Chesler E. J., et al. Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nature Genet. 37, 233-242 (2005
-
(2005)
Nature Genet
, vol.37
, pp. 233-242
-
-
Chesler, E.J.1
-
55
-
-
45149106353
-
Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks
-
Zhu J., et al. Integrating large-scale functional genomic data to dissect the complexity of yeast regulatory networks. Nature Genet. 40, 854-861 (2008
-
(2008)
Nature Genet
, vol.40
, pp. 854-861
-
-
Zhu, J.1
-
56
-
-
23644434284
-
Genetic interactions between polymorphisms that affect gene expression in yeast
-
Brem R. B., Storey J. D., Whittle J. & Kruglyak L. Genetic interactions between polymorphisms that affect gene expression in yeast. Nature 436, 701-703 (2005
-
(2005)
Nature
, vol.436
, pp. 701-703
-
-
Brem, R.B.1
Storey, J.D.2
Whittle, J.3
Kruglyak, L.4
-
57
-
-
79959812980
-
Comparative analysis of proteome and transcriptome variation in mouse
-
Ghazalpour A., et al. Comparative analysis of proteome and transcriptome variation in mouse. PLoS Genet. 7, e1001393 (2011
-
(2011)
Plos Genet
, vol.7
, pp. e1001393
-
-
Ghazalpour, A.1
-
58
-
-
8844244726
-
Genetic inheritance of gene expression in human cell lines
-
Monks S. A., et al. Genetic inheritance of gene expression in human cell lines. Am. J. Hum. Genet. 75, 1094-1105 (2004
-
(2004)
Am. J. Hum. Genet
, vol.75
, pp. 1094-1105
-
-
Monks, S.A.1
-
59
-
-
33750481513
-
Heritability and tissue specificity of expression quantitative trait loci
-
Petretto E., et al. Heritability and tissue specificity of expression quantitative trait loci. PLoS Genet. 2, e172 (2006
-
(2006)
Plos Genet
, vol.2
, pp. e172
-
-
Petretto, E.1
-
60
-
-
77957915239
-
Expression quantitative trait loci: Replication tissue- and sex-specificity in mice
-
van Nas A., et al. Expression quantitative trait loci: replication tissue- and sex-specificity in mice. Genetics 185, 1059-1068 (2010
-
(2010)
Genetics
, vol.185
, pp. 1059-1068
-
-
Van Nas, A.1
-
61
-
-
79952263851
-
Single-tissue and cross-tissue heritability of gene expression via identity-by descent in related or unrelated individuals
-
Price A. L., et al. Single-tissue and cross-tissue heritability of gene expression via identity-by descent in related or unrelated individuals. PLoS Genet. 7, e1001317 (2011
-
(2011)
Plos Genet
, vol.7
, pp. e1001317
-
-
Price, A.L.1
-
62
-
-
84866871814
-
Mapping cis- and trans-regulatory effects across multiple tissues in twins
-
Grundberg E., et al. Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nature Genet. 44, 1084-1089 (2012
-
(2012)
Nature Genet
, vol.44
, pp. 1084-1089
-
-
Grundberg, E.1
-
63
-
-
84899642574
-
Heritability and genomics of gene expression in peripheral blood
-
Wright F. A., et al. Heritability and genomics of gene expression in peripheral blood. Nature Genet. 46, 430-437 (2014
-
(2014)
Nature Genet
, vol.46
, pp. 430-437
-
-
Wright, F.A.1
-
64
-
-
77954140531
-
Common SNPs explain a large proportion of the heritability for human height
-
Yang J., et al. Common SNPs explain a large proportion of the heritability for human height. Nature Genet. 42, 565-569 (2010
-
(2010)
Nature Genet
, vol.42
, pp. 565-569
-
-
Yang, J.1
-
66
-
-
84860317030
-
Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles
-
Fairfax B. P., et al. Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles. Nature Genet. 44, 502-510 (2012
-
(2012)
Nature Genet
, vol.44
, pp. 502-510
-
-
Fairfax, B.P.1
-
67
-
-
84896742056
-
Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression
-
Fairfax B. P., et al. Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression. Science 343, 1246949 (2014
-
(2014)
Science
, vol.343
, pp. 1246949
-
-
Fairfax, B.P.1
-
68
-
-
84855267424
-
Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans
-
Rotival M., et al. Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans. PLoS Genet. 7, e1002367 (2011
-
(2011)
Plos Genet
, vol.7
, pp. e1002367
-
-
Rotival, M.1
-
69
-
-
77957126059
-
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
-
Heinig M., et al. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature 467, 460-464 (2010
-
(2010)
Nature
, vol.467
, pp. 460-464
-
-
Heinig, M.1
-
70
-
-
84885018609
-
Systematic identification of trans eQTLs as putative drivers of known disease associations
-
Westra H. J., et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genet. 45, 1238-1243 (2013
-
(2013)
Nature Genet
, vol.45
, pp. 1238-1243
-
-
Westra, H.J.1
-
71
-
-
80052322958
-
Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes with a major role for the HLA
-
Fehrmann R. S., et al. Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes with a major role for the HLA. PLoS Genet. 7, e1002197 (2011
-
(2011)
Plos Genet
, vol.7
, pp. e1002197
-
-
Fehrmann, R.S.1
-
72
-
-
84905484562
-
Cis and trans effects of human genomic variants on gene expression
-
Bryois J., et al. Cis and trans effects of human genomic variants on gene expression. PLoS Genet. 10, e1004461 (2014
-
(2014)
Plos Genet
, vol.10
, pp. e1004461
-
-
Bryois, J.1
-
73
-
-
84900338300
-
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
-
Raj T., et al. Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science 344, 519-523 (2014
-
(2014)
Science
, vol.344
, pp. 519-523
-
-
Raj, T.1
-
74
-
-
84896759364
-
Common genetic variants modulate pathogen-sensing responses in human dendritic cells
-
Lee M. N., et al. Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science 343, 1246980 (2014
-
(2014)
Science
, vol.343
, pp. 1246980
-
-
Lee, M.N.1
-
75
-
-
77950854479
-
Heritable individual-specific and allele-specific chromatin signatures in humans
-
McDaniell R., et al. Heritable individual-specific and allele-specific chromatin signatures in humans. Science 328, 235-239 (2010
-
(2010)
Science
, vol.328
, pp. 235-239
-
-
McDaniell, R.1
-
76
-
-
84859916280
-
Effects of sequence variation on differential allelic transcription factor occupancy and gene expression
-
Reddy T. E., et al. Effects of sequence variation on differential allelic transcription factor occupancy and gene expression. Genome Res. 22, 860-869 (2012
-
(2012)
Genome Res
, vol.22
, pp. 860-869
-
-
Reddy, T.E.1
-
77
-
-
77950833803
-
Variation in transcription factor binding among humans
-
Kasowski M., et al. Variation in transcription factor binding among humans. Science 328, 232-235 (2010
-
(2010)
Science
, vol.328
, pp. 232-235
-
-
Kasowski, M.1
-
78
-
-
84888641656
-
Effect of natural genetic variation on enhancer selection and function
-
Heinz S., et al. Effect of natural genetic variation on enhancer selection and function. Nature 503, 487-492 (2013
-
(2013)
Nature
, vol.503
, pp. 487-492
-
-
Heinz, S.1
-
79
-
-
84912078506
-
Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X chromosome association
-
Ding Z., et al. Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X chromosome association. PLoS Genet. 10, e1004798 (2014
-
(2014)
Plos Genet
, vol.10
, pp. e1004798
-
-
Ding, Z.1
-
80
-
-
84857111200
-
DNase i sensitivity QTLs are a major determinant of human expression variation
-
Degner J. F., et al. DNase I sensitivity QTLs are a major determinant of human expression variation. Nature 482, 390-394 (2012
-
(2012)
Nature
, vol.482
, pp. 390-394
-
-
Degner, J.F.1
-
81
-
-
84874764357
-
Genetic landscape of open chromatin in yeast
-
Lee K., et al. Genetic landscape of open chromatin in yeast. PLoS Genet. 9, e1003229 (2013
-
(2013)
Plos Genet
, vol.9
, pp. e1003229
-
-
Lee, K.1
-
82
-
-
84883703352
-
DNA methylation contributes to natural human variation
-
Heyn H., et al. DNA methylation contributes to natural human variation. Genome Res. 23, 1363-1372 (2013
-
(2013)
Genome Res
, vol.23
, pp. 1363-1372
-
-
Heyn, H.1
-
83
-
-
79960688508
-
DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines
-
Bell J. T., et al. DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. Genome Biol. 12, R10 (2011
-
(2011)
Genome Biol
, vol.12
, pp. R10
-
-
Bell, J.T.1
-
84
-
-
84907584646
-
Methylation QTLs are associated with coordinated changes in transcription factor binding histone modifications and gene expression levels
-
Banovich N. E., et al. Methylation QTLs are associated with coordinated changes in transcription factor binding histone modifications and gene expression levels. PLoS Genet. 10, e1004663 (2014
-
(2014)
Plos Genet
, vol.10
, pp. e1004663
-
-
Banovich, N.E.1
-
85
-
-
84879055641
-
Passive and active DNA methylation and the interplay with genetic variation in gene regulation
-
Gutierrez-Arcelus M., et al. Passive and active DNA methylation and the interplay with genetic variation in gene regulation. eLife 2, e00523 (2013
-
(2013)
ELife
, vol.2
, pp. e00523
-
-
Gutierrez-Arcelus, M.1
-
86
-
-
84991529670
-
Contribution of genetic variation to transgenerational inheritance of DNA methylation
-
McRae A. F., et al. Contribution of genetic variation to transgenerational inheritance of DNA methylation. Genome Biol. 15, R73 (2014
-
(2014)
Genome Biol
, vol.15
, pp. R73
-
-
McRae, A.F.1
-
87
-
-
78650689920
-
Noisy splicing drives mrna isoform diversity in human cells
-
Pickrell J. K., Pai A. A., Gilad Y. & Pritchard J. K. Noisy splicing drives mRNA isoform diversity in human cells. PLoS Genet. 6, e1001236 (2010
-
(2010)
PLoS Genet
, vol.6
, pp. e1001236
-
-
Pickrell, J.K.1
Pai, A.A.2
Gilad, Y.3
Pritchard, J.K.4
-
88
-
-
84885645853
-
Transcriptome and genome sequencing uncovers functional variation in humans
-
Lappalainen T., et al. Transcriptome and genome sequencing uncovers functional variation in humans. Nature 501, 506-511 (2013
-
(2013)
Nature
, vol.501
, pp. 506-511
-
-
Lappalainen, T.1
-
89
-
-
84895515619
-
The genetic basis for individual differences in mrna splicing and apobec1 editing activity in murine macrophages
-
Hassan M. A., Butty V., Jensen K. D. & Saeij J. P. The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages. Genome Res. 24, 377-389 (2014
-
(2014)
Genome Res
, vol.24
, pp. 377-389
-
-
Hassan, M.A.1
Butty, V.2
Jensen, K.D.3
Saeij, J.P.4
-
90
-
-
84880254076
-
Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits
-
Civelek M., et al. Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits. Hum. Mol. Genet. 22, 3023-3037 (2013
-
(2013)
Hum. Mol. Genet
, vol.22
, pp. 3023-3037
-
-
Civelek, M.1
-
91
-
-
84863641258
-
Extent causes and consequences of small RNA expression variation in human adipose tissue
-
Parts L., et al. Extent causes and consequences of small RNA expression variation in human adipose tissue. PLoS Genet. 8, e1002704 (2012
-
(2012)
Plos Genet
, vol.8
, pp. e1002704
-
-
Parts, L.1
-
93
-
-
84873489136
-
Human disease-associated genetic variation impacts large intergenic non-coding RNA expression
-
Kumar V., et al. Human disease-associated genetic variation impacts large intergenic non-coding RNA expression. PLoS Genet. 9, e1003201 (2013
-
(2013)
Plos Genet
, vol.9
, pp. e1003201
-
-
Kumar, V.1
-
94
-
-
84868154284
-
The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels
-
Pai A. A., et al. The contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels. PLoS Genet. 8, e1003000 (2012
-
(2012)
Plos Genet
, vol.8
, pp. e1003000
-
-
Pai, A.A.1
-
96
-
-
84865790047
-
An integrated encyclopedia of DNA elements in the human genome
-
ENCODE Project Consortium
-
ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57-74 (2012
-
(2012)
Nature
, vol.489
, pp. 57-74
-
-
-
97
-
-
84887322043
-
Identification of genetic variants that affect histone modifications in human cells
-
McVicker G., et al. Identification of genetic variants that affect histone modifications in human cells. Science 342, 747-749 (2013
-
(2013)
Science
, vol.342
, pp. 747-749
-
-
McVicker, G.1
-
98
-
-
84887320563
-
Coordinated effects of sequence variation on DNA binding chromatin structure and transcription
-
Kilpinen H., et al. Coordinated effects of sequence variation on DNA binding chromatin structure and transcription. Science 342, 744-747 (2013
-
(2013)
Science
, vol.342
, pp. 744-747
-
-
Kilpinen, H.1
-
99
-
-
84887320760
-
Extensive variation in chromatin states across humans
-
Kasowski M., et al. Extensive variation in chromatin states across humans. Science 342, 750-752 (2013
-
(2013)
Science
, vol.342
, pp. 750-752
-
-
Kasowski, M.1
-
100
-
-
77955499945
-
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
-
Musunuru K., et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature 466, 714-719 (2010
-
(2010)
Nature
, vol.466
, pp. 714-719
-
-
Musunuru, K.1
-
101
-
-
79951473520
-
9p21 DNA variants associated with coronary artery disease impair interferon γ signalling response
-
Harismendy O., et al. 9p21 DNA variants associated with coronary artery disease impair interferon γ signalling response. Nature 470, 264-268 (2011
-
(2011)
Nature
, vol.470
, pp. 264-268
-
-
Harismendy, O.1
-
102
-
-
77955081986
-
Differential contributions of rare and common coding and noncoding Ret mutations to multifactorial Hirschsprung disease liability
-
Emison E. S., et al. Differential contributions of rare and common coding and noncoding Ret mutations to multifactorial Hirschsprung disease liability. Am. J. Hum. Genet. 87, 60-74 (2010
-
(2010)
Am. J. Hum. Genet
, vol.87
, pp. 60-74
-
-
Emison, E.S.1
-
103
-
-
33744475085
-
A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter
-
De Gobbi M., et al. A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter. Science 312, 1215-1217 (2006
-
(2006)
Science
, vol.312
, pp. 1215-1217
-
-
De Gobbi, M.1
-
104
-
-
84884690501
-
The molecular mechanism of a cis-regulatory adaptation in yeast
-
Chang J., et al. The molecular mechanism of a cis-regulatory adaptation in yeast. PLoS Genet. 9, e1003813 (2013
-
(2013)
Plos Genet
, vol.9
, pp. e1003813
-
-
Chang, J.1
-
105
-
-
59249086642
-
Learning a prior on regulatory potential from eQTL data
-
Lee S. I., et al. Learning a prior on regulatory potential from eQTL data. PLoS Genet. 5, e1000358 (2009
-
(2009)
Plos Genet
, vol.5
, pp. e1000358
-
-
Lee, S.I.1
-
106
-
-
84907977170
-
Genetic architecture of ethanol-responsive transcriptome variation in saccharomyces cerevisiae strains
-
Lewis J. A., Broman A. T., Will J. & Gasch A. P. Genetic architecture of ethanol-responsive transcriptome variation in Saccharomyces cerevisiae strains. Genetics 198, 369-382 (2014
-
(2014)
Genetics
, vol.198
, pp. 369-382
-
-
Lewis, J.A.1
Broman, A.T.2
Will, J.3
Gasch, A.P.4
-
107
-
-
13444288378
-
Proteasomal degradation of human cyp1b1: Effect of the asn453ser polymorphism on the post-translational regulation of cyp1b1 expression
-
Bandiera S., et al. Proteasomal degradation of human CYP1B1: effect of the Asn453Ser polymorphism on the post-translational regulation of CYP1B1 expression. Mol. Pharmacol. 67, 435-443 (2005
-
(2005)
Mol. Pharmacol
, vol.67
, pp. 435-443
-
-
Bandiera, S.1
-
108
-
-
84887433583
-
Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories
-
't Hoen P. A., et al. Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories. Nature Biotech. 31, 1015-1022 (2013
-
(2013)
Nature Biotech
, vol.31
, pp. 1015-1022
-
-
T'Hoen, P.A.1
-
109
-
-
44949201115
-
A genome-wide association study identifies protein quantitative trait loci (pqtls
-
Melzer D., et al. A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet. 4, e1000072 (2008
-
(2008)
Plos Genet
, vol.4
, pp. e1000072
-
-
Melzer, D.1
-
110
-
-
77954732472
-
Identification of quantitative trait loci underlying proteome variation in human lymphoblastoid cells
-
Garge N., et al. Identification of quantitative trait loci underlying proteome variation in human lymphoblastoid cells. Mol. Cell. Proteomics 9, 1383-1399 (2010
-
(2010)
Mol. Cell. Proteomics
, vol.9
, pp. 1383-1399
-
-
Garge, N.1
-
111
-
-
84905912559
-
Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels
-
Hause R. J., et al. Identification and validation of genetic variants that influence transcription factor and cell signaling protein levels. Am. J. Hum. Genet. 95, 194-208 (2014
-
(2014)
Am. J. Hum. Genet
, vol.95
, pp. 194-208
-
-
Hause, R.J.1
-
112
-
-
84922469439
-
Impact of regulatory variation from RNA to protein
-
Battle A., et al. Impact of regulatory variation from RNA to protein. Science 347, 664-667 (2015
-
(2015)
Science
, vol.347
, pp. 664-667
-
-
Battle, A.1
-
113
-
-
84873724658
-
A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis
-
Picotti P., et al. A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis. Nature 494, 266-270 (2013
-
(2013)
Nature
, vol.494
, pp. 266-270
-
-
Picotti, P.1
-
114
-
-
84865083411
-
Identification of cis-regulatory variation influencing protein abundance levels in human plasma
-
Lourdusamy A., et al. Identification of cis-regulatory variation influencing protein abundance levels in human plasma. Hum. Mol. Genet. 21, 3719-3726 (2012
-
(2012)
Hum. Mol. Genet
, vol.21
, pp. 3719-3726
-
-
Lourdusamy, A.1
-
115
-
-
84876381289
-
Quantitative trait loci mapping of the mouse plasma proteome (pqtl
-
Holdt L. M., et al. Quantitative trait loci mapping of the mouse plasma proteome (pQTL). Genetics 193, 601-608 (2012
-
(2012)
Genetics
, vol.193
, pp. 601-608
-
-
Holdt, L.M.1
-
116
-
-
84875238998
-
Identification of genetic variants influencing the human plasma proteome
-
Johansson Å., et al. Identification of genetic variants influencing the human plasma proteome. Proc. Natl Acad. Sci. 110, 4673-4678 (2013
-
(2013)
Proc. Natl Acad. Sci
, vol.110
, pp. 4673-4678
-
-
Johansson Å.1
-
117
-
-
84879879014
-
Variation and genetic control of protein abundance in humans
-
Wu, L., et al. Variation and genetic control of protein abundance in humans. Nature 499, 79-82 (2013
-
(2013)
Nature
, vol.499
, pp. 79-82
-
-
Wu, L.1
-
118
-
-
84883698933
-
Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast
-
Skelly D. A., et al. Integrative phenomics reveals insight into the structure of phenotypic diversity in budding yeast. Genome Res. 23, 1496-1504 (2013
-
(2013)
Genome Res
, vol.23
, pp. 1496-1504
-
-
Skelly, D.A.1
-
119
-
-
35648969195
-
Genetic basis of proteome variation in yeast
-
Foss E. J., et al. Genetic basis of proteome variation in yeast. Nature Genet. 39, 1369-1375 (2007
-
(2007)
Nature Genet
, vol.39
, pp. 1369-1375
-
-
Foss, E.J.1
-
120
-
-
80053337795
-
Genetic variation shapes protein networks mainly through non-transcriptional mechanisms
-
Foss E. J., et al. Genetic variation shapes protein networks mainly through non-transcriptional mechanisms. PLoS Biol. 9, e1001144 (2011
-
(2011)
Plos Biol
, vol.9
, pp. e1001144
-
-
Foss, E.J.1
-
121
-
-
84896724814
-
Genetics of single-cell protein abundance variation in large yeast populations
-
Albert F. W., Treusch S., Shockley A. H., Bloom J. S. & Kruglyak L. Genetics of single-cell protein abundance variation in large yeast populations. Nature 506, 494-497 (2014
-
(2014)
Nature
, vol.506
, pp. 494-497
-
-
Albert, F.W.1
Treusch, S.2
Shockley, A.H.3
Bloom, J.S.4
Kruglyak, L.5
-
122
-
-
84902012139
-
Heritability and genetic basis of protein level variation in an outbred population
-
Parts L., et al. Heritability and genetic basis of protein level variation in an outbred population. Genome Res. 24, 1363-1370 (2014
-
(2014)
Genome Res
, vol.24
, pp. 1363-1370
-
-
Parts, L.1
-
123
-
-
79956322553
-
Global quantification of mammalian gene expression control
-
Schwanhäusser B., et al. Global quantification of mammalian gene expression control. Nature 473, 337-342 (2011
-
(2011)
Nature
, vol.473
, pp. 337-342
-
-
Schwanhäusser, B.1
-
124
-
-
84904514448
-
System wide analyses have underestimated protein abundances and the importance of transcription in mammals
-
Li, J. J., Bickel P. J. & Biggin M. D. System wide analyses have underestimated protein abundances and the importance of transcription in mammals. PeerJ 2, e270 (2014
-
(2014)
PeerJ
, vol.2
, pp. e270
-
-
Li, J.J.1
Bickel, P.J.2
Biggin, M.D.3
-
125
-
-
62549134121
-
Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling
-
Ingolia N. T., Ghaemmaghami S., Newman J. R. & Weissman J. S. Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. Science 324, 218-223 (2009
-
(2009)
Science
, vol.324
, pp. 218-223
-
-
Ingolia, N.T.1
Ghaemmaghami, S.2
Newman, J.R.3
Weissman, J.S.4
-
127
-
-
84901854972
-
Extensive and coordinated control of allele-specific expression by both transcription and translation in candida albicans
-
Muzzey D., Sherlock G. & Weissman J. S. Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicans. Genome Res. 24, 963-973 (2014
-
(2014)
Genome Res
, vol.24
, pp. 963-973
-
-
Muzzey, D.1
Sherlock, G.2
Weissman, J.S.3
-
128
-
-
68149180901
-
The 8q24 cancer risk variant rs6983267 shows long-range interaction with myc in colorectal cancer
-
Pomerantz M. M., et al. The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nature Genet. 41, 882-884 (2009
-
(2009)
Nature Genet
, vol.41
, pp. 882-884
-
-
Pomerantz, M.M.1
-
129
-
-
84870674626
-
Mice lacking a myc enhancer that includes human snp rs6983267 are resistant to intestinal tumors
-
Sur I. K., et al. Mice lacking a MYC enhancer that includes human SNP rs6983267 are resistant to intestinal tumors. Science 338, 1360-1363 (2012
-
(2012)
Science
, vol.338
, pp. 1360-1363
-
-
Sur, I.K.1
-
130
-
-
84899453734
-
Evolution of transcription factor binding in metazoans - Mechanisms and functional implications
-
Villar D., Flicek P. & Odom D. T. Evolution of transcription factor binding in metazoans - mechanisms and functional implications. Nature Rev. Genet. 15, 221-233 (2014
-
(2014)
Nature Rev. Genet
, vol.15
, pp. 221-233
-
-
Villar, D.1
Flicek, P.2
Odom, D.T.3
-
131
-
-
84903516869
-
A molecular basis for classic blond hair color in Europeans
-
Guenther C. A., Tasic B., Luo L., Bedell M. A. & Kingsley D. M. A molecular basis for classic blond hair color in Europeans. Nature Genet. 46, 748-752 (2014
-
(2014)
Nature Genet
, vol.46
, pp. 748-752
-
-
Guenther, C.A.1
Tasic, B.2
Luo, L.3
Bedell, M.A.4
Kingsley, D.M.5
-
132
-
-
0037423917
-
Exit from exit: Resetting the cell cycle through amn1 inhibition of g protein signaling
-
Wang Y., Shirogane T., Liu D., Harper J. W. & Elledge S. J. Exit from exit: resetting the cell cycle through Amn1 inhibition of G protein signaling. Cell 112, 697-709 (2003
-
(2003)
Cell
, vol.112
, pp. 697-709
-
-
Wang, Y.1
Shirogane, T.2
Liu, D.3
Harper, J.W.4
Elledge, S.J.5
-
133
-
-
0035028716
-
Overlapping and distinct roles of the duplicated yeast transcription factors ace2p and swi5p
-
Doolin M. T., Johnson A. L., Johnston L. H. & Butler G. Overlapping and distinct roles of the duplicated yeast transcription factors Ace2p and Swi5p. Mol. Microbiol. 40, 422-432 (2001
-
(2001)
Mol. Microbiol
, vol.40
, pp. 422-432
-
-
Doolin, M.T.1
Johnson, A.L.2
Johnston, L.H.3
Butler, G.4
-
134
-
-
0026002418
-
Chitinase is required for cell separation during growth of Saccharomyces cerevisiae
-
Kuranda M. J. & Robbins P. W. Chitinase is required for cell separation during growth of Saccharomyces cerevisiae. J. Biol. Chem. 266, 19758-19767 (1991
-
(1991)
J. Biol. Chem
, vol.266
, pp. 19758-19767
-
-
Kuranda, M.J.1
Robbins, P.W.2
-
135
-
-
84879303337
-
Nonlinear fitness consequences of variation in expression level of a eukaryotic gene
-
Rest J. S., et al. Nonlinear fitness consequences of variation in expression level of a eukaryotic gene. Mol. Biol. Evol. 30, 448-456 (2013
-
(2013)
Mol. Biol. Evol
, vol.30
, pp. 448-456
-
-
Rest, J.S.1
-
136
-
-
84884682741
-
Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype
-
Gagneur J., et al. Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype. PLoS Genet. 9, e1003803 (2013
-
(2013)
Plos Genet
, vol.9
, pp. e1003803
-
-
Gagneur, J.1
-
137
-
-
84901594797
-
Single nucleotide variants in transcription factors associate more tightly with phenotype than with gene expression
-
Sudarsanam P. & Cohen B. A. Single nucleotide variants in transcription factors associate more tightly with phenotype than with gene expression. PLoS Genet. 10, e1004325 (2014
-
(2014)
Plos Genet
, vol.10
, pp. e1004325
-
-
Sudarsanam, P.1
Cohen, B.A.2
-
138
-
-
58849139595
-
Genetic interactions between transcription factors cause natural variation in yeast
-
Gerke J., Lorenz K. & Cohen B. Genetic interactions between transcription factors cause natural variation in yeast. Science 323, 498-501 (2009
-
(2009)
Science
, vol.323
, pp. 498-501
-
-
Gerke, J.1
Lorenz, K.2
Cohen, B.3
-
139
-
-
84922273141
-
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
-
Gusev A., et al. Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases. Am. J. Hum. Genet. 95, 535-552 (2014
-
(2014)
Am. J. Hum. Genet
, vol.95
, pp. 535-552
-
-
Gusev, A.1
-
140
-
-
84865755978
-
The accessible chromatin landscape of the human genome
-
Thurman R. E., et al. The accessible chromatin landscape of the human genome. Nature 489, 75-82 (2012
-
(2012)
Nature
, vol.489
, pp. 75-82
-
-
Thurman, R.E.1
-
141
-
-
77952367694
-
Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations
-
Nica A. C., et al. Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations. PLoS Genet. 6, e1000895 (2010
-
(2010)
Plos Genet
, vol.6
, pp. e1000895
-
-
Nica, A.C.1
-
142
-
-
77951439152
-
Trait-associated snps are more likely to be eqtls: Annotation to enhance discovery from gwas
-
Nicolae D. L., et al. Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet. 6, e1000888 (2010
-
(2010)
Plos Genet
, vol.6
, pp. e1000888
-
-
Nicolae, D.L.1
-
143
-
-
84904804929
-
Biological insights from 108 schizophrenia-associated genetic loci
-
Schizophrenia Working Group of the Psychiatric Genomics Consortium
-
Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421-427 (2014
-
(2014)
Nature
, vol.511
, pp. 421-427
-
-
-
144
-
-
84922282349
-
Cross-tissue and tissue-specific eqtls: Partitioning the heritability of a complex trait
-
Torres J. M., et al. Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait. Am. J. Hum. Genet. 95, 521-534 (2014
-
(2014)
Am. J. Hum. Genet
, vol.95
, pp. 521-534
-
-
Torres, J.M.1
-
145
-
-
84902245734
-
An enhancer polymorphism at the cardiomyocyte intercalated disc protein nos1ap locus is a major regulator of the qt interval
-
Kapoor A., et al. An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval. Am. J. Hum. Genet. 94, 854-869 (2014
-
(2014)
Am. J. Hum. Genet
, vol.94
, pp. 854-869
-
-
Kapoor, A.1
-
146
-
-
84878682420
-
The genotype-tissue expression (gtex) project
-
Lonsdale J., et al. The Genotype-Tissue Expression (GTEx) project. Nature Genet. 45, 580-585 (2013
-
(2013)
Nature Genet
, vol.45
, pp. 580-585
-
-
Lonsdale, J.1
-
147
-
-
84871601885
-
Powerful identification of cis-regulatory SNPs in human primary monocytes using allele-specific gene expression
-
Almlöf J. C., et al. Powerful identification of cis-regulatory SNPs in human primary monocytes using allele-specific gene expression. PLoS ONE 7, e52260 (2012
-
(2012)
Plos One
, vol.7
, pp. e52260
-
-
Almlöf, J.C.1
-
148
-
-
77956637896
-
Genetics and beyond - The transcriptome of human monocytes and disease susceptibility
-
Zeller T., et al. Genetics and beyond - the transcriptome of human monocytes and disease susceptibility. PLoS ONE 5, e10693 (2010
-
(2010)
Plos One
, vol.5
, pp. e10693
-
-
Zeller, T.1
-
149
-
-
84910086797
-
Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs
-
Adoue V., et al. Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs. Mol. Syst. Biol. 10, 754 (2014
-
(2014)
Mol. Syst. Biol
, vol.10
, Issue.754
-
-
Adoue, V.1
-
150
-
-
84907202723
-
Intersection of population variation and autoimmunity genetics in human T cell activation
-
Ye, C. J., et al. Intersection of population variation and autoimmunity genetics in human T cell activation. Science 345, 1254665 (2014
-
(2014)
Science
, vol.345
, pp. 1254665
-
-
Ye, C.J.1
-
151
-
-
84896970908
-
Interindividual variation in human T regulatory cells
-
Ferraro A., et al. Interindividual variation in human T regulatory cells. Proc. Natl Acad. Sci. 111, E1111-E1120 (2014
-
(2014)
Proc. Natl Acad. Sci
, vol.111
, pp. E1111-E1120
-
-
Ferraro, A.1
-
152
-
-
84879645818
-
Impact of natural genetic variation on gene expression dynamics
-
Ackermann M., Sikora-Wohlfeld W. & Beyer A. Impact of natural genetic variation on gene expression dynamics. PLoS Genet. 9, e1003514 (2013
-
(2013)
Plos Genet
, vol.9
, pp. e1003514
-
-
Ackermann, M.1
Sikora-Wohlfeld, W.2
Beyer, A.3
-
153
-
-
73349119114
-
Expression quantitative trait loci are highly sensitive to cellular differentiation state
-
Gerrits A., et al. Expression quantitative trait loci are highly sensitive to cellular differentiation state. PLoS Genet. 5, e1000692 (2009
-
(2009)
Plos Genet
, vol.5
, pp. e1000692
-
-
Gerrits, A.1
-
154
-
-
84856007232
-
The promise of induced pluripotent stem cells in research and therapy
-
Robinton D. A. & Daley G. Q. The promise of induced pluripotent stem cells in research and therapy. Nature 481, 295-305 (2012
-
(2012)
Nature
, vol.481
, pp. 295-305
-
-
Robinton, D.A.1
Daley, G.Q.2
-
155
-
-
84903452732
-
Genetic background drives transcriptional variation in human induced pluripotent stem cells
-
Rouhani F., et al. Genetic background drives transcriptional variation in human induced pluripotent stem cells. PLoS Genet. 10, e1004432 (2014
-
(2014)
Plos Genet
, vol.10
, pp. e1004432
-
-
Rouhani, F.1
-
156
-
-
84922809120
-
Characterizing the genetic basis of innate immune response in TLR4 activated human monocytes
-
Kim S., et al. Characterizing the genetic basis of innate immune response in TLR4 activated human monocytes. Nature Commun. 5, 5236 (2014
-
(2014)
Nature Commun
, vol.5
, Issue.5236
-
-
Kim, S.1
-
157
-
-
84856387609
-
Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection
-
Barreiro L. B., et al. Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Proc. Natl Acad. Sci. 109, 1204-1209 (2012
-
(2012)
Proc. Natl Acad. Sci
, vol.109
, pp. 1204-1209
-
-
Barreiro, L.B.1
-
158
-
-
84904893878
-
Genetics of gene expression in immunity to infection
-
Fairfax B. P. & Knight J. C. Genetics of gene expression in immunity to infection. Curr. Opin. Immunol. 30, 63-71 (2014
-
(2014)
Curr. Opin. Immunol
, vol.30
, pp. 63-71
-
-
Fairfax, B.P.1
Knight, J.C.2
-
159
-
-
84880626687
-
Integrative genomic analysis of the human immune response to influenza vaccination
-
Franco L. M., et al. Integrative genomic analysis of the human immune response to influenza vaccination. eLife 2, e00299 (2013
-
(2013)
ELife
, vol.2
, pp. e00299
-
-
Franco, L.M.1
-
160
-
-
84865777825
-
Linking disease associations with regulatory information in the human genome
-
Schaub M. A., Boyle A. P., Kundaje A., Batzoglou S. & Snyder M. Linking disease associations with regulatory information in the human genome. Genome Res. 22, 1748-1759 (2012
-
(2012)
Genome Res
, vol.22
, pp. 1748-1759
-
-
Schaub, M.A.1
Boyle, A.P.2
Kundaje, A.3
Batzoglou, S.4
Snyder, M.5
-
161
-
-
84923326765
-
Genetic and epigenetic fine mapping of causal autoimmune disease variants
-
Farh K. K. H., et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature http://dx.doi.org/10.1038/nature13835 (2014
-
(2014)
Nature
-
-
Farh, K.K.H.1
-
162
-
-
84876847154
-
All snps are not created equal: Genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated snps
-
Schork A. J., et al. All SNPs are not created equal: genome-wide association studies reveal a consistent pattern of enrichment among functionally annotated SNPs. PLoS Genet. 9, e1003449 (2013
-
(2013)
Plos Genet
, vol.9
, pp. e1003449
-
-
Schork, A.J.1
-
163
-
-
84873086126
-
Chromatin marks identify critical cell types for fine mapping complex trait variants
-
Trynka G., et al. Chromatin marks identify critical cell types for fine mapping complex trait variants. Nature Genet. 45, 124-130 (2012
-
(2012)
Nature Genet
, vol.45
, pp. 124-130
-
-
Trynka, G.1
-
164
-
-
84898723939
-
Joint analysis of functional genomic data and genome-wide association studies of 18 human traits
-
Pickrell J. K. Joint analysis of functional genomic data and genome-wide association studies of 18 human traits. Am. J. Hum. Genet. 94, 559-573 (2014
-
(2014)
Am. J. Hum. Genet
, vol.94
, pp. 559-573
-
-
Pickrell, J.K.1
-
165
-
-
84908324508
-
Integrating functional data to prioritize causal variants in statistical fine-mapping studies
-
Kichaev G., et al. Integrating functional data to prioritize causal variants in statistical fine-mapping studies. PLoS Genet. 10, e1004722 (2014
-
(2014)
Plos Genet
, vol.10
, pp. e1004722
-
-
Kichaev, G.1
-
166
-
-
84901353125
-
Bayesian method to incorporate hundreds of functional characteristics with association evidence to improve variant prioritization
-
Gagliano S. A., Barnes M. R., Weale M. E. & Knight J. A. Bayesian method to incorporate hundreds of functional characteristics with association evidence to improve variant prioritization. PLoS ONE 9, e98122 (2014
-
(2014)
Plos One
, vol.9
, pp. e98122
-
-
Gagliano, S.A.1
Barnes, M.R.2
Weale, M.E.3
Knight, J.A.4
-
167
-
-
84912117315
-
GPA: A statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation
-
Chung D., Yang C., Li, C., Gelernter J. & Zhao H. GPA: a statistical approach to prioritizing GWAS results by integrating pleiotropy and annotation. PLoS Genet. 10, e1004787 (2014
-
(2014)
Plos Genet
, vol.10
, pp. e1004787
-
-
Chung, D.1
Yang, C.2
Li, C.3
Gelernter, J.4
Zhao, H.5
-
168
-
-
79955683639
-
Using functional annotation for the empirical determination of Bayes factors for genome-wide association study analysis
-
Knight J., Barnes M. R., Breen G. & Weale M. E. Using functional annotation for the empirical determination of Bayes factors for genome-wide association study analysis. PLoS ONE 6, e14808 (2011
-
(2011)
Plos One
, vol.6
, pp. e14808
-
-
Knight, J.1
Barnes, M.R.2
Breen, G.3
Weale, M.E.4
-
169
-
-
84856321864
-
Dissecting the regulatory architecture of gene expression QTLs
-
Gaffney D. J., et al. Dissecting the regulatory architecture of gene expression QTLs. Genome Biol. 13, R7 (2012
-
(2012)
Genome Biol
, vol.13
, pp. R7
-
-
Gaffney, D.J.1
-
170
-
-
84884611024
-
Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs
-
Brown C. D., Mangravite L. M. & Engelhardt B. E. Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs. PLoS Genet. 9, e1003649 (2013
-
(2013)
Plos Genet
, vol.9
, pp. e1003649
-
-
Brown, C.D.1
Mangravite, L.M.2
Engelhardt, B.E.3
-
171
-
-
84878476783
-
Statistical framework for joint eQTL analysis in multiple tissues
-
Flutre T., Wen X., Pritchard J. & Stephens M. A. Statistical framework for joint eQTL analysis in multiple tissues. PLoS Genet. 9, e1003486 (2013
-
(2013)
Plos Genet
, vol.9
, pp. e1003486
-
-
Flutre, T.1
Wen, X.2
Pritchard, J.3
Stephens, M.A.4
-
172
-
-
84875980888
-
Robust prediction of expression differences among human individuals using only genotype information
-
Manor O. & Segal E. Robust prediction of expression differences among human individuals using only genotype information. PLoS Genet. 9, e1003396 (2013
-
(2013)
Plos Genet
, vol.9
, pp. e1003396
-
-
Manor, O.1
Segal, E.2
-
173
-
-
84861470791
-
Using prior information from the medical literature in gwas of oral cancer identifies novel susceptibility variant on chromosome 4 - The adapt method
-
Johansson M., et al. Using prior information from the medical literature in GWAS of oral cancer identifies novel susceptibility variant on chromosome 4 - the AdAPT method. PLoS ONE 7, e36888 (2012
-
(2012)
Plos One
, vol.7
, pp. e36888
-
-
Johansson, M.1
-
174
-
-
84901631426
-
Bayesian test for colocalisation between pairs of genetic association studies using summary statistics
-
Giambartolomei C., et al. Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet. 10, e1004383 (2014
-
(2014)
Plos Genet
, vol.10
, pp. e1004383
-
-
Giambartolomei, C.1
-
175
-
-
34547216747
-
Genetic variants regulating ormdl3 expression contribute to the risk of childhood asthma
-
Moffatt M. F., et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 448, 470-473 (2007
-
(2007)
Nature
, vol.448
, pp. 470-473
-
-
Moffatt, M.F.1
-
176
-
-
79957607662
-
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
-
Small K. S., et al. Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes. Nature Genet. 43, 561-564 (2011
-
(2011)
Nature Genet
, vol.43
, pp. 561-564
-
-
Small, K.S.1
-
177
-
-
60349092402
-
Mapping complex disease traits with global gene expression
-
Cookson W., Liang L., Abecasis G., Moffatt M. & Lathrop M. Mapping complex disease traits with global gene expression. Nature Rev. Genet. 10, 184-194 (2009
-
(2009)
Nature Rev. Genet
, vol.10
, pp. 184-194
-
-
Cookson, W.1
Liang, L.2
Abecasis, G.3
Moffatt, M.4
Lathrop, M.5
-
178
-
-
34248594090
-
A common variant in the fto gene is associated with body mass index and predisposes to childhood and adult obesity
-
Frayling T. M., et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889-894 (2007
-
(2007)
Science
, vol.316
, pp. 889-894
-
-
Frayling, T.M.1
-
179
-
-
67349211789
-
Inactivation of the Fto gene protects from obesity
-
Fischer J., et al. Inactivation of the Fto gene protects from obesity. Nature 458, 894-898 (2009
-
(2009)
Nature
, vol.458
, pp. 894-898
-
-
Fischer, J.1
-
180
-
-
84897855294
-
Obesity-associated variants within fto form long-range functional connections with irx3
-
Smemo S., et al. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature 507, 371-375 (2014
-
(2014)
Nature
, vol.507
, pp. 371-375
-
-
Smemo, S.1
-
181
-
-
33750203582
-
Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions
-
Zhao Z., et al. Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Nature Genet. 38, 1341-1347 (2006
-
(2006)
Nature Genet
, vol.38
, pp. 1341-1347
-
-
Zhao, Z.1
-
182
-
-
33750212321
-
Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on chip (4C
-
Simonis M., et al. Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on chip (4C). Nature Genet. 38, 1348-1354 (2006
-
(2006)
Nature Genet
, vol.38
, pp. 1348-1354
-
-
Simonis, M.1
-
183
-
-
33749400168
-
Chromosome conformation capture carbon copy (5C): A massively parallel solution for mapping interactions between genomic elements
-
Dostie J., et al. Chromosome conformation capture carbon copy (5C): a massively parallel solution for mapping interactions between genomic elements. Genome Res. 16, 1299-1309 (2006
-
(2006)
Genome Res
, vol.16
, pp. 1299-1309
-
-
Dostie, J.1
-
184
-
-
84923823453
-
Unbiased analysis of potential targets of breast cancer susceptibility loci by capture Hi C
-
Dryden N. H., et al. Unbiased analysis of potential targets of breast cancer susceptibility loci by capture Hi C. Genome Res. 24, 1854-1868 (2014
-
(2014)
Genome Res
, vol.24
, pp. 1854-1868
-
-
Dryden, N.H.1
-
186
-
-
70349873824
-
Comprehensive mapping of long-range interactions reveals folding principles of the human genome
-
Lieberman-Aiden E., et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326, 289-293 (2009
-
(2009)
Science
, vol.326
, pp. 289-293
-
-
Lieberman-Aiden, E.1
-
188
-
-
84900529199
-
Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq
-
Treutlein B., et al. Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq. Nature 509, 371-375 (2014
-
(2014)
Nature
, vol.509
, pp. 371-375
-
-
Treutlein, B.1
-
189
-
-
84893905629
-
Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types
-
Jaitin D. A., et al. Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types. Science 343, 776-779 (2014
-
(2014)
Science
, vol.343
, pp. 776-779
-
-
Jaitin, D.A.1
-
190
-
-
13444306165
-
The landscape of genetic complexity across 5,700 gene expression traits in yeast
-
Brem R. B. & Kruglyak L. The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc. Natl Acad. Sci. 102, 1572-1577 (2005
-
(2005)
Proc. Natl Acad. Sci
, vol.102
, pp. 1572-1577
-
-
Brem, R.B.1
Kruglyak, L.2
-
191
-
-
84900302836
-
Detection and replication of epistasis influencing transcription in humans
-
Hemani G., et al. Detection and replication of epistasis influencing transcription in humans. Nature 508, 249-253 (2014
-
(2014)
Nature
, vol.508
, pp. 249-253
-
-
Hemani, G.1
-
192
-
-
84899627083
-
Genetic interactions affecting human gene expression identified by variance association mapping
-
Brown A. A., et al. Genetic interactions affecting human gene expression identified by variance association mapping. eLife 3, e01381 (2014
-
(2014)
Elife
, vol.3
, pp. e01381
-
-
Brown, A.A.1
-
193
-
-
84908046605
-
Another explanation for apparent epistasis
-
Wood A. R., et al. Another explanation for apparent epistasis. Nature 514, E3-E5 (2014
-
(2014)
Nature
, vol.514
, pp. E3-E5
-
-
Wood, A.R.1
-
194
-
-
85028171423
-
Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins
-
Buil A., et al. Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins. Nature Genet. 47, 88-91 (2015
-
(2015)
Nature Genet
, vol.47
, pp. 88-91
-
-
Buil, A.1
-
195
-
-
40149087235
-
Data and theory point to mainly additive genetic variance for complex traits
-
Hill W. G., Goddard M. E. & Visscher P. M. Data and theory point to mainly additive genetic variance for complex traits. PLoS Genet. 4, e1000008 (2008
-
(2008)
Plos Genet
, vol.4
, pp. e1000008
-
-
Hill, W.G.1
Goddard, M.E.2
Visscher, P.M.3
-
196
-
-
84907992895
-
Influence of gene interaction on complex trait variation with multilocus models
-
Maki-Tanila A. & Hill W. G. Influence of gene interaction on complex trait variation with multilocus models. Genetics 198, 355-367 (2014
-
(2014)
Genetics
, vol.198
, pp. 355-367
-
-
Maki-Tanila, A.1
Hill, W.G.2
-
197
-
-
84885864334
-
A statin-dependent QTL for GATM expression is associated with statin-induced myopathy
-
Mangravite L. M., et al. A statin-dependent QTL for GATM expression is associated with statin-induced myopathy. Nature 502, 377-380 (2013
-
(2013)
Nature
, vol.502
, pp. 377-380
-
-
Mangravite, L.M.1
-
198
-
-
84902096048
-
Development and applications of CRISPR-Cas9 for genome engineering
-
Hsu P. D., Lander E. S. & Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. Cell 157, 1262-1278 (2014
-
(2014)
Cell
, vol.157
, pp. 1262-1278
-
-
Hsu, P.D.1
Lander, E.S.2
Zhang, F.3
-
199
-
-
84900314611
-
Crispr-cas systems for editing regulating and targeting genomes
-
Sander J. D. & Joung J. K. CRISPR-Cas systems for editing regulating and targeting genomes. Nature Biotech. 32, 347-355 (2014
-
(2014)
Nature Biotech
, vol.32
, pp. 347-355
-
-
Sander, J.D.1
Joung, J.K.2
-
200
-
-
77956873627
-
Tackling the widespread and critical impact of batch effects in high-throughput data
-
Leek J. T., et al. Tackling the widespread and critical impact of batch effects in high-throughput data. Nature Rev. Genet. 11, 733-739 (2010
-
(2010)
Nature Rev. Genet
, vol.11
, pp. 733-739
-
-
Leek, J.T.1
-
201
-
-
34347326155
-
On the design and analysis of gene expression studies in human populations
-
Akey J. M., Biswas S., Leek J. T. & Storey J. D. On the design and analysis of gene expression studies in human populations. Nature Genet. 39, 807-808 (2007
-
(2007)
Nature Genet
, vol.39
, pp. 807-808
-
-
Akey, J.M.1
Biswas, S.2
Leek, J.T.3
Storey, J.D.4
-
202
-
-
34848914038
-
Capturing heterogeneity in gene expression studies by surrogate variable analysis
-
Leek J. T. & Storey J. D. Capturing heterogeneity in gene expression studies by surrogate variable analysis. PLoS Genet. 3, e161 (2007
-
(2007)
Plos Genet
, vol.3
, pp. e161
-
-
Leek, J.T.1
Storey, J.D.2
-
203
-
-
77955505742
-
Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies
-
Stegle O., Parts L., Durbin R. & Winn J. A. Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies. PLoS Comput. Biol. 6, e1000770 (2010
-
(2010)
Plos Comput. Biol
, vol.6
, pp. e1000770
-
-
Stegle, O.1
Parts, L.2
Durbin, R.3
Winn, J.A.4
-
204
-
-
84887036163
-
Genetic and nongenetic variation revealed for the principal components of human gene expression
-
Goldinger A., et al. Genetic and nongenetic variation revealed for the principal components of human gene expression. Genetics 195, 1117-1128 (2013
-
(2013)
Genetics
, vol.195
, pp. 1117-1128
-
-
Goldinger, A.1
-
205
-
-
84857467272
-
Joint modelling of confounding factors and prominent genetic regulators provides increased accuracy in genetical genomics studies
-
Fusi N., Stegle O. & Lawrence N. D. Joint modelling of confounding factors and prominent genetic regulators provides increased accuracy in genetical genomics studies. PLoS Comput. Biol. 8, e1002330 (2012
-
(2012)
Plos Comput. Biol
, vol.8
, pp. e1002330
-
-
Fusi, N.1
Stegle, O.2
Lawrence, N.D.3
-
206
-
-
84861734626
-
Using probabilistic estimation of expression residuals (peer) to obtain increased power and interpretability of gene expression analyses
-
Stegle O., Parts L., Piipari M., Winn J. & Durbin R. Using probabilistic estimation of expression residuals (PEER) to obtain increased power and interpretability of gene expression analyses. Nature Protoc. 7, 500-507 (2012
-
(2012)
Nature Protoc
, vol.7
, pp. 500-507
-
-
Stegle, O.1
Parts, L.2
Piipari, M.3
Winn, J.4
Durbin, R.5
-
207
-
-
78049312702
-
Correction for hidden confounders in the genetic analysis of gene expression
-
Listgarten J., Kadie C., Schadt E. E. & Heckerman D. Correction for hidden confounders in the genetic analysis of gene expression. Proc. Natl Acad. Sci. 107, 16465-16470 (2010
-
(2010)
Proc. Natl Acad. Sci
, vol.107
, pp. 16465-16470
-
-
Listgarten, J.1
Kadie, C.2
Schadt, E.E.3
Heckerman, D.4
-
208
-
-
61849171085
-
Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots
-
Kang H. M., Ye, C. & Eskin E. Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots. Genetics 180, 1909-1925 (2008
-
(2008)
Genetics
, vol.180
, pp. 1909-1925
-
-
Kang, H.M.1
Ye, C.2
Eskin, E.3
-
209
-
-
84893270241
-
Heft: Eqtl analysis of many thousands of expressed genes while simultaneously controlling for hidden factors
-
Gao C., et al. HEFT: eQTL analysis of many thousands of expressed genes while simultaneously controlling for hidden factors. Bioinformatics 30, 369-376 (2014
-
(2014)
Bioinformatics
, vol.30
, pp. 369-376
-
-
Gao, C.1
-
210
-
-
84876251470
-
Accounting for non-genetic factors by low-rank representation and sparse regression for eqtl mapping
-
Yang C., Wang L., Zhang S. & Zhao H. Accounting for non-genetic factors by low-rank representation and sparse regression for eQTL mapping. Bioinformatics 29, 1026-1034 (2013
-
(2013)
Bioinformatics
, vol.29
, pp. 1026-1034
-
-
Yang, C.1
Wang, L.2
Zhang, S.3
Zhao, H.4
-
211
-
-
84880399147
-
Normalizing RNA-sequencing data by modeling hidden covariates with prior knowledge
-
Mostafavi S., et al. Normalizing RNA-sequencing data by modeling hidden covariates with prior knowledge. PLoS ONE 8, e68141 (2013
-
(2013)
Plos One
, vol.8
, pp. e68141
-
-
Mostafavi, S.1
-
212
-
-
79851507206
-
Joint genetic analysis of gene expression data with inferred cellular phenotypes
-
Parts L., Stegle O., Winn J. & Durbin R. Joint genetic analysis of gene expression data with inferred cellular phenotypes. PLoS Genet. 7, e1001276 (2011
-
(2011)
Plos Genet
, vol.7
, pp. e1001276
-
-
Parts, L.1
Stegle, O.2
Winn, J.3
Durbin, R.4
-
213
-
-
77957273682
-
Identifying the genetic determinants of transcription factor activity
-
Lee E. & Bussemaker H. J. Identifying the genetic determinants of transcription factor activity. Mol. Syst. Biol. 6, 412 (2010
-
(2010)
Mol. Syst. Biol
, vol.6
, pp. 412
-
-
Lee, E.1
Bussemaker, H.J.2
-
214
-
-
84906222360
-
Harnessing natural sequence variation to dissect posttranscriptional regulatory networks in yeast
-
Fazlollahi M., et al. Harnessing natural sequence variation to dissect posttranscriptional regulatory networks in yeast. G3 (Bethesda) 4, 1539-1553 (2014
-
(2014)
G3 (Bethesda
, vol.4
, pp. 1539-1553
-
-
Fazlollahi, M.1
-
215
-
-
84892367295
-
The effects of genetic variation on gene expression dynamics during development
-
Francesconi M. & Lehner B. The effects of genetic variation on gene expression dynamics during development. Nature 505, 208-211 (2013
-
(2013)
Nature
, vol.505
, pp. 208-211
-
-
Francesconi, M.1
Lehner, B.2
-
216
-
-
84860372128
-
The Brisbane Systems Genetics Study: Genetical genomics meets complex trait genetics
-
Powell J. E., et al. The Brisbane Systems Genetics Study: genetical genomics meets complex trait genetics. PLoS ONE 7, e35430 (2012
-
(2012)
Plos One
, vol.7
, pp. e35430
-
-
Powell, J.E.1
-
217
-
-
79851479498
-
Global analysis of the impact of environmental perturbation on cis-regulation of gene expression
-
Grundberg E., et al. Global analysis of the impact of environmental perturbation on cis-regulation of gene expression. PLoS Genet. 7, e1001279 (2011
-
(2011)
Plos Genet
, vol.7
, pp. e1001279
-
-
Grundberg, E.1
-
218
-
-
84921750431
-
Genetic variability in the regulation of gene expression in ten regions of the human brain
-
Ramasamy A., et al. Genetic variability in the regulation of gene expression in ten regions of the human brain. Nature Neurosci. 17, 1418-1428 (2014
-
(2014)
Nature Neurosci
, vol.17
, pp. 1418-1428
-
-
Ramasamy, A.1
-
219
-
-
84864066707
-
Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants
-
Zou F., et al. Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. PLoS Genet. 8, e1002707 (2012
-
(2012)
Plos Genet
, vol.8
, pp. e1002707
-
-
Zou, F.1
-
220
-
-
80055015161
-
Temporal dynamics and genetic control of transcription in the human prefrontal cortex
-
Colantuoni C., et al. Temporal dynamics and genetic control of transcription in the human prefrontal cortex. Nature 478, 519-523 (2011
-
(2011)
Nature
, vol.478
, pp. 519-523
-
-
Colantuoni, C.1
-
221
-
-
77953223693
-
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain
-
Gibbs J. R., et al. Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet. 6, e1000952 (2010
-
(2010)
Plos Genet
, vol.6
, pp. e1000952
-
-
Gibbs, J.R.1
-
222
-
-
84901340791
-
Genome-wide identification of expression quantitative trait loci (eqtls) in human heart
-
Koopmann T. T., et al. Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart. PLoS ONE 9, e97380 (2014
-
(2014)
Plos One
, vol.9
, pp. e97380
-
-
Koopmann, T.T.1
-
223
-
-
79957993750
-
Identification replication and functional fine-mapping of expression quantitative trait loci in primary human liver tissue
-
Innocenti F., et al. Identification replication and functional fine-mapping of expression quantitative trait loci in primary human liver tissue. PLoS Genet. 7, e1002078 (2011
-
(2011)
Plos Genet
, vol.7
, pp. e1002078
-
-
Innocenti, F.1
-
224
-
-
45149108420
-
Mapping the genetic architecture of gene expression in human liver
-
Schadt E. E., et al. Mapping the genetic architecture of gene expression in human liver. PLoS Biol. 6, e107 (2008
-
(2008)
Plos Biol
, vol.6
, pp. e107
-
-
Schadt, E.E.1
-
225
-
-
84870713668
-
Lung eQTLs to help reveal the molecular underpinnings of asthma
-
Hao K., et al. Lung eQTLs to help reveal the molecular underpinnings of asthma. PLoS Genet. 8, e1003029 (2012
-
(2012)
Plos Genet
, vol.8
, pp. e1003029
-
-
Hao, K.1
-
226
-
-
84905581513
-
Putative cis-regulatory drivers in colorectal cancer
-
Ongen H., et al. Putative cis-regulatory drivers in colorectal cancer. Nature 512, 87-90 (2014
-
(2014)
Nature
, vol.512
, pp. 87-90
-
-
Ongen, H.1
-
227
-
-
84964315018
-
Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types
-
Li, Q., et al. Expression QTL-based analyses reveal candidate causal genes and loci across five tumor types. Hum. Mol. Genet. 23, 5294-5302 (2014
-
(2014)
Hum. Mol. Genet
, vol.23
, pp. 5294-5302
-
-
Li, Q.1
-
228
-
-
84873288058
-
Integrative eQTL-based analyses reveal the biology of breast cancer risk loci
-
Li, Q., et al. Integrative eQTL-based analyses reveal the biology of breast cancer risk loci. Cell 152, 633-641 (2013
-
(2013)
Cell
, vol.152
, pp. 633-641
-
-
Li, Q.1
|