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Volumn 17, Issue 1, 2017, Pages 21-29

Human immune system variation

Author keywords

[No Author keywords available]

Indexed keywords

PLASMA PROTEIN;

EID: 85002152554     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri.2016.125     Document Type: Review
Times cited : (473)

References (107)
  • 1
    • 27744473566 scopus 로고    scopus 로고
    • Lost in translation: Barriers to implementing clinical immunotherapeutics for autoimmunity
    • Herrath, von M. G, & Nepom G. T. Lost in translation: barriers to implementing clinical immunotherapeutics for autoimmunity. J. Exp. Med. 202, 1159-1162 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 1159-1162
    • Herrath Von, M.G.1    Nepom, G.T.2
  • 2
    • 3042722266 scopus 로고    scopus 로고
    • Immunotherapy: Bewitched, bothered, and bewildered no more
    • Steinman R. M, & Mellman I. Immunotherapy: bewitched, bothered, and bewildered no more. Science 305, 197-200 (2004).
    • (2004) Scienc , vol.305 , pp. 197-200
    • Steinman, R.M.1    Mellman, I.2
  • 3
    • 57449096122 scopus 로고    scopus 로고
    • Prescription for human immunology
    • Davis M. M. A. Prescription for human immunology. Immunity 29, 835-838 (2008).
    • (2008) Immunit , vol.29 , pp. 835-838
    • Davis, M.M.A.1
  • 4
    • 79955008772 scopus 로고    scopus 로고
    • The human condition: An immunological perspective
    • Germain R. N, & Schwartzberg P. L. The human condition: an immunological perspective. Nat. Immunol. 12, 369-372 (2011).
    • (2011) Nat. Immunol , vol.12 , pp. 369-372
    • Germain, R.N.1    Schwartzberg, P.L.2
  • 5
    • 44049084451 scopus 로고    scopus 로고
    • The habitual, diverse and surmountable obstacles to human immunology research
    • Hayday A. C, & Peakman M. The habitual, diverse and surmountable obstacles to human immunology research. Nat. Immunol. 9, 575-580 (2008).
    • (2008) Nat. Immunol , vol.9 , pp. 575-580
    • Hayday, A.C.1    Peakman, M.2
  • 6
    • 84941803445 scopus 로고    scopus 로고
    • Systems vaccinology: Enabling rational vaccine design with systems biological approaches
    • Hagan T, Nakaya H. I, Subramaniam S, & Pulendran B. Systems vaccinology: enabling rational vaccine design with systems biological approaches. Vaccine 33, 5294-5301 (2015).
    • (2015) Vaccin , vol.33 , pp. 5294-5301
    • Hagan, T.1    Nakaya, H.I.2    Subramaniam, S.3    Pulendran, B.4
  • 7
    • 44449118948 scopus 로고    scopus 로고
    • Rapid cloning of high-Affinity human monoclonal antibodies against influenza virus
    • Wrammert J, et al. Rapid cloning of high-Affinity human monoclonal antibodies against influenza virus. Nature 453, 667-671 (2008).
    • (2008) Natur , vol.453 , pp. 667-671
    • Wrammert, J.1
  • 8
    • 84881434960 scopus 로고    scopus 로고
    • Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γd T cells in celiac disease
    • Han A, et al. Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γd T cells in celiac disease. Proc. Natl Acad. Sci. USA 110, 13073-13078 (2013).
    • (2013) Proc. Natl Acad. Sci. US , vol.110 , pp. 13073-13078
    • Han, A.1
  • 9
    • 33847302982 scopus 로고    scopus 로고
    • Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients
    • Rαki M, et al. Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients. Proc. Natl Acad. Sci. USA 104, 2831-2836 (2007).
    • (2007) Proc. Natl Acad. Sci. US , vol.104 , pp. 2831-2836
    • Rki, M.1
  • 10
    • 84963547286 scopus 로고    scopus 로고
    • Powerful populations respond to viruses and vaccines
    • Brodin P. Powerful populations respond to viruses and vaccines. Immunity 43, 1035-1037 (2015).
    • (2015) Immunit , vol.43 , pp. 1035-1037
    • Brodin, P.1
  • 11
    • 84920982264 scopus 로고    scopus 로고
    • Variation in the human immune system is largely driven by non-heritable influences
    • Brodin P, et al. Variation in the human immune system is largely driven by non-heritable influences. Cell 160, 37-47 (2015).
    • (2015) Cel , vol.160 , pp. 37-47
    • Brodin, P.1
  • 12
    • 57849085182 scopus 로고    scopus 로고
    • Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans
    • Querec T. D, et al. Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. Nat. Immunol. 10, 116-125 (2008).
    • (2008) Nat. Immunol , vol.10 , pp. 116-125
    • Querec, T.D.1
  • 13
    • 84963517248 scopus 로고    scopus 로고
    • Integrated, multi-cohort analysis identifies conserved transcriptional signatures across multiple respiratory viruses
    • Andres-Terre M, et al. Integrated, multi-cohort analysis identifies conserved transcriptional signatures across multiple respiratory viruses. Immunity 43, 1199-1211 (2015).
    • (2015) Immunit , vol.43 , pp. 1199-1211
    • Andres-Terre, M.1
  • 14
    • 84955127051 scopus 로고    scopus 로고
    • Adjuvanted influenza H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events
    • Sobolev O, et al. Adjuvanted influenza H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events. Nat. Immunol. 17, 204-213 (2016).
    • (2016) Nat. Immunol , vol.17 , pp. 204-213
    • Sobolev, O.1
  • 15
    • 84898653725 scopus 로고    scopus 로고
    • Global analyses of human immune variation reveal baseline predictors of postvaccination responses
    • Tsang J. S, et al. Global analyses of human immune variation reveal baseline predictors of postvaccination responses. Cell 157, 499-513 (2014).
    • (2014) Cel , vol.157 , pp. 499-513
    • Tsang, J.S.1
  • 16
    • 84958063966 scopus 로고    scopus 로고
    • The cellular composition of the human immune system is shaped by age and cohabitation
    • Carr E. J, et al. The cellular composition of the human immune system is shaped by age and cohabitation. Nat. Immunol. 17, 461-468 (2016).
    • (2016) Nat. Immunol , vol.17 , pp. 461-468
    • Carr, E.J.1
  • 17
    • 84994565969 scopus 로고    scopus 로고
    • Defective signaling in the JAK-STAT pathway tracks with chronic inflammation and cardiovascular risk in aging humans
    • e4
    • Shen-Orr S. S, et al. Defective signaling in the JAK-STAT pathway tracks with chronic inflammation and cardiovascular risk in aging humans. Cell Syst. 3, 374-384.e4 (2016).
    • (2016) Cell Syst , vol.3 , pp. 374-384
    • Shen-Orr, S.S.1
  • 18
    • 84903533463 scopus 로고    scopus 로고
    • Ontogeny of early life immunity
    • Dowling D. J, & Levy O. Ontogeny of early life immunity. Trends Immunol. 35, 299-310 (2014).
    • (2014) Trends Immunol , vol.35 , pp. 299-310
    • Dowling, D.J.1    Levy, O.2
  • 19
    • 84952047205 scopus 로고    scopus 로고
    • Evolution of the immune system in humans from infancy to old age
    • Simon A. K, Hollander G. A, & McMichael A. Evolution of the immune system in humans from infancy to old age. Proc. Biol. Sci. 282, 20143085 (2015).
    • (2015) Proc. Biol. Sci , vol.282 , pp. 20143085
    • Simon, A.K.1    Hollander, G.A.2    McMichael, A.3
  • 20
    • 68649122780 scopus 로고    scopus 로고
    • Neonates harbour highly active gammadelta T cells with selective impairments in preterm infants
    • Gibbons D. L, et al. Neonates harbour highly active gammadelta T cells with selective impairments in preterm infants. Eur. J. Immunol. 39, 1794-1806 (2009).
    • (2009) Eur. J. Immunol , vol.39 , pp. 1794-1806
    • Gibbons, D.L.1
  • 21
    • 84921957499 scopus 로고    scopus 로고
    • Interleukin 8 (CXCL8) production is a signatory T cell effector function of human newborn infants
    • Gibbons D, et al. Interleukin 8 (CXCL8) production is a signatory T cell effector function of human newborn infants. Nat. Med. 20, 1206-1210 (2014).
    • (2014) Nat. Med , vol.20 , pp. 1206-1210
    • Gibbons, D.1
  • 23
    • 84874092680 scopus 로고    scopus 로고
    • Lineage structure of the human antibody repertoire in response to influenza vaccination
    • Jiang N, et al. Lineage structure of the human antibody repertoire in response to influenza vaccination. Sci. Transl. Med. 5, 171ra19 (2013).
    • (2013) Sci. Transl. Med , vol.5 , pp. 171ra19
    • Jiang, N.1
  • 24
    • 2342527293 scopus 로고    scopus 로고
    • Aging, autoimmunity and arthritis: T cell senescence and contraction of T cell repertoire diversity - Catalysts of autoimmunity and chronic inflammation
    • Goronzy J. J, & Weyand C. M. Aging, autoimmunity and arthritis: T cell senescence and contraction of T cell repertoire diversity - catalysts of autoimmunity and chronic inflammation. Arthritis Res. Ther. 5, 225-234 (2003).
    • (2003) Arthritis Res. Ther , vol.5 , pp. 225-234
    • Goronzy, J.J.1    Weyand, C.M.2
  • 25
    • 84907001176 scopus 로고    scopus 로고
    • Diversity and clonal selection in the human T cell repertoire
    • Qi Q, et al. Diversity and clonal selection in the human T cell repertoire. Proc. Natl Acad. Sci. USA 111, 13139-13144 (2014).
    • (2014) Proc. Natl Acad. Sci. US , vol.111 , pp. 13139-13144
    • Qi, Q.1
  • 26
    • 84896985687 scopus 로고    scopus 로고
    • Proinflammatory cytokines, aging, and age-related diseases
    • Michaud M, et al. Proinflammatory cytokines, aging, and age-related diseases. J. Am. Med. Dir. Assoc. 14, 877-882 (2013).
    • (2013) J. Am. Med. Dir. Assoc , vol.14 , pp. 877-882
    • Michaud, M.1
  • 27
    • 84907323440 scopus 로고    scopus 로고
    • Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs
    • Enroth S, Johansson Å, Enroth S. B, & Gyllensten U. Strong effects of genetic and lifestyle factors on biomarker variation and use of personalized cutoffs. Nat. Commun. 5, 4684 (2014).
    • (2014) Nat. Commun , vol.5 , pp. 4684
    • Enroth, S.1    Johansson, Å.2    Enroth, S.B.3    Gyllensten, U.4
  • 28
    • 84876516949 scopus 로고    scopus 로고
    • Apoptosis and other immune biomarkers predict influenza vaccine responsiveness
    • Furman D, et al. Apoptosis and other immune biomarkers predict influenza vaccine responsiveness. Mol. Syst. Biol. 9, 659-659 (2013).
    • (2013) Mol. Syst. Biol , vol.9 , pp. 659
    • Furman, D.1
  • 29
    • 84963631903 scopus 로고    scopus 로고
    • Systems analysis of immunity to influenza vaccination across multiple years and in diverse populations reveals shared molecular signatures
    • Nakaya H. I, et al. Systems analysis of immunity to influenza vaccination across multiple years and in diverse populations reveals shared molecular signatures. Immunity 43, 1186-1198 (2015).
    • (2015) Immunit , vol.43 , pp. 1186-1198
    • Nakaya, H.I.1
  • 30
    • 67649756856 scopus 로고    scopus 로고
    • Seasonal variation of diagnosis of Type 1 diabetes mellitus in children worldwide
    • Moltchanova E. V, Schreier N, Lammi N, & Karvonen M. Seasonal variation of diagnosis of Type 1 diabetes mellitus in children worldwide. Diabet. Med. 26, 673-678 (2009).
    • (2009) Diabet. Med , vol.26 , pp. 673-678
    • Moltchanova, E.V.1    Schreier, N.2    Lammi, N.3    Karvonen, M.4
  • 31
    • 34347270615 scopus 로고    scopus 로고
    • What?s in season for rheumatoid arthritis patients? Seasonal fluctuations in disease activity
    • Iikuni N, et al. What?s in season for rheumatoid arthritis patients?. Seasonal fluctuations in disease activity. Rheumatology 46, 846-848 (2007).
    • (2007) Rheumatolog , vol.46 , pp. 846-848
    • Iikuni, N.1
  • 32
    • 84898790496 scopus 로고    scopus 로고
    • Seasonal changes in gene expression represent cell-Type composition in whole blood
    • De Jong S, et al. Seasonal changes in gene expression represent cell-Type composition in whole blood. Hum. Mol. Genet. 23, 2721-2728 (2014).
    • (2014) Hum. Mol. Genet , vol.23 , pp. 2721-2728
    • De Jong, S.1
  • 33
    • 84964294900 scopus 로고    scopus 로고
    • Widespread seasonal gene expression reveals annual differences in human immunity and physiology
    • Dopico X. C, et al. Widespread seasonal gene expression reveals annual differences in human immunity and physiology. Nat. Commun. 6, 7000 (2015).
    • (2015) Nat. Commun , vol.6 , pp. 7000
    • Dopico, X.C.1
  • 34
    • 33847025269 scopus 로고    scopus 로고
    • Circadian rhythms in rheumatoid arthritis: Implications for pathophysiology and therapeutic management
    • Straub R. H, & Cutolo M. Circadian rhythms in rheumatoid arthritis: implications for pathophysiology and therapeutic management. Arthritis Rheum. 56, 399-408 (2007).
    • (2007) Arthritis Rheum , vol.56 , pp. 399-408
    • Straub, R.H.1    Cutolo, M.2
  • 35
    • 37649021327 scopus 로고    scopus 로고
    • Circadian rhythms in arthritis: Hormonal effects on the immune/ inflammatory reaction
    • Cutolo M, & Straub R. H. Circadian rhythms in arthritis: hormonal effects on the immune/ inflammatory reaction. Autoimmun Rev. 7, 223-228 (2008).
    • (2008) Autoimmun Rev , vol.7 , pp. 223-228
    • Cutolo, M.1    Straub, R.H.2
  • 37
    • 84965146271 scopus 로고    scopus 로고
    • Mass cytometry: Single cells, many features
    • Spitzer M. H, & Nolan G. P. Mass cytometry: single cells, many features. Cell 165, 780-791 (2016).
    • (2016) Cel , vol.165 , pp. 780-791
    • Spitzer, M.H.1    Nolan, G.P.2
  • 38
    • 80055072549 scopus 로고    scopus 로고
    • Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-Abundant proteins in human blood
    • Lundberg M, Eriksson A, Tran B, Assarsson E, & Fredriksson S. Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-Abundant proteins in human blood. Nucleic Acids Res. 39, e102 (2011).
    • (2011) Nucleic Acids Res , vol.39 , pp. e102
    • Lundberg, M.1    Eriksson, A.2    Tran, B.3    Assarsson, E.4    Fredriksson, S.5
  • 39
    • 84902478661 scopus 로고    scopus 로고
    • The use of multiplex platforms for absolute and relative protein quantification of clinical material
    • Christiansson L, et al. The use of multiplex platforms for absolute and relative protein quantification of clinical material. EuPA Open Proteom. 3, 37-47 (2014).
    • (2014) EuPA Open Proteom , vol.3 , pp. 37-47
    • Christiansson, L.1
  • 40
    • 84929162992 scopus 로고    scopus 로고
    • The genetic architecture of the human immune system: A bioresource for autoimmunity and disease pathogenesis
    • Roederer M, et al. The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis. Cell 161, 387-403 (2015).
    • (2015) Cel , vol.161 , pp. 387-403
    • Roederer, M.1
  • 41
    • 84962128086 scopus 로고    scopus 로고
    • Personalized immunomonitoring uncovers molecular networks that stratify lupus patients
    • Banchereau R, et al. Personalized immunomonitoring uncovers molecular networks that stratify lupus patients. Cell 165, 551-565 (2016).
    • (2016) Cel , vol.165 , pp. 551-565
    • Banchereau, R.1
  • 42
    • 0035554904 scopus 로고    scopus 로고
    • Sex differences in autoimmune disease
    • Whitacre C. C. Sex differences in autoimmune disease. Nat. Immunol. 2, 777-780 (2001).
    • (2001) Nat. Immunol , vol.2 , pp. 777-780
    • Whitacre, C.C.1
  • 43
    • 34248136519 scopus 로고    scopus 로고
    • Are there gender differences in severity of ankylosing spondylitis? Results from the PSOAS cohort
    • Lee W, et al. Are there gender differences in severity of ankylosing spondylitis?. Results from the PSOAS cohort. Ann. Rheum. Dis. 66, 633-638 (2007).
    • (2007) Ann. Rheum. Dis , vol.66 , pp. 633-638
    • Lee, W.1
  • 44
    • 0037452790 scopus 로고    scopus 로고
    • Individuality and variation in gene expression patterns in human blood
    • Whitney A. R, et al. Individuality and variation in gene expression patterns in human blood. Proc. Natl Acad. Sci. USA 100, 1896-1901 (2003).
    • (2003) Proc. Natl Acad. Sci. US , vol.100 , pp. 1896-1901
    • Whitney, A.R.1
  • 45
    • 4644327279 scopus 로고    scopus 로고
    • Sex hormones influence on the immune system: Basic and clinical aspects in autoimmunity
    • Cutolo M, et al. Sex hormones influence on the immune system: basic and clinical aspects in autoimmunity. Lupus 13, 635-638 (2004).
    • (2004) Lupu , vol.13 , pp. 635-638
    • Cutolo, M.1
  • 46
    • 84892562675 scopus 로고    scopus 로고
    • Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination
    • Furman D, et al. Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination. Proc. Natl Acad. Sci. USA 111, 869-874 (2014).
    • (2014) Proc. Natl Acad. Sci. US , vol.111 , pp. 869-874
    • Furman, D.1
  • 47
    • 84901459546 scopus 로고    scopus 로고
    • ImmPort: Disseminating data to the public for the future of immunology
    • Bhattacharya S, et al. ImmPort: disseminating data to the public for the future of immunology. Immunol. Res. 58, 234-239 (2014).
    • (2014) Immunol. Res , vol.58 , pp. 234-239
    • Bhattacharya, S.1
  • 48
    • 0023870774 scopus 로고
    • Genetic and environmental influences on premature death in adult adoptees
    • Sørensen T. I, Nielsen G. G, Andersen P. K, & Teasdale T. W. Genetic and environmental influences on premature death in adult adoptees. N. Engl. J. Med. 318, 727-732 (1988).
    • (1988) N. Engl. J. Med , vol.318 , pp. 727-732
    • Sørensen, T.I.1    Nielsen, G.G.2    Andersen, P.K.3    Teasdale, T.W.4
  • 49
    • 0347089095 scopus 로고    scopus 로고
    • The human model: A genetic dissection of immunity to infection in natural conditions
    • Casanova J. L, & Abel L. The human model: a genetic dissection of immunity to infection in natural conditions. Nat. Rev. Immunol. 4, 55-66 (2004).
    • (2004) Nat. Rev. Immunol , vol.4 , pp. 55-66
    • Casanova, J.L.1    Abel, L.2
  • 50
    • 77957020774 scopus 로고    scopus 로고
    • Life-Threatening infectious diseases of childhood: Single-gene inborn errors of immunity?
    • Alcaïs A, et al. Life-Threatening infectious diseases of childhood: single-gene inborn errors of immunity?. Ann. NY Acad. Sci. 1214, 18-33 (2010).
    • (2010) Ann. NY Acad. Sci , vol.1214 , pp. 18-33
    • Alcaïs, A.1
  • 51
    • 84964644414 scopus 로고    scopus 로고
    • Genetics of autoimmune diseases: Perspectives from genome-wide association studies
    • Kochi Y. Genetics of autoimmune diseases: perspectives from genome-wide association studies. Int. Immunol. 28, 155-161 (2016).
    • (2016) Int. Immunol , vol.28 , pp. 155-161
    • Kochi, Y.1
  • 52
    • 67650709487 scopus 로고    scopus 로고
    • Recent advances in the genetics of autoimmune disease
    • Gregersen P. K, & Olsson L. M. Recent advances in the genetics of autoimmune disease. Annu. Rev. Immunol. 27, 363-391 (2009).
    • (2009) Annu. Rev. Immunol , vol.27 , pp. 363-391
    • Gregersen, P.K.1    Olsson, L.M.2
  • 53
    • 33748039452 scopus 로고    scopus 로고
    • Heritability of cardiovascular and personality traits in 6,148 sardinians
    • Pilia G, et al. Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians. PLoS Genet. 2, e132 (2006).
    • (2006) PLoS Genet , vol.2 , pp. e132
    • Pilia, G.1
  • 54
    • 79959824142 scopus 로고    scopus 로고
    • Multiple loci are associated with white blood cell phenotypes
    • Nalls M. A, et al. Multiple loci are associated with white blood cell phenotypes. PLoS Genet. 7, e1002113 (2011).
    • (2011) PLoS Genet , vol.7 , pp. e1002113
    • Nalls, M.A.1
  • 55
    • 70349993594 scopus 로고    scopus 로고
    • Replication of celiac disease UK genome-wide association study results in a US population
    • Garner C. P, et al. Replication of celiac disease UK genome-wide association study results in a US population. Hum. Mol. Genet. 18, 4219-4225 (2009).
    • (2009) Hum. Mol. Genet , vol.18 , pp. 4219-4225
    • Garner, C.P.1
  • 56
    • 84884878742 scopus 로고    scopus 로고
    • Genetic variants regulating immune cell levels in health and disease
    • Orrù V, et al. Genetic variants regulating immune cell levels in health and disease. Cell 155, 242-256 (2013).
    • (2013) Cel , vol.155 , pp. 242-256
    • Orrù, V.1
  • 57
    • 33750378268 scopus 로고    scopus 로고
    • Systemic lupus erythematosus: All roads lead to type i interferons
    • Pascual V, Farkas L, & Banchereau J. Systemic lupus erythematosus: all roads lead to type I interferons. Curr. Opin. Immunol. 18, 676-682 (2006).
    • (2006) Curr. Opin. Immunol , vol.18 , pp. 676-682
    • Pascual, V.1    Farkas, L.2    Banchereau, J.3
  • 58
    • 76549136591 scopus 로고    scopus 로고
    • Genetic regulation of serum cytokines in systemic lupus erythematosus
    • Kariuki S. N, & Niewold T. B. Genetic regulation of serum cytokines in systemic lupus erythematosus. Translat. Res. 155, 109-117 (2010).
    • (2010) Translat. Res , vol.155 , pp. 109-117
    • Kariuki, S.N.1    Niewold, T.B.2
  • 59
    • 0344492212 scopus 로고    scopus 로고
    • Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus
    • Baechler E. C, et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc. Natl Acad. Sci. USA 100, 2610-2615 (2003).
    • (2003) Proc. Natl Acad. Sci. US , vol.100 , pp. 2610-2615
    • Baechler, E.C.1
  • 60
    • 34548438559 scopus 로고    scopus 로고
    • High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus
    • Niewold T. B, Hua J, Lehman T. J. A, Harley J. B, & Crow M. K. High serum IFN-α activity is a heritable risk factor for systemic lupus erythematosus. Genes Immun. 8, 492-502 (2007).
    • (2007) Genes Immun , vol.8 , pp. 492-502
    • Niewold, T.B.1    Hua, J.2    Lehman, T.J.A.3    Harley, J.B.4    Crow, M.K.5
  • 61
    • 84888198427 scopus 로고    scopus 로고
    • Novel gene variants predict serum levels of the cytokines IL 18 and IL 1ra in older adults
    • Matteini A. M, et al. Novel gene variants predict serum levels of the cytokines IL 18 and IL 1ra in older adults. Cytokine 65, 10-16 (2014).
    • (2014) Cytokin , vol.65 , pp. 10-16
    • Matteini, A.M.1
  • 62
    • 9644304486 scopus 로고    scopus 로고
    • Cytokine genes and disease susceptibility
    • Ollier W. E. R. Cytokine genes and disease susceptibility. Cytokine 28, 174-178 (2004).
    • (2004) Cytokin , vol.28 , pp. 174-178
    • Ollier, W.E.R.1
  • 63
    • 84928695024 scopus 로고    scopus 로고
    • ImmVar project: Insights and design considerations for future studies of 'healthy' immune variation
    • De Jager P. L, et al. ImmVar project: insights and design considerations for future studies of ?healthy? immune variation. Semin. Immunol. 27, 51-57 (2015).
    • (2015) Semin. Immunol , vol.27 , pp. 51-57
    • De Jager, P.L.1
  • 64
    • 79952263851 scopus 로고    scopus 로고
    • Single-Tissue and cross-Tissue heritability of gene expression via identity-by descent in related or unrelated individuals
    • Price A. L, et al. Single-Tissue and cross-Tissue heritability of gene expression via identity-by descent in related or unrelated individuals. PLoS Genet. 7, e1001317 (2011).
    • (2011) PLoS Genet , vol.7 , pp. e1001317
    • Price, A.L.1
  • 65
    • 84971320925 scopus 로고    scopus 로고
    • Drug-induced mRNA signatures are enriched for the minority of genes that are highly heritable
    • Gao T, Brodin P, Davis M. M, & Jojic V. Drug-induced mRNA signatures are enriched for the minority of genes that are highly heritable. Pac. Symp. Biocomput. 395-406 (2015).
    • (2015) Pac. Symp. Biocomput , pp. 395-406
    • Gao, T.1    Brodin, P.2    Davis, M.M.3    Jojic, V.4
  • 66
    • 84896759364 scopus 로고    scopus 로고
    • Common genetic variants modulate pathogen-sensing responses in human dendritic cells
    • Lee M. N, et al. Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science 343, 1246980 (2014).
    • (2014) Scienc , vol.343 , pp. 1246980
    • Lee, M.N.1
  • 67
    • 84907202723 scopus 로고    scopus 로고
    • Intersection of population variation and autoimmunity genetics in human T cell activation
    • Ye C. J, et al. Intersection of population variation and autoimmunity genetics in human T cell activation. Science 345, 1254665 (2014).
    • (2014) Scienc , vol.345 , pp. 1254665
    • Ye, C.J.1
  • 68
    • 0026443849 scopus 로고
    • Adaptive cellular interactions in the immune system: The tunable activation threshold and the significance of subthreshold responses
    • Grossman Z, & Paul W. E. Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses. Proc. Natl Acad. Sci. USA 89, 10365-10369 (1992).
    • (1992) Proc. Natl Acad. Sci. US , vol.89 , pp. 10365-10369
    • Grossman, Z.1    Paul, W.E.2
  • 69
    • 63149126181 scopus 로고    scopus 로고
    • NK cell education: Not an on off switch but a tunable rheostat
    • Brodin P, Krre K, & Hqglund P. NK cell education: not an on off switch but a tunable rheostat. Trends Immunol. 30, 143-149 (2009).
    • (2009) Trends Immunol , vol.30 , pp. 143-149
    • Brodin, P.1    Krre, K.2    Hqglund, P.3
  • 70
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • Fraga M. F, et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl Acad. Sci. USA 102, 10604-10609 (2005).
    • (2005) Proc. Natl Acad. Sci. US , vol.102 , pp. 10604-10609
    • Fraga, M.F.1
  • 71
    • 84977481546 scopus 로고    scopus 로고
    • Epigenome-wide association studies and the interpretation of disease-omics
    • Birney E, Smith G. D, & Greally J. M. Epigenome-wide association studies and the interpretation of disease-omics. PLoS Genet. 12, e1006105 (2016).
    • (2016) PLoS Genet , vol.12 , pp. e1006105
    • Birney, E.1    Smith, G.D.2    Greally, J.M.3
  • 72
    • 84965002935 scopus 로고    scopus 로고
    • How colonization by microbiota in early life shapes the immune system
    • Gensollen T, Iyer S. S, Kasper D. L, & Blumberg R. S. How colonization by microbiota in early life shapes the immune system. Science 352, 539-544 (2016).
    • (2016) Scienc , vol.352 , pp. 539-544
    • Gensollen, T.1    Iyer, S.S.2    Kasper, D.L.3    Blumberg, R.S.4
  • 73
    • 84862637797 scopus 로고    scopus 로고
    • Gut immune maturation depends on colonization with a host-specific microbiota
    • Chung H, et al. Gut immune maturation depends on colonization with a host-specific microbiota. Cell 149, 1578-1593 (2012).
    • (2012) Cel , vol.149 , pp. 1578-1593
    • Chung, H.1
  • 74
    • 84964918435 scopus 로고    scopus 로고
    • Normalizing the environment recapitulates adult human immune traits in laboratory mice
    • Beura L. K, et al. Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature 532, 512-516 (2016).
    • (2016) Natur , vol.532 , pp. 512-516
    • Beura, L.K.1
  • 75
    • 84963983980 scopus 로고    scopus 로고
    • Sequential infection with common pathogens promotes human-like immune gene expression and altered vaccine response
    • Reese T. A, et al. Sequential infection with common pathogens promotes human-like immune gene expression and altered vaccine response. Cell Host Microbe 19, 713-719 (2016).
    • (2016) Cell Host Microb , vol.19 , pp. 713-719
    • Reese, T.A.1
  • 76
    • 0024417450 scopus 로고
    • Hay fever, hygiene, and household size
    • Strachan D. P. Hay fever, hygiene, and household size. BMJ 299, 1259-1260 (1989).
    • (1989) BM , vol.299 , pp. 1259-1260
    • Strachan, D.P.1
  • 77
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach J. F. The effect of infections on susceptibility to autoimmune and allergic diseases. N. Engl. J. Med. 347, 911-920 (2002).
    • (2002) N. Engl. J. Med , vol.347 , pp. 911-920
    • Bach, J.F.1
  • 78
    • 0037136585 scopus 로고    scopus 로고
    • Environmental exposure to endotoxin and its relation to asthma in school-Age children
    • Braun-Fahrldnder C, et al. Environmental exposure to endotoxin and its relation to asthma in school-Age children. N. Engl. J. Med. 347, 869-877 (2002).
    • (2002) N. Engl. J. Med , vol.347 , pp. 869-877
    • Braun-Fahrldnder, C.1
  • 79
    • 84964682615 scopus 로고    scopus 로고
    • Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans
    • Vatanen T, et al. Variation in microbiome LPS immunogenicity contributes to autoimmunity in humans. Cell 165, 842-853 (2016).
    • (2016) Cel , vol.165 , pp. 842-853
    • Vatanen, T.1
  • 80
    • 84942874856 scopus 로고    scopus 로고
    • Early infancy microbial and metabolic alterations affect risk of childhood asthma
    • Arrieta M. C, et al. Early infancy microbial and metabolic alterations affect risk of childhood asthma. Sci. Transl. Med. 7, 307ra152 (2015).
    • (2015) Sci. Transl. Med , vol.7 , pp. 307ra152
    • Arrieta, M.C.1
  • 81
    • 84907557973 scopus 로고    scopus 로고
    • The microbial basis of inflammatory bowel diseases
    • Dalal S. R, & Chang E. B. The microbial basis of inflammatory bowel diseases. J. Clin. Invest. 124, 4190-4196 (2014).
    • (2014) J. Clin. Invest , vol.124 , pp. 4190-4196
    • Dalal, S.R.1    Chang, E.B.2
  • 82
    • 84861539347 scopus 로고    scopus 로고
    • Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation
    • Jenq R. R, et al. Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation. J. Exp. Med. 209, 903-911 (2012).
    • (2012) J. Exp. Med , vol.209 , pp. 903-911
    • Jenq, R.R.1
  • 83
    • 84908003512 scopus 로고    scopus 로고
    • TLR5 mediated sensing of gut microbiota Is necessary for antibody responses to seasonal influenza vaccination
    • Oh J. Z, et al. TLR5 mediated sensing of gut microbiota Is necessary for antibody responses to seasonal influenza vaccination. Immunity 41, 478-492 (2014).
    • (2014) Immunit , vol.41 , pp. 478-492
    • Oh, J.Z.1
  • 84
    • 84888059687 scopus 로고    scopus 로고
    • The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide
    • Viaud S, et al. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 342, 971-976 (2013).
    • (2013) Scienc , vol.342 , pp. 971-976
    • Viaud, S.1
  • 85
    • 84948461699 scopus 로고    scopus 로고
    • Anticancer immunotherapy by CTLA 4 blockade relies on the gut microbiota
    • V?tizou M, et al. Anticancer immunotherapy by CTLA 4 blockade relies on the gut microbiota. Science 350, 1079-1084 (2015).
    • (2015) Scienc , vol.350 , pp. 1079-1084
    • Vtizou, M.1
  • 86
    • 84948451779 scopus 로고    scopus 로고
    • Commensal Bifidobacterium promotes antitumor immunity and facilitates anti PD L1 efficacy
    • Sivan A, et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti PD L1 efficacy. Science 350, 1084-1089 (2015).
    • (2015) Scienc , vol.350 , pp. 1084-1089
    • Sivan, A.1
  • 87
    • 84930635082 scopus 로고    scopus 로고
    • Viral immunology Comprehensive serological profiling of human populations using a synthetic human virome
    • Xu G. J, et al. Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome. Science 348, aaa0698 (2015).
    • (2015) Scienc , vol.348 , pp. aaa0698
    • Xu, G.J.1
  • 88
    • 24344489044 scopus 로고    scopus 로고
    • Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
    • Sylwester A. W, et al. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J. Exp. Med. 202, 673-685 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 673-685
    • Sylwester, A.W.1
  • 89
    • 84959559396 scopus 로고    scopus 로고
    • Immune adaptation to environmental influence: The case of NK cells and HCMV
    • Rqlle A, & Brodin P. Immune adaptation to environmental influence: the case of NK cells and HCMV. Trends Immunol. 37, 233-243 (2016).
    • (2016) Trends Immunol , vol.37 , pp. 233-243
    • Rqlle, A.1    Brodin, P.2
  • 90
    • 84926442317 scopus 로고    scopus 로고
    • Cytomegalovirus infection enhances the immune response to influenza
    • Furman D, et al. Cytomegalovirus infection enhances the immune response to influenza. Sci Transl Med 7, 281ra43 (2015).
    • (2015) Sci Transl Me , vol.7 , pp. 281ra43
    • Furman, D.1
  • 91
    • 84897127283 scopus 로고    scopus 로고
    • The virome in mammalian physiology and disease
    • Virgin H. W. The virome in mammalian physiology and disease. Cell 157, 142-150 (2014).
    • (2014) Cel , vol.157 , pp. 142-150
    • Virgin, H.W.1
  • 92
    • 84889594211 scopus 로고    scopus 로고
    • Temporal response of the human virome to immunosuppression and antiviral therapy
    • De Vlaminck I, et al. Temporal response of the human virome to immunosuppression and antiviral therapy. Cell 155, 1178-1187 (2013).
    • (2013) Cel , vol.155 , pp. 1178-1187
    • De Vlaminck, I.1
  • 93
    • 0036580648 scopus 로고    scopus 로고
    • Effects of cigarette smoke on the immune system
    • Sopori M. Effects of cigarette smoke on the immune system. Nat. Rev. Immunol. 2, 372-377 (2002).
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 372-377
    • Sopori, M.1
  • 94
    • 84982267484 scopus 로고    scopus 로고
    • Current cigarette smoking is a reversible cause of elevated white blood cell count: Cross-sectional and longitudinal studies
    • Higuchi T, et al. Current cigarette smoking is a reversible cause of elevated white blood cell count: cross-sectional and longitudinal studies. Prev. Med. Rep. 4, 417-422 (2016).
    • (2016) Prev. Med. Rep , vol.4 , pp. 417-422
    • Higuchi, T.1
  • 95
    • 0018766244 scopus 로고
    • Low natural killer-cell activity and immunoglobulin levels associated with smoking in human subjects
    • Ferson M, Edwards A, Lind A, Milton G. W, & Hersey P. Low natural killer-cell activity and immunoglobulin levels associated with smoking in human subjects. Int. J. Cancer 23, 603-609 (1979).
    • (1979) Int. J. Cance , vol.23 , pp. 603-609
    • Ferson, M.1    Edwards, A.2    Lind, A.3    Milton, G.W.4    Hersey, P.5
  • 96
    • 0015901245 scopus 로고
    • Association of autoantibodies with smoking, cardiovascular morbidity, and death in the Busselton population
    • Mathews J. D, Whittingham S, Hooper B. M, Mackay I. R, & Stenhouse N. S. Association of autoantibodies with smoking, cardiovascular morbidity, and death in the Busselton population. Lancet 2, 754-758 (1973).
    • (1973) Lance , vol.2 , pp. 754-758
    • Mathews, J.D.1    Whittingham, S.2    Hooper, B.M.3    Mackay, I.R.4    Stenhouse, N.S.5
  • 97
    • 5644239636 scopus 로고    scopus 로고
    • A gene-environment interaction between smoking and shared epitope genes in HLA DR provides a high risk of seropositive rheumatoid arthritis
    • Padyukov L, et al. A gene-environment interaction between smoking and shared epitope genes in HLA DR provides a high risk of seropositive rheumatoid arthritis. Arthritis Rheum. 50, 3085-3092 (2004).
    • (2004) Arthritis Rheum , vol.50 , pp. 3085-3092
    • Padyukov, L.1
  • 98
    • 84928053009 scopus 로고    scopus 로고
    • A mine is a terrible thing to waste: High content, single cell technologies for comprehensive immune analysis
    • Chattopadhyay P. K, & Roederer M. A mine is a terrible thing to waste: high content, single cell technologies for comprehensive immune analysis. Am. J. Transplant. 15, 1155-1161 (2015).
    • (2015) Am. J Transplant , vol.15 , pp. 1155-1161
    • Chattopadhyay, P.K.1    Roederer, M.2
  • 99
    • 68849103521 scopus 로고    scopus 로고
    • Mass cytometry: Technique for real time single cell multitarget immunoassay based on inductively coupled plasma time of flight mass spectrometry
    • Bandura D. R, et al. Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time of flight mass spectrometry. Anal. Chem. 81, 6813-6822 (2009).
    • (2009) Anal. Chem , vol.81 , pp. 6813-6822
    • Bandura, D.R.1
  • 100
    • 84959248377 scopus 로고    scopus 로고
    • Highly multiplexed simultaneous detection of RNAs and proteins in single cells
    • Frei A. P, et al. Highly multiplexed simultaneous detection of RNAs and proteins in single cells. Nat. Methods 13, 269-275 (2016).
    • (2016) Nat. Method , vol.13 , pp. 269-275
    • Frei, A.P.1
  • 101
    • 84856278095 scopus 로고    scopus 로고
    • Cytometry by time of flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes
    • Newell E. W, Sigal N, Bendall S. C, Nolan G. P, & Davis M. M. Cytometry by time of flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes. Immunity 36, 142-152 (2012).
    • (2012) Immunit , vol.36 , pp. 142-152
    • Newell, E.W.1    Sigal, N.2    Bendall, S.C.3    Nolan, G.P.4    Davis, M.M.5
  • 102
    • 84866096861 scopus 로고    scopus 로고
    • Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators
    • Bodenmiller B, et al. Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators. Nat. Biotechnol. 30, 858-867 (2012).
    • (2012) Nat. Biotechnol , vol.30 , pp. 858-867
    • Bodenmiller, B.1
  • 103
    • 79955750055 scopus 로고    scopus 로고
    • Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum
    • Bendall S. C, et al. Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science 332, 687-696 (2011).
    • (2011) Scienc , vol.332 , pp. 687-696
    • Bendall, S.C.1
  • 104
    • 84929684999 scopus 로고    scopus 로고
    • Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
    • Macosko E. Z, et al. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161, 1202-1214 (2015).
    • (2015) Cel , vol.161 , pp. 1202-1214
    • Macosko, E.Z.1
  • 105
    • 84903993800 scopus 로고    scopus 로고
    • Linking T cell receptor sequence to functional phenotype at the single-cell level
    • Han A, Glanville J, Hansmann L, & Davis M. M. Linking T cell receptor sequence to functional phenotype at the single-cell level. Nat. Biotechnol. 32, 684-692 (2014).
    • (2014) Nat. Biotechnol , vol.32 , pp. 684-692
    • Han, A.1    Glanville, J.2    Hansmann, L.3    Davis, M.M.4
  • 106
    • 84960194523 scopus 로고    scopus 로고
    • T cell fate and clonality inference from single-cell transcriptomes
    • Stubbington M. J. T, et al. T cell fate and clonality inference from single-cell transcriptomes. Nat. Method 13 329-332 (2016).
    • (2016) Nat. Methods , vol.13 , pp. 329-332
    • Stubbington, M.J.T.1
  • 107
    • 84904305923 scopus 로고    scopus 로고
    • Mass spectrometry-based plasma proteomics: State of the art and future outlook
    • Pernemalm M, & Lehtiö J. Mass spectrometry-based plasma proteomics: state of the art and future outlook. Expert Rev. Proteom. 11, 431-448 (2014).
    • (2014) Expert Rev. Proteom , vol.11 , pp. 431-448
    • Pernemalm, M.1    Lehtiö, J.2


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