Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens

Cell

Volumn 167, Issue 3, 2016, Pages 657-669.e21

  Nédélec, Yohann ^a,b   Sanz, Joaquín ^a,b   Baharian, Golshid ^a,b   Szpiech, Zachary A ^c   Pacis, Alain ^a,b   Dumaine, Anne ^b   Grenier, Jean Christophe ^b   Freiman, Andrew ^d   Sams, Aaron J ^e   Hebert, Steven ^b   Pagé Sabourin, Ariane ^b   Luca, Francesca ^d   Blekhman, Ran ^f   Hernandez, Ryan D ^c,g   Pique Regi, Roger ^d   Tung, Jenny ^h   Yotova, Vania ^b   Barreiro, Luis B ^a,b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Plant Science Building   (United States)

^f UNIVERSITY OF MINNESOTA   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h DUKE UNIVERSITY   (United States)

Author keywords

bacterial infection; eQTL; immune responses; macrophages; natural selection; Neanderthal introgression; population variation

Indexed keywords

INTERFERON REGULATORY FACTOR 2; STAT4 PROTEIN;

AFRICAN; ANCESTRY GROUP; APOPTOSIS; ARTICLE; BACTERIAL COUNT; BACTERIAL GROWTH; BACTERIAL INFECTION; BACTERIUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; EUROPEAN; GENE CONTROL; GENE EXPRESSION; GENE FREQUENCY; GENETIC DRIFT; GENETIC REGULATION; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; INFLAMMATION; INNATE IMMUNITY; LISTERIA MONOCYTOGENES; LISTERIOSIS; MACROPHAGE; NATURAL SELECTION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RNA SEQUENCE; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SALMONELLOSIS; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE ACTIVATION;

EID: 84992381901     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.09.025     Document Type: Article

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