-
1
-
-
85002152554
-
Human immune system variation
-
Brodin, P. & Davis, M. M. Human immune system variation. Nat. Rev. Immunol. 17, 21-29 (2017).
-
(2017)
Nat. Rev. Immunol.
, vol.17
, pp. 21-29
-
-
Brodin, P.1
Davis, M.M.2
-
2
-
-
84877266456
-
Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli
-
Gat-Viks, I. et al. Deciphering molecular circuits from genetic variation underlying transcriptional responsiveness to stimuli. Nat. Biotechnol. 31, 342-349 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 342-349
-
-
Gat-Viks, I.1
-
3
-
-
84995678287
-
A functional genomics approach to understand variation in cytokine production in humans
-
e14
-
Li, Y. et al. A functional genomics approach to understand variation in cytokine production in humans. Cell 167, 1099-1110.e14 (2016).
-
(2016)
Cell
, vol.167
, pp. 1099-1110
-
-
Li, Y.1
-
4
-
-
85006138330
-
Functional and genomic architecture of borrelia burgdorferi-induced cytokine responses in humans
-
Oosting, M. et al. Functional and genomic architecture of borrelia burgdorferi-induced cytokine responses in humans. Cell Host. Microbe 20, 822-833 (2016).
-
(2016)
Cell Host. Microbe
, vol.20
, pp. 822-833
-
-
Oosting, M.1
-
5
-
-
85018582872
-
Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors
-
Villani, A.-C. et al. Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors. Science 356, eaah4573 (2017).
-
(2017)
Science
, vol.356
, pp. eaah4573
-
-
Villani, A.-C.1
-
6
-
-
84922809120
-
Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes
-
Kim, S. et al. Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes. Nat. Commun. 5, 5236 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 5236
-
-
Kim, S.1
-
7
-
-
84856387609
-
Deciphering the genetic architecture of variation in the immune response to mycobacterium tuberculosis infection
-
Barreiro, L. B. et al. Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection. Proc. Natl Acad. Sci. USA 109, 1204-1209 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 1204-1209
-
-
Barreiro, L.B.1
-
8
-
-
84896759364
-
Common genetic variants modulate pathogen-sensing responses in human dendritic cells
-
Lee, M. N. et al. Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science 343, 1246980 (2014).
-
(2014)
Science
, vol.343
, pp. 1246980
-
-
Lee, M.N.1
-
9
-
-
84896742056
-
Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression
-
Fairfax, B. P. et al. Innate Immune activity conditions the effect of regulatory variants upon monocyte gene expression. Science 343, 1246949 (2014).
-
(2014)
Science
, vol.343
, pp. 1246949
-
-
Fairfax, B.P.1
-
10
-
-
84992381901
-
Genetic ancestry and natural selection drive population differences in immune responses to pathogens
-
e21
-
Nédélec, Y. et al. Genetic ancestry and natural selection drive population differences in immune responses to pathogens. Cell 167, 657-664.e21 (2016).
-
(2016)
Cell
, vol.167
, pp. 657-664
-
-
Nédélec, Y.1
-
11
-
-
84992187388
-
Genetic adaptation and neandertal admixture shaped the immune system of human populations
-
e17
-
Quach, H. et al. Genetic adaptation and neandertal admixture shaped the immune system of human populations. Cell 167, 643-649.e17 (2016).
-
(2016)
Cell
, vol.167
, pp. 643-649
-
-
Quach, H.1
-
12
-
-
84898723939
-
Joint analysis of functional genomic data and genome-wide association studies of 18 human traits
-
Pickrell, J. K. Joint analysis of functional genomic data and genome-wide association studies of 18 human traits. Am. J. Hum. Genet. 94, 559-573 (2014).
-
(2014)
Am. J. Hum. Genet.
, vol.94
, pp. 559-573
-
-
Pickrell, J.K.1
-
13
-
-
84872522528
-
Latent enhancers activated by stimulation in differentiated cells
-
Ostuni, R. et al. Latent enhancers activated by stimulation in differentiated cells. Cell 152, 157-171 (2013).
-
(2013)
Cell
, vol.152
, pp. 157-171
-
-
Ostuni, R.1
-
15
-
-
33644981509
-
A map of recent positive selection in the human genome
-
Voight, B. F., Kudaravalli, S., Wen, X. & Pritchard, J. K. A map of recent positive selection in the human genome. PLoS Biol. 4, e72 (2006).
-
(2006)
PLoS Biol.
, vol.4
, pp. e72
-
-
Voight, B.F.1
Kudaravalli, S.2
Wen, X.3
Pritchard, J.K.4
-
16
-
-
84991056830
-
Detection of human adaptation during the past 2000 years
-
Field, Y. et al. Detection of human adaptation during the past 2000 years. Science 354, 760-764 (2016).
-
(2016)
Science
, vol.354
, pp. 760-764
-
-
Field, Y.1
-
17
-
-
84901631426
-
Bayesian test for colocalisation between pairs of genetic association studies using summary statistics
-
Giambartolomei, C. et al. Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet. 10, e1004383 (2014).
-
(2014)
PLoS Genet.
, vol.10
, pp. e1004383
-
-
Giambartolomei, C.1
-
18
-
-
77955505564
-
Biological, clinical and population relevance of 95 loci for blood lipids
-
Teslovich, T. M. et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-713 (2010).
-
(2010)
Nature
, vol.466
, pp. 707-713
-
-
Teslovich, T.M.1
-
19
-
-
77950243833
-
Multiple common variants for celiac disease influencing immune gene expression
-
Dubois, P. C. A. et al. Multiple common variants for celiac disease influencing immune gene expression. Nat. Genet. 42, 295-302 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 295-302
-
-
Dubois, P.C.A.1
-
20
-
-
84904804929
-
Biological insights from 108 schizophrenia-associated genetic loci
-
Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421-427 (2014).
-
(2014)
Nature
, vol.511
, pp. 421-427
-
-
-
21
-
-
84908024873
-
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
-
Perry, J. R. B. et al. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature 514, 92-97 (2014).
-
(2014)
Nature
, vol.514
, pp. 92-97
-
-
Perry, J.R.B.1
-
22
-
-
84891790401
-
The NHGRI GWAS catalog, a curated resource of SNP-trait associations
-
Welter, D. et al. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 42, D1001-D1006 (2014).
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. D1001-D1006
-
-
Welter, D.1
-
23
-
-
84968732934
-
RNA splicing is a primary link between genetic variation and disease
-
Li, Y. I. et al. RNA splicing is a primary link between genetic variation and disease. Science 352, 600-604 (2016).
-
(2016)
Science
, vol.352
, pp. 600-604
-
-
Li, Y.I.1
-
24
-
-
84949097483
-
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
-
Bentham, J. et al. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus. Nat. Genet. 47, 1457-1464 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 1457-1464
-
-
Bentham, J.1
-
25
-
-
84885645853
-
Transcriptome and genome sequencing uncovers functional variation in humans
-
Lappalainen, T. et al. Transcriptome and genome sequencing uncovers functional variation in humans. Nature 501, 506-511 (2013).
-
(2013)
Nature
, vol.501
, pp. 506-511
-
-
Lappalainen, T.1
-
28
-
-
84995752422
-
The allelic landscape of human blood cell trait variation and links to common complex disease
-
e19
-
Astle, W. J. et al. The allelic landscape of human blood cell trait variation and links to common complex disease. Cell 167, 1415-1429.e19 (2016).
-
(2016)
Cell
, vol.167
, pp. 1415-1429
-
-
Astle, W.J.1
-
29
-
-
33845432928
-
Adjusting batch effects in microarray expression data using empirical bayes methods
-
Johnson, W. E., Li, C. & Rabinovic, A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 8, 118-127 (2006).
-
(2006)
Biostatistics
, vol.8
, pp. 118-127
-
-
Johnson, W.E.1
Li, C.2
Rabinovic, A.3
-
30
-
-
84859098571
-
The sva package for removing batch effects and other unwanted variation in high-throughput experiments
-
Leek, J. T., Johnson, W. E., Parker, H. S., Jaffe, A. E. & Storey, J. D. The sva package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics 28, 882-883 (2012).
-
(2012)
Bioinformatics
, vol.28
, pp. 882-883
-
-
Leek, J.T.1
Johnson, W.E.2
Parker, H.S.3
Jaffe, A.E.4
Storey, J.D.5
-
31
-
-
33846932399
-
Linear models and empirical bayes methods for assessing differential expression in microarray experiments
-
Smyth, G. K. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat. Appl. Genet. Mol. Biol. 3, 1-25 (2011).
-
(2011)
Stat. Appl. Genet. Mol. Biol.
, vol.3
, pp. 1-25
-
-
Smyth, G.K.1
-
32
-
-
33846689706
-
Using GOstats to test gene lists for GO term association
-
Falcon, S. & Gentleman, R. Using GOstats to test gene lists for GO term association. Bioinformatics 23, 257-258 (2007).
-
(2007)
Bioinformatics
, vol.23
, pp. 257-258
-
-
Falcon, S.1
Gentleman, R.2
-
33
-
-
84901370399
-
A general approach for haplotype phasing across the full spectrum of relatedness
-
O'Connell, J. et al. A general approach for haplotype phasing across the full spectrum of relatedness. PLoS Genet. 10, e1004234-21 (2014).
-
(2014)
PLoS Genet.
, vol.10
, pp. e1004234-e1004321
-
-
O'Connell, J.1
-
34
-
-
67651222400
-
A flexible and accurate genotype imputation method for the next generation of genome-wide association studies
-
Howie, B. N., Donnelly, P. & Marchini, J. A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet. 5, e1000529 (2009).
-
(2009)
PLoS Genet.
, vol.5
, pp. e1000529
-
-
Howie, B.N.1
Donnelly, P.2
Marchini, J.3
-
35
-
-
84975795680
-
An integrated map of genetic variation from 1,092 human genomes
-
Consortium, T. 1G. P. et al. An integrated map of genetic variation from 1,092 human genomes. Nature 490, 56-65 (2012).
-
(2012)
Nature
, vol.490
, pp. 56-65
-
-
Consortium, T.G.P.1
-
36
-
-
84969945169
-
Fast and efficient QTL mapper for thousands of molecular phenotypes
-
Ongen, H., Buil, A., Brown, A. A., Dermitzakis, E. T. & Delaneau, O. Fast and efficient QTL mapper for thousands of molecular phenotypes. Bioinformatics 32, 1479-1485 (2016).
-
(2016)
Bioinformatics
, vol.32
, pp. 1479-1485
-
-
Ongen, H.1
Buil, A.2
Brown, A.A.3
Dermitzakis, E.T.4
Delaneau, O.5
-
37
-
-
84941051170
-
STRING v10: Protein-protein interaction networks, integrated over the tree of life
-
Szklarczyk, D. et al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43, D447-D452 (2015).
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. D447-D452
-
-
Szklarczyk, D.1
-
38
-
-
0042424602
-
Statistical significance for genomewide studies
-
Storey, J. D. & Tibshirani, R. Statistical significance for genomewide studies. Proc. Natl Acad. Sci. USA 100, 9440-9445 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 9440-9445
-
-
Storey, J.D.1
Tibshirani, R.2
-
39
-
-
84895858942
-
A general framework for estimating the relative pathogenicity of human genetic variants
-
Kircher, M. et al. A general framework for estimating the relative pathogenicity of human genetic variants. Nat. Genet. 46, 310-315 (2014).
-
(2014)
Nat. Genet.
, vol.46
, pp. 310-315
-
-
Kircher, M.1
-
40
-
-
84939123947
-
The ensembl regulatory build
-
Zerbino, D. R., Wilder, S. P., Johnson, N., Juettemann, T. & Flicek, P. R. The ensembl regulatory build. Genome Biol. 16, 56 (2015).
-
(2015)
Genome Biol.
, vol.16
, pp. 56
-
-
Zerbino, D.R.1
Wilder, S.P.2
Johnson, N.3
Juettemann, T.4
Flicek, P.R.5
-
41
-
-
84921569624
-
Selscan: An efficient multithreaded program to perform EHH-based scans for positive selection
-
Szpiech, Z. A. & Hernandez, R. D. Selscan: an efficient multithreaded program to perform EHH-based scans for positive selection. Mol. Biol. Evol. 31, 2824-2827 (2014).
-
(2014)
Mol. Biol. Evol.
, vol.31
, pp. 2824-2827
-
-
Szpiech, Z.A.1
Hernandez, R.D.2
-
42
-
-
77949656388
-
Genomic landscape of positive natural selection in northern european populations
-
Lappalainen, T. et al. Genomic landscape of positive natural selection in Northern European populations. Eur. J. Hum. Genet. 18, 471-478 (2009).
-
(2009)
Eur. J. Hum. Genet.
, vol.18
, pp. 471-478
-
-
Lappalainen, T.1
-
43
-
-
84968649781
-
Detection and interpretation of shared genetic influences on 42 human traits
-
Pickrell, J. K. et al. Detection and interpretation of shared genetic influences on 42 human traits. Nat. Genet. 48, 709-717 (2016).
-
(2016)
Nat. Genet.
, vol.48
, pp. 709-717
-
-
Pickrell, J.K.1
-
44
-
-
84930422605
-
Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases
-
Guo, H. et al. Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases. Hum. Mol. Genet. 24, 3305-3313 (2015).
-
(2015)
Hum. Mol. Genet.
, vol.24
, pp. 3305-3313
-
-
Guo, H.1
|