Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

Cell

Volumn 167, Issue 3, 2016, Pages 643-656.e17

  Quach, Hélène ^a,b   Rotival, Maxime ^a,b   Pothlichet, Julien ^a,b   Loh, Yong Hwee Eddie ^a,b   Dannemann, Michael ^c   Zidane, Nora ^a,b   Laval, Guillaume ^a,b   Patin, Etienne ^a,b   Harmant, Christine ^a,b   Lopez, Marie ^a,b,d   Deschamps, Matthieu ^a,b,d   Naffakh, Nadia ^a   Duffy, Darragh ^a   Coen, Anja ^e   Leroux Roels, Geert ^e   Clément, Frederic ^e   Boland, Anne ^f   Deleuze, Jean François ^f   Kelso, Janet ^c   Albert, Matthew L ^a,g   Quintana Murci, Lluis ^a,b   more..

^a INSTITUT PASTEUR   (France)

^b CNRS   (France)

^c MAX PLANCK INSTITUTE FOR EVOLUTIONARY ANTHROPOLOGY   (Germany)

^d SORBONNE UNIVERSITÉ   (France)

^e GHENT UNIVERSITY HOSPITAL   (Belgium)

^f DIF   (France)

^g GENENTECH INC   (United States)

Author keywords

eQTL mapping; evolution; immune response; monocytes; natural selection; Neandertal admixture; population genetics; transcriptional responses

Indexed keywords

INTERLEUKIN 12P40; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; RNA; TOLL LIKE RECEPTOR;

ALLELIC IMBALANCE; ARTICLE; EVOLUTIONARY ADAPTATION; EXPECTATION; GENE EXPRESSION; GENE FREQUENCY; GENETIC VARIABILITY; HOMO NEANDERTHALENSIS; HUMAN; HUMAN CELL; HUMAN GENOME; IMMUNE RESPONSE; IMMUNE SYSTEM; INFLUENZA VIRUS; NATURAL SELECTION; POPULATION DIFFERENTIATION; POPULATION GENETICS; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RNA SEQUENCE; ADAPTATION; ADAPTIVE IMMUNITY; ALLELE; ANIMAL; BACTERIAL INFECTION; BLACK PERSON; CAUCASIAN; EVOLUTION; GENE EXPRESSION REGULATION; GENETIC SELECTION; GENETIC TRANSCRIPTION; GENETIC VARIATION; GENETICS; IMMUNOLOGY; NUCLEOTIDE SEQUENCE; SEQUENCE ANALYSIS; VIRUS INFECTION;

ADAPTATION, PHYSIOLOGICAL; ADAPTIVE IMMUNITY; AFRICAN CONTINENTAL ANCESTRY GROUP; ALLELES; ANIMALS; BACTERIAL INFECTIONS; BASE SEQUENCE; BIOLOGICAL EVOLUTION; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE EXPRESSION REGULATION; GENETIC VARIATION; HUMANS; IMMUNE SYSTEM; NEANDERTHALS; QUANTITATIVE TRAIT LOCI; RNA; SELECTION, GENETIC; SEQUENCE ANALYSIS, RNA; TOLL-LIKE RECEPTORS; TRANSCRIPTION, GENETIC; VIRUS DISEASES;

EID: 84992187388     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.09.024     Document Type: Article

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