APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks

Nature Structural and Molecular Biology

Volumn 25, Issue 1, 2018, Pages 45-52

  Lei, Liqun ^a,b,c   Chen, Hongquan ^d,e   Xue, Wei ^f   Yang, Bei ^a   Hu, Bian ^a,g   Wei, Jia ^f   Wang, Lijie ^a,b,c   Cui, Yiqiang ^d   Li, Wei ^d   Wang, Jianying ^d   Yan, Lei ^a,b,c   Shang, Wanjing ^a,b,c   Gao, Jimin ^e   Sha, Jiahao ^d   Zhuang, Min ^a   Huang, Xingxu ^a   Shen, Bin ^d   Yang, Li ^f   Chen, Jia ^a  

^a SHANGHAITECH UNIVERSITY   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^d NANJING MEDICAL UNIVERSITY   (China)

^e WENZHOU MEDICAL UNIVERSITY   (China)

^f Chinese Academy of Sciences   (China)

^g NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; APE1 PROTEIN; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3B; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3C; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3D; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3F; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3H; APOLIPOPROTEIN B MRNA EDITING ENZYME CATALYTIC POLYPEPTIDE LIKE; CAS9 NICKASE; CYTIDINE; CYTIDINE DEAMINASE; DOUBLE STRAND BREAK REPAIR PROTEIN MRE11; EXO1 PROTEIN; GENOMIC DNA; NUCLEIC ACID BINDING PROTEIN; OLIGODEOXYNUCLEOTIDE DERIVATIVE; RECOMBINANT ENZYME; RIBONUCLEOPROTEIN; SINGLE STRANDED DNA; SINGLE STRANDED OLIGODEOXYNUCLEOTIDE; SMALL INTERFERING RNA; SMUG1 PROTEIN; UNCLASSIFIED DRUG; UNG PROTEIN;

ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CRISPR-CAS9 SYSTEM; DEAMINATION; DNA END JOINING REPAIR; DNA REPAIR; DOUBLE STRANDED DNA BREAK; ENZYME ACTIVITY; EXCISION REPAIR; FEMALE; GENE KNOCKDOWN; GENE MUTATION; HEK293-FT CELL LINE; HELA CELL LINE; HOMOLOGY DIRECTED REPAIR; HUMAN; HUMAN CELL; INDEL MUTATION; MUTATION RATE; MUTATIONAL ANALYSIS; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL;

EID: 85041892791     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/s41594-017-0004-6     Document Type: Article

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