Iron dysregulates APP processing accompanying with sAPPα cellular retention and β-secretase inhibition in rat cortical neurons

Acta Pharmacologica Sinica

Volumn 39, Issue 2, 2018, Pages 177-183

  Chen, Yu Ting ^a,b   Chen, Wu Yan ^a   Huang, Xiao Tian ^a   Xu, Ye Chun ^a   Zhang, Hai Yan ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Alzheimer's disease; amyloid precursor protein; iron; neurons; sAPP ; amyloid; secretase

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN ALPHA; BETA SECRETASE; FERRIC AMMONIUM CITRATE; UNCLASSIFIED DRUG; ASPARTIC PROTEINASE; BACE PROTEIN, RAT; FERRIC ION; OLIGOPEPTIDE; OM99-2; PEPTIDE FRAGMENT; QUATERNARY AMMONIUM DERIVATIVE; SECRETASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; CARBOXY TERMINAL SEQUENCE; CELL LYSATE; CONTROLLED STUDY; DOSE RESPONSE; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PURIFICATION; IC50; IRON OVERLOAD; IRON THERAPY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SECRETION; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN CORTEX; METABOLISM; NERVE CELL; SPRAGUE DAWLEY RAT;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CEREBRAL CORTEX; FERRIC COMPOUNDS; NEURONS; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; QUATERNARY AMMONIUM COMPOUNDS; RATS, SPRAGUE-DAWLEY;

EID: 85041597354     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2017.113     Document Type: Article

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