A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload

Neuroscience

Volumn 332, Issue , 2016, Pages 191-202

  Sripetchwandee, Jirapas ^a   Wongjaikam, Suwakon ^a   Krintratun, Warunsorn ^a   Chattipakorn, Nipon ^a   Chattipakorn, Siriporn C ^a,b  

^a Faculty of Medicine Chiang Mai University   (Thailand)

^b CHIANG MAI UNIVERSITY   (Thailand)

Author keywords

combined therapy; dendritic spine; iron chelator; iron overload; mitochondrial dynamic

Indexed keywords

AMYLOID BETA PROTEIN; ANTIOXIDANT; IRON CHELATING AGENT; TAU PROTEIN; ACETYLCYSTEINE; BENZOIC ACID DERIVATIVE; DEFERASIROX; DEFEROXAMINE; IRON; MAPT PROTEIN, RAT; TRIAZOLE DERIVATIVE;

ACCLIMATIZATION; ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL DENSITY; CELL ISOLATION; CONTROLLED STUDY; DENDRITIC SPINE; FLOW CYTOMETRY; HIPPOCAMPAL CA1 REGION; IRON OVERLOAD; LIPOTOXICITY; MALE; MINERAL INTAKE; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; NEUROFIBRILLARY TANGLE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; YOUNG ADULT; ANIMAL; APOPTOSIS; BRAIN; COMBINATION DRUG THERAPY; DEGENERATIVE DISEASE; DENDRITE; DIET; DISEASE MODEL; DRUG EFFECTS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; RANDOMIZATION; WISTAR RAT;

ACETYLCYSTEINE; AMYLOID BETA-PEPTIDES; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BENZOATES; BRAIN; DEFEROXAMINE; DENDRITES; DIET; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; IRON; IRON CHELATING AGENTS; IRON OVERLOAD; MALE; MITOCHONDRIAL DYNAMICS; NEURODEGENERATIVE DISEASES; PHOSPHORYLATION; RANDOM ALLOCATION; RATS, WISTAR; TAU PROTEINS; TRIAZOLES;

EID: 84978715654     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2016.07.003     Document Type: Article

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