Enhanced phosphatidylinositol 3-kinase (PI3K)/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress

Journal of Biological Chemistry

Volumn 288, Issue 27, 2013, Pages 19773-19784

  Uranga, Romina María ^a,b,c   Katz, Sebastián ^b,c   Salvador, Gabriela Alejandra ^a,b,c  

^a Instituto de Investigaciones Bioquimicas Bahia Blanca   (Argentina)

^b UNIVERSIDAD NACIONAL DEL SUR   (Argentina)

^c Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

CONSTITUTIVELY ACTIVES; CYTOSOLIC FRACTIONS; GLUTATHIONE METABOLISM; GLYCOGEN SYNTHASE KINASE-3; HIPPOCAMPAL NEURONS; PHOSPHATIDYLINOSITOL 3-KINASE; SYNAPTIC PLASTICITY; TRANSCRIPTIONAL ACTIVITY;

IRON; OXIDANTS; OXIDATIVE STRESS; TOXICITY;

NEURONS;

GLYCOGEN SYNTHASE KINASE 3BETA; IRON; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHRL1;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SYNTHESIS; GENE TRANSLOCATION; GLUTATHIONE METABOLISM; HIPPOCAMPUS; IRON OVERLOAD; LIPID PEROXIDATION; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING;

AKT; FOXO; IRON; NEURODEGENERATION; OXIDATIVE STRESS;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; FORKHEAD TRANSCRIPTION FACTORS; GLYCOGEN SYNTHASE KINASE 3; HIPPOCAMPUS; HUMANS; IRON; LIPID PEROXIDATION; MICE; NEURONS; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84880049690     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.457622     Document Type: Article

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