-
1
-
-
84870064521
-
Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it?
-
Kapur S, Phillips AG, Insel TR. 2012 Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it? Mol. Psychiatry 17, 1174–1179. (doi:10.1038/mp.2012.105)
-
(2012)
Mol. Psychiatry
, vol.17
, pp. 1174-1179
-
-
Kapur, S.1
Phillips, A.G.2
Insel, T.R.3
-
2
-
-
85015397423
-
Environmental risk factors for autism: An evidence-based review of systematic reviews and meta-analyses. Mol
-
Modabbernia A, Velthorst E, Reichenberg A. 2017 Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses. Mol. Autism 8, 13. (doi:10.1186/s13229-017-0121-4)
-
(2017)
Autism
, vol.8
, pp. 13
-
-
Modabbernia, A.1
Velthorst, E.2
Reichenberg, A.3
-
3
-
-
84879832291
-
Environmental risk factors and schizophrenia
-
Opler M, Charap J, Greig A, Stein V, Polito S, Malaspina D. 2013 Environmental risk factors and schizophrenia. Int. J. Mental Health 42, 23–32. (doi:10.2753/IMH0020-7411420102)
-
(2013)
Int. J. Mental Health
, vol.42
, pp. 23-32
-
-
Opler, M.1
Charap, J.2
Greig, A.3
Stein, V.4
Polito, S.5
Malaspina, D.6
-
4
-
-
84929394955
-
The association between autism and schizophrenia spectrum disorders: A review of eight alternate models of co-occurrence
-
Chisholm K, Lin A, Abu-Akel A, Wood SJ. 2015 The association between autism and schizophrenia spectrum disorders: a review of eight alternate models of co-occurrence. Neurosci. Biobehav. Rev. 55, 173–183. (doi:10.1016/j.neubiorev.2015. 04.012)
-
(2015)
Neurosci. Biobehav. Rev.
, vol.55
, pp. 173-183
-
-
Chisholm, K.1
Lin, A.2
Abu-Akel, A.3
Wood, S.J.4
-
5
-
-
84875117385
-
Modifiable risk factors for schizophrenia and autism–shared risk factors impacting on brain development
-
Hamlyn J, Duhig M, McGrath J, Scott J. 2013 Modifiable risk factors for schizophrenia and autism–shared risk factors impacting on brain development. Neurobiol. Dis. 53, 3–9. (doi:10. 1016/j.nbd.2012.10.023)
-
(2013)
Neurobiol. Dis
, vol.53
, pp. 3-9
-
-
Hamlyn, J.1
Duhig, M.2
McGrath, J.3
Scott, J.4
-
6
-
-
58149464318
-
Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: A population-based study
-
Lichtenstein P, Yip BH, Bjork C, Pawitan Y, Cannon TD, Sullivan PF, Hultman CM. 2009 Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 373, 234–239. (doi:10.1016/S0140-6736(09)60072-6)
-
(2009)
Lancet
, vol.373
, pp. 234-239
-
-
Lichtenstein, P.1
Yip, B.H.2
Bjork, C.3
Pawitan, Y.4
Cannon, T.D.5
Sullivan, P.F.6
Hultman, C.M.7
-
7
-
-
0344305525
-
Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies
-
Sullivan PF, Kendler KS, Neale MC. 2003 Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch. Gen. Psychiatry 60, 1187–1192. (doi:10.1001/archpsyc.60.12.1187)
-
(2003)
Arch. Gen. Psychiatry
, vol.60
, pp. 1187-1192
-
-
Sullivan, P.F.1
Kendler, K.S.2
Neale, M.C.3
-
8
-
-
0028906338
-
Autism as a strongly genetic disorder: Evidence from a British twin study
-
Bailey A, Le Couteur A, Gottesman I, Bolton P, Simonoff E, Yuzda E, Rutter M. 1995 Autism as a strongly genetic disorder: evidence from a British twin study. Psychol. Med. 25, 63–77. (doi:10.1017/S0033291700028099)
-
(1995)
Psychol. Med
, vol.25
, pp. 63-77
-
-
Bailey, A.1
Le Couteur, A.2
Gottesman, I.3
Bolton, P.4
Simonoff, E.5
Yuzda, E.6
Rutter, M.7
-
9
-
-
79952597943
-
Autism spectrum disorders and autistic traits: A decade of new twin studies
-
Ronald A, Hoekstra RA. 2011 Autism spectrum disorders and autistic traits: a decade of new twin studies. Am. J. Med. Genet. B 156B, 255–274. (doi:10.1002/ajmg.b.31159)
-
(2011)
Am. J. Med. Genet. B
, vol.156
, pp. 255-274
-
-
Ronald, A.1
Hoekstra, R.A.2
-
10
-
-
0034702026
-
Disruption of two novel genes by a translocation co-segregating with schizophrenia
-
Millar JK et al. 2000 Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum. Mol. Genet. 9, 1415–1423. (doi:10.1093/hmg/9.9.1415)
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 1415-1423
-
-
Millar, J.K.1
-
11
-
-
84901937317
-
Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: Results from the international consortium on brain and behavior in 22q11.2 deletion syndrome
-
Schneider M et al. 2014 Psychiatric disorders from childhood to adulthood in 22q11.2 deletion syndrome: results from the international consortium on brain and behavior in 22q11.2 deletion syndrome. Am. J. Psychiatry 171, 627–639. (doi:10. 1176/appi.ajp.2013.13070864)
-
(2014)
Am. J. Psychiatry
, vol.171
, pp. 627-639
-
-
Schneider, M.1
-
12
-
-
0026767610
-
Dynamic mutations: A new class of mutations causing human disease
-
Richards RI, Sutherland GR. 1992 Dynamic mutations: a new class of mutations causing human disease. Cell 70, 709–712. (doi:10.1016/0092-8674(92)90302-S)
-
(1992)
Cell
, vol.70
, pp. 709-712
-
-
Richards, R.I.1
Sutherland, G.R.2
-
13
-
-
0032830639
-
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
-
Amir RE, Van den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY. 1999 Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat. Genet. 23, 185–188. (doi:10.1038/13810)
-
(1999)
Nat. Genet.
, vol.23
, pp. 185-188
-
-
Amir, R.E.1
Van Den Veyver, I.B.2
Wan, M.3
Tran, C.Q.4
Francke, U.5
Zoghbi, H.Y.6
-
14
-
-
0037656313
-
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
-
Jamain S et al. 2003 Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat. Genet. 34, 27–29. (doi:10.1038/ng1136)
-
(2003)
Nat. Genet.
, vol.34
, pp. 27-29
-
-
Jamain, S.1
-
15
-
-
84908162497
-
Detecting epistasis in human complex traits
-
Wei WH, Hemani G, Haley CS. 2014 Detecting epistasis in human complex traits. Nat. Rev. Genet. 15, 722–733. (doi:10.1038/nrg3747)
-
(2014)
Nat. Rev. Genet.
, vol.15
, pp. 722-733
-
-
Wei, W.H.1
Hemani, G.2
Haley, C.S.3
-
16
-
-
68449086236
-
Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
-
Purcell SM, Wray NR, Stone JL, Visscher PM, O’Donovan MC, Sullivan PF, Sklar P. 2009 Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460, 748–752. (doi:10.1038/nature08185)
-
(2009)
Nature
, vol.460
, pp. 748-752
-
-
Purcell, S.M.1
Wray, N.R.2
Stone, J.L.3
Visscher, P.M.4
O’Donovan, M.C.5
Sullivan, P.F.6
Sklar, P.7
-
17
-
-
77950461601
-
Origins and functional impact of copy number variation in the human genome
-
Conrad DF et al. 2010 Origins and functional impact of copy number variation in the human genome. Nature 464, 704–712. (doi:10.1038/nature08516)
-
(2010)
Nature
, vol.464
, pp. 704-712
-
-
Conrad, D.F.1
-
18
-
-
79958032110
-
Rare de novo and transmitted copy-number variation in autistic spectrum disorders
-
Levy D et al. 2011 Rare de novo and transmitted copy-number variation in autistic spectrum disorders. Neuron 70, 886–897. (doi:10.1016/j. neuron.2011.05.015)
-
(2011)
Neuron
, vol.70
, pp. 886-897
-
-
Levy, D.1
-
19
-
-
84860780495
-
De novo mutations revealed by whole-exome sequencing are strongly associated with autism
-
Sanders SJ et al. 2012 De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature 485, 237–241. (doi:10.1038/nature10945)
-
(2012)
Nature
, vol.485
, pp. 237-241
-
-
Sanders, S.J.1
-
20
-
-
84860712363
-
Patterns and rates of exonic de novo mutations in autism spectrum disorders
-
Neale BM et al. 2012 Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature 485, 242–245. (doi:10.1038/nature11011)
-
(2012)
Nature
, vol.485
, pp. 242-245
-
-
Neale, B.M.1
-
21
-
-
84912144889
-
Synaptic, transcriptional and chromatin genes disrupted in autism
-
De Rubeis S et al. 2014 Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 515, 209–215. (doi:10.1038/nature13772)
-
(2014)
Nature
, vol.515
, pp. 209-215
-
-
De Rubeis, S.1
-
22
-
-
49949085933
-
Large recurrent microdeletions associated with schizophrenia
-
Stefansson H et al. 2008 Large recurrent microdeletions associated with schizophrenia. Nature 455, 232–236. (doi:10.1038/nature07229)
-
(2008)
Nature
, vol.455
, pp. 232-236
-
-
Stefansson, H.1
-
23
-
-
33845889998
-
Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders
-
Durand CM et al. 2007 Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nat. Genet. 39, 25–27. (doi:10.1038/ng1933)
-
(2007)
Nat. Genet.
, vol.39
, pp. 25-27
-
-
Durand, C.M.1
-
24
-
-
63449111560
-
Novel de novo SHANK3 mutation in autistic patients
-
Gauthier J et al. 2009 Novel de novo SHANK3 mutation in autistic patients. Am. J. Med. Genet. B 150B, 421–424. (doi:10.1002/ajmg.b.30822)
-
(2009)
Am. J. Med. Genet. B
, vol.150
, pp. 421-424
-
-
Gauthier, J.1
-
25
-
-
67651233780
-
Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes
-
Bucan M et al. 2009 Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. PLoS Genet. 5, e1000536. (doi:10.1371/journal. pgen.1000536)
-
(2009)
Plos Genet
, vol.5
-
-
Bucan, M.1
-
26
-
-
38749084216
-
Disruption of neurexin 1 associated with autism spectrum disorder
-
Kim HG et al. 2008 Disruption of neurexin 1 associated with autism spectrum disorder. Am. J. Hum. Genet. 82, 199–207. (doi:10.1016/j. ajhg.2007.09.011)
-
(2008)
Am. J. Hum. Genet.
, vol.82
, pp. 199-207
-
-
Kim, H.G.1
-
27
-
-
77952827032
-
Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation
-
Berkel S et al. 2010 Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation. Nat. Genet. 42, 489–491. (doi:10.1038/ng.589)
-
(2010)
Nat. Genet.
, vol.42
, pp. 489-491
-
-
Berkel, S.1
-
28
-
-
2442641704
-
Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome
-
Fernandez T, Morgan T, Davis N, Klin A, Morris A, Farhi A, Lifton RP, State MW. 2004 Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome. Am. J. Hum. Genet. 74, 1286–1293. (doi:10.1086/421474)
-
(2004)
Am. J. Hum. Genet.
, vol.74
, pp. 1286-1293
-
-
Fernandez, T.1
Morgan, T.2
Davis, N.3
Klin, A.4
Morris, A.5
Farhi, A.6
Lifton, R.P.7
State, M.W.8
-
29
-
-
45849096821
-
Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome
-
Fernandez T, Morgan T, Davis N, Klin A, Morris A, Farhi A, Lifton RP, State MW. 2008 Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome. Am. J. Hum. Genet. 82, 1385. (doi:10.1016/j.ajhg.2008.04.021)
-
(2008)
Am. J. Hum. Genet.
, vol.82
, pp. 1385
-
-
Fernandez, T.1
Morgan, T.2
Davis, N.3
Klin, A.4
Morris, A.5
Farhi, A.6
Lifton, R.P.7
State, M.W.8
-
30
-
-
67349182343
-
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
-
Glessner JT et al. 2009 Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature 459, 569–573. (doi:10.1038/nature07953)
-
(2009)
Nature
, vol.459
, pp. 569-573
-
-
Glessner, J.T.1
-
31
-
-
38749099110
-
Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders
-
Bakkaloglu B et al. 2008 Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. Am. J. Hum. Genet. 82, 165–173. (doi:10.1016/j. ajhg.2007.09.017)
-
(2008)
Am. J. Hum. Genet.
, vol.82
, pp. 165-173
-
-
Bakkaloglu, B.1
-
32
-
-
33645415686
-
Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2
-
Strauss KA, Puffenberger EG, Huentelman MJ, Gottlieb S, Dobrin SE, Parod JM, Stephan DA, Morton DH. 2006 Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2. N. Engl. J. Med. 354, 1370–1377. (doi:10. 1056/NEJMoa052773)
-
(2006)
N. Engl. J. Med
, vol.354
, pp. 1370-1377
-
-
Strauss, K.A.1
Puffenberger, E.G.2
Huentelman, M.J.3
Gottlieb, S.4
Dobrin, S.E.5
Parod, J.M.6
Stephan, D.A.7
Morton, D.H.8
-
33
-
-
84907363627
-
Schizophrenia genetics comes of age
-
Need AC, Goldstein DB. 2014 Schizophrenia genetics comes of age. Neuron 83, 760–763. (doi:10.1016/j. neuron.2014.08.015)
-
(2014)
Neuron
, vol.83
, pp. 760-763
-
-
Need, A.C.1
Goldstein, D.B.2
-
34
-
-
84942195521
-
GABA circuitry, cells and molecular regulation in schizophrenia: Life in the graveyard
-
Harrison PJ. 2015 GABA circuitry, cells and molecular regulation in schizophrenia: life in the graveyard. Schizophr. Res. 167, 108–110. (doi:10. 1016/j.schres.2015.02.003)
-
(2015)
Schizophr. Res
, vol.167
, pp. 108-110
-
-
Harrison, P.J.1
-
35
-
-
84922261705
-
Schizophrenia or schizophrenias? The challenge of genetic parsing of a complex disorder
-
Jablensky A. 2015 Schizophrenia or schizophrenias? The challenge of genetic parsing of a complex disorder. Am. J. Psychiatry 172, 105–107. (doi:10. 1176/appi.ajp.2014.14111452)
-
(2015)
Am. J. Psychiatry
, vol.172
, pp. 105-107
-
-
Jablensky, A.1
-
36
-
-
84904804929
-
Biological insights from 108 schizophrenia-associated genetic loci
-
Schizophrenia Working Group of the Psychiatric Genomics Consortium. 2014 Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427. (doi:10.1038/nature13595)
-
(2014)
Nature
, vol.511
, pp. 421-427
-
-
-
37
-
-
85032452147
-
Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia
-
Li Z et al. 2017 Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia. Nature Genetics 49, 1576–1583. (doi:10.1038/ng.3973)
-
(2017)
Nature Genetics
, vol.49
, pp. 1576-1583
-
-
Li, Z.1
-
38
-
-
84953729873
-
Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci
-
Hannon E et al. 2016 Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci. Nat. Neurosci. 19, 48–54. (doi:10.1038/nn.4182)
-
(2016)
Nat. Neurosci.
, vol.19
, pp. 48-54
-
-
Hannon, E.1
-
39
-
-
84893904007
-
A polygenic burden of rare disruptive mutations in schizophrenia
-
Purcell SM et al. 2014 A polygenic burden of rare disruptive mutations in schizophrenia. Nature 506, 185–190. (doi:10.1038/nature12975)
-
(2014)
Nature
, vol.506
, pp. 185-190
-
-
Purcell, S.M.1
-
40
-
-
80052720242
-
Differential activity by polymorphic variants of a remote enhancer that supports galanin expression in the hypothalamus and amygdala: Implications for obesity, depression and alcoholism
-
Davidson S et al. 2011 Differential activity by polymorphic variants of a remote enhancer that supports galanin expression in the hypothalamus and amygdala: implications for obesity, depression and alcoholism. Neuropsychopharmacology 36, 2211–2221. (doi:10.1038/npp.2011.93)
-
(2011)
Neuropsychopharmacology
, vol.36
, pp. 2211-2221
-
-
Davidson, S.1
-
41
-
-
84858246435
-
A polymorphism associated with depressive disorders differentially regulates brain derived neurotrophic factor promoter IV activity
-
Hing B, Davidson S, Lear M, Breen G, Quinn J, McGuffin P, MacKenzie A. 2012 A polymorphism associated with depressive disorders differentially regulates brain derived neurotrophic factor promoter IV activity. Biol. Psychiatry 71, 618–626. (doi:10. 1016/j.biopsych.2011.11.030)
-
(2012)
Biol. Psychiatry
, vol.71
, pp. 618-626
-
-
Hing, B.1
Davidson, S.2
Lear, M.3
Breen, G.4
Quinn, J.5
McGuffin, P.6
Mackenzie, A.7
-
42
-
-
85020941675
-
An expanded view of complex traits: From polygenic to omnigenic
-
Boyle EA, Li YI, Pritchard JK. 2017 An expanded view of complex traits: from polygenic to omnigenic. Cell 169, 1177–1186. (doi:10.1016/j. cell.2017.05.038)
-
(2017)
Cell
, vol.169
, pp. 1177-1186
-
-
Boyle, E.A.1
Li, Y.I.2
Pritchard, J.K.3
-
43
-
-
84962890386
-
Advancing the understanding of autism disease mechanisms through genetics
-
de la Torre-Ubieta L, Won H, Stein JL, Geschwind DH. 2016 Advancing the understanding of autism disease mechanisms through genetics. Nat. Med. 22, 345–361. (doi:10.1038/nm.4071)
-
(2016)
Nat. Med.
, vol.22
, pp. 345-361
-
-
De La Torre-Ubieta, L.1
Won, H.2
Stein, J.L.3
Geschwind, D.H.4
-
44
-
-
84940647911
-
Addressing the genetics of human mental health disorders in model organisms
-
McCammon JM, Sive H. 2015 Addressing the genetics of human mental health disorders in model organisms. Annu. Rev. Genomics Hum. Genet. 16, 173–197. (doi:10.1146/annurev-genom-090314-050048)
-
(2015)
Annu. Rev. Genomics Hum. Genet.
, vol.16
, pp. 173-197
-
-
McCammon, J.M.1
Sive, H.2
-
45
-
-
77953800799
-
Behavioural phenotyping assays for mouse models of autism
-
Silverman JL, Yang M, Lord C, Crawley JN. 2010 Behavioural phenotyping assays for mouse models of autism. Nat. Rev. Neurosci. 11, 490–502. (doi:10. 1038/nrn2851)
-
(2010)
Nat. Rev. Neurosci
, vol.11
, pp. 490-502
-
-
Silverman, J.L.1
Yang, M.2
Lord, C.3
Crawley, J.N.4
-
46
-
-
79955884485
-
Modelling schizophrenia using human induced pluripotent stem cells
-
Brennand KJ et al. 2011 Modelling schizophrenia using human induced pluripotent stem cells. Nature 473, 221–225. (doi:10.1038/nature09915)
-
(2011)
Nature
, vol.473
, pp. 221-225
-
-
Brennand, K.J.1
-
47
-
-
84904001347
-
Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity
-
Yoon KJ et al. 2014 Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity. Cell Stem Cell 15, 79–91. (doi:10.1016/j. stem.2014.05.003)
-
(2014)
Cell Stem Cell
, vol.15
, pp. 79-91
-
-
Yoon, K.J.1
-
48
-
-
84934442315
-
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
-
Pasca AM et al. 2015 Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture. Nat. Methods 12, 671–678. (doi:10. 1038/nmeth.3415)
-
(2015)
Nat. Methods
, vol.12
, pp. 671-678
-
-
Pasca, A.M.1
-
49
-
-
85018412815
-
Assembly of functionally integrated human forebrain spheroids
-
Birey F et al. 2017 Assembly of functionally integrated human forebrain spheroids. Nature 545, 54–59. (doi:10.1038/nature22330)
-
(2017)
Nature
, vol.545
, pp. 54-59
-
-
Birey, F.1
-
50
-
-
84926039213
-
Generation of cerebral organoids from human pluripotent stem cells
-
Lancaster MA, Knoblich JA. 2014 Generation of cerebral organoids from human pluripotent stem cells. Nat. Protoc. 9, 2329–2340. (doi:10.1038/nprot.2014.158)
-
(2014)
Nat. Protoc.
, vol.9
, pp. 2329-2340
-
-
Lancaster, M.A.1
Knoblich, J.A.2
-
51
-
-
84884414984
-
Cerebral organoids model human brain development and microcephaly
-
Lancaster MA et al. 2013 Cerebral organoids model human brain development and microcephaly. Nature 501, 373–379. (doi:10.1038/nature12517)
-
(2013)
Nature
, vol.501
, pp. 373-379
-
-
Lancaster, M.A.1
-
52
-
-
84890282623
-
Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex
-
Kadoshima T, Sakaguchi H, Nakano T, Soen M, Ando S, Eiraku M, Sasai Y. 2013 Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex. Proc. Natl. Acad. Sci. USA 110, 20 284–20 289. (doi:10.1073/pnas. 1315710110)
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 284-320
-
-
Kadoshima, T.1
Sakaguchi, H.2
Nakano, T.3
Soen, M.4
Ando, S.5
Eiraku, M.6
Sasai, Y.7
-
53
-
-
14544296563
-
Directed differentiation of telencephalic precursors from embryonic stem cells
-
Watanabe K, Kamiya D, Nishiyama A, Katayama T, Nozaki S, Kawasaki H, Watanabe Y, Mizuseki K, Sasai Y. 2005 Directed differentiation of telencephalic precursors from embryonic stem cells. Nat. Neurosci. 8, 288–296. (doi:10.1038/nn1402)
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 288-296
-
-
Watanabe, K.1
Kamiya, D.2
Nishiyama, A.3
Katayama, T.4
Nozaki, S.5
Kawasaki, H.6
Watanabe, Y.7
Mizuseki, K.8
Sasai, Y.9
-
54
-
-
84922791023
-
Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells
-
Muguruma K, Nishiyama A, Kawakami H, Hashimoto K, Sasai Y. 2015 Self-organization of polarized cerebellar tissue in 3D culture of human pluripotent stem cells. Cell Rep. 10, 537–550. (doi:10.1016/j.celrep.2014.12.051)
-
(2015)
Cell Rep
, vol.10
, pp. 537-550
-
-
Muguruma, K.1
Nishiyama, A.2
Kawakami, H.3
Hashimoto, K.4
Sasai, Y.5
-
55
-
-
84994275774
-
Neural tube morphogenesis in synthetic 3D microenvironments
-
Ranga A, Girgin M, Meinhardt A, Eberle D, Caiazzo M, Tanaka EM, Lutolf MP. 2016 Neural tube morphogenesis in synthetic 3D microenvironments. Proc. Natl Acad. Sci. USA 113, E6831–E6839. (doi:10.1073/pnas.1603529113)
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. E6831-E6839
-
-
Ranga, A.1
Girgin, M.2
Meinhardt, A.3
Eberle, D.4
Caiazzo, M.5
Tanaka, E.M.6
Lutolf, M.P.7
-
56
-
-
85008658919
-
Beta-catenin is required in the neural crest and mesencephalon for pituitary gland organogenesis
-
Davis SW, Mortensen AH, Keisler JL, Zacharias AL, Gage PJ, Yamamura K, Camper SA. 2016 Beta-catenin is required in the neural crest and mesencephalon for pituitary gland organogenesis. BMC Dev. Biol. 16, 16. (doi:10.1186/s12861-016-0118-9)
-
(2016)
BMC Dev. Biol
, vol.16
, pp. 16
-
-
Davis, S.W.1
Mortensen, A.H.2
Keisler, J.L.3
Zacharias, A.L.4
Gage, P.J.5
Yamamura, K.6
Camper, S.A.7
-
57
-
-
84947292300
-
Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue
-
Sakaguchi H, Kadoshima T, Soen M, Narii N, Ishida Y, Ohgushi M, Takahashi J, Eiraku M, Sasai Y. 2015 Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue. Nat. Commun. 6, 8896. (doi:10.1038/ncomms9896)
-
(2015)
Nat. Commun
, vol.6
, pp. 8896
-
-
Sakaguchi, H.1
Kadoshima, T.2
Soen, M.3
Narii, N.4
Ishida, Y.5
Ohgushi, M.6
Takahashi, J.7
Eiraku, M.8
Sasai, Y.9
-
58
-
-
84860233475
-
Mouse embryonic stem cell culture for generation of three-dimensional retinal and cortical tissues
-
Eiraku M, Sasai Y. 2011 Mouse embryonic stem cell culture for generation of three-dimensional retinal and cortical tissues. Nat. Protoc. 7, 69–79. (doi:10. 1038/nprot.2011.429)
-
(2011)
Nat. Protoc.
, vol.7
, pp. 69-79
-
-
Eiraku, M.1
Sasai, Y.2
-
59
-
-
84923365108
-
Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue
-
Kuwahara A, Ozone C, Nakano T, Saito K, Eiraku M, Sasai Y. 2015 Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue. Nat. Commun. 6, 6286. (doi:10.1038/ncomms7286)
-
(2015)
Nat. Commun
, vol.6
, pp. 6286
-
-
Kuwahara, A.1
Ozone, C.2
Nakano, T.3
Saito, K.4
Eiraku, M.5
Sasai, Y.6
-
60
-
-
84959159139
-
Proportion of collagen type II in the extracellular matrix promotes the differentiation of human adipose-derived mesenchymal stem cells into nucleus pulposus cells
-
Tao Y, Zhou X, Liu D, Li H, Liang C, Li F, Chen Q. 2016 Proportion of collagen type II in the extracellular matrix promotes the differentiation of human adipose-derived mesenchymal stem cells into nucleus pulposus cells. Biofactors 42, 212–223. (doi:10.1002/biof.1266)
-
(2016)
Biofactors
, vol.42
, pp. 212-223
-
-
Tao, Y.1
Zhou, X.2
Liu, D.3
Li, H.4
Liang, C.5
Li, F.6
Chen, Q.7
-
61
-
-
84893943964
-
Lineage origins of GABAergic versus glutamatergic neurons in the neocortex
-
Marin O, Muller U. 2014 Lineage origins of GABAergic versus glutamatergic neurons in the neocortex. Curr. Opin. Neurobiol. 26, 132–141. (doi:10.1016/j.conb.2014.01.015)
-
(2014)
Curr. Opin. Neurobiol.
, vol.26
, pp. 132-141
-
-
Marin, O.1
Muller, U.2
-
62
-
-
84884201630
-
Integration of GABAergic interneurons into cortical cell assemblies: Lessons from embryos and adults
-
Bartolini G, Ciceri G, Marin O. 2013 Integration of GABAergic interneurons into cortical cell assemblies: lessons from embryos and adults. Neuron 79, 849–864. (doi:10.1016/j.neuron.2013.08.014)
-
(2013)
Neuron
, vol.79
, pp. 849-864
-
-
Bartolini, G.1
Ciceri, G.2
Marin, O.3
-
63
-
-
4344592974
-
Derivation of midbrain dopamine neurons from human embryonic stem cells
-
Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses J, Topf N, Harrison NL, Studer L. 2004 Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc. Natl Acad. Sci. USA 101, 12 543– 12 548. (doi:10.1073/pnas.0404700101)
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 543-612
-
-
Perrier, A.L.1
Tabar, V.2
Barberi, T.3
Rubio, M.E.4
Bruses, J.5
Topf, N.6
Harrison, N.L.7
Studer, L.8
-
64
-
-
13844271605
-
Specification of motoneurons from human embryonic stem cells
-
Li XJ, Du ZW, Zarnowska ED, Pankratz M, Hansen LO, Pearce RA, Zhang SC. 2005 Specification of motoneurons from human embryonic stem cells. Nat. Biotechnol. 23, 215–221. (doi:10.1038/nbt1063)
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 215-221
-
-
Li, X.J.1
Du, Z.W.2
Zarnowska, E.D.3
Pankratz, M.4
Hansen, L.O.5
Pearce, R.A.6
Zhang, S.C.7
-
65
-
-
84928680622
-
Diverse subtypes of astrocytes and their development during corticogenesis
-
Tabata H. 2015 Diverse subtypes of astrocytes and their development during corticogenesis. Front. Neurosci. 9, 114. (doi:10.3389/fnins.2015.00114)
-
(2015)
Front. Neurosci
, vol.9
, pp. 114
-
-
Tabata, H.1
-
66
-
-
84873599764
-
Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination
-
Wang S et al. 2013 Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination. Cell Stem Cell 12, 252–264. (doi:10.1016/j.stem.2012.12.002)
-
(2013)
Cell Stem Cell
, vol.12
, pp. 252-264
-
-
Wang, S.1
-
67
-
-
54949102049
-
Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals
-
Eiraku M et al. 2008 Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell 3, 519–532. (doi:10.1016/j.stem.2008.09.002)
-
(2008)
Cell Stem Cell
, vol.3
, pp. 519-532
-
-
Eiraku, M.1
-
68
-
-
85016994481
-
An update on stem cell biology and engineering for brain development
-
Parr CJC, Yamanaka S, Saito H. 2017 An update on stem cell biology and engineering for brain development. Mol. Psychiatry 22, 808–819. (doi:10.1038/mp.2017.66)
-
(2017)
Mol. Psychiatry
, vol.22
, pp. 808-819
-
-
Parr, C.J.C.1
Yamanaka, S.2
Saito, H.3
-
69
-
-
84901610587
-
Thinking out of the dish: What to learn about cortical development using pluripotent stem cells
-
van den Ameele J, Tiberi L, Vanderhaeghen P, Espuny-Camacho I. 2014 Thinking out of the dish: what to learn about cortical development using pluripotent stem cells. Trends Neurosci. 37, 334–342. (doi:10.1016/j.tins.2014.03.005)
-
(2014)
Trends Neurosci
, vol.37
, pp. 334-342
-
-
Van Den Ameele, J.1
Tiberi, L.2
Vanderhaeghen, P.3
Espuny-Camacho, I.4
-
70
-
-
84898865041
-
Cortical neurogenesis from pluripotent stem cells: Complexity emerging from simplicity
-
Anderson S, Vanderhaeghen P. 2014 Cortical neurogenesis from pluripotent stem cells: complexity emerging from simplicity. Curr. Opin. Neurobiol. 27, 151–157. (doi:10.1016/j.conb.2014.03.012)
-
(2014)
Curr. Opin. Neurobiol.
, vol.27
, pp. 151-157
-
-
Anderson, S.1
Vanderhaeghen, P.2
-
71
-
-
84964619895
-
Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure
-
Qian X et al. 2016 Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure. Cell 165, 1238–1254. (doi:10.1016/j.cell.2016.04.032)
-
(2016)
Cell
, vol.165
, pp. 1238-1254
-
-
Qian, X.1
-
72
-
-
85017393117
-
Microfluidic technology for the generation of cell spheroids and their applications
-
Vadivelu RK, Kamble H, Shiddiky MJA, Nguyen N-T. 2017 Microfluidic technology for the generation of cell spheroids and their applications. Micromachines 8, 94. (doi:10.3390/mi8040094)
-
(2017)
Micromachines
, vol.8
, pp. 94
-
-
Vadivelu, R.K.1
Kamble, H.2
Shiddiky, M.J.A.3
Nguyen, N.-T.4
-
73
-
-
85020668535
-
Guided self-organization and cortical plate formation in human brain organoids
-
Lancaster MA et al. 2017 Guided self-organization and cortical plate formation in human brain organoids. Nat. Biotechnol. 35, 659–666. (doi:10. 1038/nbt.3906)
-
(2017)
Nat. Biotechnol.
, vol.35
, pp. 659-666
-
-
Lancaster, M.A.1
-
74
-
-
85018435810
-
Cell diversity and network dynamics in photosensitive human brain organoids
-
Quadrato G et al. 2017 Cell diversity and network dynamics in photosensitive human brain organoids. Nature 545, 48–53. (doi:10.1038/nature22047)
-
(2017)
Nature
, vol.545
, pp. 48-53
-
-
Quadrato, G.1
-
75
-
-
84958074030
-
Schizophrenia risk from complex variation of complement component 4
-
Sekar A et al. 2016 Schizophrenia risk from complex variation of complement component 4. Nature 530, 177–183. (doi:10.1038/nature16549)
-
(2016)
Nature
, vol.530
, pp. 177-183
-
-
Sekar, A.1
-
76
-
-
84857605371
-
Abnormal synaptic pruning in schizophrenia: Urban myth or reality?
-
Boksa P. 2012 Abnormal synaptic pruning in schizophrenia: urban myth or reality? J. Psychiatry Neurosci. 37, 75–77. (doi:10.1503/jpn.120007)
-
(2012)
J. Psychiatry Neurosci.
, vol.37
, pp. 75-77
-
-
Boksa, P.1
-
77
-
-
84885020424
-
Genome-wide association analysis identifies 13 new risk loci for schizophrenia
-
Ripke S et al. 2013 Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat. Genet. 45, 1150–1159. (doi:10.1038/ng.2742)
-
(2013)
Nat. Genet.
, vol.45
, pp. 1150-1159
-
-
Ripke, S.1
-
78
-
-
84856088804
-
Using iPSC-derived neurons to uncover cellular phenotypes associated with timothy syndrome
-
Pasca SP et al. 2011 Using iPSC-derived neurons to uncover cellular phenotypes associated with timothy syndrome. Nat. Med. 17, 1657–1662. (doi:10.1038/nm.2576)
-
(2011)
Nat. Med.
, vol.17
, pp. 1657-1662
-
-
Pasca, S.P.1
-
79
-
-
64149128876
-
KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner
-
Bortone D, Polleux F. 2009 KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner. Neuron 62, 53–71. (doi:10.1016/j.neuron. 2009.01.034)
-
(2009)
Neuron
, vol.62
, pp. 53-71
-
-
Bortone, D.1
Polleux, F.2
-
80
-
-
84874634237
-
Interpreting the role of de novo protein-coding mutations in neuropsychiatric disease
-
Gratten J, Visscher PM, Mowry BJ, Wray NR. 2013 Interpreting the role of de novo protein-coding mutations in neuropsychiatric disease. Nat. Genet. 45, 234–238. (doi:10.1038/ng.2555)
-
(2013)
Nat. Genet.
, vol.45
, pp. 234-238
-
-
Gratten, J.1
Visscher, P.M.2
Mowry, B.J.3
Wray, N.R.4
-
81
-
-
84893186892
-
DISC1 as a genetic risk factor for schizophrenia and related major mental illness: Response to Sullivan
-
Porteous DJ et al. 2014 DISC1 as a genetic risk factor for schizophrenia and related major mental illness: response to Sullivan. Mol. Psychiatry 19, 141–143. (doi:10.1038/mp.2013.160)
-
(2014)
Mol. Psychiatry
, vol.19
, pp. 141-143
-
-
Porteous, D.J.1
-
82
-
-
81555203199
-
Linking neurodevelopmental and synaptic theories of mental illness through DISC1
-
Brandon NJ, Sawa A. 2011 Linking neurodevelopmental and synaptic theories of mental illness through DISC1. Nat. Rev. Neurosci. 12, 707–722. (doi:10.1038/nrn3120)
-
(2011)
Nat. Rev. Neurosci.
, vol.12
, pp. 707-722
-
-
Brandon, N.J.1
Sawa, A.2
-
83
-
-
0025277392
-
Association within a family of a balanced autosomal translocation with major mental illness
-
Clair S, Blackwood D, Muir D, Carothers W, Walker A, Spowart M, Gosden G, Evans HJ. 1990 Association within a family of a balanced autosomal translocation with major mental illness. Lancet 336, 13–16. (doi:10.1016/0140-6736(90)91520-K)
-
(1990)
Lancet
, vol.336
, pp. 13-16
-
-
Clair, S.1
Blackwood, D.2
Muir, D.3
Carothers, W.4
Walker, A.5
Spowart, M.6
Gosden, G.7
Evans, H.J.8
-
84
-
-
0034927864
-
Schizophrenia and affective disorders—cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: Clinical and P300 findings in a family
-
Blackwood DH, Fordyce A, Walker MT, St Clair DM, Porteous DJ, Muir WJ. 2001 Schizophrenia and affective disorders—cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am. J. Hum. Genet. 69, 428–433. (doi:10.1086/321969)
-
(2001)
Am. J. Hum. Genet.
, vol.69
, pp. 428-433
-
-
Blackwood, D.H.1
Fordyce, A.2
Walker, M.T.3
St Clair, D.M.4
Porteous, D.J.5
Muir, W.J.6
-
85
-
-
84874870865
-
Implication of a rare deletion at distal 16p11.2 in schizophrenia
-
Guha S et al. 2013 Implication of a rare deletion at distal 16p11.2 in schizophrenia. JAMA Psychiatry 70, 253–260. (doi:10.1001/2013.jamapsychiatry.71)
-
(2013)
JAMA Psychiatry
, vol.70
, pp. 253-260
-
-
Guha, S.1
-
86
-
-
50149121170
-
Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus
-
Meyer KD, Morris JA. 2008 Immunohistochemical analysis of Disc1 expression in the developing and adult hippocampus. Gene Expr. Patterns 8, 494–501. (doi:10.1016/j.gep.2008.06.005)
-
(2008)
Gene Expr. Patterns
, vol.8
, pp. 494-501
-
-
Meyer, K.D.1
Morris, J.A.2
-
87
-
-
34548806900
-
Disrupted-in-schizophrenia 1 regulates integration of newly generated neurons in the adult brain
-
Duan X et al. 2007 Disrupted-in-schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell 130, 1146–1158. (doi:10. 1016/j.cell.2007.07.010)
-
(2007)
Cell
, vol.130
, pp. 1146-1158
-
-
Duan, X.1
-
88
-
-
33645828206
-
Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs
-
Lipska BK et al. 2006 Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs. Hum. Mol. Genet. 15, 1245–1258. (doi:10.1093/hmg/ddl040)
-
(2006)
Hum. Mol. Genet.
, vol.15
, pp. 1245-1258
-
-
Lipska, B.K.1
-
89
-
-
0037422609
-
Disrupted-in-schizophrenia-1 (DISC-1): Mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth
-
Ozeki Y et al. 2003 Disrupted-in-schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. Proc. Natl Acad. Sci. USA 100, 289–294. (doi:10. 1073/pnas.0136913100)
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 289-294
-
-
Ozeki, Y.1
-
90
-
-
0042622356
-
Disrupted-in-schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth
-
Miyoshi K, Honda A, Baba K, Taniguchi M, Oono K, Fujita T, Kuroda S, Katayama T, Tohyama M. 2003 Disrupted-in-schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol. Psychiatry 8, 685–694. (doi:10.1038/sj.mp. 4001352)
-
(2003)
Mol. Psychiatry
, vol.8
, pp. 685-694
-
-
Miyoshi, K.1
Honda, A.2
Baba, K.3
Taniguchi, M.4
Oono, K.5
Fujita, T.6
Kuroda, S.7
Katayama, T.8
Tohyama, M.9
-
91
-
-
28544453286
-
A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development
-
Kamiya A et al. 2005 A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development. Nat. Cell Biol. 7, 1167–1178. (doi:10. 1038/ncb1328)
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 1167-1178
-
-
Kamiya, A.1
-
92
-
-
84956494037
-
Utility and validity of DISC1 mouse models in biological psychiatry
-
Tomoda T, Sumitomo A, Jaaro-Peled H, Sawa A. 2016 Utility and validity of DISC1 mouse models in biological psychiatry. Neuroscience 321, 99–107. (doi:10.1016/j.neuroscience.2015.12.061)
-
(2016)
Neuroscience
, vol.321
, pp. 99-107
-
-
Tomoda, T.1
Sumitomo, A.2
Jaaro-Peled, H.3
Sawa, A.4
-
93
-
-
58149174266
-
Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1
-
Shen S et al. 2008 Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. J. Neurosci. 28, 10 893–10 904. (doi:10.1523/JNEUROSCI.3299-08.2008)
-
(2008)
J. Neurosci
, vol.28
, pp. 893-910
-
-
Shen, S.1
-
94
-
-
76849102959
-
Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits
-
Niwa M et al. 2010 Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron 65, 480–489. (doi:10. 1016/j.neuron.2010.01.019)
-
(2010)
Neuron
, vol.65
, pp. 480-489
-
-
Niwa, M.1
-
95
-
-
85018580830
-
A structural organization for the disrupted in schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations
-
Yerabham ASK et al. 2017 A structural organization for the disrupted in schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations. J. Biol. Chem. 292, 6468–6477. (doi:10.1074/jbc.M116.773903)
-
(2017)
J. Biol. Chem.
, vol.292
, pp. 6468-6477
-
-
Yerabham, A.S.K.1
-
96
-
-
56449090534
-
Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly
-
Sawamura N et al. 2008 Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly. Mol. Psychiatry 13, 1138–1148, 1069. (doi:10.1038/mp.2008.101)
-
(2008)
Mol. Psychiatry
, vol.13
, pp. 1138-1148
-
-
Sawamura, N.1
-
97
-
-
84983371976
-
Visualization of DISC1-Dysbindin interaction in glutamatergic synaptic termini in fruit flies
-
Furukubo-Tokunaga K et al. 2016 Visualization of DISC1-Dysbindin interaction in glutamatergic synaptic termini in fruit flies. Mol. Psychiatry 21, 1157. (doi:10.1038/mp.2016.142)
-
(2016)
Mol. Psychiatry
, vol.21
, pp. 1157
-
-
Furukubo-Tokunaga, K.1
-
98
-
-
81355150792
-
Common DISC1 polymorphisms disrupt Wnt/GSK3beta signaling and brain development
-
Singh KK et al. 2011 Common DISC1 polymorphisms disrupt Wnt/GSK3beta signaling and brain development. Neuron 72, 545–558. (doi:10.1016/j. neuron.2011.09.030)
-
(2011)
Neuron
, vol.72
, pp. 545-558
-
-
Singh, K.K.1
-
99
-
-
84940787011
-
Genomic DISC1 disruption in hiPSCs alters Wnt signaling and neural cell fate
-
Srikanth P et al. 2015 Genomic DISC1 disruption in hiPSCs alters Wnt signaling and neural cell fate. Cell Rep. 12, 1414–1429. (doi:10.1016/j.celrep. 2015.07.061)
-
(2015)
Cell Rep
, vol.12
, pp. 1414-1429
-
-
Srikanth, P.1
-
100
-
-
79953048441
-
Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation
-
Chiang CH, Su Y, Wen Z, Yoritomo N, Ross CA, Margolis RL, Song H, Ming GL. 2011 Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation. Mol. Psychiatry 16, 358–360. (doi:10.1038/mp.2011.13)
-
(2011)
Mol. Psychiatry
, vol.16
, pp. 358-360
-
-
Chiang, C.H.1
Su, Y.2
Wen, Z.3
Yoritomo, N.4
Ross, C.A.5
Margolis, R.L.6
Song, H.7
Ming, G.L.8
-
101
-
-
84911360325
-
Synaptic dysregulation in a human iPS cell model of mental disorders
-
Wen Z et al. 2014 Synaptic dysregulation in a human iPS cell model of mental disorders. Nature 515, 414–418. (doi:10.1038/nature13716)
-
(2014)
Nature
, vol.515
, pp. 414-418
-
-
Wen, Z.1
-
102
-
-
84859133061
-
Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses
-
Maher BJ, LoTurco JJ. 2012 Disrupted-in-schizophrenia (DISC1) functions presynaptically at glutamatergic synapses. PLoS ONE 7, e34053. (doi:10.1371/journal.pone.0034053)
-
(2012)
Plos ONE
, vol.7
-
-
Maher, B.J.1
Loturco, J.J.2
-
103
-
-
84994047716
-
Stimulation of synaptic vesicle exocytosis by the mental disease gene DISC1 is mediated by N-type voltage-gated calcium channels
-
Tang W, Thevathasan JV, Lin Q, Lim KB, Kuroda K, Kaibuchi K, Bilger M, Soong TW, Fivaz M. 2016 Stimulation of synaptic vesicle exocytosis by the mental disease gene DISC1 is mediated by N-type voltage-gated calcium channels. Front. Synaptic Neurosci. 8, 15. (doi:10.3389/fnsyn.2016.00015)
-
(2016)
Front. Synaptic Neurosci.
, vol.8
, pp. 15
-
-
Tang, W.1
Thevathasan, J.V.2
Lin, Q.3
Lim, K.B.4
Kuroda, K.5
Kaibuchi, K.6
Bilger, M.7
Soong, T.W.8
Fivaz, M.9
-
104
-
-
85018581596
-
Alteration of neuronal excitability and short-term synaptic plasticity in the prefrontal cortex of a mouse model of mental illness
-
Crabtree GW et al. 2017 Alteration of neuronal excitability and short-term synaptic plasticity in the prefrontal cortex of a mouse model of mental illness. J. Neurosci. 37, 4158–4180. (doi:10.1523/JNEUROSCI.4345-15.2017)
-
(2017)
J. Neurosci.
, vol.37
, pp. 4158-4180
-
-
Crabtree, G.W.1
-
105
-
-
78149428430
-
Rethinking schizophrenia
-
Insel TR. 2010 Rethinking schizophrenia. Nature 468, 187–193. (doi:10.1038/nature09552)
-
(2010)
Nature
, vol.468
, pp. 187-193
-
-
Insel, T.R.1
-
106
-
-
0038643584
-
White matter changes in schizophrenia: Evidence for myelin-related dysfunction
-
Davis KL, Stewart DG, Friedman JI, Buchsbaum M, Harvey PD, Hof PR, Buxbaum J, Haroutunian V. 2003 White matter changes in schizophrenia: evidence for myelin-related dysfunction. Arch. Gen. Psychiatry 60, 443–456. (doi:10.1001/archpsyc.60. 5.443)
-
(2003)
Arch. Gen. Psychiatry
, vol.60
, pp. 443-456
-
-
Davis, K.L.1
Stewart, D.G.2
Friedman, J.I.3
Buchsbaum, M.4
Harvey, P.D.5
Hof, P.R.6
Buxbaum, J.7
Haroutunian, V.8
-
107
-
-
20444453636
-
Evidence for white matter abnormalities in schizophrenia
-
Kubicki M, McCarley RW, Shenton ME. 2005 Evidence for white matter abnormalities in schizophrenia. Curr. Opin. Psychiatry 18, 121–134. (doi:10.1097/00001504-200503000-00004)
-
(2005)
Curr. Opin. Psychiatry
, vol.18
, pp. 121-134
-
-
Kubicki, M.1
McCarley, R.W.2
Shenton, M.E.3
-
108
-
-
84939173179
-
Effects of a balanced translocation between chromosomes 1 and 11 disrupting the disc1 locus on white matter integrity
-
Whalley HC et al. 2015 Effects of a balanced translocation between chromosomes 1 and 11 disrupting the disc1 locus on white matter integrity. PLoS ONE 10, e0130900. (doi:10.1371/journal.pone. 0130900)
-
(2015)
Plos ONE
, vol.10
-
-
Whalley, H.C.1
-
109
-
-
84883387241
-
Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells
-
Liu Y, Liu H, Sauvey C, Yao L, Zarnowska ED, Zhang SC. 2013 Directed differentiation of forebrain GABA interneurons from human pluripotent stem cells. Nat. Protoc. 8, 1670–1679. (doi:10.1038/nprot. 2013.106)
-
(2013)
Nat. Protoc.
, vol.8
, pp. 1670-1679
-
-
Liu, Y.1
Liu, H.2
Sauvey, C.3
Yao, L.4
Zarnowska, E.D.5
Zhang, S.C.6
-
110
-
-
79955824315
-
Human mutations in NDE1 cause extreme microcephaly with lissencephaly [corrected]
-
Alkuraya FS et al. 2011 Human mutations in NDE1 cause extreme microcephaly with lissencephaly [corrected]. Am. J. Hum. Genet. 88, 536–547. (doi:10.1016/j.ajhg.2011.04.003)
-
(2011)
Am. J. Hum. Genet.
, vol.88
, pp. 536-547
-
-
Alkuraya, F.S.1
-
111
-
-
35348827304
-
Recurrent reciprocal genomic rearrangements of 17q12 are associated with renal disease, diabetes, and epilepsy
-
Mefford HC et al. 2007 Recurrent reciprocal genomic rearrangements of 17q12 are associated with renal disease, diabetes, and epilepsy. Am. J. Hum. Genet. 81, 1057–1069. (doi:10.1086/522591)
-
(2007)
Am. J. Hum. Genet.
, vol.81
, pp. 1057-1069
-
-
Mefford, H.C.1
-
112
-
-
34447278070
-
Array CGH identifies reciprocal 16p13.1 duplications and deletions that predispose to autism and/or mental retardation
-
Ullmann R et al. 2007 Array CGH identifies reciprocal 16p13.1 duplications and deletions that predispose to autism and/or mental retardation. Hum. Mutat. 28, 674–682. (doi:10.1002/humu.20546)
-
(2007)
Hum. Mutat.
, vol.28
, pp. 674-682
-
-
Ullmann, R.1
-
113
-
-
78049303903
-
Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: A genome-wide analysis
-
Williams NM et al. 2010 Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. Lancet 376, 1401–1408. (doi:10.1016/S0140-6736(10)61109-9)
-
(2010)
Lancet
, vol.376
, pp. 1401-1408
-
-
Williams, N.M.1
-
114
-
-
64549147485
-
Support for the involvement of large copy number variants in the pathogenesis of schizophrenia
-
Kirov G, Grozeva D, Norton N, Ivanov D, Mantripragada KK, Holmans P, Craddock N, Owen MJ, O’Donovan MC. 2009 Support for the involvement of large copy number variants in the pathogenesis of schizophrenia. Hum. Mol. Genet. 18, 1497–1503. (doi:10.1093/hmg/ddp043)
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 1497-1503
-
-
Kirov, G.1
Grozeva, D.2
Norton, N.3
Ivanov, D.4
Mantripragada, K.K.5
Holmans, P.6
Craddock, N.7
Owen, M.J.8
O’Donovan, M.C.9
-
115
-
-
84947649513
-
Copy number variations of chromosome 16p13.1 region associated with schizophrenia
-
Ingason A et al. 2011 Copy number variations of chromosome 16p13.1 region associated with schizophrenia. Mol. Psychiatry 16, 17–25. (doi:10. 1038/mp.2009.101)
-
(2011)
Mol. Psychiatry
, vol.16
, pp. 17-25
-
-
Ingason, A.1
-
116
-
-
85056025693
-
Copy number variations in DISC1 and DISC1-interacting partners in major mental illness. Mol
-
Johnstone M et al. 2015 Copy number variations in DISC1 and DISC1-interacting partners in major mental illness. Mol. Neuropsychiatry 1, 175–190. (doi:10.1159/000438788)
-
(2015)
Neuropsychiatry
, vol.1
, pp. 175-190
-
-
Johnstone, M.1
-
117
-
-
34047152928
-
Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1
-
Hennah W et al. 2007 Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1. Hum. Mol. Genet. 16, 453–462. (doi:10.1093/hmg/ddl462)
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 453-462
-
-
Hennah, W.1
-
118
-
-
0034517593
-
LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome
-
Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA. 2000 LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron 28, 665–679. (doi:10.1016/S0896-6273(00) 00145-8)
-
(2000)
Neuron
, vol.28
, pp. 665-679
-
-
Feng, Y.1
Olson, E.C.2
Stukenberg, P.T.3
Flanagan, L.A.4
Kirschner, M.W.5
Walsh, C.A.6
-
119
-
-
0034618076
-
The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein
-
Efimov VP, Morris NR. 2000 The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein. J. Cell Biol. 150, 681–688. (doi:10.1083/jcb.150.3.681)
-
(2000)
J. Cell Biol.
, vol.150
, pp. 681-688
-
-
Efimov, V.P.1
Morris, N.R.2
-
120
-
-
0034637504
-
Direct association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDE
-
Kitagawa M, Umezu M, Aoki J, Koizumi H, Arai H, Inoue K. 2000 Direct association of LIS1, the lissencephaly gene product, with a mammalian homologue of a fungal nuclear distribution protein, rNUDE. FEBS Lett. 479, 57–62. (doi:10.1016/S0014-5793(00)01856-1)
-
(2000)
FEBS Lett
, vol.479
, pp. 57-62
-
-
Kitagawa, M.1
Umezu, M.2
Aoki, J.3
Koizumi, H.4
Arai, H.5
Inoue, K.6
-
121
-
-
0034520636
-
NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein
-
Niethammer M, Smith DS, Ayala R, Peng J, Ko J, Lee MS, Morabito M, Tsai LH. 2000 NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. Neuron 28, 697–711. (doi:10. 1016/S0896-6273(00)00147-1)
-
(2000)
Neuron
, vol.28
, pp. 697-711
-
-
Niethammer, M.1
Smith, D.S.2
Ayala, R.3
Peng, J.4
Ko, J.5
Lee, M.S.6
Morabito, M.7
Tsai, L.H.8
-
122
-
-
23844559241
-
Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality
-
Sasaki S et al. 2005 Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol. Cell. Biol. 25, 7812–7827. (doi:10. 1128/MCB.25.17.7812-7827.2005)
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 7812-7827
-
-
Sasaki, S.1
-
123
-
-
0037315489
-
Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle
-
Yan X, Li F, Liang Y, Shen Y, Zhao X, Huang Q, Zhu X. 2003 Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle. Mol. Cell. Biol. 23, 1239–1250. (doi:10.1128/MCB.23.4.1239-1250.2003)
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 1239-1250
-
-
Yan, X.1
Li, F.2
Liang, Y.3
Shen, Y.4
Zhao, X.5
Huang, Q.6
Zhu, X.7
-
124
-
-
5144228139
-
Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning
-
Shu T, Ayala R, Nguyen MD, Xie Z, Gleeson JG, Tsai LH. 2004 Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning. Neuron 44, 263–277. (doi:10.1016/j.neuron.2004.09.030)
-
(2004)
Neuron
, vol.44
, pp. 263-277
-
-
Shu, T.1
Ayala, R.2
Nguyen, M.D.3
Xie, Z.4
Gleeson, J.G.5
Tsai, L.H.6
-
125
-
-
22144491144
-
NudEL targets dynein to microtubule ends through LIS1
-
Li J, Lee WL, Cooper JA. 2005 NudEL targets dynein to microtubule ends through LIS1. Nat. Cell Biol. 7, 686–690. (doi:10.1038/ncb1273)
-
(2005)
Nat. Cell Biol.
, vol.7
, pp. 686-690
-
-
Li, J.1
Lee, W.L.2
Cooper, J.A.3
-
126
-
-
34547958546
-
NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores
-
Stehman SA, Chen Y, McKenney RJ, Vallee RB. 2007 NudE and NudEL are required for mitotic progression and are involved in dynein recruitment to kinetochores. J. Cell Biol. 178, 583–594. (doi:10. 1083/jcb.200610112)
-
(2007)
J. Cell Biol.
, vol.178
, pp. 583-594
-
-
Stehman, S.A.1
Chen, Y.2
McKenney, R.J.3
Vallee, R.B.4
-
127
-
-
34250833558
-
Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes
-
Vergnolle MA, Taylor SS. 2007 Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes. Curr. Biol. 17, 1173–1179. (doi:10.1016/j.cub.2007.05.077)
-
(2007)
Curr. Biol.
, vol.17
, pp. 1173-1179
-
-
Vergnolle, M.A.1
Taylor, S.S.2
-
128
-
-
56349168458
-
DISC1, PDE4B, and NDE1 at the centrosome and synapse
-
Bradshaw NJ, Ogawa F, Antolin-Fontes B, Chubb JE, Carlyle BC, Christie S, Claessens A, Porteous DJ, Millar JK. 2008 DISC1, PDE4B, and NDE1 at the centrosome and synapse. Biochem. Biophys. Res. Commun. 377, 1091–1096. (doi:10.1016/j.bbrc. 2008.10.120)
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.377
, pp. 1091-1096
-
-
Bradshaw, N.J.1
Ogawa, F.2
Antolin-Fontes, B.3
Chubb, J.E.4
Carlyle, B.C.5
Christie, S.6
Claessens, A.7
Porteous, D.J.8
Millar, J.K.9
-
129
-
-
48249116693
-
Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: Evidence of epistasis and competitive binding
-
Burdick KE et al. 2008 Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Hum. Mol. Genet. 17, 2462–2473. (doi:10. 1093/hmg/ddn146)
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 2462-2473
-
-
Burdick, K.E.1
-
130
-
-
73849148044
-
Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning
-
Lam C, Vergnolle MA, Thorpe L, Woodman PG, Allan VJ. 2010 Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning. J. Cell Sci. 123, 202–212. (doi:10.1242/jcs.059337)
-
(2010)
J. Cell Sci.
, vol.123
, pp. 202-212
-
-
Lam, C.1
Vergnolle, M.A.2
Thorpe, L.3
Woodman, P.G.4
Allan, V.J.5
-
131
-
-
77951701022
-
LIS1 and NudE induce a persistent dynein force-producing state
-
McKenney RJ, Vershinin M, Kunwar A, Vallee RB, Gross SP. 2010 LIS1 and NudE induce a persistent dynein force-producing state. Cell 141, 304–314. (doi:10.1016/j.cell.2010.02.035)
-
(2010)
Cell
, vol.141
, pp. 304-314
-
-
McKenney, R.J.1
Vershinin, M.2
Kunwar, A.3
Vallee, R.B.4
Gross, S.P.5
-
132
-
-
75649100553
-
Ndel1 palmitoylation: A new mean to regulate cytoplasmic dynein activity
-
Shmueli A et al. 2010 Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity. EMBO J. 29, 107–119. (doi:10.1038/emboj. 2009.325)
-
(2010)
EMBO J
, vol.29
, pp. 107-119
-
-
Shmueli, A.1
-
134
-
-
80052510244
-
Cytoplasmic dynein
-
Allan VJ. 2011 Cytoplasmic dynein. Biochem. Soc. Trans. 39, 1169–1178. (doi:10.1042/BST0391169)
-
(2011)
Biochem. Soc. Trans.
, vol.39
, pp. 1169-1178
-
-
Allan, V.J.1
-
135
-
-
70450228589
-
Regulators of the cytoplasmic dynein motor
-
Kardon JR, Vale RD. 2009 Regulators of the cytoplasmic dynein motor. Nat. Rev. Mol. Cell Biol. 10, 854–865. (doi:10.1038/nrm2804)
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 854-865
-
-
Kardon, J.R.1
Vale, R.D.2
-
136
-
-
0031848149
-
Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality
-
Hirotsune S, Fleck MW, Gambello MJ, Bix GJ, Chen A, Clark GD, Ledbetter DH, McBain CJ, Wynshaw-Boris A. 1998 Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality. Nat. Genet. 19, 333–339. (doi:10.1038/1221)
-
(1998)
Nat. Genet
, vol.19
, pp. 333-339
-
-
Hirotsune, S.1
Fleck, M.W.2
Gambello, M.J.3
Bix, G.J.4
Chen, A.5
Clark, G.D.6
Ledbetter, D.H.7
McBain, C.J.8
Wynshaw-Boris, A.9
-
137
-
-
0032698126
-
Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice
-
Paylor R, Hirotsune S, Gambello MJ, Yuva-Paylor L, Crawley JN, Wynshaw-Boris A. 1999 Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice. Learn. Mem. 6, 521–537. (doi:10.1101/lm.6.5.521)
-
(1999)
Learn. Mem.
, vol.6
, pp. 521-537
-
-
Paylor, R.1
Hirotsune, S.2
Gambello, M.J.3
Yuva-Paylor, L.4
Crawley, J.N.5
Wynshaw-Boris, A.6
-
138
-
-
5144222593
-
Mitotic spindle regulation by Nde1 controls cerebral cortical size
-
Feng Y, Walsh CA. 2004 Mitotic spindle regulation by Nde1 controls cerebral cortical size. Neuron 44, 279–293. (doi:10.1016/j.neuron.2004.09.023)
-
(2004)
Neuron
, vol.44
, pp. 279-293
-
-
Feng, Y.1
Walsh, C.A.2
-
139
-
-
79955789917
-
The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis
-
Bakircioglu M et al. 2011 The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis. Am. J. Hum. Genet. 88, 523–535. (doi:10.1016/j.ajhg.2011.03.019)
-
(2011)
Am. J. Hum. Genet.
, vol.88
, pp. 523-535
-
-
Bakircioglu, M.1
-
140
-
-
84926068205
-
The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation
-
Houlihan SL, Feng Y. 2014 The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation. eLife 3, e03297. (doi:10.7554/eLife.03297)
-
(2014)
Elife
, vol.3
-
-
Houlihan, S.L.1
Feng, Y.2
-
141
-
-
84984636132
-
Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages
-
Doobin DJ, Kemal S, Dantas TJ, Vallee RB. 2016 Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages. Nat. Commun. 7, 12551. (doi:10. 1038/ncomms12551)
-
(2016)
Nat. Commun.
, vol.7
-
-
Doobin, D.J.1
Kemal, S.2
Dantas, T.J.3
Vallee, R.B.4
-
142
-
-
84876337451
-
Male-biased autosomal effect of 16p13.11 copy number variation in neurodevelopmental disorders
-
Tropeano M et al. 2013 Male-biased autosomal effect of 16p13.11 copy number variation in neurodevelopmental disorders. PLoS ONE 8, e61365. (doi:10.1371/journal.pone.0061365)
-
(2013)
Plos ONE
, vol.8
-
-
Tropeano, M.1
-
143
-
-
84930538918
-
Identification of rare, single-nucleotide mutations in NDE1 and their contributions to schizophrenia susceptibility
-
Kimura H et al. 2015 Identification of rare, single-nucleotide mutations in NDE1 and their contributions to schizophrenia susceptibility. Schizophr. Bull. 41, 744–753. (doi:10.1093/schbul/sbu147)
-
(2015)
Schizophr. Bull.
, vol.41
, pp. 744-753
-
-
Kimura, H.1
-
144
-
-
84857169578
-
DISC1 conditioned GWAS for psychosis proneness in a large Finnish birth cohort
-
Tomppo L, Ekelund J, Lichtermann D, Veijola J, Jarvelin MR, Hennah W. 2012 DISC1 conditioned GWAS for psychosis proneness in a large Finnish birth cohort. PLoS ONE 7, e30643. (doi:10.1371/journal.pone.0030643)
-
(2012)
Plos ONE
, vol.7
-
-
Tomppo, L.1
Ekelund, J.2
Lichtermann, D.3
Veijola, J.4
Jarvelin, M.R.5
Hennah, W.6
-
145
-
-
77952867780
-
OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
-
Fietz SA et al. 2010 OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling. Nat. Neurosci. 13, 690–699. (doi:10.1038/nn.2553)
-
(2010)
Nat. Neurosci.
, vol.13
, pp. 690-699
-
-
Fietz, S.A.1
-
146
-
-
77950076985
-
Neurogenic radial glia in the outer subventricular zone of human neocortex
-
Hansen DV, Lui JH, Parker PR, Kriegstein AR. 2010 Neurogenic radial glia in the outer subventricular zone of human neocortex. Nature 464, 554–561. (doi:10.1038/nature08845)
-
(2010)
Nature
, vol.464
, pp. 554-561
-
-
Hansen, D.V.1
Lui, J.H.2
Parker, P.R.3
Kriegstein, A.R.4
-
147
-
-
84858434210
-
CNVs: Harbingers of a rare variant revolution in psychiatric genetics
-
Malhotra D, Sebat J. 2012 CNVs: harbingers of a rare variant revolution in psychiatric genetics. Cell 148, 1223–1241. (doi:10.1016/j.cell.2012.02.039)
-
(2012)
Cell
, vol.148
, pp. 1223-1241
-
-
Malhotra, D.1
Sebat, J.2
-
148
-
-
77953260190
-
Confirmed rare copy number variants implicate novel genes in schizophrenia
-
Tam GW et al. 2010 Confirmed rare copy number variants implicate novel genes in schizophrenia. Biochem. Soc. Trans. 38, 445–451. (doi:10.1042/BST0380445)
-
(2010)
Biochem. Soc. Trans.
, vol.38
, pp. 445-451
-
-
Tam, G.W.1
-
149
-
-
84876585949
-
Rare CNVs and tag SNPs at 15q11.2 are associated with schizophrenia in the Han Chinese population
-
Zhao Q et al. 2013 Rare CNVs and tag SNPs at 15q11.2 are associated with schizophrenia in the Han Chinese population. Schizophr. Bull. 39, 712–719. (doi:10.1093/schbul/sbr197)
-
(2013)
Schizophr. Bull.
, vol.39
, pp. 712-719
-
-
Zhao, Q.1
-
150
-
-
84892620880
-
CNVs conferring risk of autism or schizophrenia affect cognition in controls
-
Stefansson H et al. 2014 CNVs conferring risk of autism or schizophrenia affect cognition in controls. Nature 505, 361–366. (doi:10.1038/nature12818)
-
(2014)
Nature
, vol.505
, pp. 361-366
-
-
Stefansson, H.1
-
151
-
-
0031972690
-
P140Sra-1 (Specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase
-
Kobayashi K et al. 1998 p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. J. Biol. Chem. 273, 291–295. (doi:10.1074/jbc.273.1.291)
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 291-295
-
-
Kobayashi, K.1
-
152
-
-
0035902466
-
A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P
-
Schenck A, Bardoni B, Moro A, Bagni C, Mandel JL. 2001 A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P. Proc. Natl Acad. Sci. USA 98, 8844–8849. (doi:10.1073/pnas.151231598)
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 8844-8849
-
-
Schenck, A.1
Bardoni, B.2
Moro, A.3
Bagni, C.4
Mandel, J.L.5
-
153
-
-
51549108502
-
The fragile ☓ syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP
-
Napoli I et al. 2008 The fragile ☓ syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell 134, 1042–1054. (doi:10. 1016/j.cell.2008.07.031)
-
(2008)
Cell
, vol.134
, pp. 1042-1054
-
-
Napoli, I.1
-
154
-
-
0242286595
-
Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions
-
Kunda P, Craig G, Dominguez V, Baum B. 2003 Abi, Sra1, and Kette control the stability and localization of SCAR/WAVE to regulate the formation of actin-based protrusions. Curr. Biol. 13, 1867–1875. (doi:10.1016/j.cub.2003.10.005)
-
(2003)
Curr. Biol.
, vol.13
, pp. 1867-1875
-
-
Kunda, P.1
Craig, G.2
Dominguez, V.3
Baum, B.4
-
155
-
-
1842562381
-
Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation
-
Steffen A, Rottner K, Ehinger J, Innocenti M, Scita G, Wehland J, Stradal TE. 2004 Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation. EMBO J. 23, 749–759. (doi:10.1038/sj.emboj.7600084)
-
(2004)
EMBO J
, vol.23
, pp. 749-759
-
-
Steffen, A.1
Rottner, K.2
Ehinger, J.3
Innocenti, M.4
Scita, G.5
Wehland, J.6
Stradal, T.E.7
-
156
-
-
82555196668
-
Mutations causing syndromic autism define an axis of synaptic pathophysiology
-
Auerbach BD, Osterweil EK, Bear MF. 2011 Mutations causing syndromic autism define an axis of synaptic pathophysiology. Nature 480, 63–68. (doi:10.1038/nature10658)
-
(2011)
Nature
, vol.480
, pp. 63-68
-
-
Auerbach, B.D.1
Osterweil, E.K.2
Bear, M.F.3
-
157
-
-
84860741138
-
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
-
O’Roak BJ et al. 2012 Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature 485, 246–250. (doi:10.1038/nature10989)
-
(2012)
Nature
, vol.485
, pp. 246-250
-
-
O’Roak, B.J.1
-
158
-
-
70350688091
-
Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1
-
Zhou J, Brugarolas J, Parada LF. 2009 Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1. Hum. Mol. Genet. 18, 4428–4441. (doi:10.1093/hmg/ddp398)
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 4428-4441
-
-
Zhou, J.1
Brugarolas, J.2
Parada, L.F.3
-
159
-
-
84859420878
-
Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome
-
Hoeffer CA et al. 2012 Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome. Genes Brain Behav. 11, 332–341. (doi:10.1111/j.1601-183X.2012.00768.x)
-
(2012)
Genes Brain Behav
, vol.11
, pp. 332-341
-
-
Hoeffer, C.A.1
-
160
-
-
85010089346
-
Modeling fragile ☓ syndrome in the Fmr1 knockout mouse
-
Kazdoba TM, Leach PT, Silverman JL, Crawley JN. 2014 Modeling fragile ☓ syndrome in the Fmr1 knockout mouse. Intractable Rare Dis. Res. 3, 118– 133. (doi:10.5582/irdr.2014.01024).
-
(2014)
Intractable Rare Dis. Res.
, vol.3
, pp. 118-133
-
-
Kazdoba, T.M.1
Leach, P.T.2
Silverman, J.L.3
Crawley, J.N.4
-
161
-
-
0142059641
-
A genomewide screen of 345 families for autism-susceptibility loci
-
Yonan AL et al. 2003 A genomewide screen of 345 families for autism-susceptibility loci. Am. J. Hum. Genet. 73, 886–897. (doi:10.1086/378778)
-
(2003)
Am. J. Hum. Genet.
, vol.73
, pp. 886-897
-
-
Yonan, A.L.1
-
162
-
-
70450208984
-
Deregulation of EIF4E: A novel mechanism for autism
-
Neves-Pereira M, Muller B, Massie D, Williams JH, O’Brien PC, Hughes A, Shen SB, Clair DS, Miedzybrodzka Z. 2009 Deregulation of EIF4E: a novel mechanism for autism. J. Med. Genet. 46, 759–765. (doi:10.1136/jmg.2009. 066852)
-
(2009)
J. Med. Genet.
, vol.46
, pp. 759-765
-
-
Neves-Pereira, M.1
Muller, B.2
Massie, D.3
Williams, J.H.4
O’Brien, P.C.5
Hughes, A.6
Shen, S.B.7
Clair, D.S.8
Miedzybrodzka, Z.9
-
163
-
-
84872595085
-
Autism-related deficits via dysregulated eIF4E-dependent translational control
-
Gkogkas CG et al. 2013 Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature 493, 371–377. (doi:10.1038/nature11628)
-
(2013)
Nature
, vol.493
, pp. 371-377
-
-
Gkogkas, C.G.1
-
164
-
-
84872617263
-
Exaggerated translation causes synaptic and behavioural aberrations associated with autism
-
Santini E, Huynh TN, MacAskill AF, Carter AG, Pierre P, Ruggero D, Kaphzan H, Klann E. 2013 Exaggerated translation causes synaptic and behavioural aberrations associated with autism. Nature 493, 411–415. (doi:10.1038/nature11782)
-
(2013)
Nature
, vol.493
, pp. 411-415
-
-
Santini, E.1
Huynh, T.N.2
Macaskill, A.F.3
Carter, A.G.4
Pierre, P.5
Ruggero, D.6
Kaphzan, H.7
Klann, E.8
|