A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations

Journal of Biological Chemistry

Volumn 292, Issue 16, 2017, Pages 6468-6477

  Yerabham, Antony S K ^a   Mas, Philippe J ^b   Decker, Christina ^c   Soares, Dinesh C ^d   Weiergräber, Oliver H ^e   Nagel Steger, Luitgard ^c,e   Willbold, Dieter ^c,e   Hart, Darren J ^b   Bradshaw, Nicholas J ^a   Korth, Carsten ^a  

^a Department of Neuropathology ^*  (France)

^b UNIV GRENOBLE ALPES   (France)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; PROTEINS; RECOMBINANT PROTEINS; SCAFFOLDS (BIOLOGY); THROUGHPUT;

CHROMOSOMAL TRANSLOCATIONS; DOMAIN ARCHITECTURES; FRAME-SHIFT MUTATION; HIGH THROUGHPUT SCREENING; INCREMENTAL TRUNCATIONS; PROTEIN-PROTEIN INTERACTIONS; SECONDARY STRUCTURES; STRUCTURAL ORGANIZATION;

DISEASES;

DISRUPTED IN SCHIZOPHRENIA 1; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG; DISC1 PROTEIN, HUMAN; NERVE PROTEIN; RECOMBINANT PROTEIN;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CHROMOSOME TRANSLOCATION; COMPLEX FORMATION; CONTROLLED STUDY; EXPRESSION OF SOLUBLE PROTEINS BY RANDOM INCREMENTAL TRUNCATION; FRAMESHIFT MUTATION; HIGH THROUGHPUT SCREENING; HUMAN; OLIGOMERIZATION; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SOLUBILITY; CHEMISTRY; GENETICS; METABOLISM; MUTATION; NERVE CELL; PROTEIN ANALYSIS; PROTEIN DENATURATION; PSYCHOSIS; SIGNAL TRANSDUCTION;

FRAMESHIFT MUTATION; HUMANS; MUTATION; NERVE TISSUE PROTEINS; NEURONS; PROTEIN DENATURATION; PROTEIN DOMAINS; PROTEIN FOLDING; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, SECONDARY; PSYCHOTIC DISORDERS; RECOMBINANT PROTEINS; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

EID: 85018580830     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.773903     Document Type: Article

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