Modeling a genetic risk for schizophrenia in iPSCs and Mice reveals neural stem cell deficits associated with adherens junctions and polarity

Cell Stem Cell

Volumn 15, Issue 1, 2014, Pages 79-91

  Yoon, Ki Jun ^a   Nguyen, Ha Nam ^a   Ursini, Gianluca ^a   Zhang, Fengyu ^a   Kim, Nam Shik ^a   Wen, Zhexing ^a   Makri, Georgia ^a   Nauen, David ^a   Shin, Joo Heon ^a   Park, Youngbin ^a   Chung, Raeeun ^a   Pekle, Eva ^a   Zhang, Ce ^a   Towe, Maxwell ^a   Hussaini, Syed Mohammed Qasim ^a   Lee, Yohan ^b   Rujescu, Dan ^c   St Clair, David ^d   Kleinman, Joel E ^a   Hyde, Thomas M ^a   Krauss, Gregory ^a   Christian, Kimberly M ^a   Rapoport, Judith L ^b   Weinberger, Daniel R ^a   Song, Hongjun ^a   Ming, Guo Li ^a   more..

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYFIP1 PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; WAVE PROTEIN; ACTIN RELATED PROTEIN 2; CYFIP1 PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; WASF1 PROTEIN, HUMAN; WISKOTT ALDRICH SYNDROME PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTISM; BRAIN VENTRICLE; CELL FUNCTION; CELL JUNCTION; CELL POLARITY; CHROMOSOME DELETION; CHROMOSOME DELETION 15Q11.2; CHROMOSOME DUPLICATION; CONTROLLED STUDY; COPY NUMBER VARIATION; CYTOSKELETON; EMBRYO; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; HAPLOINSUFFICIENCY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MACROGLIA; MAJOR CLINICAL STUDY; MALE; MEDIATOR; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; NEURAL STEM CELL; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RISK FACTOR; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; ANIMAL; CAUCASIAN; CELL LINE; CHROMOSOME 15; CHROMOSOME ABERRATION; EPISTASIS; GENETICS; INBRED MOUSE STRAIN; INTELLECTUAL IMPAIRMENT; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; RISK; ANIMAL CELL; BRAIN CORTEX; CYFIP1 GENE; DYNAMICS; GENE; GENETIC RISK;

ACTIN-RELATED PROTEIN 2; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADHERENS JUNCTIONS; ADULT; ANIMALS; AUTISTIC DISORDER; CELL LINE; CELL POLARITY; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 15; DNA COPY NUMBER VARIATIONS; EPISTASIS, GENETIC; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC ASSOCIATION STUDIES; HAPLOINSUFFICIENCY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INTELLECTUAL DISABILITY; MALE; MICE; MICE, INBRED STRAINS; MIDDLE AGED; NEURAL STEM CELLS; RISK; SCHIZOPHRENIA; WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY;

MUS;

EID: 84904001347     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2014.05.003     Document Type: Article

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