Abnormal synaptic pruning in schizophrenia: Urban myth or reality?

Journal of Psychiatry and Neuroscience

Volumn 37, Issue 2, 2012, Pages 75-77

  Boksa, Patricia ^a  

^a DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE; AMPA RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MESSENGER RNA; N ACETYLASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID; PHOSPHODIESTERASE; PHOSPHOLIPID; PROTEIN CDC42; RAC1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ACTIN FILAMENT; ADOLESCENCE; BRAIN SIZE; EDITORIAL; ELECTRON MICROSCOPY; FRONTAL LOBE; GRAY MATTER; HUMAN; NEUROIMAGING; NEUROPATHOLOGY; NEUROPIL; PHOSPHOLIPID SYNTHESIS; PREFRONTAL CORTEX; PSYCHOSIS; SCHIZOPHRENIA; TEMPORAL LOBE; WHITE MATTER;

EID: 84857605371     PISSN: 11804882     EISSN: 14882434     Source Type: Journal    
DOI: 10.1503/jpn.120007     Document Type: Editorial

References (32)

1. Andreasen NC, Nopoulos P, Magnotta V, et al. Progressive brain change in schizophrenia: a prospective longitudinal study of firstepisode schizophrenia. Biol Psychiatry 2011;70:672-9.
2. Fusar-Poli P, Borgwardt S, Crescini A, et al. Neuroanatomy of vulnerability to psychosis: a voxel-based meta-analysis. Neurosci Biobehav Rev 2011;35:1175-85.
3. Huttenlocher PR. Synaptic density in human frontal cortex - developmental changes and effects of aging. Brain Res 1979;163: 195-205.
4. Huttenlocher PR, Dabholkar AS. Regional differences in synaptogenesis in human cerebral cortex. J Comp Neurol 1997;387:167-78.
5. Colantuoni C, Lipska BK, Ye T, et al. Temporal dynamics and genetic control of transcription in the human prefrontal cortex. Nature 2011;478:519-23.
6. Petanjek Z, Judaš M, Šimic G, et al. Extraordinary neoteny of synaptic spines in the human prefrontal cortex. Proc Natl Acad Sci USA 2011;108:13281-6.
7. Hua JY, Smith SJ. Neural activity and the dynamics of central nervous system development. Nat Neurosci 2004;7:327-32.
8. Feinberg I. Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence? J Psychiatr Res 1982-1983;17:319-34.
9. Faludi G, Mirnics K. Synaptic changes in the brain of subjects with schizophrenia. Int J Dev Neurosci 2011;29:305-9.
10. Glantz LA, Lewis DA. Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch Gen Psychiatry 2000;57:65-73.
11. Garey L. When cortical development goes wrong: schizophrenia as a neurodevelopmental disease of microcircuits. J Anat 2010;217: 324-33.
12. Kalus P, Müller TJ, Zuschratter W, et al. The dendritic architecture of prefrontal pyramidal neurons in schizophrenic patients. Neuro report 2000;11:3621-5.
13. Broadbelt K, Byne W, Jones LB. Evidence for a decrease in basilar dendrites of pyramidal cells in schizophrenic medial prefrontal cortex. Schizophr Res 2002;58:75-81.
14. Sun D, Stuart GW, Jenkinson M, et al. Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging study. Mol Psychiatry 2009;14:976-86.
15. Pettegrew JW, Keshavan MS, Panchalingam K, et al. Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics. A pilot study of the dorsal prefrontal cortex by in vivo phosphorus 31 nuclear magnetic resonance spectroscopy. Arch Gen Psychiatry 1991;48:563-8.
16. Stanley JA, Williamson PC, Drost DJ, et al. An in vivo study of the prefrontal cortex of schizophrenic patients at different stages of illness via phosphorus magnetic resonance spectroscopy. Arch Gen Psychiatry 1995;52:399-406.
17. Volz HP, Rzanny R, Rössger G, et al. 31Phosphorus magnetic resonance spectroscopy of the dorsolateral prefrontal region in schizophrenics - a study including 50 patients and 36 controls. Biol Psychiatry 1998;44:399-404.
18. Yacubian J, de Castro CC, Ometto M, et al. 31P-spectroscopy of frontal lobe in schizophrenia: alterations in phospholipid and high-energy phosphate metabolism. Schizophr Res 2002;58:117-22.
19. Smesny S, Rosburg T, Nenadic I, et al. Metabolic mapping using 2D 31P-MR spectroscopy reveals frontal and thalamic metabolic abnormalities in schizophrenia. Neuroimage 2007;35:729-37.
20. Brugger S, Davis JM, Leucht S, et al. Proton magnetic resonance spectroscopy and illness stage in schizophrenia - a systematic review and meta-analysis. Biol Psychiatry 2011;69:495-503.
21. Moffett JR, Ross B, Arun P, et al. N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Prog Neurobiol 2007;81:89-131.
22. Hua JY, Smith SJ. Neural activity and the dynamics of central nervous system development. Nat Neurosci 2004;7:327-32.
23. McKinney RA. Excitatory amino acid involvement in dendritic spine formation, maintenance and remodelling. J Physiol 2010;588: 107-16.
24. Tolias KF, Duman JG, Um K. Control of synapse development and plasticity by Rho GTPase regulatory proteins. Prog Neurobiol 2011; 94: 133-48.
25. Hayashi-Takagi A, Takaki M, Graziane N, et al. Disrupted-in- Schizophrenia 1 (Drosoph Inf ServC1) regulates spines of the glutamate synapse via Rac1. Nat Neurosci 2010;13:327-32.
26. Lee FH, Kaidanovich-Beilin O, Roder JC, et al. Genetic inactivation of GSK3α rescues spine deficits in Disc1-L100P mutant mice. Schizophr Res 2011;129:74-9.
27. Hill JJ, Hashimoto T, Lewis DA. Molecular mechanisms contributing to dendritic spine alterations in the prefrontal cortex of subjects with schizophrenia. Mol Psychiatry 2006;11:557-66.
28. Ide M, Lewis DA. Altered cortical CDC42 signaling pathways in schizophrenia: implications for dendritic spine deficits. Biol Psychiatry 2010;68:25-32.
29. Chai X, Förster E, Zhao S, et al. Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3. J Neurosci 2009;29:288-99.
30. Balu DT, Coyle JT. Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia. Neurosci Biobehav Rev 2011; 35:848-70.
31. Hill JJ, Kolluri N, Hashimoto T, et al. Analysis of pyramidal neuron morphology in an inducible knockout of brain-derived neurotrophic factor. Biol Psychiatry 2005;57:932-4.
32. Paolicelli RC, Bolasco G, Pagani F, et al. Synaptic pruning by microglia is necessary for normal brain development. Science 2011; 333: 1456-8.