What causes psychosis? An umbrella review of risk and protective factors

World Psychiatry

Volumn 17, Issue 1, 2018, Pages 49-66

  Radua, Joaquim ^a,b,c   Ramella Cravaro, Valentina ^a,d   Ioannidis, John P A ^e,f,g   Reichenberg, Abraham ^a,h   Phiphopthatsanee, Nacharin ^a   Amir, Taha ^a   Yenn Thoo, Hyi ^a   Oliver, Dominic ^a   Davies, Cathy ^a   Morgan, Craig ^a,i   McGuire, Philip ^a,i   Murray, Robin M ^a,i   Fusar Poli, Paolo ^a,i,j  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF FLORENCE   (Italy)

^e Stanford Prevention Research Center   (United States)

^f STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g STANFORD UNIVERSITY   (United States)

^h MOUNT SINAI SCHOOL OF MEDICINE   (United States)

ⁱ King s College London   (United Kingdom)

^j SOUTH LONDON AND MAUDSLEY NHS FOUNDATION TRUST   (United Kingdom)

more..

Author keywords

antecedents; Black Caribbean ethnicity; environment; parental factors; perinatal factors; psychosis; risk; Schizophrenia; socio demographic factors; ultra high risk state for psychosis; urbanicity

Indexed keywords

DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE ASSOCIATION; ETHNICITY; HIGH RISK PATIENT; HUMAN; IMMIGRANT; INTERNATIONAL CLASSIFICATION OF DISEASES; PERINATAL PERIOD; PRACTICE GUIDELINE; PREDICTION; PRIORITY JOURNAL; PSYCHOSIS; PSYCHOSOCIAL WITHDRAWAL; PSYCHOTRAUMA; REVIEW; RISK FACTOR; SENSITIVITY ANALYSIS; SOCIAL STATUS; URBAN AREA;

EID: 85040741812     PISSN: 17238617     EISSN: 20515545     Source Type: Journal    
DOI: 10.1002/wps.20490     Document Type: Review

References (157)

1. Global Burden of Disease Study Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2015;386:743-800.
2. Kirkbride JB, Errazuriz A, Croudace TJ et al. Incidence of schizophrenia and other psychoses in England, 1950–2009: a systematic review and meta-analyses. PLoS One 2012;7:e31660.
3. Cloutier M, Aigbogun MS, Guerin A et al. The economic burden of schizophrenia in the United States in 2013. J Clin Psychiatry 2016;77:764-71.
4. Fusar-Poli P, McGorry PD, Kane J. Improving outcomes of first-episode psychosis: an overview. World Psychiatry 2017;16:251-65.
5. van Os J, Rutten BPF, Poulton R. Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions. Schizophr Bull 2008;34:1066-82.
6. Howes OD, Murray RM. Schizophrenia: an integrated sociodevelopmental-cognitive model. Lancet 2014;383:1677-87.
7. Matheson SL, Shepherd AM, Laurens KR et al. A systematic meta-review grading the evidence for non-genetic risk factors and putative antecedents of schizophrenia. Schizophr Res 2011;133:133-42.
8. Laurens KR, Luo L, Matheson SL et al. Common or distinct pathways to psychosis? A systematic review of evidence from prospective studies for developmental risk factors and antecedents of the schizophrenia spectrum disorders and affective psychoses. BMC Psychiatry 2015;15:205.
9. Dean K MR. Environmental risk factors for psychosis. Dialogues Clin Neurosci 2005;7:69-80.
10. Fusar-Poli P. The Clinical High-Risk State for Psychosis (CHR-P), Version II. Schizophr Bull 2017;43:44-7.
11. Fusar-Poli P, Schultze-Lutter F. Predicting the onset of psychosis in patients at clinical high risk: practical guide to probabilistic prognostic reasoning. Evid Based Ment Health 2016;19:10-5.
12. Ioannidis JP, Munafo MR, Fusar-Poli P et al. Publication and other reporting biases in cognitive sciences: detection, prevalence, and prevention. Trends Cogn Sci 2014;18:235-41.
13. van Os J, Kenis G, Rutten BPF. The environment and schizophrenia. Nature 2010;468:203-12.
14. Aromataris E, Fernandez R, Godfrey CM et al. Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach. Int J Evid Based Health 2015;13:132-40.
15. Dinu M, Pagliai G, Casini A et al. Mediterranean diet and multiple health outcomes: an umbrella review of meta-analyses of observational studies and randomised trials. Eur J Clin Nutr (in press).
16. Bortolato B, Kohler CA, Evangelou E et al. Systematic assessment of environmental risk factors for bipolar disorder: an umbrella review of systematic reviews and meta-analyses. Bipolar Disord 2017;19:84-96.
17. Kyrgiou M, Kalliala I, Markozannes G et al. Adiposity and cancer at major anatomical sites: umbrella review of the literature. BMJ 2017;356:j477.
18. Dragioti E, Karathanos V, Gerdle B et al. Does psychotherapy work? An umbrella review of meta-analyses of randomized controlled trials. Acta Psychiatr Scand 2017;136:236-46.
19. Markozannes G, Tzoulaki I, Karli D et al. Diet, body size, physical activity and risk of prostate cancer: an umbrella review of the evidence. Eur J Cancer 2016;69:61-9.
20. Belbasis L, Savvidou MD, Kanu C et al. Birth weight in relation to health and disease in later life: an umbrella review of systematic reviews and meta-analyses. BMC Med 2016;14:147.
21. Belbasis L, Stefanaki I, Stratigos AJ et al. Non-genetic risk factors for cutaneous melanoma and keratinocyte skin cancers: an umbrella review of meta-analyses. J Dermatol Sci 2016;84:330-9.
22. Papageorgiou PN, Deschner J, Papageorgiou SN. Effectiveness and adverse effects of deep brain stimulation: umbrella review of meta-analyses. J Neurol Surg A Cent Eur Neurosurg 2017;78:180-90.
23. Bellou V, Belbasis L, Tzoulaki I et al. Systematic evaluation of the associations between environmental risk factors and dementia: an umbrella review of systematic reviews and meta-analyses. Alzheimers Dement 2017;13:406-18.
24. Carvalho AF, Kohler CA, Fernandes BS et al. Bias in emerging biomarkers for bipolar disorder. Psychol Med 2016;46:2287-97.
25. Bellou V, Belbasis L, Tzoulaki I et al. Environmental risk factors and Parkinson's disease: an umbrella review of meta-analyses. Parkinsonism Relat Disord 2016;23:1-9.
26. Belbasis L, Bellou V, Evangelou E. Environmental risk factors and amyotrophic lateral sclerosis: an umbrella review and critical assessment of current evidence from systematic reviews and meta-analyses of observational studies. Neuroepidemiology 2016;46:96-105.
27. Belbasis L, Bellou V, Evangelou E et al. Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses. Lancet Neurol 2015;14:263-73.
28. Tsilidis KK, Kasimis JC, Lopez DS et al. Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies. BMJ 2015;350:g7607.
29. Theodoratou E, Tzoulaki I, Zgaga L et al. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ 2014;348:g2035.
30. Tonelli AR, Zein J, Adams J et al. Effects of interventions on survival in acute respiratory distress syndrome: an umbrella review of 159 published randomized trials and 29 meta-analyses. Intensive Care Med 2014;40:769-87.
31. Ioannidis JP, Zhou Y, Chang CQ et al. Potential increased risk of cancer from commonly used medications: an umbrella review of meta-analyses. Ann Oncol 2014;25:16-23.
32. Doufas AG, Panagiotou OA, Ioannidis JP. Concordance of sleep and pain outcomes of diverse interventions: an umbrella review. PLoS One 2012;7:e40891.
33. Contopoulos-Ioannidis DG, Ioannidis JP. Claims for improved survival from systemic corticosteroids in diverse conditions: an umbrella review. Eur J Clin Invest 2012;42:233-44.
34. Fleischhacker WW. A meta view on meta-analyses. JAMA Psychiatry 2017;74:684-5.
35. Ioannidis JPA. Integration of evidence from multiple meta-analyses: a primer on umbrella reviews, treatment networks and multiple treatments meta-analyses. CMAJ 2009;181:488-93.
36. Geddes JR, Verdoux H, Takei N et al. Schizophrenia and complications of pregnancy and labor: an individual patient data meta-analysis. Schizophr Bull 1999;25:413-23.
37. Cannon M, Jones PB, Murray RM. Obstetric complications and schizophrenia: historical and meta-analytic review. Am J Psychiatry 2002;159:1080-92.
38. Woodberry KA, Giuliano AJ, Seidman LJ. Premorbid IQ in schizophrenia: a meta-analytic review. Am J Psychiatry 2008;165:579-87.
39. Khandaker GM, Barnett JH, White IR et al. A quantitative meta-analysis of population-based studies of premorbid intelligence and schizophrenia. Schizophr Res 2011;132:220-7.
40. Cai L, Wan CL, He L et al. Gestational influenza increases the risk of psychosis in adults. Med Chem 2015;11:676-82.
41. Selten J-P, Termorshuizen F. The serological evidence for maternal influenza as risk factor for psychosis in offspring is insufficient: critical review and meta-analysis. Schizophr Res 2017;183:2-9.
42. Tarbox SI, Pogue-Geile MF. Development of social functioning in preschizophrenia children and adolescents: a systematic review. Psychol Bull 2008;134:561-83.
43. Matheson SL, Vijayan H, Dickson H et al. Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9-14 years. J Psychiatr Res 2013;47:1061-8.
44. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014;511:421-7.
45. O'Dushlaine C, Rossin L, Lee PH et al. Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways. Nat Neurosci 2015;18:199-209.
46. Xu T, Chan RCK, Compton MT. Minor physical anomalies in patients with schizophrenia, unaffected first-degree relatives, and healthy controls: a meta-analysis. PLoS One 2011;6:e24129.
47. Hirnstein M, Hugdahl K. Excess of non-right-handedness in schizophrenia: meta-analysis of gender effects and potential biases in handedness assessment. Br J Psychiatry 2014;205:260-7.
48. Golembo-Smith S, Walder DJ, Daly MP et al. The presentation of dermatoglyphic abnormalities in schizophrenia: a meta-analytic review. Schizophr Res 2012;142:1-11.
49. Neelam K, Garg D, Marshall M. A systematic review and meta-analysis of neurological soft signs in relatives of people with schizophrenia. BMC Psychiatry 2011;11:139.
50. Christesen HT, Elvander C, Lamont RF et al. The impact of vitamin D in pregnancy on extraskeletal health in children: a systematic review. Acta Obstet Gynecol Scand 2012;91:1368-80.
51. Moher D, Liberati A, Tetzlaff J et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 2009;62:1006-12.
52. Stroup DF, Berlin JA, Morton SC et al. Meta-analysis of observational studies in epidemiology - a proposal for reporting. JAMA 2000;283:2008-12.
53. Bourque F, van der Ven E, Malla A. A meta-analysis of the risk for psychotic disorders among first- and second-generation immigrants. Psychol Med 2011;41:897-910.
54. Varese F, Smeets F, Drukker M et al. Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies. Schizophr Bull 2012;38:661-71.
55. Kinney DK, Teixeira P, Hsu D et al. Relation of schizophrenia prevalence to latitude, climate, fish consumption, infant mortality, and skin color: a role for prenatal vitamin D deficiency and infections? Schizophr Bull 2009;35:582-95.
56. Saha S, Chant D, Welham J et al. A systematic review of the prevalence of schizophrenia. PLoS Med 2005;2:413-33.
57. Rohatgi A. WebPlotDigitizer 3.10. arohatgi.info/WebPlotDigitizer/.
58. Shea BJ, Grimshaw JM, Wells GA et al. Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews. BMC Med Res Methodol 2007;7:10.
59. Shea BJ, Bouter LM, Peterson J et al. External validation of a measurement tool to assess systematic reviews (AMSTAR). PLoS One 2007;2:e1350.
60. Pieper D, Mathes T, Eikermann M. Can AMSTAR also be applied to systematic reviews of non-randomized studies? BMC Res Notes 2014;7:609.
61. R Development Core Team. R: a language and environment for statistical computing. Vienna: R Foundation for Statistical Computing, 2011.
62. Higgins JPT, Green S (eds). Cochrane handbook for systematic reviews of interventions version 5.1.0. The Cochrane Collaboration, 2011.
63. Moberg P, Kamath V, Marchetto D et al. Meta-analysis of olfactory function in schizophrenia, first-degree family members, and youths at-risk for psychosis. Schizophr Bull 2014;40:50-9.
64. Rubia K, Alegria AA, Cubillo AI et al. Effects of stimulants on brain function in attention-deficit/hyperactivity disorder: a systematic review and meta-analysis. Biol Psychiatry 2014;76:616-28.
65. Schwarzer G. Meta: an R package for meta-analysis. R News 2007;7:40-5.
66. Higgins JPT, Thompson SG, Spiegelhalter DJ. A re-evaluation of random-effects meta-analysis. J R Stat Soc A Stat 2009;172:137-59.
67. Jackson D, Kirkbride J, Croudace T et al. Meta-analytic approaches to determine gender differences in the age-incidence characteristics of schizophrenia and related psychoses. Int J Methods Psychiatr Res 2013;22:36-45.
68. Egger M, Smith GD, Schneider M et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997;315:629-34.
69. Ioannidis JPA, Trikalinos TA. An exploratory test for an excess of significant findings. Clin Trials 2007;4:245-53.
70. Chinn S. A simple method for converting an odds ratio to effect size for use in meta-analysis. Stat Med 2000;19:3127-31.
71. Bosqui TJ, Hoy K, Shannon C. A systematic review and meta-analysis of the ethnic density effect in psychotic disorders. Soc Psychiatry Psychiatr Epidemiol 2014;49:519-29.
72. Torrey EF, Buka S, Cannon TD et al. Paternal age as a risk factor for schizophrenia: how important is it? Schizophr Res 2009;114:1-5.
73. Kwok W. Is there evidence that social class at birth increases risk of psychosis? A systematic review. Int J Soc Psychiatry 2014;60:801-8.
74. O'Donoghue B, Roche E, Lane A. Neighbourhood level social deprivation and the risk of psychotic disorders: a systematic review. Soc Psychiatry Psychiatr Epidemiol 2016;51:941-50.
75. Rasic D, Hajek T, Alda M et al. Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: a meta-analysis of family high-risk studies. Schizophr Bull 2014;40:28-38.
76. Tortelli A, Errazuriz A, Croudace T et al. Schizophrenia and other psychotic disorders in Caribbean-born migrants and their descendants in England: systematic review and meta-analysis of incidence rates, 1950–2013. Soc Psychiatry Psychiatr Epidemiol 2015;50:1039-55.
77. van der Ven E, Veling W, Tortelli A et al. Evidence of an excessive gender gap in the risk of psychotic disorder among North African immigrants in Europe: a systematic review and meta-analysis. Soc Psychiatry Psychiatr Epidemiol 2016;51:1603-13.
78. Vassos E, Pedersen CB, Murray RM et al. Meta-analysis of the association of urbanicity with schizophrenia. Schizophr Bull 2012;38:1118-23.
79. Davies G, Welham J, Chant D et al. A systematic review and meta-analysis of Northern Hemisphere season of birth studies in schizophrenia. Schizophr Bull 2003;29:587-93.
80. McGrath JJ, Welham JL. Season of birth and schizophrenia: a systematic review and meta-analysis of data from the Southern Hemisphere. Schizophr Res 1999;35:237-42.
81. Geddes JR, Lawrie SM. Obstetric complications and schizophrenia: a meta-analysis. Br J Psychiatry 1995;167:786-93.
82. Van Lieshout RJ, Taylor VH, Boyle MH. Pre-pregnancy and pregnancy obesity and neurodevelopmental outcomes in offspring: a systematic review. Obes Rev 2011;12:e548-59.
83. Arias I, Sorlozano A, Villegas E et al. Infectious agents associated with schizophrenia: a meta-analysis. Schizophr Res 2012;136:128-36.
84. Attademo L, Bernardini F, Garinella R et al. Environmental pollution and risk of psychotic disorders: a review of the science to date. Schizophr Res 2017;181:55-9.
85. Beards S, Gayer-Anderson C, Borges S et al. Life events and psychosis: a review and meta-analysis. Schizophr Bull 2013;39:740-7.
86. Clancy MJ, Clarke MC, Connor DJ et al. The prevalence of psychosis in epilepsy; a systematic review and meta-analysis. BMC Psychiatry 2014;14:75.
87. Cunningham T, Hoy K, Shannon C. Does childhood bullying lead to the development of psychotic symptoms? A meta-analysis and review of prospective studies. Psychosis 2015;8:48-59.
88. de Sousa P, Varese F, Sellwood W et al. Parental communication and psychosis: a meta-analysis. Schizophr Bull 2014;40:756-68.
89. Gurillo P, Jauhar S, Murray RM et al. Does tobacco use cause psychosis? Systematic review and meta-analysis. Lancet Psychiatry 2015;2:718-25.
90. Gutierrez-Fernandez J, de Dios Luna del Castillo J, Mananes-Gonzalez S et al. Different presence of Chlamydia pneumoniae, herpes simplex virus type 1, human herpes virus 6, and Toxoplasma gondii in schizophrenia: meta-analysis and analytical study. Neuropsychiatr Dis Treat 2015;11:843-52.
91. Khandaker GM, Zimbron J, Dalman C et al. Childhood infection and adult schizophrenia: a meta-analysis of population-based studies. Schizophr Res 2012;139:161-8.
92. Linszen MMJ, Brouwer RM, Heringa SM et al. Increased risk of psychosis in patients with hearing impairment: review and meta-analyses. Neurosci Biobehav Rev 2016;62:1-20.
93. Marconi A, Di Forti M, Lewis CM et al. Meta-analysis of the association between the level of cannabis use and risk of psychosis. Schizophr Bull 2016;42:1262-9.
94. Molloy C, Conroy RM, Cotter DR et al. Is traumatic brain injury a risk factor for schizophrenia? A meta-analysis of case-controlled population-based studies. Schizophr Bull 2011;37:1104-10.
95. Sutterland AL, Fond G, Kuin A et al. Beyond the association. Toxoplasma gondii in schizophrenia, bipolar disorder, and addiction: systematic review and meta-analysis. Acta Psychiatr Scand 2015;132:161-79.
96. Dickson H, Laurens KR, Cullen AE et al. Meta-analyses of cognitive and motor function in youth aged 16 years and younger who subsequently develop schizophrenia. Psychol Med 2012;42:743-55.
97. Filatova S, Koivumaa-Honkanen H, Hirvonen N et al. Early motor developmental milestones and schizophrenia: a systematic review and meta-analysis. Schizophr Res 2017;188:13-20.
98. Fusar-Poli P, Cappucciati M, Rutigliano G et al. At risk or not at risk? A meta-analysis of the prognostic accuracy of psychometric interviews for psychosis prediction. World Psychiatry 2015;14:322-32.
99. Kaymaz N, Drukker M, Lieb R et al. Do subthreshold psychotic experiences predict clinical outcomes in unselected non-help-seeking population-based samples? A systematic review and meta-analysis, enriched with new results. Psychol Med 2012;42:2239-53.
100. Koning JPF, Tenback DE, van Os J et al. Dyskinesia and Parkinsonism in antipsychotic-naive patients with schizophrenia, first-degree relatives and healthy controls: a meta-analysis. Schizophr Bull 2010;36:723-31.
101. Ohi K, Hashimoto R, Yasuda Y et al. Personality traits and schizophrenia: evidence from a case-control study and meta-analysis. Psychiatry Res 2012;198:7-11.
102. Ohi K, Shimada T, Nitta Y et al. The Five-Factor Model personality traits in schizophrenia: a meta-analysis. Psychiatry Res 2016;240:34-41.
103. Potvin S, Marchand S. Hypoalgesia in schizophrenia is independent of antipsychotic drugs: a systematic quantitative review of experimental studies. Pain 2008;138:70-8.
104. Ward KE, Friedman L, Wise A et al. Meta-analysis of brain and cranial size in schizophrenia. Schizophr Res 1996;22:197-213.
105. Yan C, Cao Y, Zhang Y et al. Trait and state positive emotional experience in schizophrenia: a meta-analysis. PLoS One 2012;7:e40672.
106. Selten JP, Cantor-Graae E, Nahon D et al. No relationship between risk of schizophrenia and prenatal exposure to stress during the Six-Day War or Yom Kippur War in Israel. Schizophr Res 2003;63:131-5.
107. O'Rourke K. An historical perspective on meta-analysis: dealing quantitatively with varying study results. J Roy Soc Med 2007;100:579-82.
108. Fusar-Poli P, Borgwardt S, Bechdolf A et al. The psychosis high-risk state: a comprehensive state-of-the-art review. JAMA Psychiatry 2013;70:107-20.
109. Fusar-Poli P, Rutigliano G, Stahl D et al. Long-term validity of the At Risk Mental State (ARMS) for predicting psychotic and non-psychotic mental disorders. Eur Psychiatry 2017;42:49-54.
110. Kempton MJ, Bonoldi I, Valmaggia L et al. Speed of psychosis progression in people at ultra-high clinical risk: a complementary meta-analysis. JAMA Psychiatry 2015;72:622-3.
111. Fusar-Poli P, Cappucciati M, De Micheli A et al. Diagnostic and prognostic significance of brief limited intermittent psychotic symptoms (BLIPS) in individuals at ultra high risk. Schizophr Bull 2017;43:48-56.
112. Fusar-Poli P, Cappucciati M, Bonoldi I et al. Prognosis of brief psychotic episodes: a meta-analysis. JAMA Psychiatry 2016;73:211-20.
113. Falkenberg I, Valmaggia L, Byrnes M et al. Why are help-seeking subjects at ultra-high risk for psychosis help-seeking? Psychiatry Res 2015;228:808-15.
114. Fusar-Poli P, Rocchetti M, Sardella A et al. Disorder, not just state of risk: meta-analysis of functioning and quality of life in people at high risk of psychosis. Br J Psychiatry 2015;207:198-206.
115. Fusar-Poli P, Cappucciati M, Borgwardt S et al. Heterogeneity of psychosis risk within individuals at clinical high risk: a meta-analytical stratification. JAMA Psychiatry 2016;73:113-20.
116. Fusar-Poli P, Cappucciati M, Rutigliano G et al. Towards a standard psychometric diagnostic interview for subjects at ultra high risk of psychosis: CAARMS versus SIPS. Psychiatry J 2016; 2016:7146341.
117. Fusar-Poli P, Tantardini M, De Simone S et al. Deconstructing vulnerability for psychosis: meta-analysis of environmental risk factors for psychosis in subjects at ultra high-risk. Eur Psychiatry 2017;40:65-75.
118. Fusar-Poli P, Rutigliano G, Stahl D et al. Deconstructing pretest risk enrichment to optimize prediction of psychosis in individuals at clinical high risk. JAMA Psychiatry 2016;73:1260-7.
119. Fusar-Poli P, Schultze-Lutter F, Cappucciati M et al. The dark side of the moon: meta-analytical impact of recruitment strategies on risk enrichment in the clinical high risk state for psychosis. Schizophr Bull 2016;42:732-43.
120. Fusar-Poli P, Schultze-Lutter F, Addington J. Intensive community outreach for those at ultra high risk of psychosis: dilution, not solution. Lancet Psychiatry 2016;3:18.
121. Fusar-Poli P, Palombini E, Davies C et al. Why transition risk to psychosis is not declining at the OASIS ultra high risk service: the hidden role of stable pretest risk enrichment. Schizophr Res (in press).
122. Fusar-Poli P. Why ultra high risk criteria for psychosis prediction do not work well outside clinical samples and what to do about it. World Psychiatry 2017;16:212-3.
123. Kirkbride J, Hameed Y, Ankireddypalli G et al. The epidemiology of first-episode psychosis in early intervention in psychosis services: findings from the Social Epidemiology of Psychoses in East Anglia [SEPEA] Study. Am J Psychiatry 2017;174:143-53.
124. Heinz A, Deserno L, Reininghaus U. Urbanicity, social adversity and psychosis. World Psychiatry 2013;12:187-97.
125. Selten J-P, van Os J, Cantor-Graae E. The social defeat hypothesis of schizophrenia: issues of measurement and reverse causality. World Psychiatry 2016;15:294-5.
126. Mizrahi R. Social stress and psychosis risk: common neurochemical substrates? Neuropsychopharmacology 2016;41:666-74.
127. Holtzman CW, Trotman HD, Goulding SM et al. Stress and neurodevelopmental processes in the emergence of psychosis. Neuroscience 2013;249:172-91.
128. Steinheuser V, Ackermann K, Schonfeld P et al. Stress and the city: impact of urban upbringing on the (re)activity of the hypothalamus-pituitary-adrenal axis. Psychosom Med 2014;76:678-85.
129. Mewes R, Reich H, Skoluda N et al. Elevated hair cortisol concentrations in recently fled asylum seekers in comparison to permanently settled immigrants and non-immigrants. Transl Psychiatry 2017;7:e1051.
130. Powell ND, Sloan EK, Bailey MT et al. Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via beta-adrenergic induction of myelopoiesis. Proc Natl Acad Sci USA 2013;110:16574-9.
131. Akdeniz C, Tost H, Streit F et al. Neuroimaging evidence for a role of neural social stress processing in ethnic minority-associated environmental risk. JAMA Psychiatry 2014;71:672-80.
132. Lederbogen F, Kirsch P, Haddad L et al. City living and urban upbringing affect neural social stress processing in humans. Nature 2011;474:498-501.
133. Haddad L, Schafer A, Streit F et al. Brain structure correlates of urban upbringing, an environmental risk factor for schizophrenia. Schizophr Bull 2015;41:115-22.
134. Selten JP, Booij J, Buwalda B et al. Biological mechanisms whereby social exclusion may contribute to the etiology of psychosis: a narrative review. Schizophr Bull (in press).
135. Egerton A, Howes OD, Houle S et al. Elevated striatal dopamine function in immigrants and their children: a risk mechanism for psychosis. Schizophr Bull 2017;43:293-301.
136. Frissen A, van Os J, Habets P et al. No evidence of association between childhood urban environment and cortical thinning in psychotic disorder. PLoS One 2017;12:e0166651.
137. Keskinen E, Marttila R, Koivumaa-Honkanen H et al. Search for protective factors for psychosis - a population-based sample with special interest in unaffected individuals with parental psychosis. Early Interv Psychiatry (in press).
138. Millan MJ, Andrieux A, Bartzokis G et al. Altering the course of schizophrenia: progress and perspectives. Nat Rev Drug Discov 2016;15:485-515.
139. Uher R, Zwicker A. Etiology in psychiatry: embracing the reality of poly-gene-environmental causation of mental illness. World Psychiatry 2017;16:121-9.
140. Vassos E, Di Forti M, Coleman J et al. An examination of polygenic score risk prediction in individuals with first episode psychosis. Biol Psychiatry 2016;81:470-7.
141. Fusar-Poli P, Rutigliano G, Stahl D et al. Development and validation of a clinically based risk calculator for the transdiagnostic prediction of psychosis. JAMA Psychiatry 2017;74:493-500.
142. Iyegbe C, Campbell D, Butler A et al. The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for GxE research. Soc Psychiatry Psychiatr Epidemiol 2014;49:169-82.
143. Hartley S, Barrowclough C, Haddock G. Anxiety and depression in psychosis: a systematic review of associations with positive psychotic symptoms. Acta Psychiatr Scand 2013;128:327-46.
144. Mishara AL, Fusar-Poli P. The phenomenology and neurobiology of delusion formation during psychosis onset: Jaspers, Truman symptoms, and aberrant salience. Schizophr Bull 2013;39:278-86.
145. Achim AM, Maziade M, Raymond E et al. How prevalent are anxiety disorders in schizophrenia? A meta-analysis and critical review on a significant association. Schizophr Bull 2011;37:811-21.
146. Newton-Howes G, Tyrer P, North B et al. The prevalence of personality disorder in schizophrenia and psychotic disorders: systematic review of rates and explanatory modelling. Psychol Med 2008;38:1075-82.
147. Gumley AI, Taylor HEF, Schwannauer M et al. A systematic review of attachment and psychosis: measurement, construct validity and outcomes. Acta Psychiatr Scand 2014;129:257-74.
148. Large M, Sharma S, Compton MT et al. Cannabis use and earlier onset of psychosis. Arch Gen Psychiatry 2011;68:555-61.
149. Murray RM, Quigley H, Quattrone D et al. Traditional marijuana, high-potency cannabis and synthetic cannabinoids: increasing risk for psychosis. World Psychiatry 2016;15:195-204.
150. Bramness JG, Rognli EB. Psychosis induced by amphetamines. Curr Opin Psychiatry 2016;29:236-41.
151. Roncero C, Ros-Cucurull E, Daigre C et al. Prevalence and risk factors of psychotic symptoms in cocaine-dependent patients. Actas Esp Psiquiatr 2012;40:187-97.
152. Reeve S, Sheaves B, Freeman D. The role of sleep dysfunction in the occurrence of delusions and hallucinations: a systematic review. Clin Psychol Rev 2015;42:96-115.
153. Folsom D, Jeste DV. Schizophrenia in homeless persons: a systematic review of the literature. Acta Psychiatr Scand 2002;105:404-13.
154. Padgett FE, Miltsiou E, Tiffin PA. The co-occurrence of nonaffective psychosis and the pervasive developmental disorders: a systematic review. J Intellect Dev Disabil 2010;35:187-98.
155. Ioannidis JP. The mass production of redundant, misleading, and conflicted systematic reviews and meta-analyses. Milbank Q 2016;94:485-514.
156. Siontis KC, Hernandez-Boussard T, Ioannidis JP. Overlapping meta-analyses on the same topic: survey of published studies. BMJ 2013;347:f4501.
157. Millan MJ. An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy. Neuropharmacology 2013;68:2-82.