Urbanicity, social adversity and psychosis

World Psychiatry

Volumn 12, Issue 3, 2013, Pages 187-197

  Heinz, Andreas ^a   Deserno, Lorenz ^a,b   Reininghaus, Ulrich ^c  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX PLANCK INSTITUTE FOR HUMAN COGNITIVE AND BRAIN SCIENCES   (Germany)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

discrimination; isolation; psychosis; schizophrenia; social adversity; social fragmentation; stress; Urbanicity

Indexed keywords

MONOAMINE;

ADULTHOOD; AIR POLLUTION; ARTICLE; BIRTH; CANNABIS SMOKING; CHILDHOOD; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; GEOGRAPHIC DISTRIBUTION; HIGH RISK POPULATION; HUMAN; INCIDENCE; NONHUMAN; POPULATION DENSITY; PREGNANCY COMPLICATION; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOPHRENIA; SEASONAL VARIATION; SOCIAL ASPECT; SOCIAL CLASS; SOCIAL CONTROL; SOCIAL DISCRIMINATION; SOCIAL ENVIRONMENT; SOCIAL ISOLATION; SOCIAL STRESS; TRAFFIC; URBAN AREA;

EID: 84885150676     PISSN: 17238617     EISSN: 20515545     Source Type: Journal    
DOI: 10.1002/wps.20056     Document Type: Article

References (144)

1. Morgan C, Charalambides M, Hutchinson G, et al. Migration, ethnicity, and psychosis: toward a sociodevelopmental model. Schizophr Bull 2010; 36: 655-64.
2. Heinz A, Schlagenhauf F,. Dopaminergic dysfunction in schizophrenia: salience attribution revisited. Schizophr Bull 2010; 36: 472-85.
3. Meyer-Lindenberg A, Tost H,. Neural mechanisms of social risk for psychiatric disorders. Nat Neurosci 2012; 15: 663-8.
4. van Os J, Kenis G, Rutten BP,. The environment and schizophrenia. Nature 2010; 468: 203-12.
5. Kirkbride JB, Jones PB,. The prevention of schizophrenia-what can we learn from eco-epidemiology? Schizophr Bull 2011; 37: 262-71.
6. Rowitz L, Levy L,. Ecological analysis of treated mental disorders in Chicago. Arch Gen Psychiatry 1968; 19: 571-9.
7. Rowitz L, Levy L,. The state mental hospital in transition: an approach to the study of mental hospital decentralization. Ment Hyg 1971; 55: 68-76.
8. Levy L, Rowitz L,. The spatial distribution of treated mental disorders in Chicago. Soc Psychiatry 1970; 5: 1-11.
9. Faris REL, Dunham HW,. Mental disorders in urban areas: an ecological study of schizophrenia and other psychoses. Oxford: University of Chicago Press, 1939.
10. Hare EH,. Mental illness and social conditions in Bristol. J Ment Sci 1956; 102: 349-57.
11. Clark RE,. Psychoses, income, and occupational prestige. Am J Sociol 1949; 54: 433-40.
12. Hare EH,. Family setting and the urban distribution of schizophrenia. J Ment Sci 1956; 102: 753-60.
13. Giggs JA,. Mental disorders and ecological structure in Nottingham. Soc Sci Med 1986; 23: 945-61.
14. Giggs JA,. Schizophrenia and ecological structure in Nottingham. In:, Glashan ND, Blunden JR, (eds). Geographical aspects of health. London: Academic Press, 1983: 191-222.
15. Hafner H,. Model concepts in social psychiatry, demonstrated using the example of psychiatric and epidemiologic research results. Z Psychother Med Psychol 1969; 19: 85-114.
16. Weyerer S, Hafner H,. The stability of the ecological distribution of the incidence of treated mental disorders in the city of Mannheim. Soc Psychiatry Psychiatr Epidemiol 1989; 24: 57-62.
17. Pedersen CB, Mortensen PB,. Evidence of a dose-response relationship between urbanicity during upbringing and schizophrenia risk. Arch Gen Psychiatry 2001; 58: 1039-46.
18. Pedersen CB, Mortensen PB,. Family history, place and season of birth as risk factors for schizophrenia in Denmark: a replication and reanalysis. Br J Psychiatry 2001; 179: 46-52.
19. Allardyce J, Boydell J, Van Os J, et al. Comparison of the incidence of schizophrenia in rural Dumfries and Galloway and urban Camberwell. Br J Psychiatry 2001; 179: 335-9.
20. Eaton WW,. Residence, social class, and schizophrenia. J Health Soc Behav 1974; 15: 289-99.
21. Eaton WW, Mortensen PB, Frydenberg M,. Obstetric factors, urbanization and psychosis. Schizophr Res 2000; 43: 117-23.
22. Harrison G, Fouskakis D, Rasmussen F, et al. Association between psychotic disorder and urban place of birth is not mediated by obstetric complications or childhood socio-economic position: a cohort study. Psychol Med 2003; 33: 723-31.
23. Haukka J, Suvisaari J, Varilo T,. Regional variation in the incidence of schizophrenia in Finland: a study of birth cohorts born from 1950 to 1969. Psychol Med 2001; 31: 1045-53.
24. Lewis G, David A, Andreasson S,. Schizophrenia and city life. Lancet 1992; 340: 137-40.
25. Kirkbride JB, Fearon P, Morgan C, et al. Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes: findings from the 3-center AeSOP study. Arch Gen Psychiatry 2006; 63: 250-8.
26. Marcelis M, Navarro-Mateu F, Murray R, et al. Urbanization and psychosis: a study of 1942-1978 birth cohorts in The Netherlands. Psychol Med 1998; 28: 871-9.
27. Marcelis M, Takei N, van Os J,. Urbanization and risk for schizophrenia: does the effect operate before or around the time of illness onset? Psychol Med 1999; 29: 1197-203.
28. Mortensen PB, Pedersen CB, Westergaard J, et al. Effects of family history and place and season of birth on the risk of schizophrenia. N Engl J Med 1999; 340: 603-8.
29. Schelin EM, Munk-Jorgensen P, Olesen AV, et al. Regional differences in schizophrenia incidence in Denmark. Acta Psychiatr Scand 2000; 101: 293-9.
30. Torrey EF, Mortensen PB, Pedersen CB, et al. Risk factors and confounders in the geographical clustering of schizophrenia. Schizophr Res 2001; 49: 295-9.
31. Vassos E, Pedersen CB, Murray RM, et al. Meta-analysis of the association of urbanicity with schizophrenia. Schizophr Bull 2012; 38: 1118-23.
32. Thornicroft G, Bisoffi G, De Salvia D, et al. Urban-rural differences in the associations between social deprivation and psychiatric service utilization in schizophrenia and all diagnoses: a case-register study in Northern Italy. Psychol Med 1993; 23: 487-96.
33. van Os J, Pedersen CB, Mortensen PB,. Confirmation of synergy between urbanicity and familial liability in the causation of psychosis. Am J Psychiatry 2004; 161: 2312-4.
34. Pedersen CB, Mortensen PB,. Are the cause(s) responsible for urban-rural differences in schizophrenia risk rooted in families or in individuals? Am J Epidemiol 2006; 163: 971-8.
35. Pedersen CB, Mortensen PB,. Urbanization and traffic related exposures as risk factors for schizophrenia. BMC Psychiatry 2006; 6: 2.
36. Scully PJ, Owens JM, Kinsella A, et al. Schizophrenia, schizoaffective and bipolar disorder within an epidemiologically complete, homogeneous population in rural Ireland: small area variation in rate. Schizophr Res 2004; 67: 143-55.
37. Sundquist K, Frank G, Sundquist J,. Urbanisation and incidence of psychosis and depression: follow-up study of 4.4 million women and men in Sweden. Br J Psychiatry 2004; 184: 293-8.
38. Takei N, Sham PC, O'Callaghan E, et al. Schizophrenia: increased risk associated with winter and city birth-a case-control study in 12 regions within England and Wales. J Epidemiol Community Health 1995; 49: 106-7.
39. Zammit S, Lewis G, Rasbash J, et al. Individuals, schools, and neighborhood: a multilevel longitudinal study of variation in incidence of psychotic disorders. Arch Gen Psychiatry 2010; 67: 914-22.
40. Kelly BD, O'Callaghan E, Waddington JL, et al. Schizophrenia and the city: a review of literature and prospective study of psychosis and urbanicity in Ireland. Schizophr Res 2010; 116: 75-89.
41. March D, Hatch SL, Morgan C, et al. Psychosis and place. Epidemiol Rev 2008; 30: 84-100.
42. Kirkbride JB, Jones PB, Ullrich S, et al. Social deprivation, inequality, and the neighborhood-level incidence of psychotic syndromes in East London. Schizophr Bull (in press).
43. McGrath J, Saha S, Welham J, et al. A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology. BMC Med 2004; 2: 13.
44. Pedersen CB, Mortensen PB,. Urbanicity during upbringing and bipolar affective disorders in Denmark. Bipolar Disord 2006; 8: 242-7.
45. Peen J, Schoevers RA, Beekman AT, et al. The current status of urban-rural differences in psychiatric disorders. Acta Psychiatr Scand 2010; 121: 84-93.
46. Laursen TM, Munk-Olsen T, Nordentoft M, et al. A comparison of selected risk factors for unipolar depressive disorder, bipolar affective disorder, schizoaffective disorder, and schizophrenia from a Danish population-based cohort. J Clin Psychiatry 2007; 68: 1673-81.
47. Veling W, Susser E, van Os J, et al. Ethnic density of neighborhoods and incidence of psychotic disorders among immigrants. Am J Psychiatry 2008; 165: 66-73.
48. Lofors J, Sundquist K,. Low-linking social capital as a predictor of mental disorders: a cohort study of 4.5 million Swedes. Soc Sci Med 2007; 64: 21-34.
49. Kirkbride JB, Boydell J, Ploubidis GB, et al. Testing the association between the incidence of schizophrenia and social capital in an urban area. Psychol Med 2008; 38: 1083-94.
50. Allardyce J, Gilmour H, Atkinson J, et al. Social fragmentation, deprivation and urbanicity: relation to first-admission rates for psychoses. Br J Psychiatry 2005; 187: 401-6.
51. Boardman AP, Hodgson RE, Lewis M, et al. Social indicators and the prediction of psychiatric admission in different diagnostic groups. Br J Psychiatry 1997; 171: 457-62.
52. Croudace TJ, Kayne R, Jones PB, et al. Non-linear relationship between an index of social deprivation, psychiatric admission prevalence and the incidence of psychosis. Psychol Med 2000; 30: 177-85.
53. Dauncey K, Giggs J, Baker K, et al. Schizophrenia in Nottingham: lifelong residential mobility of a cohort. Br J Psychiatry 1993; 163: 613-9.
54. Drukker M, Krabbendam L, Driessen G, et al. Social disadvantage and schizophrenia. A combined neighbourhood and individual-level analysis. Soc Psychiatry Psychiatr Epidemiol 2006; 41: 595-604.
55. Harrison J, Barrow S, Creed F,. Social deprivation and psychiatric admission rates among different diagnostic groups. Br J Psychiatry 1995; 167: 456-62.
56. Kirkbride JB, Fearon P, Morgan C, et al. Neighbourhood variation in the incidence of psychotic disorders in Southeast London. Soc Psychiatry Psychiatr Epidemiol 2007; 42: 438-45.
57. Kirkbride JB, Morgan C, Fearon P, et al. Neighbourhood-level effects on psychoses: re-examining the role of context. Psychol Med 2007; 37: 1413-25.
58. Loffler W, Hafner H,. Ecological pattern of first admitted schizophrenics in two German cities over 25 years. Soc Sci Med 1999; 49: 93-108.
59. van Os J, Driessen G, Gunther N, et al. Neighbourhood variation in incidence of schizophrenia. Evidence for person-environment interaction. Br J Psychiatry 2000; 176: 243-8.
60. Boydell J, van Os J, McKenzie K, et al. Incidence of schizophrenia in ethnic minorities in London: ecological study into interactions with environment. BMJ 2001; 323: 1336-8.
61. Thomas H, Weaver N, Patterson P, et al. Mental health and quality of residential environment. Br J Psychiatry 2007; 191: 500-5.
62. Skapinakis P, Lewis G, Araya R, et al. Mental health inequalities in Wales, UK: multi-level investigation of the effect of area deprivation. Br J Psychiatry 2005; 186: 417-22.
63. Wainwright NW, Surtees PG,. Area and individual circumstances and mood disorder prevalence. Br J Psychiatry 2004; 185: 227-32.
64. Weich S, Holt G, Twigg L, et al. Geographic variation in the prevalence of common mental disorders in Britain: a multilevel investigation. Am J Epidemiol 2003; 157: 730-7.
65. Duncan C, Jones K, Moon G,. Psychiatric morbidity: a multilevel approach to regional variations in the UK. J Epidemiol Community Health 1995; 49: 290-5.
66. Fone D, Dunstan F, Williams G, et al. Places, people and mental health: a multilevel analysis of economic inactivity. Soc Sci Med 2007; 4: 633-45.
67. Kirkbride JB, Errazuriz A, Croudace TJ, et al. Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses. PLoS One 2012; 7: e31660.
68. Cantor-Graae E, Selten JP,. Schizophrenia and migration: a meta-analysis and review. Am J Psychiatry 2005; 162: 12-24.
69. Reininghaus UA, Morgan C, Simpson J, et al. Unemployment, social isolation, achievement-expectation mismatch and psychosis: findings from the AESOP Study. Soc Psychiatry Psychiatr Epidemiol 2008; 43: 743-51.
70. Cooper C, Morgan C, Byrne M, et al. Perceptions of disadvantage, ethnicity and psychosis. Br J Psychiatry 2008; 192: 185-90.
71. Veling W, Selten JP, Susser E, et al. Discrimination and the incidence of psychotic disorders among ethnic minorities in The Netherlands. Int J Epidemiol 2007; 36: 761-8.
72. Morgan C, Kirkbride J, Hutchinson G, et al. Cumulative social disadvantage, ethnicity and first-episode psychosis: a case-control study. Psychol Med 2008; 38: 1701-15.
73. Janssen I, Hanssen M, Bak M, et al. Discrimination and delusional ideation. Br J Psychiatry 2003; 182: 71-6.
74. McKenzie K, Bhui K,. Institutional racism in mental health care. BMJ 2007; 334: 649-50.
75. Murray RM, Fearon P,. Searching for racists under the psychiatric bed. The Psychiatrist 2007; 31: 365-6.
76. Morgan C, Mallett R, Hutchinson G, et al. Pathways to care and ethnicity. 1: Sample characteristics and compulsory admission. Report from the AESOP study. Br J Psychiatry 2005; 186: 281-9.
77. Heinz A,. Dopaminergic dysfunction in alcoholism and schizophrenia- psychopathological and behavioral correlates. Eur Psychiatry 2002; 17: 9-16.
78. Selten JP, Cantor-Graae E,. Social defeat: risk factor for schizophrenia? Br J Psychiatry 2005; 187: 101-2.
79. Tidey JW, Miczek KA,. Social defeat stress selectively alters mesocorticolimbic dopamine release: an in vivo microdialysis study. Brain Res 1996; 721: 140-9.
80. Kaplan JR, Manuck SB, Fontenot MB, et al. Central nervous system monoamine correlates of social dominance in cynomolgus monkeys (Macaca fascicularis). Neuropsychopharmacology 2002; 26: 431-43.
81. Lieberman JA, Sheitman BB, Kinon BJ,. Neurochemical sensitization in the pathophysiology of schizophrenia: deficits and dysfunction in neuronal regulation and plasticity. Neuropsychopharmacology 1997; 17: 205-29.
82. Zammit S, Spurlock G, Williams H, et al. Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use. Br J Psychiatry 2007; 191: 402-7.
83. Kuepper R, van Os J, Lieb R, et al. Do cannabis and urbanicity co-participate in causing psychosis? Evidence from a 10-year follow-up cohort study. Psychol Med 2011; 41: 2121-9.
84. Pedersen CB, Raaschou-Nielsen O, Hertel O, et al. Air pollution from traffic and schizophrenia risk. Schizophr Res 2004; 66: 83-5.
85. Wicks S, Hjern A, Gunnell D, et al. Social adversity in childhood and the risk of developing psychosis: a national cohort study. Am J Psychiatry 2005; 162: 1652-7.
86. van Os J, Hanssen M, Bijl RV, et al. Prevalence of psychotic disorder and community level of psychotic symptoms: an urban-rural comparison. Arch Gen Psychiatry 2001; 58: 663-8.
87. Spauwen J, Krabbendam L, Lieb R, et al. Does urbanicity shift the population expression of psychosis? J Psychiatr Res 2004; 38: 613-8.
88. Silver E, Mulvey EP, Swanson JW,. Neighborhood structural characteristics and mental disorder: Faris and Dunham revisited. Soc Sci Med 2002; 55: 1457-70.
89. Schofield P, Ashworth M, Jones R,. Ethnic isolation and psychosis: re-examining the ethnic density effect. Psychol Med 2011; 41: 1263-9.
90. Das-Munshi J, Becares L, Boydell JE, et al. Ethnic density as a buffer for psychotic experiences: findings from a national survey (EMPIRIC). Br J Psychiatry 2012; 201: 282-90.
91. Heinz A, Weinberger DR,. Schizophrenie: Die neurobiologische Entwicklungshypothese. In:, Helmchen H, Lauter H, Henn F, et al (eds). Psychiatrie der Gegenwart 5: Schizophrene und affektive Störungen. Berlin: Springer, 2000: 89-103.
92. Takei N, Sham P, Callaghan E, et al. Early risk factors in schizophrenia: place and season of birth. Eur Psychiatry 1995; 10: 165-70.
93. Arseneault L, Cannon M, Witton J, et al. Causal association between cannabis and psychosis: examination of the evidence. Br J Psychiatry 2004; 184: 110-7.
94. Moore TH, Zammit S, Lingford-Hughes A, et al. Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. Lancet 2007; 370: 319-28.
95. van Os J, Hanssen M, Bak M, et al. Do urbanicity and familial liability coparticipate in causing psychosis? Am J Psychiatry 2003; 160: 477-82.
96. Kluge U, Bogic M, Deville W, et al. Health services and the treatment of immigrants: data on service use, interpreting services and immigrant staff members in services across Europe. Eur Psychiatry 2012; 27 (Suppl. 2): S56-62.
97. Penka S, Heimann H, Heinz A, et al. Explanatory models of addictive behaviour among native German, Russian-German, and Turkish youth. Eur Psychiatry 2008; 23 (Suppl. 1): 36-42.
98. Kleinman A,. Patients and healers in the context of culture. An exploration of the borderland between anthropology, medicine, and psychiatry. San Francisco: University of California Press, 1980.
99. Bhugra D, Gupta S, Bhui K, et al. WPA guidance on mental health and mental health care in migrants. World Psychiatry 2011; 10: 2-10.
100. Grusser SM, Wolfling K, Morsen CP, et al. Immigration-associated variables and substance dependence. J Stud Alcohol 2005; 66: 98-104.
101. Reininghaus U, Priebe S,. Measuring patient-reported outcomes in psychosis: conceptual and methodological review. Br J Psychiatry 2012; 201: 262-7.
102. Morgan C, Burns T, Fitzpatrick R, et al. Social exclusion and mental health: conceptual and methodological review. Br J Psychiatry 2007; 191: 477-83.
103. Becares L, Nazroo J, Stafford M,. The buffering effects of ethnic density on experienced racism and health. Health Place 2009; 15: 670-8.
104. Krabbendam L, van Os J,. Schizophrenia and urbanicity: a major environmental influence-conditional on genetic risk. Schizophr Bull 2005; 31: 795-9.
105. Weiser M, van Os J, Reichenberg A, et al. Social and cognitive functioning, urbanicity and risk for schizophrenia. Br J Psychiatry 2007; 191: 320-4.
106. Mahy GE, Mallett R, Leff J, et al. First-contact incidence rate of schizophrenia on Barbados. Br J Psychiatry 1999; 175: 28-33.
107. Bhugra D, Hilwig M, Hossein B, et al. First-contact incidence rates of schizophrenia in Trinidad and one-year follow-up. Br J Psychiatry 1996; 169: 587-92.
108. Jablensky A, Sartorius N,. What did the WHO studies really find? Schizophr Bull 2008; 34: 253-5.
109. Jablensky A, Sartorius N, Ernberg G, et al. Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychol Med Monogr Suppl 1992; 20: 1-97.
110. Stephan KE, Friston KJ, Frith CD,. Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring. Schizophr Bull 2009; 35: 509-27.
111. Friston KJ, Frith CD,. Schizophrenia: a disconnection syndrome? Clin Neurosci 1995; 3: 89-97.
112. Rolls ET, Loh M, Deco G, et al. Computational models of schizophrenia and dopamine modulation in the prefrontal cortex. Nat Rev Neurosci 2008; 9: 696-709.
113. Deserno L, Sterzer P, Wustenberg T, et al. Reduced prefrontal-parietal effective connectivity and working memory deficits in schizophrenia. J Neurosci 2012; 32: 12-20.
114. Fusar-Poli P, Howes OD, Allen P, et al. Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study. Arch Gen Psychiatry 2010; 67: 683-91.
115. Pettersson-Yeo W, Allen P, Benetti S, et al. Dysconnectivity in schizophrenia: where are we now? Neurosci Biobehav Rev 2011; 35: 1110-24.
116. Blankenburg W,. Der Verlust der natürlichen Selbstverstä ndlichkeit: Ein Beitrag zur Psychopathologie der symptomarmen Schizophrenien. Stuttgart: Enke, 1971.
117. Howes OD, Kambeitz J, Kim E, et al. The nature of dopamine dysfunction in schizophrenia and what this means for treatment. Arch Gen Psychiatry 2012; 69: 776-86.
118. Kumakura Y, Cumming P, Vernaleken I, et al. Elevated (18F)fluorodopamine turnover in brain of patients with schizophrenia: an (18F)fluorodopa/positron emission tomography study. J Neurosci 2007; 27: 8080-7.
119. Abi-Dargham A, Rodenhiser J, Printz D, et al. Increased baseline occupancy of D2 receptors by dopamine in schizophrenia. Proc Natl Acad Sci USA 2000; 97: 8104-9.
120. Kapur S,. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry 2003; 160: 13-23.
121. Howes OD, Bose SK, Turkheimer F, et al. Dopamine synthesis capacity before onset of psychosis: a prospective (18F)-DOPA PET imaging study. Am J Psychiatry 2011; 168: 1311-7.
122. Morgan D, Grant KA, Gage HD, et al. Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nat Neurosci 2002; 5: 169-74.
123. Nader MA, Morgan D, Gage HD, et al. PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys. Nat Neurosci 2006; 9: 1050-6.
124. Robinson TE, Berridge KC,. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res Brain Res Rev 1993; 18: 247-91.
125. Saunders RC, Kolachana BS, Bachevalier J, et al. Neonatal lesions of the medial temporal lobe disrupt prefrontal cortical regulation of striatal dopamine. Nature 1998; 393: 169-71.
126. Heinz A, Saunders RC, Kolachana BS, et al. Striatal dopamine receptors and transporters in monkeys with neonatal temporal limbic damage. Synapse 1999; 32: 71-9.
127. Fusar-Poli P, Meyer-Lindenberg A,. Striatal presynaptic dopamine in schizophrenia, part II: meta-analysis of ((18)F/(11)C)-DOPA PET studies. Schizophr Bull 2013; 39: 33-42.
128. Stokes PR, Shotbolt P, Mehta MA, et al. Nature or nurture? Determining the heritability of human striatal dopamine function: an (18F)-DOPA PET study. Neuropsychopharmacology 2013; 38: 485-91.
129. Lederbogen F, Kirsch P, Haddad L, et al. City living and urban upbringing affect neural social stress processing in humans. Nature 2011; 474: 498-501.
130. Bentall RP, Myin-Germeys I, Smith A, et al. Hypomanic personality, stability of self-esteem and response styles to negative mood. Clin Psychol Psychother 2011; 18: 397-410.
131. Schlagenhauf F, Sterzer P, Schmack K, et al. Reward feedback alterations in unmedicated schizophrenia patients: relevance for delusions. Biol Psychiatry 2009; 65: 1032-9.
132. Friedel E, Schlagenhauf F, Sterzer P, et al. 5-HTT genotype effect on prefrontal-amygdala coupling differs between major depression and controls. Psychopharmacology 2009; 205: 261-71.
133. Heinz A, Higley JD, Gorey JG, et al. In vivo association between alcohol intoxication, aggression, and serotonin transporter availability in nonhuman primates. Am J Psychiatry 1998; 155: 1023-8.
134. Heinz A, Jones DW, Gorey JG, et al. Serotonin transporter availability correlates with alcohol intake in non-human primates. Mol Psychiatry 2003; 8: 231-4.
135. Heinz A, Braus DF, Smolka MN, et al. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat Neurosci 2005; 8: 20-1.
136. Heinz AJ, Beck A, Meyer-Lindenberg A, et al. Cognitive and neurobiological mechanisms of alcohol-related aggression. Nat Rev Neurosci 2011; 12: 400-13.
137. Gur RE, McGrath C, Chan RM, et al. An fMRI study of facial emotion processing in patients with schizophrenia. Am J Psychiatry 2002; 159: 1992-9.
138. Anticevic A, Van Snellenberg JX, Cohen RE, et al. Amygdala recruitment in schizophrenia in response to aversive emotional material: a meta-analysis of neuroimaging studies. Schizophr Bull 2012; 38: 608-21.
139. Schneider F, Weiss U, Kessler C, et al. Differential amygdala activation in schizophrenia during sadness. Schizophr Res 1998; 34: 133-42.
140. Pankow A, Friedel E, Sterzer P, et al. Altered amygdala activation in schizophrenia patients during emotion processing. Schizophr Res (in press).
141. Kienast T, Hariri AR, Schlagenhauf F, et al. Dopamine in amygdala gates limbic processing of aversive stimuli in humans. Nat Neurosci 2008; 11: 1381-2.
142. Smolka MN, Schumann G, Wrase J, et al. Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci 2005; 25: 836-42.
143. Hariri AR, Mattay VS, Tessitore A, et al. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002; 297: 400-3.
144. Puls I, Mohr J, Wrase J, et al. A model comparison of COMT effects on central processing of affective stimuli. Neuroimage 2009; 46: 683-91.