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Volumn 81, Issue 6, 2017, Pages 470-477

An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis

(30)  Vassos, Evangelos a   Di Forti, Marta a   Coleman, Jonathan a   Iyegbe, Conrad a   Prata, Diana a,b   Euesden, Jack a   O'Reilly, Paul a   Curtis, Charles a,c   Kolliakou, Anna a   Patel, Hamel a,c   Newhouse, Stephen a,c   Traylor, Matthew a   Ajnakina, Olesya a   Mondelli, Valeria a,b   Marques, Tiago Reis a   Gardner Sood, Poonam a   Aitchison, Katherine J a,d   Powell, John a   Atakan, Zerrin a   Greenwood, Kathryn E e   more..


Author keywords

Genetics; GWAS; Polygenic score; Psychosis; Risk prediction; Schizophrenia

Indexed keywords

ADULT; AFRICAN; ANCESTRY GROUP; ARTICLE; CONTROLLED STUDY; ETHNIC DIFFERENCE; EUROPEAN; FEMALE; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; META ANALYSIS (TOPIC); POLYGENIC RISK SCORE; PRIORITY JOURNAL; PSYCHOSIS; RISK ASSESSMENT; SCHIZOPHRENIA; SCORING SYSTEM; BLACK PERSON; CASE CONTROL STUDY; CAUCASIAN; GENETIC PREDISPOSITION; GENETICS; MULTIFACTORIAL INHERITANCE; PSYCHOTIC DISORDERS; RISK FACTOR; YOUNG ADULT;

EID: 85005846735     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2016.06.028     Document Type: Article
Times cited : (158)

References (46)
  • 1
    • 84855925920 scopus 로고    scopus 로고
    • Rare and common variants: Twenty arguments
    • 1 Gibson, G., Rare and common variants: Twenty arguments. Nat Rev Genet 13 (2012), 135–145.
    • (2012) Nat Rev Genet , vol.13 , pp. 135-145
    • Gibson, G.1
  • 2
    • 84904804929 scopus 로고    scopus 로고
    • Biological insights from 108 schizophrenia-associated genetic loci
    • 2 Psychiatric Genomics Consortium Schizophrenia Working Group. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511 (2014), 421–427.
    • (2014) Nature , vol.511 , pp. 421-427
  • 3
    • 79955824808 scopus 로고    scopus 로고
    • Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening
    • 3 So, H.C., Kwan, J.S., Cherny, S.S., Sham, P.C., Risk prediction of complex diseases from family history and known susceptibility loci, with applications for cancer screening. Am J Hum Genet 88 (2011), 548–565.
    • (2011) Am J Hum Genet , vol.88 , pp. 548-565
    • So, H.C.1    Kwan, J.S.2    Cherny, S.S.3    Sham, P.C.4
  • 4
    • 84925130699 scopus 로고    scopus 로고
    • Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder
    • 4 Maier, R., Moser, G., Chen, G.B., Ripke, S., Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Coryell, W., et al. Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder. Am J Hum Genet 96 (2015), 283–294.
    • (2015) Am J Hum Genet , vol.96 , pp. 283-294
    • Maier, R.1    Moser, G.2    Chen, G.B.3    Ripke, S.4    Coryell, W.5
  • 5
    • 68449086236 scopus 로고    scopus 로고
    • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    • 5 International Schizophrenia Consortium, Purcell, S.M., Wray, N.R., Stone, J.L., Visscher, P.M., O'Donovan, M.C., Sullivan, P.F., et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460 (2009), 748–752.
    • (2009) Nature , vol.460 , pp. 748-752
    • Purcell, S.M.1    Wray, N.R.2    Stone, J.L.3    Visscher, P.M.4    O'Donovan, M.C.5    Sullivan, P.F.6
  • 6
    • 84875700256 scopus 로고    scopus 로고
    • Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies
    • 405e1–3
    • 6 Chatterjee, N., Wheeler, B., Sampson, J., Hartge, P., Chanock, S.J., Park, J.H., Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies. Nat Genet 45 (2013), 400–405 405e1–3.
    • (2013) Nat Genet , vol.45 , pp. 400-405
    • Chatterjee, N.1    Wheeler, B.2    Sampson, J.3    Hartge, P.4    Chanock, S.J.5    Park, J.H.6
  • 7
    • 84876007072 scopus 로고    scopus 로고
    • Power and predictive accuracy of polygenic risk scores
    • 7 Dudbridge, F., Power and predictive accuracy of polygenic risk scores. PLoS Genet, 9, 2013, e1003348.
    • (2013) PLoS Genet , vol.9 , pp. e1003348
    • Dudbridge, F.1
  • 8
    • 79955781073 scopus 로고    scopus 로고
    • Strengthening the reporting of genetic risk prediction studies (GRIPS): Explanation and elaboration
    • p preceding 494
    • 8 Janssens, A.C., Ioannidis, J.P., Bedrosian, S., Boffetta, P., Dolan, S.M., Dowling, N., et al. Strengthening the reporting of genetic risk prediction studies (GRIPS): Explanation and elaboration. Eur J Hum Genet, 19, 2011, 18 p preceding 494.
    • (2011) Eur J Hum Genet , vol.19 , pp. 18
    • Janssens, A.C.1    Ioannidis, J.P.2    Bedrosian, S.3    Boffetta, P.4    Dolan, S.M.5    Dowling, N.6
  • 9
    • 84867743306 scopus 로고    scopus 로고
    • Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users
    • 9 Di Forti, M., Iyegbe, C., Sallis, H., Kolliakou, A., Falcone, M.A., Paparelli, A., et al. Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users. Biol Psychiatry 72 (2012), 811–816.
    • (2012) Biol Psychiatry , vol.72 , pp. 811-816
    • Di Forti, M.1    Iyegbe, C.2    Sallis, H.3    Kolliakou, A.4    Falcone, M.A.5    Paparelli, A.6
  • 10
    • 0038756630 scopus 로고
    • The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines
    • WHO Geneva
    • 10 World Health Organization. The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. 1992, WHO, Geneva.
    • (1992)
  • 11
    • 85012043993 scopus 로고    scopus 로고
    • Division of Mental Health (): Schedules for Clinical Assessment in Neuropsychiatry (Version 2.1), 2.1. ed. Geneva: WHO Assessment, Classification and Epidemiology.
    • 11 World Health Organization, Division of Mental Health (1999): Schedules for Clinical Assessment in Neuropsychiatry (Version 2.1), 2.1. ed. Geneva: WHO Assessment, Classification and Epidemiology.
    • (1999)
  • 12
    • 33746310587 scopus 로고
    • The Psychosis Screening Questionnaire
    • 12 Bebbington, P., Nayani, T., The Psychosis Screening Questionnaire. Int J Method Psych 5 (1995), 11–19.
    • (1995) Int J Method Psych , vol.5 , pp. 11-19
    • Bebbington, P.1    Nayani, T.2
  • 13
    • 0030716801 scopus 로고    scopus 로고
    • The evaluation and treatment of first-episode psychosis
    • 13 Sheitman, B.B., Lee, H., Strous, R., Lieberman, J.A., The evaluation and treatment of first-episode psychosis. Schizophr Bull 23 (1997), 653–661.
    • (1997) Schizophr Bull , vol.23 , pp. 653-661
    • Sheitman, B.B.1    Lee, H.2    Strous, R.3    Lieberman, J.A.4
  • 14
    • 0026410654 scopus 로고
    • A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system
    • 14 McGuffin, P., Farmer, A., Harvey, I., A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system. Arch Gen Psychiatry 48 (1991), 764–770.
    • (1991) Arch Gen Psychiatry , vol.48 , pp. 764-770
    • McGuffin, P.1    Farmer, A.2    Harvey, I.3
  • 15
    • 84885454858 scopus 로고    scopus 로고
    • Improving physical health and reducing substance use in psychosis—Randomised control trial (IMPACT RCT): Study protocol for a cluster randomised controlled trial
    • 15 Gaughran, F., Stahl, D., Ismail, K., Atakan, Z., Lally, J., Gardner-Sood, P., et al. Improving physical health and reducing substance use in psychosis—Randomised control trial (IMPACT RCT): Study protocol for a cluster randomised controlled trial. BMC Psychiatry, 13, 2013, 263.
    • (2013) BMC Psychiatry , vol.13 , pp. 263
    • Gaughran, F.1    Stahl, D.2    Ismail, K.3    Atakan, Z.4    Lally, J.5    Gardner-Sood, P.6
  • 16
    • 84938579554 scopus 로고    scopus 로고
    • Cardiovascular risk factors and metabolic syndrome in people with established psychotic illnesses: Baseline data from the IMPaCT randomized controlled trial
    • 16 Gardner-Sood, P., Lally, J., Smith, S., Atakan, Z., Ismail, K., Greenwood, K.E., et al. Cardiovascular risk factors and metabolic syndrome in people with established psychotic illnesses: Baseline data from the IMPaCT randomized controlled trial. Psychol Med 45 (2015), 2619–2629.
    • (2015) Psychol Med , vol.45 , pp. 2619-2629
    • Gardner-Sood, P.1    Lally, J.2    Smith, S.3    Atakan, Z.4    Ismail, K.5    Greenwood, K.E.6
  • 17
    • 55749102084 scopus 로고    scopus 로고
    • Homocysteine and its relationship to stroke subtypes in a UK black population: The south London ethnicity and stroke study
    • 17 Khan, U., Crossley, C., Kalra, L., Rudd, A., Wolfe, C.D., Collinson, P., et al. Homocysteine and its relationship to stroke subtypes in a UK black population: The south London ethnicity and stroke study. Stroke 39 (2008), 2943–2949.
    • (2008) Stroke , vol.39 , pp. 2943-2949
    • Khan, U.1    Crossley, C.2    Kalra, L.3    Rudd, A.4    Wolfe, C.D.5    Collinson, P.6
  • 18
    • 67651222400 scopus 로고    scopus 로고
    • A flexible and accurate genotype imputation method for the next generation of genome-wide association studies
    • 18 Howie, B.N., Donnelly, P., Marchini, J., A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. Plos Genet, 5, 2009, e1000529.
    • (2009) Plos Genet , vol.5 , pp. e1000529
    • Howie, B.N.1    Donnelly, P.2    Marchini, J.3
  • 19
    • 84975795680 scopus 로고    scopus 로고
    • An integrated map of genetic variation from 1,092 human genomes
    • 19 1000 Genomes Project Corsortium, Abecasis, G.R., Auton, A., Brooks, L.D., DePristo, M.A., Durbin, R.M., et al. An integrated map of genetic variation from 1,092 human genomes. Nature 491 (2012), 56–65.
    • (2012) Nature , vol.491 , pp. 56-65
    • Abecasis, G.R.1    Auton, A.2    Brooks, L.D.3    DePristo, M.A.4    Durbin, R.M.5
  • 20
    • 84863845193 scopus 로고    scopus 로고
    • Genotype imputation with thousands of genomes
    • 20 Howie, B., Marchini, J., Stephens, M., Genotype imputation with thousands of genomes. G3 (Bethesda) 1 (2011), 457–470.
    • (2011) G3 (Bethesda) , vol.1 , pp. 457-470
    • Howie, B.1    Marchini, J.2    Stephens, M.3
  • 22
    • 84893814574 scopus 로고    scopus 로고
    • A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation
    • 22 Psychosis Endophenotypes International Consortium, Wellcome Trust Case-Control Consortium 2, Bramon, E., Pirinen, M., Strange, A., Lin, K., et al. A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation. Biol Psychiatry 75 (2014), 386–397.
    • (2014) Biol Psychiatry , vol.75 , pp. 386-397
    • Bramon, E.1    Pirinen, M.2    Strange, A.3    Lin, K.4
  • 23
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • 23 Price, A.L., Patterson, N.J., Plenge, R.M., Weinblatt, M.E., Shadick, N.A., Reich, D., Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38 (2006), 904–909.
    • (2006) Nat Genet , vol.38 , pp. 904-909
    • Price, A.L.1    Patterson, N.J.2    Plenge, R.M.3    Weinblatt, M.E.4    Shadick, N.A.5    Reich, D.6
  • 24
    • 84946158905 scopus 로고    scopus 로고
    • PRSice: Polygenic Risk Score software
    • 24 Euesden, J., Lewis, C.M., O'Reilly, P.F., PRSice: Polygenic Risk Score software. Bioinformatics 31 (2015), 1466–1468.
    • (2015) Bioinformatics , vol.31 , pp. 1466-1468
    • Euesden, J.1    Lewis, C.M.2    O'Reilly, P.F.3
  • 25
    • 22144432283 scopus 로고    scopus 로고
    • A systematic review of the prevalence of schizophrenia
    • 25 Saha, S., Chant, D., Welham, J., McGrath, J., A systematic review of the prevalence of schizophrenia. PLoS Med, 2, 2005, e141.
    • (2005) PLoS Med , vol.2 , pp. e141
    • Saha, S.1    Chant, D.2    Welham, J.3    McGrath, J.4
  • 26
    • 84935119369 scopus 로고    scopus 로고
    • Polygenic risk score, parental socioeconomic status, family history of psychiatric disorders, and the risk for schizophrenia: A Danish population-based study and meta-analysis
    • 26 Agerbo, E., Sullivan, P.F., Vilhjalmsson, B.J., Pedersen, C.B., Mors, O., Borglum, A.D., et al. Polygenic risk score, parental socioeconomic status, family history of psychiatric disorders, and the risk for schizophrenia: A Danish population-based study and meta-analysis. JAMA Psychiatry 72 (2015), 635–641.
    • (2015) JAMA Psychiatry , vol.72 , pp. 635-641
    • Agerbo, E.1    Sullivan, P.F.2    Vilhjalmsson, B.J.3    Pedersen, C.B.4    Mors, O.5    Borglum, A.D.6
  • 27
    • 33845317988 scopus 로고    scopus 로고
    • First episode psychosis and ethnicity: Initial findings from the AESOP study
    • 27 Morgan, C., Dazzan, P., Morgan, K., Jones, P., Harrison, G., Leff, J., et al. First episode psychosis and ethnicity: Initial findings from the AESOP study. World Psychiatry 5 (2006), 40–46.
    • (2006) World Psychiatry , vol.5 , pp. 40-46
    • Morgan, C.1    Dazzan, P.2    Morgan, K.3    Jones, P.4    Harrison, G.5    Leff, J.6
  • 28
    • 84871267120 scopus 로고    scopus 로고
    • The emerging spectrum of allelic variation in schizophrenia: Current evidence and strategies for the identification and functional characterization of common and rare variants
    • 28 Mowry, B.J., Gratten, J., The emerging spectrum of allelic variation in schizophrenia: Current evidence and strategies for the identification and functional characterization of common and rare variants. Mol Psychiatry 18 (2013), 38–52.
    • (2013) Mol Psychiatry , vol.18 , pp. 38-52
    • Mowry, B.J.1    Gratten, J.2
  • 31
    • 84884131228 scopus 로고    scopus 로고
    • Prevalence of bullying victimisation amongst first-episode psychosis patients and unaffected controls
    • 31 Trotta, A., Di Forti, M., Mondelli, V., Dazzan, P., Pariante, C., David, A., et al. Prevalence of bullying victimisation amongst first-episode psychosis patients and unaffected controls. Schizophr Res 150 (2013), 169–175.
    • (2013) Schizophr Res , vol.150 , pp. 169-175
    • Trotta, A.1    Di Forti, M.2    Mondelli, V.3    Dazzan, P.4    Pariante, C.5    David, A.6
  • 32
  • 33
    • 84923298138 scopus 로고    scopus 로고
    • Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: A case-control study
    • 33 Di Forti, M., Marconi, A., Carra, E., Fraietta, S., Trotta, A., Bonomo, M., et al. Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: A case-control study. Lancet Psychiat 2 (2015), 233–238.
    • (2015) Lancet Psychiat , vol.2 , pp. 233-238
    • Di Forti, M.1    Marconi, A.2    Carra, E.3    Fraietta, S.4    Trotta, A.5    Bonomo, M.6
  • 38
    • 33748804424 scopus 로고    scopus 로고
    • A tutorial on statistical methods for population association studies
    • 38 Balding, D.J., A tutorial on statistical methods for population association studies. Nat Rev Genet 7 (2006), 781–791.
    • (2006) Nat Rev Genet , vol.7 , pp. 781-791
    • Balding, D.J.1
  • 39
    • 0031029394 scopus 로고    scopus 로고
    • Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish Study of High-Density Schizophrenia Families: Evidence for possible etiologic heterogeneity
    • 39 Kendler, K.S., Karkowski-Shuman, L., O'Neill, F.A., Straub, R.E., MacLean, C.J., Walsh, D., Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish Study of High-Density Schizophrenia Families: Evidence for possible etiologic heterogeneity. Am J Psychiatry 154 (1997), 191–198.
    • (1997) Am J Psychiatry , vol.154 , pp. 191-198
    • Kendler, K.S.1    Karkowski-Shuman, L.2    O'Neill, F.A.3    Straub, R.E.4    MacLean, C.J.5    Walsh, D.6
  • 40
    • 46449113977 scopus 로고    scopus 로고
    • Schizophrenia, “just the facts” what we know in 2008. 2. Epidemiology and etiology
    • 40 Tandon, R., Keshavan, M.S., Nasrallah, H.A., Schizophrenia, “just the facts” what we know in 2008. 2. Epidemiology and etiology. Schizophr Res 102 (2008), 1–18.
    • (2008) Schizophr Res , vol.102 , pp. 1-18
    • Tandon, R.1    Keshavan, M.S.2    Nasrallah, H.A.3
  • 41
    • 9644263985 scopus 로고    scopus 로고
    • ‘Racial’ differences in genetic effects for complex diseases
    • 41 Ioannidis, J.P., Ntzani, E.E., Trikalinos, T.A., ‘Racial’ differences in genetic effects for complex diseases. Nat Genet 36 (2004), 1312–1318.
    • (2004) Nat Genet , vol.36 , pp. 1312-1318
    • Ioannidis, J.P.1    Ntzani, E.E.2    Trikalinos, T.A.3
  • 42
    • 84883778249 scopus 로고    scopus 로고
    • Additive genetic variation in schizophrenia risk is shared by populations of African and European descent
    • 42 de Candia, T.R., Lee, S.H., Yang, J., Browning, B.L., Gejman, P.V., Levinson, D.F., et al. Additive genetic variation in schizophrenia risk is shared by populations of African and European descent. Am J Hum Genet 93 (2013), 463–470.
    • (2013) Am J Hum Genet , vol.93 , pp. 463-470
    • de Candia, T.R.1    Lee, S.H.2    Yang, J.3    Browning, B.L.4    Gejman, P.V.5    Levinson, D.F.6
  • 43
    • 18644367074 scopus 로고    scopus 로고
    • Immigration and schizophrenia: The social causation hypothesis revisited
    • 43 Cooper, B., Immigration and schizophrenia: The social causation hypothesis revisited. Br J Psychiatry 186 (2005), 361–363.
    • (2005) Br J Psychiatry , vol.186 , pp. 361-363
    • Cooper, B.1
  • 44
    • 33750062845 scopus 로고    scopus 로고
    • Incidence of schizophrenia and other psychoses in ethnic minority groups: Results from the MRC AESOP Study
    • 44 Fearon, P., Kirkbride, J.B., Morgan, C., Dazzan, P., Morgan, K., Lloyd, T., et al. Incidence of schizophrenia and other psychoses in ethnic minority groups: Results from the MRC AESOP Study. Psychol Med 36 (2006), 1541–1550.
    • (2006) Psychol Med , vol.36 , pp. 1541-1550
    • Fearon, P.1    Kirkbride, J.B.2    Morgan, C.3    Dazzan, P.4    Morgan, K.5    Lloyd, T.6
  • 45
    • 0034093264 scopus 로고    scopus 로고
    • Clinician attributions associated with the diagnosis of schizophrenia in African American and non-African American patients
    • 45 Trierweiler, S.J., Neighbors, H.W., Munday, C., Thompson, E.E., Binion, V.J., Gomez, J.P., Clinician attributions associated with the diagnosis of schizophrenia in African American and non-African American patients. J Consult Clin Psychol 68 (2000), 171–175.
    • (2000) J Consult Clin Psychol , vol.68 , pp. 171-175
    • Trierweiler, S.J.1    Neighbors, H.W.2    Munday, C.3    Thompson, E.E.4    Binion, V.J.5    Gomez, J.P.6
  • 46
    • 84926372408 scopus 로고    scopus 로고
    • Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: The Generation R Study
    • 46 Medina-Gomez, C., Felix, J.F., Estrada, K., Peters, M.J., Herrera, L., Kruithof, C.J., et al. Challenges in conducting genome-wide association studies in highly admixed multi-ethnic populations: The Generation R Study. Eur J Epidemiol 30 (2015), 317–330.
    • (2015) Eur J Epidemiol , vol.30 , pp. 317-330
    • Medina-Gomez, C.1    Felix, J.F.2    Estrada, K.3    Peters, M.J.4    Herrera, L.5    Kruithof, C.J.6


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