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Volumn 49, Issue 2, 2014, Pages 169-182

The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for GxE research

Author keywords

Gene environment interaction; GWAS; GWEIS; Polygenic risk score; Prediction; Schizophrenia

Indexed keywords

ENVIRONMENT; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MOLECULAR BIOLOGY; PROCEDURES; PSYCHOLOGICAL MODEL; RISK FACTOR; SCHIZOPHRENIA; SOCIAL ENVIRONMENT; STATISTICAL MODEL;

EID: 84896697148     PISSN: 09337954     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00127-014-0823-2     Document Type: Review
Times cited : (65)

References (136)
  • 1
    • 0035003730 scopus 로고    scopus 로고
    • Recovery from psychotic illness: A 15- and 25-year international follow-up study
    • 1:STN:280:DC%2BD3Mzhs1answ%3D%3D 11388966
    • Harrison G, Hopper K, Craig T et al (2001) Recovery from psychotic illness: a 15- and 25-year international follow-up study. Br J Psychiatry 178:506-517
    • (2001) Br J Psychiatry , vol.178 , pp. 506-517
    • Harrison, G.1    Hopper, K.2    Craig, T.3
  • 2
    • 22144432283 scopus 로고    scopus 로고
    • A systematic review of the prevalence of schizophrenia
    • 1140952 15916472
    • Saha S, Chant D, Welham J, McGrath J (2005) A systematic review of the prevalence of schizophrenia. PLoS Med 2(5):e141
    • (2005) PLoS Med , vol.2 , Issue.5 , pp. 141
    • Saha, S.1    Chant, D.2    Welham, J.3    McGrath, J.4
  • 3
    • 79959244407 scopus 로고    scopus 로고
    • Estimating cost-offsets of new medications: Use of new antipsychotics and mental health costs for schizophrenia
    • 3601436 21520217
    • O'Malley AJ, Frank RG, Normand SL (2011) Estimating cost-offsets of new medications: use of new antipsychotics and mental health costs for schizophrenia. Stat Med 30(16):1971-1988
    • (2011) Stat Med , vol.30 , Issue.16 , pp. 1971-1988
    • O'Malley, A.J.1    Frank, R.G.2    Normand, S.L.3
  • 4
    • 38349057998 scopus 로고    scopus 로고
    • The burden of schizophrenia on caregivers: A review
    • 18198934
    • Awad AG, Voruganti LN (2008) The burden of schizophrenia on caregivers: a review. Pharmacoeconomics 26(2):149-162
    • (2008) Pharmacoeconomics , vol.26 , Issue.2 , pp. 149-162
    • Awad, A.G.1    Voruganti, L.N.2
  • 5
    • 80053557101 scopus 로고    scopus 로고
    • Global perspective of burden of family caregivers for persons with schizophrenia
    • 21978802
    • Chan SW (2011) Global perspective of burden of family caregivers for persons with schizophrenia. Arch Psychiatr Nurs 25(5):339-349
    • (2011) Arch Psychiatr Nurs , vol.25 , Issue.5 , pp. 339-349
    • Chan, S.W.1
  • 6
    • 79952130605 scopus 로고    scopus 로고
    • Translating the epidemiology of psychosis into public mental health: Evidence, challenges and future prospects
    • 3001284 21160544
    • Kirkbride J, Coid JW, Morgan C et al (2010) Translating the epidemiology of psychosis into public mental health: evidence, challenges and future prospects. J Public Ment Health 9(2):4-14
    • (2010) J Public Ment Health , vol.9 , Issue.2 , pp. 4-14
    • Kirkbride, J.1    Coid, J.W.2    Morgan, C.3
  • 7
    • 77649209124 scopus 로고    scopus 로고
    • The genetic interpretation of area under the ROC curve in genomic profiling
    • 2829056 20195508
    • Wray NR, Yang J, Goddard ME, Visscher PM (2010) The genetic interpretation of area under the ROC curve in genomic profiling. PLoS Genet 6(2):e1000864
    • (2010) PLoS Genet , vol.6 , Issue.2 , pp. 1000864
    • Wray, N.R.1    Yang, J.2    Goddard, M.E.3    Visscher, P.M.4
  • 8
    • 0033040141 scopus 로고    scopus 로고
    • Heritability estimates for psychotic disorders: The Maudsley twin psychosis series
    • 1:STN:280:DyaK1M7kvVejug%3D%3D 10025441
    • Cardno AG, Marshall EJ, Coid B et al (1999) Heritability estimates for psychotic disorders: the Maudsley twin psychosis series. Arch Gen Psychiatry 56(2):162-168
    • (1999) Arch Gen Psychiatry , vol.56 , Issue.2 , pp. 162-168
    • Cardno, A.G.1    Marshall, E.J.2    Coid, B.3
  • 9
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • 1:CAS:528:DC%2BD3MXhsFCjtLc%3D 11237011
    • Lander ES, Linton LM, Birren B et al (2001) Initial sequencing and analysis of the human genome. Nature 409(6822):860-921
    • (2001) Nature , vol.409 , Issue.6822 , pp. 860-921
    • Lander, E.S.1    Linton, L.M.2    Birren, B.3
  • 10
    • 78650856517 scopus 로고    scopus 로고
    • GCTA: A tool for genome-wide complex trait analysis
    • 1:CAS:528:DC%2BC3MXktVejtg%3D%3D 3014363 21167468
    • Yang J, Lee SH, Goddard ME, Visscher PM (2011) GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet 88(1):76-82
    • (2011) Am J Hum Genet , vol.88 , Issue.1 , pp. 76-82
    • Yang, J.1    Lee, S.H.2    Goddard, M.E.3    Visscher, P.M.4
  • 11
    • 73949152919 scopus 로고    scopus 로고
    • Narrowing the boundaries of the genetic architecture of schizophrenia
    • 19996148
    • Wray NR, Visscher PM (2010) Narrowing the boundaries of the genetic architecture of schizophrenia. Schizophr Bull 36(1):14-23
    • (2010) Schizophr Bull , vol.36 , Issue.1 , pp. 14-23
    • Wray, N.R.1    Visscher, P.M.2
  • 12
    • 0344305525 scopus 로고    scopus 로고
    • Schizophrenia as a complex trait: Evidence from a meta-analysis of twin studies
    • 14662550
    • Sullivan PF, Kendler KS, Neale MC (2003) Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 60(12):1187-1192
    • (2003) Arch Gen Psychiatry , vol.60 , Issue.12 , pp. 1187-1192
    • Sullivan, P.F.1    Kendler, K.S.2    Neale, M.C.3
  • 13
    • 58149464318 scopus 로고    scopus 로고
    • Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: A population-based study
    • 1:CAS:528:DC%2BD1MXmvVKitQ%3D%3D 19150704
    • Lichtenstein P, Yip BH, Bjork C et al (2009) Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 373(9659):234-239
    • (2009) Lancet , vol.373 , Issue.9659 , pp. 234-239
    • Lichtenstein, P.1    Yip, B.H.2    Bjork, C.3
  • 14
    • 84860151961 scopus 로고    scopus 로고
    • Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses
    • 1:CAS:528:DC%2BC38XlvFSnsbo%3D 21670730
    • Visscher PM, Goddard ME, Derks EM, Wray NR (2012) Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses. Mol Psychiatry 17(5):474-485
    • (2012) Mol Psychiatry , vol.17 , Issue.5 , pp. 474-485
    • Visscher, P.M.1    Goddard, M.E.2    Derks, E.M.3    Wray, N.R.4
  • 15
    • 77955364508 scopus 로고    scopus 로고
    • Penetrance for copy number variants associated with schizophrenia
    • 1:CAS:528:DC%2BC3cXpvVKjsL4%3D 20587603
    • Vassos E, Collier DA, Holden S et al (2010) Penetrance for copy number variants associated with schizophrenia. Hum Mol Genet 19(17):3477-3481
    • (2010) Hum Mol Genet , vol.19 , Issue.17 , pp. 3477-3481
    • Vassos, E.1    Collier, D.A.2    Holden, S.3
  • 16
    • 84885150676 scopus 로고    scopus 로고
    • Urbanicity, social adversity and psychosis
    • 3799240 24096775
    • Heinz A, Deserno L, Reininghaus U (2013) Urbanicity, social adversity and psychosis. World Psychiatry 12(3):187-197
    • (2013) World Psychiatry , vol.12 , Issue.3 , pp. 187-197
    • Heinz, A.1    Deserno, L.2    Reininghaus, U.3
  • 17
    • 71849093384 scopus 로고    scopus 로고
    • Schizophrenia and the city: A review of literature and prospective study of psychosis and urbanicity in Ireland
    • 19897342
    • Kelly BD, O'Callaghan E, Waddington JL et al (2010) Schizophrenia and the city: a review of literature and prospective study of psychosis and urbanicity in Ireland. Schizophr Res 116(1):75-89
    • (2010) Schizophr Res , vol.116 , Issue.1 , pp. 75-89
    • Kelly, B.D.1    O'Callaghan, E.2    Waddington, J.L.3
  • 19
    • 78249256348 scopus 로고    scopus 로고
    • The environment and susceptibility to schizophrenia
    • 1:CAS:528:DC%2BC3MXhslOmsr4%3D 3521525 20955757
    • Brown AS (2011) The environment and susceptibility to schizophrenia. Prog Neurobiol 93(1):23-58
    • (2011) Prog Neurobiol , vol.93 , Issue.1 , pp. 23-58
    • Brown, A.S.1
  • 20
    • 78650315578 scopus 로고    scopus 로고
    • Migration and psychotic disorders
    • 21158556
    • Veling W, Susser E (2011) Migration and psychotic disorders. Expert Rev Neurother 11(1):65-76
    • (2011) Expert Rev Neurother , vol.11 , Issue.1 , pp. 65-76
    • Veling, W.1    Susser, E.2
  • 21
    • 33748787145 scopus 로고    scopus 로고
    • Review: The wider social environment and schizophrenia
    • 16849399
    • Allardyce J, Boydell J (2006) Review: the wider social environment and schizophrenia. Schizophr Bull 32(4):592-598
    • (2006) Schizophr Bull , vol.32 , Issue.4 , pp. 592-598
    • Allardyce, J.1    Boydell, J.2
  • 22
    • 11844301246 scopus 로고    scopus 로고
    • Schizophrenia and migration: A meta-analysis and review
    • 15625195
    • Cantor-Graae E, Selten JP (2005) Schizophrenia and migration: a meta-analysis and review. Am J Psychiatry 162(1):12-24
    • (2005) Am J Psychiatry , vol.162 , Issue.1 , pp. 12-24
    • Cantor-Graae, E.1    Selten, J.P.2
  • 23
    • 77956595644 scopus 로고    scopus 로고
    • Migration, ethnicity, and psychosis: Toward a sociodevelopmental model
    • 20513653
    • Morgan C, Charalambides M, Hutchinson G, Murray RM (2010) Migration, ethnicity, and psychosis: toward a sociodevelopmental model. Schizophr Bull 36(4):655-664
    • (2010) Schizophr Bull , vol.36 , Issue.4 , pp. 655-664
    • Morgan, C.1    Charalambides, M.2    Hutchinson, G.3    Murray, R.M.4
  • 24
    • 77950919457 scopus 로고    scopus 로고
    • Ethnic origin and increased risk for schizophrenia in immigrants to countries of recent and longstanding immigration
    • 20105146
    • Dealberto MJ (2010) Ethnic origin and increased risk for schizophrenia in immigrants to countries of recent and longstanding immigration. Acta Psychiatr Scand 121(5):325-339
    • (2010) Acta Psychiatr Scand , vol.121 , Issue.5 , pp. 325-339
    • Dealberto, M.J.1
  • 25
    • 24344470642 scopus 로고    scopus 로고
    • The environment and schizophrenia: The role of cannabis use
    • 15976013
    • Henquet C, Murray R, Linszen D, van Os J (2005) The environment and schizophrenia: the role of cannabis use. Schizophr Bull 31(3):608-612
    • (2005) Schizophr Bull , vol.31 , Issue.3 , pp. 608-612
    • Henquet, C.1    Murray, R.2    Linszen, D.3    Van Os, J.4
  • 26
    • 17744379225 scopus 로고    scopus 로고
    • Cannabis as a risk factor for psychosis: Systematic review
    • 15871146
    • Semple DM, McIntosh AM, Lawrie SM (2005) Cannabis as a risk factor for psychosis: systematic review. J Psychopharmacol 19(2):187-194
    • (2005) J Psychopharmacol , vol.19 , Issue.2 , pp. 187-194
    • Semple, D.M.1    McIntosh, A.M.2    Lawrie, S.M.3
  • 27
    • 0442307621 scopus 로고    scopus 로고
    • Causal association between cannabis and psychosis: Examination of the evidence
    • 14754822
    • Arseneault L, Cannon M, Witton J, Murray RM (2004) Causal association between cannabis and psychosis: examination of the evidence. Br J Psychiatry 184:110-117
    • (2004) Br J Psychiatry , vol.184 , pp. 110-117
    • Arseneault, L.1    Cannon, M.2    Witton, J.3    Murray, R.M.4
  • 28
    • 34447619511 scopus 로고    scopus 로고
    • Cannabis use and risk of psychotic or affective mental health outcomes: A systematic review
    • 17662880
    • Moore TH, Zammit S, Lingford-Hughes A et al (2007) Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. Lancet 370(9584):319-328
    • (2007) Lancet , vol.370 , Issue.9584 , pp. 319-328
    • Moore, T.H.1    Zammit, S.2    Lingford-Hughes, A.3
  • 29
    • 84883767497 scopus 로고    scopus 로고
    • Cannabis and psychosis: Have we found the missing links?
    • 23810133
    • Parakh P, Basu D (2013) Cannabis and psychosis: have we found the missing links? Asian J Psychiatr 6(4):281-287
    • (2013) Asian J Psychiatr , vol.6 , Issue.4 , pp. 281-287
    • Parakh, P.1    Basu, D.2
  • 30
    • 82255170602 scopus 로고    scopus 로고
    • Childhood trauma and psychosis - What is the evidence?
    • 3182006 22033827
    • Schafer I, Fisher HL (2011) Childhood trauma and psychosis - what is the evidence? Dialogues Clin Neurosci 13(3):360-365
    • (2011) Dialogues Clin Neurosci , vol.13 , Issue.3 , pp. 360-365
    • Schafer, I.1    Fisher, H.L.2
  • 31
    • 33845904134 scopus 로고    scopus 로고
    • Environment and schizophrenia: Environmental factors in schizophrenia: Childhood trauma - A critical review
    • 17105965
    • Morgan C, Fisher H (2007) Environment and schizophrenia: environmental factors in schizophrenia: childhood trauma - a critical review. Schizophr Bull 33(1):3-10
    • (2007) Schizophr Bull , vol.33 , Issue.1 , pp. 3-10
    • Morgan, C.1    Fisher, H.2
  • 32
    • 84861647648 scopus 로고    scopus 로고
    • Childhood adversities increase the risk of psychosis: A meta-analysis of patient-control, prospective- and cross-sectional cohort studies
    • 22461484
    • Varese F, Smeets F, Drukker M et al (2012) Childhood adversities increase the risk of psychosis: a meta-analysis of patient-control, prospective- and cross-sectional cohort studies. Schizophr Bull 38(4):661-671
    • (2012) Schizophr Bull , vol.38 , Issue.4 , pp. 661-671
    • Varese, F.1    Smeets, F.2    Drukker, M.3
  • 33
    • 77955055326 scopus 로고    scopus 로고
    • Paternal age and mortality in nonaffective psychosis
    • 20163936
    • Miller B, Pihlajamaa J, Haukka J et al (2010) Paternal age and mortality in nonaffective psychosis. Schizophr Res 121(1-3):218-226
    • (2010) Schizophr Res , vol.121 , Issue.1-3 , pp. 218-226
    • Miller, B.1    Pihlajamaa, J.2    Haukka, J.3
  • 34
    • 80052238644 scopus 로고    scopus 로고
    • Meta-analysis of paternal age and schizophrenia risk in male versus female offspring
    • 20185538
    • Miller B, Messias E, Miettunen J et al (2011) Meta-analysis of paternal age and schizophrenia risk in male versus female offspring. Schizophr Bull 37(5):1039-1047
    • (2011) Schizophr Bull , vol.37 , Issue.5 , pp. 1039-1047
    • Miller, B.1    Messias, E.2    Miettunen, J.3
  • 35
    • 0242269084 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of Northern Hemisphere season of birth studies in schizophrenia
    • 14609251
    • Davies G, Welham J, Chant D, Torrey EF, McGrath J (2003) A systematic review and meta-analysis of Northern Hemisphere season of birth studies in schizophrenia. Schizophr Bull 29(3):587-593
    • (2003) Schizophr Bull , vol.29 , Issue.3 , pp. 587-593
    • Davies, G.1    Welham, J.2    Chant, D.3    Torrey, E.F.4    McGrath, J.5
  • 36
    • 77952491554 scopus 로고    scopus 로고
    • Evidence for maternal-fetal genotype incompatibility as a risk factor for schizophrenia
    • 2850511 20379378
    • Palmer CG (2010) Evidence for maternal-fetal genotype incompatibility as a risk factor for schizophrenia. J Biomed Biotechnol 2010:576318
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 576318
    • Palmer, C.G.1
  • 37
    • 33745786545 scopus 로고    scopus 로고
    • Exposure to obstetric complications and subsequent development of bipolar disorder: Systematic review
    • 16816299
    • Scott J, McNeill Y, Cavanagh J, Cannon M, Murray R (2006) Exposure to obstetric complications and subsequent development of bipolar disorder: systematic review. Br J Psychiatry 189:3-11
    • (2006) Br J Psychiatry , vol.189 , pp. 3-11
    • Scott, J.1    McNeill, Y.2    Cavanagh, J.3    Cannon, M.4    Murray, R.5
  • 38
    • 77956376319 scopus 로고    scopus 로고
    • Neonatal vitamin D status and risk of schizophrenia: A population-based case-control study
    • 1:CAS:528:DC%2BC3MXit1enu78%3D 20819982
    • McGrath JJ, Eyles DW, Pedersen CB et al (2010) Neonatal vitamin D status and risk of schizophrenia: a population-based case-control study. Arch Gen Psychiatry 67(9):889-894
    • (2010) Arch Gen Psychiatry , vol.67 , Issue.9 , pp. 889-894
    • McGrath, J.J.1    Eyles, D.W.2    Pedersen, C.B.3
  • 39
    • 84872118489 scopus 로고    scopus 로고
    • Prenatal maternal infection, neurodevelopment and adult schizophrenia: A systematic review of population-based studies
    • 1:STN:280:DC%2BC38jjsVKjsg%3D%3D 3479084 22717193
    • Khandaker GM, Zimbron J, Lewis G, Jones PB (2013) Prenatal maternal infection, neurodevelopment and adult schizophrenia: a systematic review of population-based studies. Psychol Med 43(2):239-257
    • (2013) Psychol Med , vol.43 , Issue.2 , pp. 239-257
    • Khandaker, G.M.1    Zimbron, J.2    Lewis, G.3    Jones, P.B.4
  • 40
    • 84865839322 scopus 로고    scopus 로고
    • Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism
    • 3435457 22488761
    • Brown AS (2012) Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism. Dev Neurobiol 72(10):1272-1276
    • (2012) Dev Neurobiol , vol.72 , Issue.10 , pp. 1272-1276
    • Brown, A.S.1
  • 41
    • 40049097964 scopus 로고    scopus 로고
    • Questioning an axiom: Better prognosis for schizophrenia in the developing world?
    • 17905787
    • Cohen A, Patel V, Thara R, Gureje O (2008) Questioning an axiom: better prognosis for schizophrenia in the developing world? Schizophr Bull 34(2):229-244
    • (2008) Schizophr Bull , vol.34 , Issue.2 , pp. 229-244
    • Cohen, A.1    Patel, V.2    Thara, R.3    Gureje, O.4
  • 42
    • 0037639116 scopus 로고    scopus 로고
    • Sex differences in the risk of schizophrenia: Evidence from meta-analysis
    • 12796219
    • Aleman A, Kahn RS, Selten JP (2003) Sex differences in the risk of schizophrenia: evidence from meta-analysis. Arch Gen Psychiatry 60(6):565-571
    • (2003) Arch Gen Psychiatry , vol.60 , Issue.6 , pp. 565-571
    • Aleman, A.1    Kahn, R.S.2    Selten, J.P.3
  • 43
    • 4243057297 scopus 로고    scopus 로고
    • A systematic review of the incidence of schizophrenia: The distribution of rates and the influence of sex, urbanicity, migrant status and methodology
    • 421751 15115547
    • McGrath J, Saha S, Welham J, El Saadi O, MacCauley C, Chant D (2004) A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology. BMC Med 2:13
    • (2004) BMC Med , vol.2 , pp. 13
    • McGrath, J.1    Saha, S.2    Welham, J.3    El Saadi, O.4    Maccauley, C.5    Chant, D.6
  • 44
    • 46449113977 scopus 로고    scopus 로고
    • Schizophrenia, "just the facts" what we know in 2008. 2. Epidemiology and etiology
    • 18514488
    • Tandon R, Keshavan MS, Nasrallah HA (2008) Schizophrenia, "just the facts" what we know in 2008. 2. Epidemiology and etiology. Schizophr Res 102(1-3):1-18
    • (2008) Schizophr Res , vol.102 , Issue.1-3 , pp. 1-18
    • Tandon, R.1    Keshavan, M.S.2    Nasrallah, H.A.3
  • 45
    • 18144425478 scopus 로고    scopus 로고
    • A genome-wide scalable SNP genotyping assay using microarray technology
    • 1:CAS:528:DC%2BD2MXjsF2ks74%3D 15838508
    • Gunderson KL, Steemers FJ, Lee G, Mendoza LG, Chee MS (2005) A genome-wide scalable SNP genotyping assay using microarray technology. Nat Genet 37(5):549-554
    • (2005) Nat Genet , vol.37 , Issue.5 , pp. 549-554
    • Gunderson, K.L.1    Steemers, F.J.2    Lee, G.3    Mendoza, L.G.4    Chee, M.S.5
  • 46
    • 0032524383 scopus 로고    scopus 로고
    • Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome
    • 1:CAS:528:DyaK1cXjt1egsb0%3D 9582121
    • Wang DG, Fan JB, Siao CJ et al (1998) Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science 280(5366):1077-1082
    • (1998) Science , vol.280 , Issue.5366 , pp. 1077-1082
    • Wang, D.G.1    Fan, J.B.2    Siao, C.J.3
  • 47
    • 68449086236 scopus 로고    scopus 로고
    • Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
    • 1:CAS:528:DC%2BD1MXotVSgtLg%3D 19571811
    • Purcell SM, Wray NR, Stone JL et al (2009) Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460(7256):748-752
    • (2009) Nature , vol.460 , Issue.7256 , pp. 748-752
    • Purcell, S.M.1    Wray, N.R.2    Stone, J.L.3
  • 48
    • 42349088634 scopus 로고    scopus 로고
    • Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia
    • 1:CAS:528:DC%2BD1cXkvFGkt7s%3D 18369103
    • Walsh T, McClellan JM, McCarthy SE et al (2008) Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 320(5875):539-543
    • (2008) Science , vol.320 , Issue.5875 , pp. 539-543
    • Walsh, T.1    McClellan, J.M.2    McCarthy, S.E.3
  • 49
    • 84885020424 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies 13 new risk loci for schizophrenia
    • 1:CAS:528:DC%2BC3sXhtlWkur3N 23974872
    • Ripke S, O'Dushlaine C, Chambert K et al (2013) Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet 45(10):1150-1159
    • (2013) Nat Genet , vol.45 , Issue.10 , pp. 1150-1159
    • Ripke, S.1    O'Dushlaine, C.2    Chambert, K.3
  • 50
    • 84896703397 scopus 로고    scopus 로고
    • Psychiatric Genetics Consortium (2014) in preparation
    • Psychiatric Genetics Consortium (2014) in preparation
  • 51
    • 0033810465 scopus 로고    scopus 로고
    • Genetic epidemiology of major depression: Review and meta-analysis
    • 1:STN:280:DC%2BD3M%2FgvVOitQ%3D%3D 11007705
    • Sullivan PF, Neale MC, Kendler KS (2000) Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 157(10):1552-1562
    • (2000) Am J Psychiatry , vol.157 , Issue.10 , pp. 1552-1562
    • Sullivan, P.F.1    Neale, M.C.2    Kendler, K.S.3
  • 52
    • 84975742565 scopus 로고    scopus 로고
    • A map of human genome variation from population-scale sequencing
    • 20981092
    • Abecasis GR, Altshuler D, Auton A et al (2010) A map of human genome variation from population-scale sequencing. Nature 467(7319):1061-1073
    • (2010) Nature , vol.467 , Issue.7319 , pp. 1061-1073
    • Abecasis, G.R.1    Altshuler, D.2    Auton, A.3
  • 53
    • 3242808027 scopus 로고    scopus 로고
    • Large-scale copy number polymorphism in the human genome
    • 1:CAS:528:DC%2BD2cXlvVOkur4%3D 15273396
    • Sebat J, Lakshmi B, Troge J et al (2004) Large-scale copy number polymorphism in the human genome. Science 305(5683):525-528
    • (2004) Science , vol.305 , Issue.5683 , pp. 525-528
    • Sebat, J.1    Lakshmi, B.2    Troge, J.3
  • 54
    • 4444291843 scopus 로고    scopus 로고
    • Detection of large-scale variation in the human genome
    • 1:CAS:528:DC%2BD2cXntFSku7w%3D 15286789
    • Iafrate AJ, Feuk L, Rivera MN et al (2004) Detection of large-scale variation in the human genome. Nat Genet 36(9):949-951
    • (2004) Nat Genet , vol.36 , Issue.9 , pp. 949-951
    • Iafrate, A.J.1    Feuk, L.2    Rivera, M.N.3
  • 55
    • 70450224887 scopus 로고    scopus 로고
    • The role of genetic variation in the causation of mental illness: An evolution-informed framework
    • 1:STN:280:DC%2BD1MjmsFOgtw%3D%3D 19704409
    • Uher R (2009) The role of genetic variation in the causation of mental illness: an evolution-informed framework. Mol Psychiatry 14(12):1072-1082
    • (2009) Mol Psychiatry , vol.14 , Issue.12 , pp. 1072-1082
    • Uher, R.1
  • 56
    • 46249093584 scopus 로고    scopus 로고
    • Strong association of de novo copy number mutations with sporadic schizophrenia
    • 1:CAS:528:DC%2BD1cXnslKktbc%3D 18511947
    • Xu B, Roos JL, Levy S, van Rensburg EJ, Gogos JA, Karayiorgou M (2008) Strong association of de novo copy number mutations with sporadic schizophrenia. Nat Genet 40(7):880-885
    • (2008) Nat Genet , vol.40 , Issue.7 , pp. 880-885
    • Xu, B.1    Roos, J.L.2    Levy, S.3    Van Rensburg, E.J.4    Gogos, J.A.5    Karayiorgou, M.6
  • 58
    • 18344371152 scopus 로고    scopus 로고
    • Paternal age and sporadic schizophrenia: Evidence for de novo mutations
    • 2982144 11920852
    • Malaspina D, Corcoran C, Fahim C et al (2002) Paternal age and sporadic schizophrenia: evidence for de novo mutations. Am J Med Genet 114(3):299-303
    • (2002) Am J Med Genet , vol.114 , Issue.3 , pp. 299-303
    • Malaspina, D.1    Corcoran, C.2    Fahim, C.3
  • 59
    • 0013375948 scopus 로고    scopus 로고
    • Neuregulin 1 and susceptibility to schizophrenia
    • 378543 12145742
    • Stefansson H, Sigurdsson E, Steinthorsdottir V et al (2002) Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 71(4):877-892
    • (2002) Am J Hum Genet , vol.71 , Issue.4 , pp. 877-892
    • Stefansson, H.1    Sigurdsson, E.2    Steinthorsdottir, V.3
  • 60
    • 0034927864 scopus 로고    scopus 로고
    • Schizophrenia and affective disorders - Cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: Clinical and P300 findings in a family
    • 1:CAS:528:DC%2BD3MXmtFektrg%3D 1235314 11443544
    • Blackwood DH, Fordyce A, Walker MT, St Clair DM, Porteous DJ, Muir WJ (2001) Schizophrenia and affective disorders - cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet 69(2):428-433
    • (2001) Am J Hum Genet , vol.69 , Issue.2 , pp. 428-433
    • Blackwood, D.H.1    Fordyce, A.2    Walker, M.T.3    St Clair, D.M.4    Porteous, D.J.5    Muir, W.J.6
  • 61
    • 0038003196 scopus 로고    scopus 로고
    • Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia
    • 1:CAS:528:DC%2BD3sXlsVOitL8%3D 1180588 12802786
    • Lewis CM, Levinson DF, Wise LH et al (2003) Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia. Am J Hum Genet 73(1):34-48
    • (2003) Am J Hum Genet , vol.73 , Issue.1 , pp. 34-48
    • Lewis, C.M.1    Levinson, D.F.2    Wise, L.H.3
  • 62
    • 67651160485 scopus 로고    scopus 로고
    • Meta-analysis of 32 genome-wide linkage studies of schizophrenia
    • 1:CAS:528:DC%2BD1MXptVCjtbo%3D 2715392 19349958
    • Ng MY, Levinson DF, Faraone SV et al (2009) Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Mol Psychiatry 14(8):774-785
    • (2009) Mol Psychiatry , vol.14 , Issue.8 , pp. 774-785
    • Ng, M.Y.1    Levinson, D.F.2    Faraone, S.V.3
  • 63
    • 78149436172 scopus 로고    scopus 로고
    • New copy number variations in schizophrenia
    • 2954184 20967226
    • Magri C, Sacchetti E, Traversa M et al (2010) New copy number variations in schizophrenia. PLoS One 5(10):e13422
    • (2010) PLoS One , vol.5 , Issue.10 , pp. 13422
    • Magri, C.1    Sacchetti, E.2    Traversa, M.3
  • 64
    • 84893611579 scopus 로고    scopus 로고
    • Analysis of copy number variations at 15 schizophrenia-associated loci
    • [Epub ahead of print]
    • Rees E, Walters JT, Georgieva L et al (2013) Analysis of copy number variations at 15 schizophrenia-associated loci. Br J Psychiatry [Epub ahead of print]
    • (2013) Br J Psychiatry
    • Rees, E.1    Walters, J.T.2    Et Al., G.L.3
  • 65
    • 51649107017 scopus 로고    scopus 로고
    • Rare chromosomal deletions and duplications increase risk of schizophrenia
    • International Schizophrenia Consortium
    • International Schizophrenia Consortium (2008) Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 455(7210):237-241
    • (2008) Nature , vol.455 , Issue.7210 , pp. 237-241
  • 66
    • 79952710338 scopus 로고    scopus 로고
    • Copy number variants in schizophrenia: Confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications
    • 21285140
    • Levinson DF, Duan J, Oh S et al (2011) Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications. Am J Psychiatry 168(3):302-316
    • (2011) Am J Psychiatry , vol.168 , Issue.3 , pp. 302-316
    • Levinson, D.F.1    Duan, J.2    Oh, S.3
  • 67
    • 77955568656 scopus 로고    scopus 로고
    • Microdeletions of 3q29 confer high risk for schizophrenia
    • 1:CAS:528:DC%2BC3cXpvFWrs7c%3D 2917706 20691406
    • Mulle JG, Dodd AF, McGrath JA et al (2010) Microdeletions of 3q29 confer high risk for schizophrenia. Am J Hum Genet 87(2):229-236
    • (2010) Am J Hum Genet , vol.87 , Issue.2 , pp. 229-236
    • Mulle, J.G.1    Dodd, A.F.2    McGrath, J.A.3
  • 68
    • 40149105889 scopus 로고    scopus 로고
    • Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women
    • 2242812 18282107
    • Shifman S, Johannesson M, Bronstein M et al (2008) Genome-wide association identifies a common variant in the reelin gene that increases the risk of schizophrenia only in women. PLoS Genet 4(2):e28
    • (2008) PLoS Genet , vol.4 , Issue.2 , pp. 28
    • Shifman, S.1    Johannesson, M.2    Bronstein, M.3
  • 69
    • 50449100461 scopus 로고    scopus 로고
    • Identification of loci associated with schizophrenia by genome-wide association and follow-up
    • 18677311
    • O'Donovan MC, Craddock N, Norton N et al (2008) Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet 40(9):1053-1055
    • (2008) Nat Genet , vol.40 , Issue.9 , pp. 1053-1055
    • O'Donovan, M.C.1    Craddock, N.2    Norton, N.3
  • 70
    • 55549147191 scopus 로고    scopus 로고
    • Personal genomes: The case of the missing heritability
    • 1:CAS:528:DC%2BD1cXhtlCjtrnM 18987709
    • Maher B (2008) Personal genomes: the case of the missing heritability. Nature 456(7218):18-21
    • (2008) Nature , vol.456 , Issue.7218 , pp. 18-21
    • Maher, B.1
  • 71
    • 84862667477 scopus 로고    scopus 로고
    • Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: A polygenic risk score analysis
    • 1:CAS:528:DC%2BC38XpsVWrtLk%3D 3382234 22761660
    • Derks EM, Vorstman JA, Ripke S, Kahn RS, Ophoff RA (2012) Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis. PLoS One 7(6):e37852
    • (2012) PLoS One , vol.7 , Issue.6 , pp. 37852
    • Derks, E.M.1    Vorstman, J.A.2    Ripke, S.3    Kahn, R.S.4    Ophoff, R.A.5
  • 72
    • 84874542049 scopus 로고    scopus 로고
    • Genetic schizophrenia risk variants jointly modulate total brain and white matter volume
    • 23039932
    • Terwisscha van Scheltinga AF, Bakker SC, van Haren NE et al (2013) Genetic schizophrenia risk variants jointly modulate total brain and white matter volume. Biol Psychiatry 73(6):525-531
    • (2013) Biol Psychiatry , vol.73 , Issue.6 , pp. 525-531
    • Terwisscha Van Scheltinga, A.F.1    Bakker, S.C.2    Van Haren, N.E.3
  • 73
    • 69449102525 scopus 로고    scopus 로고
    • Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk
    • 1:CAS:528:DC%2BD1MXhtVehurfN 19553258
    • Evans DM, Visscher PM, Wray NR (2009) Harnessing the information contained within genome-wide association studies to improve individual prediction of complex disease risk. Hum Mol Genet 18(18):3525-3531
    • (2009) Hum Mol Genet , vol.18 , Issue.18 , pp. 3525-3531
    • Evans, D.M.1    Visscher, P.M.2    Wray, N.R.3
  • 74
    • 84876007072 scopus 로고    scopus 로고
    • Power and predictive accuracy of polygenic risk scores
    • 1:CAS:528:DC%2BC3sXlvValtLY%3D 3605113 23555274
    • Dudbridge F (2013) Power and predictive accuracy of polygenic risk scores. PLoS Genet 9(3):e1003348
    • (2013) PLoS Genet , vol.9 , Issue.3 , pp. 1003348
    • Dudbridge, F.1
  • 75
    • 84862777863 scopus 로고    scopus 로고
    • Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs
    • 1:CAS:528:DC%2BC38XisVKrsr8%3D 3327879 22344220
    • Lee SH, DeCandia TR, Ripke S et al (2012) Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs. Nat Genet 44(3):247-250
    • (2012) Nat Genet , vol.44 , Issue.3 , pp. 247-250
    • Lee, S.H.1    Decandia, T.R.2    Ripke, S.3
  • 76
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • International HapMap Consortium
    • International HapMap Consortium (2005) A haplotype map of the human genome. Nature 437(7063):1299-1320
    • (2005) Nature , vol.437 , Issue.7063 , pp. 1299-1320
  • 77
    • 84883778249 scopus 로고    scopus 로고
    • Additive genetic variation in schizophrenia risk is shared by populations of African and European descent
    • 3845872 23954163
    • de Candia TR, Lee SH, Yang J et al (2013) Additive genetic variation in schizophrenia risk is shared by populations of African and European descent. Am J Hum Genet 93(3):463-470
    • (2013) Am J Hum Genet , vol.93 , Issue.3 , pp. 463-470
    • De Candia, T.R.1    Lee, S.H.2    Yang, J.3
  • 79
    • 84896736674 scopus 로고    scopus 로고
    • The p factor: One general psychopathology factor in the structure of psychiatric disorders
    • [Epub ahead of print]
    • Avshalom Caspi RMH, Belsky DW et al (2013) The p factor: one general psychopathology factor in the structure of psychiatric disorders? Clin Psychol Sci [Epub ahead of print]
    • (2013) Clin Psychol Sci
    • Avshalom Caspi, R.M.H.1    Belsky, D.W.2
  • 80
    • 84883465830 scopus 로고    scopus 로고
    • Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
    • 1:CAS:528:DC%2BC3sXht1Cgt77O 23933821
    • Lee SH, Ripke S, Neale BM et al (2013) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet 45(9):984-994
    • (2013) Nat Genet , vol.45 , Issue.9 , pp. 984-994
    • Lee, S.H.1    Ripke, S.2    Neale, B.M.3
  • 81
    • 84876296688 scopus 로고    scopus 로고
    • Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis
    • 1:CAS:528:DC%2BC3sXjsFCnsrk%3D
    • Smoller JW, Craddock N, Kendler K et al (2013) Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 381(9875):1371-1379
    • (2013) Lancet , vol.381 , Issue.9875 , pp. 1371-1379
    • Smoller, J.W.1    Craddock, N.2    Kendler, K.3
  • 82
    • 30344447674 scopus 로고    scopus 로고
    • Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology
    • 16319375
    • Craddock N, O'Donovan MC, Owen MJ (2006) Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophr Bull 32(1):9-16
    • (2006) Schizophr Bull , vol.32 , Issue.1 , pp. 9-16
    • Craddock, N.1    O'Donovan, M.C.2    Owen, M.J.3
  • 83
    • 84875700256 scopus 로고    scopus 로고
    • Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies
    • 1:CAS:528:DC%2BC3sXjtlOisLY%3D 3729116 23455638 (pp 405e401-403)
    • Chatterjee N, Wheeler B, Sampson J, Hartge P, Chanock SJ, Park JH (2013) Projecting the performance of risk prediction based on polygenic analyses of genome-wide association studies. Nat Genet 45(4):400-405 (pp 405e401-403)
    • (2013) Nat Genet , vol.45 , Issue.4 , pp. 400-405
    • Chatterjee, N.1    Wheeler, B.2    Sampson, J.3    Hartge, P.4    Chanock, S.J.5    Park, J.H.6
  • 84
    • 78650687187 scopus 로고    scopus 로고
    • A unifying framework for evaluating the predictive power of genetic variants based on the level of heritability explained
    • 2996330 21151957
    • So HC, Sham PC (2010) A unifying framework for evaluating the predictive power of genetic variants based on the level of heritability explained. PLoS Genet 6(12):e1001230
    • (2010) PLoS Genet , vol.6 , Issue.12 , pp. 1001230
    • So, H.C.1    Sham, P.C.2
  • 85
    • 34548028293 scopus 로고    scopus 로고
    • The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases
    • 17700391
    • Janssens AC, Moonesinghe R, Yang Q, Steyerberg EW, van Duijn CM, Khoury MJ (2007) The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases. Genet Med 9(8):528-535
    • (2007) Genet Med , vol.9 , Issue.8 , pp. 528-535
    • Janssens, A.C.1    Moonesinghe, R.2    Yang, Q.3    Steyerberg, E.W.4    Van Duijn, C.M.5    Khoury, M.J.6
  • 86
    • 80051817547 scopus 로고    scopus 로고
    • Evaluation of polygenic risk scores for predicting breast and prostate cancer risk
    • 21618606
    • Machiela MJ, Chen CY, Chen C, Chanock SJ, Hunter DJ, Kraft P (2011) Evaluation of polygenic risk scores for predicting breast and prostate cancer risk. Genet Epidemiol 35(6):506-514
    • (2011) Genet Epidemiol , vol.35 , Issue.6 , pp. 506-514
    • Machiela, M.J.1    Chen, C.Y.2    Chen, C.3    Chanock, S.J.4    Hunter, D.J.5    Kraft, P.6
  • 87
    • 84867741263 scopus 로고    scopus 로고
    • Toward a roadmap in global biobanking for health
    • 22713808
    • Harris JR, Burton P, Knoppers BM et al (2012) Toward a roadmap in global biobanking for health. Eur J Hum Genet 20(11):1105-1111
    • (2012) Eur J Hum Genet , vol.20 , Issue.11 , pp. 1105-1111
    • Harris, J.R.1    Burton, P.2    Knoppers, B.M.3
  • 88
    • 84886277462 scopus 로고    scopus 로고
    • Old obstacles on new horizons: The challenge of implementing gene X environment discoveries in schizophrenia research
    • Maddock J (ed) InTech, Croatia
    • Iyegbe C, Modinos G, Rivera M (2012) Old obstacles on new horizons: The challenge of implementing gene X environment discoveries in schizophrenia research. In: Maddock J (ed) Public Health: Methodology, Environmental and Systems Issues, vol 1. InTech, Croatia, pp 77-106
    • (2012) Public Health: Methodology, Environmental and Systems Issues , vol.1 , pp. 77-106
    • Iyegbe, C.1    Modinos, G.2    Rivera, M.3
  • 89
    • 46249126356 scopus 로고    scopus 로고
    • Estimating coverage and power for genetic association studies using near-complete variation data
    • 1:CAS:528:DC%2BD1cXnslKrsr0%3D 18568023
    • Bhangale TR, Rieder MJ, Nickerson DA (2008) Estimating coverage and power for genetic association studies using near-complete variation data. Nat Genet 40(7):841-843
    • (2008) Nat Genet , vol.40 , Issue.7 , pp. 841-843
    • Bhangale, T.R.1    Rieder, M.J.2    Nickerson, D.A.3
  • 90
    • 0023615675 scopus 로고
    • Sporadic vs familial classification given etiologic heterogeneity: I. Sensitivity, specificity, and positive and negative predictive value
    • 1:STN:280:DyaL1c%2FosVentw%3D%3D 3692132
    • Kendler KS (1987) Sporadic vs familial classification given etiologic heterogeneity: I. Sensitivity, specificity, and positive and negative predictive value. Genet Epidemiol 4(5):313-330
    • (1987) Genet Epidemiol , vol.4 , Issue.5 , pp. 313-330
    • Kendler, K.S.1
  • 91
    • 84876918129 scopus 로고    scopus 로고
    • Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: Evidence from a 4-decade longitudinal study
    • 23536134
    • Belsky DW, Moffitt TE, Baker TB et al (2013) Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study. JAMA Psychiatry 70(5):534-542
    • (2013) JAMA Psychiatry , vol.70 , Issue.5 , pp. 534-542
    • Belsky, D.W.1    Moffitt, T.E.2    Baker, T.B.3
  • 92
    • 0028903746 scopus 로고
    • Morbid risk of schizophrenia for relatives of patients with cannabis-associated psychosis
    • 1:STN:280:DyaK2MzlvFSkuw%3D%3D 7632625
    • McGuire PK, Jones P, Harvey I, Williams M, McGuffin P, Murray RM (1995) Morbid risk of schizophrenia for relatives of patients with cannabis-associated psychosis. Schizophr Res 15(3):277-281
    • (1995) Schizophr Res , vol.15 , Issue.3 , pp. 277-281
    • McGuire, P.K.1    Jones, P.2    Harvey, I.3    Williams, M.4    McGuffin, P.5    Murray, R.M.6
  • 93
    • 55749104091 scopus 로고    scopus 로고
    • Familial predisposition for psychiatric disorder: Comparison of subjects treated for cannabis-induced psychosis and schizophrenia
    • 18981338
    • Arendt M, Mortensen PB, Rosenberg R, Pedersen CB, Waltoft BL (2008) Familial predisposition for psychiatric disorder: comparison of subjects treated for cannabis-induced psychosis and schizophrenia. Arch Gen Psychiatry 65(11):1269-1274
    • (2008) Arch Gen Psychiatry , vol.65 , Issue.11 , pp. 1269-1274
    • Arendt, M.1    Mortensen, P.B.2    Rosenberg, R.3    Pedersen, C.B.4    Waltoft, B.L.5
  • 94
    • 0037362632 scopus 로고    scopus 로고
    • Do urbanicity and familial liability coparticipate in causing psychosis?
    • 12611828
    • van Os J, Hanssen M, Bak M, Bijl RV, Vollebergh W (2003) Do urbanicity and familial liability coparticipate in causing psychosis? Am J Psychiatry 160(3):477-482
    • (2003) Am J Psychiatry , vol.160 , Issue.3 , pp. 477-482
    • Van Os, J.1    Hanssen, M.2    Bak, M.3    Bijl, R.V.4    Vollebergh, W.5
  • 95
    • 69949109765 scopus 로고    scopus 로고
    • Evidence for an interaction between familial liability and prenatal exposure to infection in the causation of schizophrenia
    • 19487391
    • Clarke MC, Tanskanen A, Huttunen M, Whittaker JC, Cannon M (2009) Evidence for an interaction between familial liability and prenatal exposure to infection in the causation of schizophrenia. Am J Psychiatry 166(9):1025-1030
    • (2009) Am J Psychiatry , vol.166 , Issue.9 , pp. 1025-1030
    • Clarke, M.C.1    Tanskanen, A.2    Huttunen, M.3    Whittaker, J.C.4    Cannon, M.5
  • 96
    • 79953892294 scopus 로고    scopus 로고
    • Familial liability, obstetric complications and childhood development abnormalities in early onset schizophrenia: A case control study
    • 3090339 21492438
    • Margari F, Petruzzelli MG, Lecce PA et al (2011) Familial liability, obstetric complications and childhood development abnormalities in early onset schizophrenia: a case control study. BMC Psychiatry 11:60
    • (2011) BMC Psychiatry , vol.11 , pp. 60
    • Margari, F.1    Petruzzelli, M.G.2    Lecce, P.A.3
  • 97
    • 77957960391 scopus 로고    scopus 로고
    • Social risk or genetic liability for psychosis? A study of children born in Sweden and reared by adoptive parents
    • 20686186
    • Wicks S, Hjern A, Dalman C (2010) Social risk or genetic liability for psychosis? A study of children born in Sweden and reared by adoptive parents. Am J Psychiatry 167(10):1240-1246
    • (2010) Am J Psychiatry , vol.167 , Issue.10 , pp. 1240-1246
    • Wicks, S.1    Hjern, A.2    Dalman, C.3
  • 98
    • 77956823162 scopus 로고    scopus 로고
    • Interpretation of interactions: Guide for the perplexed
    • 20807958
    • Kendler KS, Gardner CO (2010) Interpretation of interactions: guide for the perplexed. Br J Psychiatry 197(3):170-171
    • (2010) Br J Psychiatry , vol.197 , Issue.3 , pp. 170-171
    • Kendler, K.S.1    Gardner, C.O.2
  • 99
    • 77956818240 scopus 로고    scopus 로고
    • Examining interactions between risk factors for psychosis
    • 20807965
    • Zammit S, Lewis G, Dalman C, Allebeck P (2010) Examining interactions between risk factors for psychosis. Br J Psychiatry 197(3):207-211
    • (2010) Br J Psychiatry , vol.197 , Issue.3 , pp. 207-211
    • Zammit, S.1    Lewis, G.2    Dalman, C.3    Allebeck, P.4
  • 100
    • 0017271975 scopus 로고
    • Causes
    • 1:STN:280:DyaE2s%2FmtlWisQ%3D%3D 998606
    • Rothman KJ (1976) Causes. Am J Epidemiol 104(6):587-592
    • (1976) Am J Epidemiol , vol.104 , Issue.6 , pp. 587-592
    • Rothman, K.J.1
  • 101
    • 61449255938 scopus 로고    scopus 로고
    • STrengthening the REporting of Genetic Association Studies (STREGA): An extension of the STROBE statement
    • 19192942
    • Little J, Higgins JP, Ioannidis JP et al (2009) STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. PLoS Med 6(2):e22
    • (2009) PLoS Med , vol.6 , Issue.2 , pp. 22
    • Little, J.1    Higgins, J.P.2    Ioannidis, J.P.3
  • 102
    • 84886295886 scopus 로고    scopus 로고
    • Molecular genetic gene-environment studies using candidate genes in schizophrenia: A systematic review
    • 24094883
    • Modinos G, Iyegbe C, Prata D et al (2013) Molecular genetic gene-environment studies using candidate genes in schizophrenia: a systematic review. Schizophr Res 150(2-3):356-365
    • (2013) Schizophr Res , vol.150 , Issue.2-3 , pp. 356-365
    • Modinos, G.1    Iyegbe, C.2    Prata, D.3
  • 103
    • 80051953349 scopus 로고    scopus 로고
    • A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry
    • 3222234 21890791
    • Duncan LE, Keller MC (2011) A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. Am J Psychiatry 168(10):1041-1049
    • (2011) Am J Psychiatry , vol.168 , Issue.10 , pp. 1041-1049
    • Duncan, L.E.1    Keller, M.C.2
  • 105
    • 20944446077 scopus 로고    scopus 로고
    • Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction
    • 1:CAS:528:DC%2BD2MXjslKht70%3D 15866551
    • Caspi A, Moffitt TE, Cannon M et al (2005) Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction. Biol Psychiatry 57(10):1117-1127
    • (2005) Biol Psychiatry , vol.57 , Issue.10 , pp. 1117-1127
    • Caspi, A.1    Moffitt, T.E.2    Cannon, M.3
  • 106
    • 0021137170 scopus 로고
    • The design of case-control studies: The influence of confounding and interaction effects
    • 1:STN:280:DyaL2M%2FivFKitg%3D%3D 6386716
    • Smith PG, Day NE (1984) The design of case-control studies: the influence of confounding and interaction effects. Int J Epidemiol 13(3):356-365
    • (1984) Int J Epidemiol , vol.13 , Issue.3 , pp. 356-365
    • Smith, P.G.1    Day, N.E.2
  • 107
    • 84867743306 scopus 로고    scopus 로고
    • Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users
    • 22831980
    • Di Forti M, Iyegbe C, Sallis H et al (2012) Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users. Biol Psychiatry 72(10):811-816
    • (2012) Biol Psychiatry , vol.72 , Issue.10 , pp. 811-816
    • Di Forti, M.1    Iyegbe, C.2    Sallis, H.3
  • 108
    • 84870053882 scopus 로고    scopus 로고
    • Preliminary report of biological basis of sensitivity to the effects of cannabis on psychosis: AKT1 and DAT1 genotype modulates the effects of delta-9-tetrahydrocannabinol on midbrain and striatal function
    • 1:CAS:528:DC%2BC38XhslahtrfM 22290123
    • Bhattacharyya S, Atakan Z, Martin-Santos R et al (2012) Preliminary report of biological basis of sensitivity to the effects of cannabis on psychosis: AKT1 and DAT1 genotype modulates the effects of delta-9- tetrahydrocannabinol on midbrain and striatal function. Mol Psychiatry 17(12):1152-1155
    • (2012) Mol Psychiatry , vol.17 , Issue.12 , pp. 1152-1155
    • Bhattacharyya, S.1    Atakan, Z.2    Martin-Santos, R.3
  • 109
    • 79951472497 scopus 로고    scopus 로고
    • Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: Sibling analysis and proband follow-up
    • 21041608
    • van Winkel R (2011) Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up. Arch Gen Psychiatry 68(2):148-157
    • (2011) Arch Gen Psychiatry , vol.68 , Issue.2 , pp. 148-157
    • Van Winkel, R.1
  • 110
    • 71449103952 scopus 로고    scopus 로고
    • Adolescent cannabis use, psychosis and catechol-O-methyltransferase genotype in African Americans and Caucasians
    • 2888694 19633959
    • Kantrowitz JT, Nolan KA, Sen S, Simen AA, Lachman HM, Bowers MB Jr (2009) Adolescent cannabis use, psychosis and catechol-O-methyltransferase genotype in African Americans and Caucasians. Psychiatr Q 80(4):213-218
    • (2009) Psychiatr Q , vol.80 , Issue.4 , pp. 213-218
    • Kantrowitz, J.T.1    Nolan, K.A.2    Sen, S.3    Simen, A.A.4    Lachman, H.M.5    Bowers, Jr.M.B.6
  • 111
    • 58449110608 scopus 로고    scopus 로고
    • COMT ValMet moderation of cannabis-induced psychosis: A momentary assessment study of 'switching on' hallucinations in the flow of daily life
    • 1:STN:280:DC%2BD1M%2FntVGmtQ%3D%3D 18808401
    • Henquet C, Rosa A, Delespaul P et al (2009) COMT ValMet moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life. Acta Psychiatr Scand 119(2):156-160
    • (2009) Acta Psychiatr Scand , vol.119 , Issue.2 , pp. 156-160
    • Henquet, C.1    Rosa, A.2    Delespaul, P.3
  • 112
    • 35948986314 scopus 로고    scopus 로고
    • Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: Interactions with tobacco and cannabis use
    • 17978319
    • Zammit S, Spurlock G, Williams H et al (2007) Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use. Br J Psychiatry 191:402-407
    • (2007) Br J Psychiatry , vol.191 , pp. 402-407
    • Zammit, S.1    Spurlock, G.2    Williams, H.3
  • 113
    • 33751119258 scopus 로고    scopus 로고
    • An experimental study of catechol-O-methyltransferase Val158Met moderation of delta-9-tetrahydrocannabinol-induced effects on psychosis and cognition
    • 1:CAS:528:DC%2BD28Xht1Srtb3J 16936704
    • Henquet C, Rosa A, Krabbendam L et al (2006) An experimental study of catechol-O-methyltransferase Val158Met moderation of delta-9- tetrahydrocannabinol-induced effects on psychosis and cognition. Neuropsychopharmacology 31(12):2748-2757
    • (2006) Neuropsychopharmacology , vol.31 , Issue.12 , pp. 2748-2757
    • Henquet, C.1    Rosa, A.2    Krabbendam, L.3
  • 114
    • 79960088614 scopus 로고    scopus 로고
    • Childhood abuse, the BDNF-Val66Met polymorphism and adult psychotic-like experiences
    • 21719879
    • Alemany S, Arias B, Aguilera M et al (2011) Childhood abuse, the BDNF-Val66Met polymorphism and adult psychotic-like experiences. Br J Psychiatry 199(1):38-42
    • (2011) Br J Psychiatry , vol.199 , Issue.1 , pp. 38-42
    • Alemany, S.1    Arias, B.2    Aguilera, M.3
  • 116
    • 0037628112 scopus 로고    scopus 로고
    • Gene-environment interaction in psychiatric disorders as indicated by season of birth variations in tryptophan hydroxylase (TPH), serotonin transporter (5-HTTLPR) and dopamine receptor (DRD4) gene polymorphisms
    • 1:CAS:528:DC%2BD3sXlsVahtrY%3D 12860364
    • Chotai J, Serretti A, Lattuada E, Lorenzi C, Lilli R (2003) Gene-environment interaction in psychiatric disorders as indicated by season of birth variations in tryptophan hydroxylase (TPH), serotonin transporter (5-HTTLPR) and dopamine receptor (DRD4) gene polymorphisms. Psychiatry Res 119(1-2):99-111
    • (2003) Psychiatry Res , vol.119 , Issue.1-2 , pp. 99-111
    • Chotai, J.1    Serretti, A.2    Lattuada, E.3    Lorenzi, C.4    Lilli, R.5
  • 117
    • 0037199668 scopus 로고    scopus 로고
    • Human leukocyte antigen-A specificities and its relation with season of birth in Japanese patients with schizophrenia
    • 1:CAS:528:DC%2BD38XmtVWmtL4%3D 12165412
    • Tochigi M, Ohashi J, Umekage T et al (2002) Human leukocyte antigen-A specificities and its relation with season of birth in Japanese patients with schizophrenia. Neurosci Lett 329(2):201-204
    • (2002) Neurosci Lett , vol.329 , Issue.2 , pp. 201-204
    • Tochigi, M.1    Ohashi, J.2    Umekage, T.3
  • 118
    • 0033945426 scopus 로고    scopus 로고
    • Human leukocyte antigen and season of birth in Japanese patients with schizophrenia
    • 1:STN:280:DC%2BD3czjsVWnsA%3D%3D 10873932
    • Narita K, Sasaki T, Akaho R et al (2000) Human leukocyte antigen and season of birth in Japanese patients with schizophrenia. Am J Psychiatry 157(7):1173-1175
    • (2000) Am J Psychiatry , vol.157 , Issue.7 , pp. 1173-1175
    • Narita, K.1    Sasaki, T.2    Akaho, R.3
  • 119
    • 45349094387 scopus 로고    scopus 로고
    • Serious obstetric complications interact with hypoxia-regulated/vascular- expression genes to influence schizophrenia risk
    • 1:CAS:528:DC%2BD1cXhtVShtrrI 18195713
    • Nicodemus KK, Marenco S, Batten AJ et al (2008) Serious obstetric complications interact with hypoxia-regulated/vascular-expression genes to influence schizophrenia risk. Mol Psychiatry 13(9):873-877
    • (2008) Mol Psychiatry , vol.13 , Issue.9 , pp. 873-877
    • Nicodemus, K.K.1    Marenco, S.2    Batten, A.J.3
  • 120
    • 84856975637 scopus 로고    scopus 로고
    • Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress
    • 1:CAS:528:DC%2BC38XlsVWju70%3D 22128864
    • Peerbooms O, Rutten BP, Collip D et al (2012) Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress. Acta Psychiatr Scand 125(3):247-256
    • (2012) Acta Psychiatr Scand , vol.125 , Issue.3 , pp. 247-256
    • Peerbooms, O.1    Rutten, B.P.2    Collip, D.3
  • 121
    • 82455217216 scopus 로고    scopus 로고
    • COMT Val158Met-stress interaction in psychosis: Role of background psychosis risk
    • 21073668
    • Collip D, van Winkel R, Peerbooms O et al (2011) COMT Val158Met-stress interaction in psychosis: role of background psychosis risk. CNS Neurosci Ther 17(6):612-619
    • (2011) CNS Neurosci Ther , vol.17 , Issue.6 , pp. 612-619
    • Collip, D.1    Van Winkel, R.2    Peerbooms, O.3
  • 122
    • 63449100784 scopus 로고    scopus 로고
    • A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia
    • 1:CAS:528:DC%2BD1MXkvFCkurw%3D 18543275
    • Keri S, Kiss I, Seres I, Kelemen O (2009) A polymorphism of the neuregulin 1 gene (SNP8NRG243177/rs6994992) affects reactivity to expressed emotion in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 150B(3):418-420
    • (2009) Am J Med Genet B Neuropsychiatr Genet , vol.150 , Issue.3 , pp. 418-420
    • Keri, S.1    Kiss, I.2    Seres, I.3    Kelemen, O.4
  • 123
    • 59149106719 scopus 로고    scopus 로고
    • Subtle gene-environment interactions driving paranoia in daily life
    • 1:CAS:528:DC%2BD1MXjslalsr8%3D 18721261
    • Simons CJ, Wichers M, Derom C et al (2009) Subtle gene-environment interactions driving paranoia in daily life. Genes Brain Behav 8(1):5-12
    • (2009) Genes Brain Behav , vol.8 , Issue.1 , pp. 5-12
    • Simons, C.J.1    Wichers, M.2    Derom, C.3
  • 124
    • 37849038622 scopus 로고    scopus 로고
    • Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress in psychosis: An experience-sampling study
    • 17525974
    • van Winkel R, Henquet C, Rosa A et al (2008) Evidence that the COMT(Val158Met) polymorphism moderates sensitivity to stress in psychosis: an experience-sampling study. Am J Med Genet B Neuropsychiatr Genet 147B(1):10-17
    • (2008) Am J Med Genet B Neuropsychiatr Genet , vol.147 , Issue.1 , pp. 10-17
    • Van Winkel, R.1    Henquet, C.2    Rosa, A.3
  • 125
    • 35349014220 scopus 로고    scopus 로고
    • COMT Val158Met moderation of stress-induced psychosis
    • 17640440
    • Stefanis NC, Henquet C, Avramopoulos D et al (2007) COMT Val158Met moderation of stress-induced psychosis. Psychol Med 37(11):1651-1656
    • (2007) Psychol Med , vol.37 , Issue.11 , pp. 1651-1656
    • Stefanis, N.C.1    Henquet, C.2    Avramopoulos, D.3
  • 126
    • 84866733920 scopus 로고    scopus 로고
    • Challenges and opportunities in genome-wide environmental interaction (GWEI) studies
    • 3677711 22760307
    • Aschard H, Lutz S, Maus B et al (2012) Challenges and opportunities in genome-wide environmental interaction (GWEI) studies. Hum Genet 131(10):1591-1613
    • (2012) Hum Genet , vol.131 , Issue.10 , pp. 1591-1613
    • Aschard, H.1    Lutz, S.2    Maus, B.3
  • 127
    • 0035922669 scopus 로고    scopus 로고
    • Epidemiological methods for studying genes and environmental factors in complex diseases
    • 1:CAS:528:DC%2BD3MXnvFCmsr4%3D 11684236
    • Clayton D, McKeigue PM (2001) Epidemiological methods for studying genes and environmental factors in complex diseases. Lancet 358(9290):1356-1360
    • (2001) Lancet , vol.358 , Issue.9290 , pp. 1356-1360
    • Clayton, D.1    McKeigue, P.M.2
  • 128
    • 13144306071 scopus 로고    scopus 로고
    • Genome-wide association studies for common diseases and complex traits
    • 1:CAS:528:DC%2BD2MXhtFyjsr8%3D 15716906
    • Hirschhorn JN, Daly MJ (2005) Genome-wide association studies for common diseases and complex traits. Nat Rev Genet 6(2):95-108
    • (2005) Nat Rev Genet , vol.6 , Issue.2 , pp. 95-108
    • Hirschhorn, J.N.1    Daly, M.J.2
  • 129
    • 13144265739 scopus 로고    scopus 로고
    • Genome-wide association studies: Theoretical and practical concerns
    • 1:CAS:528:DC%2BD2MXhtFyjsrw%3D 15716907
    • Wang WY, Barratt BJ, Clayton DG, Todd JA (2005) Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet 6(2):109-118
    • (2005) Nat Rev Genet , vol.6 , Issue.2 , pp. 109-118
    • Wang, W.Y.1    Barratt, B.J.2    Clayton, D.G.3    Todd, J.A.4
  • 130
    • 33847059098 scopus 로고    scopus 로고
    • Exploiting gene-environment interaction to detect genetic associations
    • 1:CAS:528:DC%2BD2sXhvVSmsrY%3D 17283440
    • Kraft P, Yen YC, Stram DO, Morrison J, Gauderman WJ (2007) Exploiting gene-environment interaction to detect genetic associations. Hum Hered 63(2):111-119
    • (2007) Hum Hered , vol.63 , Issue.2 , pp. 111-119
    • Kraft, P.1    Yen, Y.C.2    Stram, D.O.3    Morrison, J.4    Gauderman, W.J.5
  • 131
    • 84886524046 scopus 로고    scopus 로고
    • Comparisons of power of statistical methods for gene-environment interaction analyses
    • 24005774
    • Ege MJ, Strachan DP (2013) Comparisons of power of statistical methods for gene-environment interaction analyses. Eur J Epidemiol 28(10):785-797
    • (2013) Eur J Epidemiol , vol.28 , Issue.10 , pp. 785-797
    • Ege, M.J.1    Strachan, D.P.2
  • 132
    • 43349097737 scopus 로고    scopus 로고
    • No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: Implications for psychiatric genetics
    • 18198266
    • Sanders AR, Duan J, Levinson DF et al (2008) No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am J Psychiatry 165(4):497-506
    • (2008) Am J Psychiatry , vol.165 , Issue.4 , pp. 497-506
    • Sanders, A.R.1    Duan, J.2    Levinson, D.F.3
  • 133
    • 84856035474 scopus 로고    scopus 로고
    • Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results
    • 1:STN:280:DC%2BC387mtlOgsQ%3D%3D 21854684
    • Collins AL, Kim Y, Sklar P, O'Donovan MC, Sullivan PF (2012) Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results. Psychol Med 42(3):607-616
    • (2012) Psychol Med , vol.42 , Issue.3 , pp. 607-616
    • Collins, A.L.1    Kim, Y.2    Sklar, P.3    O'Donovan, M.C.4    Sullivan, P.F.5
  • 134
    • 84894557694 scopus 로고    scopus 로고
    • Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci
    • doi: 10.1038/mp.2013.2
    • Borglum AD, Demontis D, Grove J et al (2013) Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. Mol Psychiatry. doi: 10.1038/mp.2013.2
    • (2013) Mol Psychiatry
    • Borglum, A.D.1    Demontis, D.2    Et Al., G.J.3
  • 135
    • 34547822508 scopus 로고    scopus 로고
    • Gene-environment studies: Any advantage over environmental studies?
    • 17389613
    • Bermejo JL, Hemminki K (2007) Gene-environment studies: any advantage over environmental studies? Carcinogenesis 28(7):1526-1532
    • (2007) Carcinogenesis , vol.28 , Issue.7 , pp. 1526-1532
    • Bermejo, J.L.1    Hemminki, K.2
  • 136
    • 1542401054 scopus 로고    scopus 로고
    • Estimation of magnitude in gene-environment interactions in the presence of measurement error
    • 1:STN:280:DC%2BD2c7jsVCkuw%3D%3D 15027084
    • Wong MY, Day NE, Luan JA, Wareham NJ (2004) Estimation of magnitude in gene-environment interactions in the presence of measurement error. Stat Med 23(6):987-998
    • (2004) Stat Med , vol.23 , Issue.6 , pp. 987-998
    • Wong, M.Y.1    Day, N.E.2    Luan, J.A.3    Wareham, N.J.4


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