Does tobacco use cause psychosis? Systematic review and meta-analysis

The Lancet Psychiatry

Volumn 2, Issue 8, 2015, Pages 718-725

  Gurillo, Pedro ^a   Jauhar, Sameer ^b   Murray, Robin M ^b   MacCabe, James H ^b  

^a Hospital Torrevieja   (Spain)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AGE; ARTICLE; CASE CONTROL STUDY; CROSS-SECTIONAL STUDY; EMBASE; HUMAN; MEDLINE; MENTAL PATIENT; OBSERVATIONAL STUDY; ONSET AGE; PREVALENCE; PROSPECTIVE STUDY; PSYCHOSIS; PSYCINFO; PUBLISHING; RISK FACTOR; SMOKING; SYSTEMATIC REVIEW; TOBACCO USE; ADVERSE EFFECTS; META ANALYSIS; PSYCHOSES, SUBSTANCE-INDUCED; PSYCHOTIC DISORDERS; TOBACCO USE DISORDER;

AGE OF ONSET; HUMANS; PSYCHOSES, SUBSTANCE-INDUCED; PSYCHOTIC DISORDERS; SMOKING; TOBACCO USE DISORDER;

EID: 84938292772     PISSN: 22150366     EISSN: 22150374     Source Type: Journal    
DOI: 10.1016/S2215-0366(15)00152-2     Document Type: Article

References (95)

1. De Leon J, Diaz FJ A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors. Schizophr Res 2005, 76:135-157.
2. Kumari V, Postma P Nicotine use in schizophrenia: the self medication hypotheses. Neurosci Biobehav Rev 2005, 29:1021-1034.
3. Eranti SV, MacCabe JH, Bundy H, Murray RM Gender difference in age at onset of schizophrenia: a meta-analysis. Psychol Med 2013, 43:155-167.
4. Casadio P, Fernandes C, Murray RM, Di Forti M Cannabis use in young people: the risk for schizophrenia. Neurosci Biobehav Rev 2011, 35:1779-1787.
5. Di Forti M, Iyegbe C, Sallis H, et al. Confirmation that the AKT1 (rs2494732) genotype influences the risk of psychosis in cannabis users. Biol Psychiatry 2012, 72:811-816.
6. Arseneault L, Cannon M, Witton J, Murray RM Causal association between cannabis and psychosis: examination of the evidence. Br J Psychiatry 2004, 184:110-117.
7. Sara G, Burgess P, Malhi GS, Whiteford H, Hall W Differences in associations between cannabis and stimulant disorders in first admission psychosis. Schizophr Res 2013, 147:216-222.
8. Large M, Sharma S, Compton MT, Slade T, Nielssen O Cannabis use and earlier onset of psychosis: a systematic meta-analysis. Arch Gen Psychiatry 2011, 68:555-561.
9. Myles N, Newall HD, Curtis J, Nielssen O, Shiers D, Large M Tobacco use before, at, and after first-episode psychosis: a systematic meta-analysis. J Clin Psychiatry 2012, 73:468-475.
10. Myles N, Newall H, Compton MT, Curtis J, Nielssen O, Large M The age at onset of psychosis and tobacco use: a systematic meta-analysis. Soc Psychiatry Psychiatr Epidemiol 2012, 47:1243-1250.
11. deRuiter WK, Cheng C, Gehrs M, Langley J, Dewa CS Substance abuse and smoking among a Canadian cohort of first episode psychosis patients. Community Ment Health J 2013, 49:815-821.
12. Jiang J, See YM, Subramaniam M, Lee J Investigation of cigarette smoking among male schizophrenia patients. PLoS One 2013, 8:e71343.
13. Petrovsky N, Ettinger U, Quednow BB, et al. Nicotine enhances antisaccade performance in schizophrenia patients and healthy controls. Int J Neuropsychopharmacol 2013, 16:1473-1481.
14. Tidey JW, Rohsenow DJ, Kaplan GB, Swift RM, Ahnallen CG Separate and combined effects of very low nicotine cigarettes and nicotine replacement in smokers with schizophrenia and controls. Nicotine Tob Res 2013, 15:121-129.
15. Zhang XY, Chen DC, Xiu MH, et al. Cigarette smoking, psychopathology and cognitive function in first-episode drug-naive patients with schizophrenia: a case-control study. Psychol Med 2013, 43:1651-1660.
16. Stroup DF, Berlin JA, Morton SC, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. JAMA 2000, 283:2008-2012. for the Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group.
17. Moher D, Liberati A, Tetzlaff J, Altman DG Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009, 6:e1000097. the PRISMA Group.
18. Sørensen HJ, Mortensen EL, Reinisch JM, Mednick SA A prospective study of smoking in young women and risk of later psychiatric hospitalization. Nord J Psychiatry 2011, 65:3-8.
19. Riala K, Hakko H, Isohanni M, Pouta A, Räsänen P Is initiation of smoking associated with the prodromal phase of schizophrenia?. J Psychiatry Neurosci 2005, 30:26-32.
20. Weiser M, Reichenberg A, Grotto I, et al. Higher rates of cigarette smoking in male adolescents before the onset of schizophrenia: a historical-prospective cohort study. Am J Psychiatry 2004, 161:1219-1223.
21. Luty J, Kelly C, McCreadie RG Smoking habits, body mass index and risk of heart disease: prospective 21/2-year follow-up of first episode schizophrenic patients. J Subst Use 2002, 7:15-18.
22. Kopala LC, Clark C, Hurwitz T Olfactory deficits in neuroleptic naive patients with schizophrenia. Schizophr Res 1992, 8:245-250.
23. Smesny S, Kinder D, Willhardt I, et al. Increased calcium-independent phospholipase A2 activity in first but not in multiepisode chronic schizophrenia. Biol Psychiatry 2005, 57:399-405.
24. Diaz FJ, Velásquez DM, Susce MT, de Leon J The association between schizophrenia and smoking: unexplained by either the illness or the prodromal period. Schizophr Res 2008, 104:214-219.
25. Sandyk R, Kay SR Tobacco addiction as a marker of age at onset of schizophrenia. Int J Neurosci 1991, 57:259-262.
26. Beratis S, Katrivanou A, Gourzis P Factors affecting smoking in schizophrenia. Compr Psychiatry 2001, 42:393-402.
27. Fawzi MH, Fawzi MM, Khedr HH, Fawzi MM Tobacco smoking in Egyptian schizophrenia patients with and without obsessive-compulsive symptoms. Schizophr Res 2007, 95:236-246.
28. Goff DC, Henderson DC, Amico E Cigarette smoking in schizophrenia: relationship to psychopathology and medication side effects. Am J Psychiatry 1992, 149:1189-1194.
29. Zabala A, Eguiluz JI, Segarra R, et al. Cognitive performance and cigarette smoking in first-episode psychosis. Eur Arch Psychiatry Clin Neurosci 2009, 259:65-71.
30. Uzun O, Cansever A, Basoğlu C, Ozşahin A Smoking and substance abuse in outpatients with schizophrenia: a 2-year follow-up study in Turkey. Drug Alcohol Depend 2003, 70:187-192.
31. Brewer WJ, Pantelis C, Anderson V, et al. Stability of olfactory identification deficits in neuroleptic-naive patients with first-episode psychosis. Am J Psychiatry 2001, 158:107-115.
32. Samele C, Patel M, Boydell J, Leese M, Wessely S, Murray R Physical illness and lifestyle risk factors in people with their first presentation of psychosis. Soc Psychiatry Psychiatr Epidemiol 2007, 42:117-124.
33. Kristensen K, Cadenhead KS Cannabis abuse and risk for psychosis in a prodromal sample. Psychiatry Res 2007, 151:151-154.
34. Cadenhead KS Startle reactivity and prepulse inhibition in prodromal and early psychosis: effects of age, antipsychotics, tobacco and cannabis in a vulnerable population. Psychiatry Res 2011, 188:208-216.
35. Reddy R, Keshavan M, Yao JK Reduced plasma antioxidants in first-episode patients with schizophrenia. Schizophr Res 2003, 62:205-212.
36. Reddy RD, Keshavan MS, Yao JK Reduced red blood cell membrane essential polyunsaturated fatty acids in first episode schizophrenia at neuroleptic-naive baseline. Schizophr Bull 2004, 30:901-911.
37. Sengupta S, Parrilla-Escobar MA, Klink R, et al. Are metabolic indices different between drug-naïve first-episode psychosis patients and healthy controls?. Schizophr Res 2008, 102:329-336.
38. Smesny S, Klemm S, Stockebrand M, et al. Endophenotype properties of niacin sensitivity as marker of impaired prostaglandin signalling in schizophrenia. Prostaglandins Leukot Essent Fatty Acids 2007, 77:79-85.
39. Strassnig M, Miewald J, Keshavan M, Ganguli R Weight gain in newly diagnosed first-episode psychosis patients and healthy comparisons: one-year analysis. Schizophr Res 2007, 93:90-98.
40. Cooper J, Mancuso SG, Borland R, Slade T, Galletly C, Castle D Tobacco smoking among people living with a psychotic illness: the second Australian Survey of Psychosis. Aust N Z J Psychiatry 2012, 46:851-863.
41. Dervaux A, Baylé FJ, Laqueille X, et al. Nicotine use in schizophrenia and disinhibition. Psychiatry Res 2004, 128:229-234.
42. Patkar AA, Gopalakrishnan R, Lundy A, Leone FT, Certa KM, Weinstein SP Relationship between tobacco smoking and positive and negative symptoms in schizophrenia. J Nerv Ment Dis 2002, 190:604-610.
43. Kelly C, McCreadie RG Smoking habits, current symptoms, and premorbid characteristics of schizophrenic patients in Nithsdale, Scotland. Am J Psychiatry 1999, 156:1751-1757.
44. Etter M, Mohr S, Garin C, Etter JF Stages of change in smokers with schizophrenia or schizoaffective disorder and in the general population. Schizophr Bull 2004, 30:459-468.
45. Roick C, Fritz-Wieacker A, Matschinger H, et al. Health habits of patients with schizophrenia. Soc Psychiatry Psychiatr Epidemiol 2007, 42:268-276.
46. Zammit S, Allebeck P, Dalman C, Lundberg I, Hemmingsson T, Lewis G Investigating the association between cigarette smoking and schizophrenia in a cohort study. Am J Psychiatry 2003, 160:2216-2221.
47. Begg CB, Mazumdar M Operating characteristics of a rank correlation test for publication bias. Biometrics 1994, 50:1088-1101.
48. Egger M, Davey Smith G, Schneider M, Minder C Bias in meta-analysis detected by a simple, graphical test. BMJ 1997, 315:629-634.
49. Baeza I, Graell M, Moreno D, et al. Cannabis use in children and adolescents with first episode psychosis: influence on psychopathology and short-term outcome (CAFEPS study). Schizophr Res 2009, 113:129-137.
50. Compton MT, Kelley ME, Ramsay CE, et al. Association of pre-onset cannabis, alcohol, and tobacco use with age at onset of prodrome and age at onset of psychosis in first-episode patients. Am J Psychiatry 2009, 166:1251-1257.
51. Hakko H, Lintunen J, Lappalainen J, Mäkikyrö T, Räsänen P, Timonen M Nicotine use and dependence and their association to psychiatric disorders in a large sample of adolescent psychiatric inpatients. Addict Behav 2006, 31:1873-1880. the STUDY-70 Workgroup.
52. Ilomäki R, Riala K, Hakko H, et al. Temporal association of onset of daily smoking with adolescent substance use and psychiatric morbidity. Eur Psychiatry 2008, 23:85-91. the Study 70 Workgroup.
53. Smith GN, Wong H, MacEwan GW, et al. Predictors of starting to smoke cigarettes in patients with first episode psychosis. Schizophr Res 2009, 108:258-264.
54. Perez-Iglesias R, Mata I, Pelayo-Teran JM, et al. Glucose and lipid disturbances after 1 year of antipsychotic treatment in a drug-naïve population. Schizophr Res 2009, 107:115-121.
55. Smith GN, Macewan GW, Kopala LC, et al. Prenatal tobacco exposure in first-episode psychosis. Schizophr Res 2010, 119:271-272.
56. Harrison I, Joyce EM, Mutsatsa SH, et al. Naturalistic follow-up of co-morbid substance use in schizophrenia: the West London first-episode study. Psychol Med 2008, 38:79-88.
57. Curtis J, Henry C, Watkins A, Newall H, Samaras K, Ward PB Metabolic abnormalities in an early psychosis service: a retrospective, naturalistic cross-sectional study. Early Interv Psychiatry 2011, 5:108-114.
58. Hides L, Cotton SM, Berger G, et al. The reliability and validity of the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) in first-episode psychosis. Addict Behav 2009, 34:821-825.
59. Kotov R, Guey LT, Bromet EJ, Schwartz JE Smoking in schizophrenia: diagnostic specificity, symptom correlates, and illness severity. Schizophr Bull 2010, 36:173-181.
60. Barrigón ML, Gurpegui M, Ruiz-Veguilla M, et al. Temporal relationship of first-episode non-affective psychosis with cannabis use: a clinical verification of an epidemiological hypothesis. J Psychiatr Res 2010, 44:413-420.
61. Berk M, Henry LP, Elkins KS, et al. The impact of smoking on clinical outcomes after first episode psychosis: longer-term outcome findings from the EPPIC 800 follow-up study. J Dual Diagn 2010, 6:212-234.
62. McCreadie RG, Paterson JR, Blacklock C, et al. Smoking habits and plasma lipid peroxide and vitamin E levels in never-treated first-episode patients with schizophrenia. Br J Psychiatry 2000, 176:290-293. the Scottish Schizophrenia Research Group.
63. McEvoy JP, Brown S Smoking in first-episode patients with schizophrenia. Am J Psychiatry 1999, 156:1120-1121.
64. Wade D, Harrigan S, Edwards J, Burgess PM, Whelan G, McGorry PD Patterns and predictors of substance use disorders and daily tobacco use in first-episode psychosis. Aust N Z J Psychiatry 2005, 39:892-898.
65. Hilti CC, Delko T, Orosz AT, et al. Sustained attention and planning deficits but intact attentional set-shifting in neuroleptic-naïve first-episode schizophrenia patients. Neuropsychobiology 2010, 61:79-86.
66. Kendler KS, Lönn SL, Sundquist J, Sundquist K Smoking and schizophrenia in population cohorts of Swedish women and men: a prospective co-relative control study. Am J Psychiatry 2015, published online June 5. 10.1176/appi.ajp.2015.15010126.
67. Segarra R, Zabala A, Eguíluz JI, et al. Cognitive performance and smoking in first-episode psychosis: the self-medication hypothesis. Eur Arch Psychiatry Clin Neurosci 2011, 261:241-250.
68. Wade D, Harrigan S, Edwards J, Burgess PM, Whelan G, McGorry PD Course of substance misuse and daily tobacco use in first-episode psychosis. Schizophr Res 2006, 81:145-150.
69. Akvardar Y, Tumuklu M, Akdede BB, Ulas H, Kitis A, Alptekin K Substance use among patients with schizophrenia in a university hospital. Bull Clin Psychopharmacol 2004, 14:191-197.
70. Salokangas RK, Vilkman H, Ilonen T, et al. High levels of dopamine activity in the basal ganglia of cigarette smokers. Am J Psychiatry 2000, 157:632-634.
71. Yildiz M, Yazici A, Böke O Demographic and clinical characteristics in schizophrenia: a multi center cross-sectional case record study. Turk Psikiyatri Derg 2010, 21:213-224. (in Turkish).
72. Kobayashi M, Ito H, Okumura Y, Mayahara K, Matsumoto Y, Hirakawa J Hospital readmission in first-time admitted patients with schizophrenia: smoking patients had higher hospital readmission rate than non-smoking patients. Int J Psychiatry Med 2010, 40:247-257.
73. Mori T, Sasaki T, Iwanami A, et al. Smoking habits in Japanese patients with schizophrenia. Psychiatry Res 2003, 120:207-209.
74. Turan T, Dolu N, Ozsoy S, Esel E Effects of smoking on P50 waveform in schizophrenic patients. Bull Clin Psychopharmacol 2009, 19:227-235.
75. Gelman A Analysis of variance? Why it is more important than ever. Ann Stat 2005, 33:1-53.
76. Zhang XY, Li CB, Li M, et al. Smoking initiation and schizophrenia: a replication study in a Chinese Han population. Schizophr Res 2010, 119:110-114.
77. Ng M, Freeman MK, Fleming TD, et al. Smoking prevalence and cigarette consumption in 187 countries, 1980-2012. JAMA 2014, 311:183-192.
78. McGrath JJ, Najman J, Williams G, Bor W, Scott J Age at first tobacco use and risk of subsequent psychosis-related outcomes: a birth cohort and nested sibling-pair study. In: Abstracts of the 14th International Congress on Schizophrenia Research. Schizophr Bull 2013, 39(suppl 1):S1-376. (S69).
79. Giovino GA, Mirza SA, Samet JM, et al. Tobacco use in 3 billion individuals from 16 countries: an analysis of nationally representative cross-sectional household surveys. Lancet 2012, 380:668-679. the GATS Collaborative Group.
80. Hou YZ, Xiang YT, Yan F, et al. Cigarette smoking in community-dwelling patients with schizophrenia in China. J Psychiatr Res 2011, 45:1551-1556.
81. Sacco KA, Termine A, Seyal A, et al. Effects of cigarette smoking on spatial working memory and attentional deficits in schizophrenia: involvement of nicotinic receptor mechanisms. Arch Gen Psychiatry 2005, 62:649-659.
82. Jacobsen LK, D'Souza DC, Mencl WE, Pugh KR, Skudlarski P, Krystal JH Nicotine effects on brain function and functional connectivity in schizophrenia. Biol Psychiatry 2004, 55:850-858.
83. Chen XS, Li CB, Smith RC, Xiao ZP, Wang JJ Differential sensory gating functions between smokers and non-smokers among drug-naive first episode schizophrenic patients. Psychiatry Res 2011, 188:327-333.
84. Schnur P, Hoffman AC Nicotinic modulation of attentional deficits in schizophrenia. Latent inhibition: cognition, neuroscience and applications to schizophrenia 2010, 477-499. Cambridge University Press, New York. R.E. Lubow, I. Weiner (Eds.).
85. Prochaska JJ, Hall SM, Bero LA Tobacco use among individuals with schizophrenia: what role has the tobacco industry played?. Schizophr Bull 2008, 34:555-567.
86. Hahn B, Harvey AN, Concheiro-Guisan M, Huestis MA, Holcomb HH, Gold JM A test of the cognitive self-medication hypothesis of tobacco smoking in schizophrenia. Biol Psychiatry 2013, 74:436-443.
87. Bradford Hill A The environment and disease: association or causation?. Proc R Soc Med 1965, 58:295-300.
88. Krishnadas R, Jauhar S, Telfer S, Shivashankar S, McCreadie RG Nicotine dependence and illness severity in schizophrenia. Br J Psychiatry 2012, 201:306-312.
89. Seeman P All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2(high) receptors. CNS Neurosci Ther 2011, 17:118-132.
90. Quik M Smoking, nicotine and Parkinson's disease. Trends Neurosci 2004, 27:561-568.
91. Brody AL, Olmstead RE, London ED, et al. Smoking-induced ventral striatum dopamine release. Am J Psychiatry 2004, 161:1211-1218.
92. Howes OD, Kapur S The dopamine hypothesis of schizophrenia: version III-the final common pathway. Schizophr Bull 2009, 35:549-562.
93. Novak G, Seeman P, Le Foll B Exposure to nicotine produces an increase in dopamine D2(high) receptors: a possible mechanism for dopamine hypersensitivity. Int J Neurosci 2010, 120:691-697.
94. Biological insights from 108 schizophrenia-associated genetic loci. Nature 2014, 511:421-427. Schizophrenia Working Group of the Psychiatric Genomics Consortium.
95. Tsoi DT, Porwal M, Webster AC Interventions for smoking cessation and reduction in individuals with schizophrenia. Cochrane Database Syst Rev 2013, 2. CD007253.