메뉴 건너뛰기




Volumn 114, Issue 52, 2017, Pages E11285-E11292

Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice

Author keywords

Ceramides; Diacylglycerol; Mitochondria; Protein kinase ; Protein kinase

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE; ARYLAMINE ACETYLTRANSFERASE 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; DIACYLGLYCEROL; ISOENZYME; N-ACETYLTRANSFERASE 1; PRKCE PROTEIN, MOUSE; PROTEIN KINASE C EPSILON;

EID: 85039703472     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1716990115     Document Type: Article
Times cited : (51)

References (41)
  • 1
    • 0028031569 scopus 로고
    • Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha
    • Hotamisligil GS, Budavari A, Murray D, Spiegelman BM (1994) Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J Clin Invest 94:1543-1549.
    • (1994) J Clin Invest , vol.94 , pp. 1543-1549
    • Hotamisligil, G.S.1    Budavari, A.2    Murray, D.3    Spiegelman, B.M.4
  • 2
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science 259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 3
    • 84991475874 scopus 로고    scopus 로고
    • Calcium signalling and ER stress in insulin resistance and atherosclerosis
    • Ozcan L, Tabas I (2016) Calcium signalling and ER stress in insulin resistance and atherosclerosis. J Intern Med 280:457-464.
    • (2016) J Intern Med , vol.280 , pp. 457-464
    • Ozcan, L.1    Tabas, I.2
  • 4
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: Common threads and missing links
    • Samuel VT, Shulman GI (2012) Mechanisms for insulin resistance: Common threads and missing links. Cell 148:852-871.
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 5
    • 84956666350 scopus 로고    scopus 로고
    • The pathogenesis of insulin resistance: Integrating signaling pathways and substrate flux
    • Samuel VT, Shulman GI (2016) The pathogenesis of insulin resistance: Integrating signaling pathways and substrate flux. J Clin Invest 126:12-22.
    • (2016) J Clin Invest , vol.126 , pp. 12-22
    • Samuel, V.T.1    Shulman, G.I.2
  • 6
    • 84874607649 scopus 로고    scopus 로고
    • Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance
    • Camporez JP, et al. (2013) Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance. Endocrinology 154:1021-1028.
    • (2013) Endocrinology , vol.154 , pp. 1021-1028
    • Camporez, J.P.1
  • 7
    • 84862908245 scopus 로고    scopus 로고
    • Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-boxbinding protein-1 (XBP1) knock-out mice
    • Jurczak MJ, et al. (2012) Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-boxbinding protein-1 (XBP1) knock-out mice. J Biol Chem 287:2558-2567.
    • (2012) J Biol Chem , vol.287 , pp. 2558-2567
    • Jurczak, M.J.1
  • 8
    • 85025647041 scopus 로고    scopus 로고
    • Mitochondrial-targeted catalase protects against high-fat dietinduced muscle insulin resistance by decreasing intramuscular lipid accumulation
    • Lee HY, et al. (2017) Mitochondrial-targeted catalase protects against high-fat dietinduced muscle insulin resistance by decreasing intramuscular lipid accumulation. Diabetes 66:2072-2081.
    • (2017) Diabetes , vol.66 , pp. 2072-2081
    • Lee, H.Y.1
  • 9
    • 84907386500 scopus 로고    scopus 로고
    • Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease
    • Shulman GI (2014) Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med 371:1131-1141.
    • (2014) N Engl J Med , vol.371 , pp. 1131-1141
    • Shulman, G.I.1
  • 10
    • 78651260799 scopus 로고    scopus 로고
    • Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin
    • Holland WL, et al. (2011) Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat Med 17:55-63.
    • (2011) Nat Med , vol.17 , pp. 55-63
    • Holland, W.L.1
  • 11
    • 84938569966 scopus 로고    scopus 로고
    • Targeted induction of ceramide degradation leads to improved systemic metabolism and reduced hepatic steatosis
    • Xia JY, et al. (2015) Targeted induction of ceramide degradation leads to improved systemic metabolism and reduced hepatic steatosis. Cell Metab 22:266-278.
    • (2015) Cell Metab , vol.22 , pp. 266-278
    • Xia, J.Y.1
  • 12
    • 84890467958 scopus 로고    scopus 로고
    • The adipokine/ceramide axis: Key aspects of insulin sensitization
    • Xia JY, Morley TS, Scherer PE (2014) The adipokine/ceramide axis: Key aspects of insulin sensitization. Biochimie 96:130-139.
    • (2014) Biochimie , vol.96 , pp. 130-139
    • Xia, J.Y.1    Morley, T.S.2    Scherer, P.E.3
  • 13
    • 84926364999 scopus 로고    scopus 로고
    • Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene
    • RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) Consortium; EUGENE2 (European Network on Functional Genomics of Type 2 Diabetes) Study; GUARDIAN (Genetics UndeRlying DIAbetes in HispaNics) Consortium; SAPPHIRe (Stanford Asian and Pacific Program for Hypertension and Insulin Resistance) Study
    • Knowles JW, et al.; RISC (Relationship between Insulin Sensitivity and Cardiovascular Disease) Consortium; EUGENE2 (European Network on Functional Genomics of Type 2 Diabetes) Study; GUARDIAN (Genetics UndeRlying DIAbetes in HispaNics) Consortium; SAPPHIRe (Stanford Asian and Pacific Program for Hypertension and Insulin Resistance) Study (2015) Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene. J Clin Invest 125:1739-1751.
    • (2015) J Clin Invest , vol.125 , pp. 1739-1751
    • Knowles, J.W.1
  • 14
    • 84883167011 scopus 로고    scopus 로고
    • Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice
    • Camporez JP, et al. (2013) Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice. Endocrinology 154:3099-3109.
    • (2013) Endocrinology , vol.154 , pp. 3099-3109
    • Camporez, J.P.1
  • 15
    • 84944554813 scopus 로고    scopus 로고
    • Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21
    • Camporez JP, et al. (2015) Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21. J Endocrinol 226:207-217.
    • (2015) J Endocrinol , vol.226 , pp. 207-217
    • Camporez, J.P.1
  • 16
    • 84924530326 scopus 로고    scopus 로고
    • ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content
    • Camporez JP, et al. (2015) ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content. J Lipid Res 56:526-536.
    • (2015) J Lipid Res , vol.56 , pp. 526-536
    • Camporez, J.P.1
  • 17
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • Samuel VT, et al. (2004) Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 279:32345-32353.
    • (2004) J Biol Chem , vol.279 , pp. 32345-32353
    • Samuel, V.T.1
  • 18
    • 33847404482 scopus 로고    scopus 로고
    • Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease
    • Samuel VT, et al. (2007) Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease. J Clin Invest 117:739-745.
    • (2007) J Clin Invest , vol.117 , pp. 739-745
    • Samuel, V.T.1
  • 19
    • 84994613956 scopus 로고    scopus 로고
    • Insulin receptor Thr1160 phosphorylation mediates lipidinduced hepatic insulin resistance
    • Petersen MC, et al. (2016) Insulin receptor Thr1160 phosphorylation mediates lipidinduced hepatic insulin resistance. J Clin Invest 126:4361-4371.
    • (2016) J Clin Invest , vol.126 , pp. 4361-4371
    • Petersen, M.C.1
  • 20
    • 0038025371 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the elderly: Possible role in insulin resistance
    • Petersen KF, et al. (2003) Mitochondrial dysfunction in the elderly: Possible role in insulin resistance. Science 300:1140-1142.
    • (2003) Science , vol.300 , pp. 1140-1142
    • Petersen, K.F.1
  • 21
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • Petersen KF, Dufour S, Befroy D, Garcia R, Shulman GI (2004) Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350:664-671.
    • (2004) N Engl J Med , vol.350 , pp. 664-671
    • Petersen, K.F.1    Dufour, S.2    Befroy, D.3    Garcia, R.4    Shulman, G.I.5
  • 22
    • 84941236856 scopus 로고    scopus 로고
    • Effect of aging on muscle mitochondrial substrate utilization in humans
    • Petersen KF, et al. (2015) Effect of aging on muscle mitochondrial substrate utilization in humans. Proc Natl Acad Sci USA 112:11330-11334.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. 11330-11334
    • Petersen, K.F.1
  • 23
    • 34248141686 scopus 로고    scopus 로고
    • Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients
    • Befroy DE, et al. (2007) Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients. Diabetes 56:1376-1381.
    • (2007) Diabetes , vol.56 , pp. 1376-1381
    • Befroy, D.E.1
  • 24
    • 84922709227 scopus 로고    scopus 로고
    • Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes
    • Perry RJ, et al. (2015) Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell 160:745-758.
    • (2015) Cell , vol.160 , pp. 745-758
    • Perry, R.J.1
  • 25
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI (2000) Cellular mechanisms of insulin resistance. J Clin Invest 106:171-176.
    • (2000) J Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 26
    • 77953868236 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance: Unravelling the mechanism
    • Samuel VT, Petersen KF, Shulman GI (2010) Lipid-induced insulin resistance: Unravelling the mechanism. Lancet 375:2267-2277.
    • (2010) Lancet , vol.375 , pp. 2267-2277
    • Samuel, V.T.1    Petersen, K.F.2    Shulman, G.I.3
  • 27
    • 78649497300 scopus 로고    scopus 로고
    • Targeted expression of catalase to mitochondria prevents ageassociated reductions in mitochondrial function and insulin resistance
    • Lee HY, et al. (2010) Targeted expression of catalase to mitochondria prevents ageassociated reductions in mitochondrial function and insulin resistance. Cell Metab 12: 668-674.
    • (2010) Cell Metab , vol.12 , pp. 668-674
    • Lee, H.Y.1
  • 28
    • 34447130778 scopus 로고    scopus 로고
    • Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance
    • Choi CS, et al. (2007) Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. J Clin Invest 117:1995-2003.
    • (2007) J Clin Invest , vol.117 , pp. 1995-2003
    • Choi, C.S.1
  • 29
    • 8544244084 scopus 로고    scopus 로고
    • PKC-theta knockout mice are protected from fat-induced insulin resistance
    • Kim JK, et al. (2004) PKC-theta knockout mice are protected from fat-induced insulin resistance. J Clin Invest 114:823-827.
    • (2004) J Clin Invest , vol.114 , pp. 823-827
    • Kim, J.K.1
  • 30
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu C, et al. (2002) Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277:50230-50236.
    • (2002) J Biol Chem , vol.277 , pp. 50230-50236
    • Yu, C.1
  • 31
    • 80053627289 scopus 로고    scopus 로고
    • Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
    • Kumashiro N, et al. (2011) Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc Natl Acad Sci USA 108:16381-16385.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 16381-16385
    • Kumashiro, N.1
  • 32
    • 85020297753 scopus 로고    scopus 로고
    • Hepatic diacylglycerol-associated protein kinase Ce translocation links hepatic steatosis to hepatic insulin resistance in humans
    • Ter Horst KW, et al. (2017) Hepatic diacylglycerol-associated protein kinase Ce translocation links hepatic steatosis to hepatic insulin resistance in humans. Cell Rep 19:1997-2004.
    • (2017) Cell Rep , vol.19 , pp. 1997-2004
    • Ter Horst, K.W.1
  • 33
    • 84903691827 scopus 로고    scopus 로고
    • Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
    • Szendroedi J, et al. (2014) Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans. Proc Natl Acad Sci USA 111:9597-9602.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 9597-9602
    • Szendroedi, J.1
  • 34
    • 84887432240 scopus 로고    scopus 로고
    • Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler
    • Perry RJ, et al. (2013) Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. Cell Metab 18:740-748.
    • (2013) Cell Metab , vol.18 , pp. 740-748
    • Perry, R.J.1
  • 35
    • 84924778498 scopus 로고    scopus 로고
    • Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats
    • Perry RJ, Zhang D, Zhang XM, Boyer JL, Shulman GI (2015) Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats. Science 347: 1253-1256.
    • (2015) Science , vol.347 , pp. 1253-1256
    • Perry, R.J.1    Zhang, D.2    Zhang, X.M.3    Boyer, J.L.4    Shulman, G.I.5
  • 36
    • 85004191320 scopus 로고    scopus 로고
    • Nat1 deficiency is associated with mitochondrial dysfunction and exercise intolerance in mice
    • Chennamsetty I, et al. (2016) Nat1 deficiency is associated with mitochondrial dysfunction and exercise intolerance in mice. Cell Rep 17:527-540.
    • (2016) Cell Rep , vol.17 , pp. 527-540
    • Chennamsetty, I.1
  • 37
    • 84856442945 scopus 로고    scopus 로고
    • A guide to analysis of mouse energy metabolism
    • Tschöp MH, et al. (2011) A guide to analysis of mouse energy metabolism. Nat Methods 9:57-63.
    • (2011) Nat Methods , vol.9 , pp. 57-63
    • Tschöp, M.H.1
  • 38
    • 38849199866 scopus 로고    scopus 로고
    • Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice
    • Bonnard C, et al. (2008) Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J Clin Invest 118:789-800.
    • (2008) J Clin Invest , vol.118 , pp. 789-800
    • Bonnard, C.1
  • 39
    • 36749082168 scopus 로고    scopus 로고
    • Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance
    • Zhang D, et al. (2007) Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance. Proc Natl Acad Sci USA 104:17075-17080.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 17075-17080
    • Zhang, D.1
  • 40
    • 31044433308 scopus 로고    scopus 로고
    • Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
    • Morino K, et al. (2005) Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest 115:3587-3593.
    • (2005) J Clin Invest , vol.115 , pp. 3587-3593
    • Morino, K.1
  • 41
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.