메뉴 건너뛰기




Volumn 96, Issue 1, 2014, Pages 130-139

The adipokine/ceramide axis: Key aspects of insulin sensitization

Author keywords

Ceramide target tissues; Ceramides; Insulin sensitivity; Plasma ceramide levels; Sphingolipids

Indexed keywords

ACYL COENZYME A; ADIPOCYTOKINE; ADIPONECTIN; CERAMIDE; CERAMIDE 1 PHOSPHATE; DIACYLGLYCEROL; FIBROBLAST GROWTH FACTOR 21; FINGOLIMOD; FUMONISIN; G PROTEIN COUPLED RECEPTOR; HIGH DENSITY LIPOPROTEIN; INSULIN; LEPTIN; LIPOPROTEIN LIPASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; UNSATURATED FATTY ACID;

EID: 84890467958     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2013.08.013     Document Type: Review
Times cited : (46)

References (104)
  • 1
    • 45149106053 scopus 로고    scopus 로고
    • Sphingolipids, insulin resistance, and metabolic disease: New insights from in vivo manipulation of sphingolipid metabolism
    • W.L. Holland, and S.A. Summers Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism Endocr. Rev. 29 2008 381 402
    • (2008) Endocr. Rev. , vol.29 , pp. 381-402
    • Holland, W.L.1    Summers, S.A.2
  • 4
    • 84860497397 scopus 로고    scopus 로고
    • Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance
    • F.R. Jornayvaz, and G.I. Shulman Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance Cell Metab. 15 2012 574 584
    • (2012) Cell Metab. , vol.15 , pp. 574-584
    • Jornayvaz, F.R.1    Shulman, G.I.2
  • 6
    • 84876440399 scopus 로고    scopus 로고
    • Nutritional challenges and health implications of takeaway and fast food
    • A. Jaworowska, T. Blackham, I.G. Davies, and L. Stevenson Nutritional challenges and health implications of takeaway and fast food Nutr. Rev. 71 2013 310 318
    • (2013) Nutr. Rev. , vol.71 , pp. 310-318
    • Jaworowska, A.1    Blackham, T.2    Davies, I.G.3    Stevenson, L.4
  • 8
    • 78049518892 scopus 로고    scopus 로고
    • An overview of sphingolipid metabolism: From synthesis to breakdown
    • C.R. Gault, L.M. Obeid, and Y.A. Hannun An overview of sphingolipid metabolism: from synthesis to breakdown Adv. Exp. Med. Biol. 688 2010 1 23
    • (2010) Adv. Exp. Med. Biol. , vol.688 , pp. 1-23
    • Gault, C.R.1    Obeid, L.M.2    Hannun, Y.A.3
  • 9
    • 77956040410 scopus 로고    scopus 로고
    • Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: Reversal and improvement of glucose tolerance by lipid metabolism inhibitors
    • G. Frangioudakis, J. Garrard, K. Raddatz, J.L. Nadler, T.W. Mitchell, and C. Schmitz-Peiffer Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors Endocrinology 151 2010 4187 4196
    • (2010) Endocrinology , vol.151 , pp. 4187-4196
    • Frangioudakis, G.1    Garrard, J.2    Raddatz, K.3    Nadler, J.L.4    Mitchell, T.W.5    Schmitz-Peiffer, C.6
  • 11
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • K.T. Uysal, S.M. Wiesbrock, M.W. Marino, and G.S. Hotamisligil Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function Nature 389 1997 610 614
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 13
    • 33845292894 scopus 로고    scopus 로고
    • Neutral sphingomyelinases and nSMase2: Bridging the gaps
    • C.J. Clarke, and Y.A. Hannun Neutral sphingomyelinases and nSMase2: bridging the gaps Biochim. Biophys. Acta 1758 2006 1893 1901
    • (2006) Biochim. Biophys. Acta , vol.1758 , pp. 1893-1901
    • Clarke, C.J.1    Hannun, Y.A.2
  • 14
    • 84873048185 scopus 로고    scopus 로고
    • Plasma ceramides target skeletal muscle in type 2 diabetes
    • J.P. Kirwan Plasma ceramides target skeletal muscle in type 2 diabetes Diabetes 62 2013 352 354
    • (2013) Diabetes , vol.62 , pp. 352-354
    • Kirwan, J.P.1
  • 15
    • 63249117466 scopus 로고    scopus 로고
    • Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
    • J.M. Haus, S.R. Kashyap, T. Kasumov, R. Zhang, K.R. Kelly, R.A. Defronzo, and J.P. Kirwan Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance Diabetes 58 2009 337 343
    • (2009) Diabetes , vol.58 , pp. 337-343
    • Haus, J.M.1    Kashyap, S.R.2    Kasumov, T.3    Zhang, R.4    Kelly, K.R.5    Defronzo, R.A.6    Kirwan, J.P.7
  • 17
    • 64349124701 scopus 로고    scopus 로고
    • Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry
    • P. Wiesner, K. Leidl, A. Boettcher, G. Schmitz, and G. Liebisch Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry J. Lipid Res. 50 2009 574 585
    • (2009) J. Lipid Res. , vol.50 , pp. 574-585
    • Wiesner, P.1    Leidl, K.2    Boettcher, A.3    Schmitz, G.4    Liebisch, G.5
  • 18
    • 84862274671 scopus 로고    scopus 로고
    • Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): Potential mechanism of apoptosis induction in Alzheimer disease (AD)
    • G. Wang, M. Dinkins, Q. He, G. Zhu, C. Poirier, A. Campbell, M. Mayer-Proschel, and E. Bieberich Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD) J. Biol. Chem. 287 2012 21384 21395
    • (2012) J. Biol. Chem. , vol.287 , pp. 21384-21395
    • Wang, G.1    Dinkins, M.2    He, Q.3    Zhu, G.4    Poirier, C.5    Campbell, A.6    Mayer-Proschel, M.7    Bieberich, E.8
  • 23
    • 0347985272 scopus 로고    scopus 로고
    • Obesity-induced inflammatory changes in adipose tissue
    • K.E. Wellen, and G.S. Hotamisligil Obesity-induced inflammatory changes in adipose tissue J. Clin. Invest. 112 2003 1785 1788
    • (2003) J. Clin. Invest. , vol.112 , pp. 1785-1788
    • Wellen, K.E.1    Hotamisligil, G.S.2
  • 25
    • 19044393872 scopus 로고    scopus 로고
    • Adipose tissue, inflammation, and cardiovascular disease
    • A.H. Berg, and P.E. Scherer Adipose tissue, inflammation, and cardiovascular disease Circ. Res. 96 2005 939 949
    • (2005) Circ. Res. , vol.96 , pp. 939-949
    • Berg, A.H.1    Scherer, P.E.2
  • 27
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    • C.N. Lumeng, S.M. Deyoung, J.L. Bodzin, and A.R. Saltiel Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity Diabetes 56 2007 16 23
    • (2007) Diabetes , vol.56 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3    Saltiel, A.R.4
  • 30
    • 71849107705 scopus 로고    scopus 로고
    • Distinct receptor-mediated activities in macrophages for natural ceramide-1-phosphate (C1P) and for phospho-ceramide analogue-1 (PCERA-1)
    • M. Levi, M.M. Meijler, A. Gomez-Munoz, and T. Zor Distinct receptor-mediated activities in macrophages for natural ceramide-1-phosphate (C1P) and for phospho-ceramide analogue-1 (PCERA-1) Mol. Cell. Endocrinol. 314 2010 248 255
    • (2010) Mol. Cell. Endocrinol. , vol.314 , pp. 248-255
    • Levi, M.1    Meijler, M.M.2    Gomez-Munoz, A.3    Zor, T.4
  • 31
    • 0037352702 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages
    • M. Ojaniemi, V. Glumoff, K. Harju, M. Liljeroos, K. Vuori, and M. Hallman Phosphatidylinositol 3-kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages Eur. J. Immunol. 33 2003 597 605
    • (2003) Eur. J. Immunol. , vol.33 , pp. 597-605
    • Ojaniemi, M.1    Glumoff, V.2    Harju, K.3    Liljeroos, M.4    Vuori, K.5    Hallman, M.6
  • 32
    • 79961209264 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-kinase-Akt signaling pathway in the age-related cytokine dysregulation in splenic macrophages stimulated via TLR-2 or TLR-4 receptors
    • M.P. Fallah, R.L. Chelvarajan, B.A. Garvy, and S. Bondada Role of phosphoinositide 3-kinase-Akt signaling pathway in the age-related cytokine dysregulation in splenic macrophages stimulated via TLR-2 or TLR-4 receptors Mech. Ageing Dev. 132 2011 274 286
    • (2011) Mech. Ageing Dev. , vol.132 , pp. 274-286
    • Fallah, M.P.1    Chelvarajan, R.L.2    Garvy, B.A.3    Bondada, S.4
  • 33
    • 0842282983 scopus 로고    scopus 로고
    • Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages
    • A. Gomez-Munoz, J.Y. Kong, B. Salh, and U.P. Steinbrecher Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages J. Lipid Res. 45 2004 99 105
    • (2004) J. Lipid Res. , vol.45 , pp. 99-105
    • Gomez-Munoz, A.1    Kong, J.Y.2    Salh, B.3    Steinbrecher, U.P.4
  • 34
    • 39149141339 scopus 로고    scopus 로고
    • Ceramide 1-phosphate stimulates macrophage proliferation through activation of the PI3-kinase/PKB, JNK and ERK1/2 pathways
    • P. Gangoiti, M.H. Granado, S.W. Wang, J.Y. Kong, U.P. Steinbrecher, and A. Gomez-Munoz Ceramide 1-phosphate stimulates macrophage proliferation through activation of the PI3-kinase/PKB, JNK and ERK1/2 pathways Cell Signal 20 2008 726 736
    • (2008) Cell Signal , vol.20 , pp. 726-736
    • Gangoiti, P.1    Granado, M.H.2    Wang, S.W.3    Kong, J.Y.4    Steinbrecher, U.P.5    Gomez-Munoz, A.6
  • 37
    • 84864802528 scopus 로고    scopus 로고
    • The sphingosine-1-phosphate analogue FTY720 impairs mucosal immunity and clearance of the enteric pathogen Citrobacter rodentium
    • C.T. Murphy, L.J. Hall, G. Hurley, A. Quinlan, J. MacSharry, F. Shanahan, K. Nally, and S. Melgar The sphingosine-1-phosphate analogue FTY720 impairs mucosal immunity and clearance of the enteric pathogen Citrobacter rodentium Infect. Immun. 80 2012 2712 2723
    • (2012) Infect. Immun. , vol.80 , pp. 2712-2723
    • Murphy, C.T.1    Hall, L.J.2    Hurley, G.3    Quinlan, A.4    MacSharry, J.5    Shanahan, F.6    Nally, K.7    Melgar, S.8
  • 39
    • 79751527693 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis
    • P. Keul, S. Lucke, K. von Wnuck Lipinski, C. Bode, M. Graler, G. Heusch, and B. Levkau Sphingosine-1-phosphate receptor 3 promotes recruitment of monocyte/macrophages in inflammation and atherosclerosis Circ. Res. 108 2011 314 323
    • (2011) Circ. Res. , vol.108 , pp. 314-323
    • Keul, P.1    Lucke, S.2    Von Wnuck Lipinski, K.3    Bode, C.4    Graler, M.5    Heusch, G.6    Levkau, B.7
  • 41
    • 33846688688 scopus 로고    scopus 로고
    • FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice
    • J.R. Nofer, M. Bot, M. Brodde, P.J. Taylor, P. Salm, V. Brinkmann, T. van Berkel, G. Assmann, and E.A. Biessen FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice Circulation 115 2007 501 508
    • (2007) Circulation , vol.115 , pp. 501-508
    • Nofer, J.R.1    Bot, M.2    Brodde, M.3    Taylor, P.J.4    Salm, P.5    Brinkmann, V.6    Van Berkel, T.7    Assmann, G.8    Biessen, E.A.9
  • 43
    • 52949142682 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A manifestation of the metabolic syndrome
    • C.H. Kim, and Z.M. Younossi Nonalcoholic fatty liver disease: a manifestation of the metabolic syndrome Cleve. Clin. J. Med. 75 2008 721 728
    • (2008) Cleve. Clin. J. Med. , vol.75 , pp. 721-728
    • Kim, C.H.1    Younossi, Z.M.2
  • 44
    • 34548306754 scopus 로고    scopus 로고
    • Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: Present and future
    • A. Wieckowska, A.J. McCullough, and A.E. Feldstein Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future Hepatology 46 2007 582 589
    • (2007) Hepatology , vol.46 , pp. 582-589
    • Wieckowska, A.1    McCullough, A.J.2    Feldstein, A.E.3
  • 45
    • 33748150370 scopus 로고    scopus 로고
    • Pathophysiology of nonalcoholic steatohepatitis
    • A.J. McCullough Pathophysiology of nonalcoholic steatohepatitis J. Clin. Gastroenterol. 40 Suppl. 1 2006 S17 S29
    • (2006) J. Clin. Gastroenterol. , vol.40 , Issue.SUPPL. 1
    • McCullough, A.J.1
  • 46
    • 48649110854 scopus 로고    scopus 로고
    • The role of fatty acids in the development and progression of nonalcoholic fatty liver disease
    • C.L. Gentile, and M.J. Pagliassotti The role of fatty acids in the development and progression of nonalcoholic fatty liver disease J. Nutr. Biochem. 19 2008 567 576
    • (2008) J. Nutr. Biochem. , vol.19 , pp. 567-576
    • Gentile, C.L.1    Pagliassotti, M.J.2
  • 47
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two «hits»?
    • C.P. Day, and O.F. James Steatohepatitis: a tale of two «hits»? Gastroenterology 114 1998 842 845
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 48
    • 0032478314 scopus 로고    scopus 로고
    • Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
    • M. Shimabukuro, Y.T. Zhou, M. Levi, and R.H. Unger Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes Proc. Natl. Acad. Sci. U S A 95 1998 2498 2502
    • (1998) Proc. Natl. Acad. Sci. U S A , vol.95 , pp. 2498-2502
    • Shimabukuro, M.1    Zhou, Y.T.2    Levi, M.3    Unger, R.H.4
  • 49
    • 20444405347 scopus 로고    scopus 로고
    • Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1
    • T. Yamazaki, E. Sasaki, C. Kakinuma, T. Yano, S. Miura, and O. Ezaki Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1 J. Biol. Chem. 280 2005 21506 21514
    • (2005) J. Biol. Chem. , vol.280 , pp. 21506-21514
    • Yamazaki, T.1    Sasaki, E.2    Kakinuma, C.3    Yano, T.4    Miura, S.5    Ezaki, O.6
  • 50
    • 79959517565 scopus 로고    scopus 로고
    • Human fatty liver disease: Old questions and new insights
    • J.C. Cohen, J.D. Horton, and H.H. Hobbs Human fatty liver disease: old questions and new insights Science 332 2011 1519 1523
    • (2011) Science , vol.332 , pp. 1519-1523
    • Cohen, J.C.1    Horton, J.D.2    Hobbs, H.H.3
  • 55
    • 0141844653 scopus 로고    scopus 로고
    • Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids
    • J.Y. Lee, J. Ye, Z. Gao, H.S. Youn, W.H. Lee, L. Zhao, N. Sizemore, and D.H. Hwang Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids J. Biol. Chem. 278 2003 37041 37051
    • (2003) J. Biol. Chem. , vol.278 , pp. 37041-37051
    • Lee, J.Y.1    Ye, J.2    Gao, Z.3    Youn, H.S.4    Lee, W.H.5    Zhao, L.6    Sizemore, N.7    Hwang, D.H.8
  • 56
    • 0035907302 scopus 로고    scopus 로고
    • Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    • J.Y. Lee, K.H. Sohn, S.H. Rhee, and D. Hwang Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4 J. Biol. Chem. 276 2001 16683 16689
    • (2001) J. Biol. Chem. , vol.276 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 57
    • 33745828301 scopus 로고    scopus 로고
    • Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
    • Y. Wei, D. Wang, F. Topczewski, and M.J. Pagliassotti Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells Am. J. Physiol. Endocrinol. Metab. 291 2006 E275 E281
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.291
    • Wei, Y.1    Wang, D.2    Topczewski, F.3    Pagliassotti, M.J.4
  • 61
    • 56649094325 scopus 로고    scopus 로고
    • Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
    • H. Malhi, and G.J. Gores Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease Semin. Liver Dis. 28 2008 360 369
    • (2008) Semin. Liver Dis. , vol.28 , pp. 360-369
    • Malhi, H.1    Gores, G.J.2
  • 62
    • 43249092409 scopus 로고    scopus 로고
    • Hepatic triglyceride synthesis and nonalcoholic fatty liver disease
    • S.S. Choi, and A.M. Diehl Hepatic triglyceride synthesis and nonalcoholic fatty liver disease Curr. Opin. Lipidol. 19 2008 295 300
    • (2008) Curr. Opin. Lipidol. , vol.19 , pp. 295-300
    • Choi, S.S.1    Diehl, A.M.2
  • 63
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • P.E. Scherer, S. Williams, M. Fogliano, G. Baldini, and H.F. Lodish A novel serum protein similar to C1q, produced exclusively in adipocytes J. Biol. Chem. 270 1995 26746 26749
    • (1995) J. Biol. Chem. , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 64
    • 84866133825 scopus 로고    scopus 로고
    • Adiponectin: Mechanistic insights and clinical implications
    • A.T. Turer, and P.E. Scherer Adiponectin: mechanistic insights and clinical implications Diabetologia 55 2012 2319 2326
    • (2012) Diabetologia , vol.55 , pp. 2319-2326
    • Turer, A.T.1    Scherer, P.E.2
  • 66
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • A.H. Berg, T. Combs, X. Du, M. Brownlee, and P.E. Scherer The adipocyte-secreted protein Acrp30 enhances hepatic insulin action Nat. Med. 7 2001 947 953
    • (2001) Nat. Med. , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 67
    • 0035663963 scopus 로고    scopus 로고
    • Endogenous glucose production is inhibited by the adipose-derived protein Acrp30
    • T.P. Combs, A.H. Berg, S. Obici, P.E. Scherer, and L. Rossetti Endogenous glucose production is inhibited by the adipose-derived protein Acrp30 J. Clin. Invest. 108 2001 1875 1881
    • (2001) J. Clin. Invest. , vol.108 , pp. 1875-1881
    • Combs, T.P.1    Berg, A.H.2    Obici, S.3    Scherer, P.E.4    Rossetti, L.5
  • 69
    • 58849119649 scopus 로고    scopus 로고
    • Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease
    • H. Ma, V. Gomez, L. Lu, X. Yang, X. Wu, and S.Y. Xiao Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease J. Gastroenterol. Hepatol. 24 2009 233 237
    • (2009) J. Gastroenterol. Hepatol. , vol.24 , pp. 233-237
    • Ma, H.1    Gomez, V.2    Lu, L.3    Yang, X.4    Wu, X.5    Xiao, S.Y.6
  • 71
    • 0032569026 scopus 로고    scopus 로고
    • Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis
    • H. Zhou, S.A. Summers, M.J. Birnbaum, and R.N. Pittman Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis J. Biol. Chem. 273 1998 16568 16575
    • (1998) J. Biol. Chem. , vol.273 , pp. 16568-16575
    • Zhou, H.1    Summers, S.A.2    Birnbaum, M.J.3    Pittman, R.N.4
  • 72
    • 0031841949 scopus 로고    scopus 로고
    • Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide
    • S.A. Summers, L.A. Garza, H. Zhou, and M.J. Birnbaum Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide Mol. Cell. Biol. 18 1998 5457 5464
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 5457-5464
    • Summers, S.A.1    Garza, L.A.2    Zhou, H.3    Birnbaum, M.J.4
  • 73
    • 33645799492 scopus 로고    scopus 로고
    • Mechanisms of liver Injury. I. TNF-alpha-induced liver injury: Role of IKK, JNK, and ROS pathways
    • R.F. Schwabe, and D.A. Brenner Mechanisms of liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways Am. J. Physiol. Gastrointest. Liver Physiol. 290 2006 G583 G589
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.290
    • Schwabe, R.F.1    Brenner, D.A.2
  • 74
    • 31644443192 scopus 로고    scopus 로고
    • Ceramides in insulin resistance and lipotoxicity
    • S.A. Summers Ceramides in insulin resistance and lipotoxicity Prog. Lipid Res. 45 2006 42 72
    • (2006) Prog. Lipid Res. , vol.45 , pp. 42-72
    • Summers, S.A.1
  • 75
    • 33747356154 scopus 로고    scopus 로고
    • Adipose tissue: From lipid storage compartment to endocrine organ
    • P.E. Scherer Adipose tissue: from lipid storage compartment to endocrine organ Diabetes 55 2006 1537 1545
    • (2006) Diabetes , vol.55 , pp. 1537-1545
    • Scherer, P.E.1
  • 77
    • 0027324558 scopus 로고
    • Through thick and thin: Wasting, obesity, and TNFa
    • B.M. Spiegelman, and G.S. Hotamisligil Through thick and thin: wasting, obesity, and TNFa Cell 73 1993 625 627
    • (1993) Cell , vol.73 , pp. 625-627
    • Spiegelman, B.M.1    Hotamisligil, G.S.2
  • 78
    • 0028587742 scopus 로고
    • Tumor necrosis factor alpha: A key component of the obesity-diabetes link
    • G.S. Hotamisligil, and B.M. Spiegelman Tumor necrosis factor alpha: a key component of the obesity-diabetes link Diabetes 43 1994 1271 1278
    • (1994) Diabetes , vol.43 , pp. 1271-1278
    • Hotamisligil, G.S.1    Spiegelman, B.M.2
  • 79
    • 0029853098 scopus 로고    scopus 로고
    • Lipid mediators of insulin resistance: Ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes
    • S.D. Long, and P.H. Pekala Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes Biochem. J. 319 Pt 1 1996 179 184
    • (1996) Biochem. J. , vol.319 , Issue.PART 1 , pp. 179-184
    • Long, S.D.1    Pekala, P.H.2
  • 82
    • 0032484132 scopus 로고    scopus 로고
    • Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression
    • M. Shimabukuro, M. Higa, Y.T. Zhou, M.Y. Wang, C.B. Newgard, and R.H. Unger Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression J. Biol. Chem. 273 1998 32487 32490
    • (1998) J. Biol. Chem. , vol.273 , pp. 32487-32490
    • Shimabukuro, M.1    Higa, M.2    Zhou, Y.T.3    Wang, M.Y.4    Newgard, C.B.5    Unger, R.H.6
  • 83
    • 79952836464 scopus 로고    scopus 로고
    • A lipidomic screen of palmitate-treated MIN6 beta-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking
    • E. Boslem, G. MacIntosh, A.M. Preston, C. Bartley, A.K. Busch, M. Fuller, D.R. Laybutt, P.J. Meikle, and T.J. Biden A lipidomic screen of palmitate-treated MIN6 beta-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking Biochem. J. 435 2011 267 276
    • (2011) Biochem. J. , vol.435 , pp. 267-276
    • Boslem, E.1    MacIntosh, G.2    Preston, A.M.3    Bartley, C.4    Busch, A.K.5    Fuller, M.6    Laybutt, D.R.7    Meikle, P.J.8    Biden, T.J.9
  • 84
    • 23944484541 scopus 로고    scopus 로고
    • Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: Potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell
    • R. Veluthakal, R. Palanivel, Y. Zhao, P. McDonald, S. Gruber, and A. Kowluru Ceramide induces mitochondrial abnormalities in insulin-secreting INS-1 cells: potential mechanisms underlying ceramide-mediated metabolic dysfunction of the beta cell Apoptosis 10 2005 841 850
    • (2005) Apoptosis , vol.10 , pp. 841-850
    • Veluthakal, R.1    Palanivel, R.2    Zhao, Y.3    McDonald, P.4    Gruber, S.5    Kowluru, A.6
  • 85
    • 0035156817 scopus 로고    scopus 로고
    • Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function
    • K. Maedler, G.A. Spinas, D. Dyntar, W. Moritz, N. Kaiser, and M.Y. Donath Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function Diabetes 50 2001 69 76
    • (2001) Diabetes , vol.50 , pp. 69-76
    • Maedler, K.1    Spinas, G.A.2    Dyntar, D.3    Moritz, W.4    Kaiser, N.5    Donath, M.Y.6
  • 88
    • 0034612304 scopus 로고    scopus 로고
    • Ceramide interaction with the respiratory chain of heart mitochondria
    • M. Di Paola, T. Cocco, and M. Lorusso Ceramide interaction with the respiratory chain of heart mitochondria Biochemistry 39 2000 6660 6668
    • (2000) Biochemistry , vol.39 , pp. 6660-6668
    • Di Paola, M.1    Cocco, T.2    Lorusso, M.3
  • 91
  • 96
    • 0032971214 scopus 로고    scopus 로고
    • Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats
    • Y. Minokoshi, M.S. Haque, and T. Shimazu Microinjection of leptin into the ventromedial hypothalamus increases glucose uptake in peripheral tissues in rats Diabetes 48 1999 287 291
    • (1999) Diabetes , vol.48 , pp. 287-291
    • Minokoshi, Y.1    Haque, M.S.2    Shimazu, T.3
  • 97
    • 58149458134 scopus 로고    scopus 로고
    • Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue
    • E. Bonzon-Kulichenko, D. Schwudke, N. Gallardo, E. Molto, T. Fernandez-Agullo, A. Shevchenko, and A. Andres Central leptin regulates total ceramide content and sterol regulatory element binding protein-1C proteolytic maturation in rat white adipose tissue Endocrinology 150 2009 169 178
    • (2009) Endocrinology , vol.150 , pp. 169-178
    • Bonzon-Kulichenko, E.1    Schwudke, D.2    Gallardo, N.3    Molto, E.4    Fernandez-Agullo, T.5    Shevchenko, A.6    Andres, A.7
  • 98
    • 84857185764 scopus 로고    scopus 로고
    • Endocrine fibroblast growth factors 15/19 and 21: From feast to famine
    • M.J. Potthoff, S.A. Kliewer, and D.J. Mangelsdorf Endocrine fibroblast growth factors 15/19 and 21: from feast to famine Genes Dev. 26 2012 312 324
    • (2012) Genes Dev. , vol.26 , pp. 312-324
    • Potthoff, M.J.1    Kliewer, S.A.2    Mangelsdorf, D.J.3
  • 101
    • 84863012459 scopus 로고    scopus 로고
    • Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones
    • P.A. Dutchak, T. Katafuchi, A.L. Bookout, J.H. Choi, R.T. Yu, D.J. Mangelsdorf, and S.A. Kliewer Fibroblast growth factor-21 regulates PPARgamma activity and the antidiabetic actions of thiazolidinediones Cell 148 2012 556 567
    • (2012) Cell , vol.148 , pp. 556-567
    • Dutchak, P.A.1    Katafuchi, T.2    Bookout, A.L.3    Choi, J.H.4    Yu, R.T.5    Mangelsdorf, D.J.6    Kliewer, S.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.