Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes

Science Signaling

Volumn 10, Issue 509, 2017, Pages

  Molony, Ryan D ^a   Nguyen, Jenny T ^a   Kong, Yong ^a   Montgomery, Ruth R ^a   Shaw, Albert C ^a   Iwasaki, Akiko ^a,b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERFERON; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON L1; INTERFERON REGULATORY FACTOR 1; INTERFERON REGULATORY FACTOR 2; INTERFERON REGULATORY FACTOR 3; INTERFERON REGULATORY FACTOR 4; INTERFERON REGULATORY FACTOR 5; INTERFERON REGULATORY FACTOR 6; INTERFERON REGULATORY FACTOR 7; INTERFERON REGULATORY FACTOR 9; MESSENGER RNA; RETINOIC ACID INDUCIBLE PROTEIN I; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; UNCLASSIFIED DRUG; DDX58 PROTEIN, HUMAN;

ADULT; AGED; AGING; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; INFLUENZA A VIRUS; INTERFERON INDUCTION; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; CYTOLOGY; FEMALE; IMMUNOLOGY; INNATE IMMUNITY; MALE; MONOCYTE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AGING; DEAD BOX PROTEIN 58; FEMALE; HUMANS; IMMUNITY, INNATE; INTERFERONS; MALE; MONOCYTES; SIGNAL TRANSDUCTION;

EID: 85038420367     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.aan2392     Document Type: Article

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